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Protein

Hepatoma-derived growth factor-related protein 3

Gene

Hdgfl3

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Enhances DNA synthesis and may play a role in cell proliferation.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGrowth factor

Names & Taxonomyi

Protein namesi
Recommended name:
Hepatoma-derived growth factor-related protein 3
Short name:
HRP-3
Gene namesi
Name:Hdgfl3
Synonyms:Hdgfrp3, Hrp3
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi628773. Hdgfrp3.

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001917051 – 202Hepatoma-derived growth factor-related protein 3Add BLAST202

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei110PhosphothreonineBy similarity1
Modified residuei121PhosphoserineCombined sources1
Modified residuei122PhosphoserineCombined sources1
Modified residuei161PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ923W4.

PTM databases

iPTMnetiQ923W4.
PhosphoSitePlusiQ923W4.

Expressioni

Gene expression databases

BgeeiENSRNOG00000019740.
GenevisibleiQ923W4. RN.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi251682. 1 interactor.
STRINGi10116.ENSRNOP00000026754.

Structurei

3D structure databases

ProteinModelPortaliQ923W4.
SMRiQ923W4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini11 – 68PWWPPROSITE-ProRule annotationAdd BLAST58

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi135 – 147Nuclear localization signalSequence analysisAdd BLAST13

Phylogenomic databases

eggNOGiENOG410KCQ5. Eukaryota.
ENOG41127WD. LUCA.
GeneTreeiENSGT00530000063013.
HOGENOMiHOG000112874.
HOVERGENiHBG010574.
InParanoidiQ923W4.
OMAiFTGYQAM.
OrthoDBiEOG091G045X.
PhylomeDBiQ923W4.

Family and domain databases

CDDicd05834. HDGF_related. 1 hit.
InterProiView protein in InterPro
IPR035496. HDGF-rel_PWWP.
IPR000313. PWWP_dom.
PfamiView protein in Pfam
PF00855. PWWP. 1 hit.
SMARTiView protein in SMART
SM00293. PWWP. 1 hit.
PROSITEiView protein in PROSITE
PS50812. PWWP. 1 hit.

Sequencei

Sequence statusi: Complete.

Q923W4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARPRPREYK AGDLVFAKMK GYPHWPARID ELPEGAVKPP ANKYPIFFFG
60 70 80 90 100
THETAFLGPK DLFPYKEYKD KFGKSNKRKG FNEGLWEIEN NPGVKFTGYQ
110 120 130 140 150
TIQQQSSSET EGEGGNTADA SSEEEGDRVE DGKGKRKNEK GGSKRKKSYT
160 170 180 190 200
SKKSSKQSRK SPGDEDDKDC KEEENKSSSE GGDAGNDTRN TTSDLQKAGE

GT
Length:202
Mass (Da):22,447
Last modified:December 1, 2001 - v1
Checksum:iFCCDEBBD2BEAB8D6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF389347 mRNA. Translation: AAK72965.1.
RefSeqiNP_665728.1. NM_145785.1.
UniGeneiRn.17383.

Genome annotation databases

EnsembliENSRNOT00000026754; ENSRNOP00000026754; ENSRNOG00000019740.
GeneIDi252941.
KEGGirno:252941.
UCSCiRGD:628773. rat.

Similar proteinsi

Entry informationi

Entry nameiHDGR3_RAT
AccessioniPrimary (citable) accession number: Q923W4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 21, 2005
Last sequence update: December 1, 2001
Last modified: August 30, 2017
This is version 80 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome