Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Hepatoma-derived growth factor-related protein 3

Gene

Hdgfrp3

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Enhances DNA synthesis and may play a role in cell proliferation.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Growth factor

Names & Taxonomyi

Protein namesi
Recommended name:
Hepatoma-derived growth factor-related protein 3
Short name:
HRP-3
Gene namesi
Name:Hdgfrp3
Synonyms:Hrp3
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi628773. Hdgfrp3.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 202202Hepatoma-derived growth factor-related protein 3PRO_0000191705Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei110 – 1101PhosphothreonineBy similarity
Modified residuei121 – 1211PhosphoserineCombined sources
Modified residuei122 – 1221PhosphoserineCombined sources
Modified residuei161 – 1611PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ923W4.

PTM databases

iPTMnetiQ923W4.
PhosphoSiteiQ923W4.

Expressioni

Gene expression databases

GenevisibleiQ923W4. RN.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi251682. 1 interaction.
STRINGi10116.ENSRNOP00000026754.

Structurei

3D structure databases

ProteinModelPortaliQ923W4.
SMRiQ923W4. Positions 8-91.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini11 – 6858PWWPPROSITE-ProRule annotationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi135 – 14713Nuclear localization signalSequence analysisAdd
BLAST

Sequence similaritiesi

Contains 1 PWWP domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG410KCQ5. Eukaryota.
ENOG41127WD. LUCA.
GeneTreeiENSGT00530000063013.
HOGENOMiHOG000112874.
HOVERGENiHBG010574.
InParanoidiQ923W4.
OMAiFTGYQAM.
OrthoDBiEOG7NKKMQ.
PhylomeDBiQ923W4.

Family and domain databases

InterProiIPR000313. PWWP_dom.
[Graphical view]
PfamiPF00855. PWWP. 1 hit.
[Graphical view]
SMARTiSM00293. PWWP. 1 hit.
[Graphical view]
PROSITEiPS50812. PWWP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q923W4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARPRPREYK AGDLVFAKMK GYPHWPARID ELPEGAVKPP ANKYPIFFFG
60 70 80 90 100
THETAFLGPK DLFPYKEYKD KFGKSNKRKG FNEGLWEIEN NPGVKFTGYQ
110 120 130 140 150
TIQQQSSSET EGEGGNTADA SSEEEGDRVE DGKGKRKNEK GGSKRKKSYT
160 170 180 190 200
SKKSSKQSRK SPGDEDDKDC KEEENKSSSE GGDAGNDTRN TTSDLQKAGE

GT
Length:202
Mass (Da):22,447
Last modified:December 1, 2001 - v1
Checksum:iFCCDEBBD2BEAB8D6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF389347 mRNA. Translation: AAK72965.1.
RefSeqiNP_665728.1. NM_145785.1.
UniGeneiRn.17383.

Genome annotation databases

EnsembliENSRNOT00000026754; ENSRNOP00000026754; ENSRNOG00000019740.
GeneIDi252941.
KEGGirno:252941.
UCSCiRGD:628773. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF389347 mRNA. Translation: AAK72965.1.
RefSeqiNP_665728.1. NM_145785.1.
UniGeneiRn.17383.

3D structure databases

ProteinModelPortaliQ923W4.
SMRiQ923W4. Positions 8-91.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi251682. 1 interaction.
STRINGi10116.ENSRNOP00000026754.

PTM databases

iPTMnetiQ923W4.
PhosphoSiteiQ923W4.

Proteomic databases

PaxDbiQ923W4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000026754; ENSRNOP00000026754; ENSRNOG00000019740.
GeneIDi252941.
KEGGirno:252941.
UCSCiRGD:628773. rat.

Organism-specific databases

CTDi50810.
RGDi628773. Hdgfrp3.

Phylogenomic databases

eggNOGiENOG410KCQ5. Eukaryota.
ENOG41127WD. LUCA.
GeneTreeiENSGT00530000063013.
HOGENOMiHOG000112874.
HOVERGENiHBG010574.
InParanoidiQ923W4.
OMAiFTGYQAM.
OrthoDBiEOG7NKKMQ.
PhylomeDBiQ923W4.

Miscellaneous databases

PROiQ923W4.

Gene expression databases

GenevisibleiQ923W4. RN.

Family and domain databases

InterProiIPR000313. PWWP_dom.
[Graphical view]
PfamiPF00855. PWWP. 1 hit.
[Graphical view]
SMARTiSM00293. PWWP. 1 hit.
[Graphical view]
PROSITEiPS50812. PWWP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Yu L.
    Submitted (JUN-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues."
    Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C., Olsen J.V.
    Nat. Commun. 3:876-876(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-121; SER-122 AND SER-161, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiHDGR3_RAT
AccessioniPrimary (citable) accession number: Q923W4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 21, 2005
Last sequence update: December 1, 2001
Last modified: June 8, 2016
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.