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Protein

Solute carrier family 40 member 1

Gene

Slc40a1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in iron export from duodenal epithelial cell and also in transfer of iron between maternal and fetal circulation. Mediates iron efflux in the presence of a ferroxidase (hephaestin and/or ceruloplasmin) (By similarity).By similarity

GO - Molecular functioni

  • iron ion transmembrane transporter activity Source: RGD

GO - Biological processi

  • iron ion homeostasis Source: UniProtKB-KW
  • iron ion transport Source: RGD
Complete GO annotation...

Keywords - Biological processi

Ion transport, Iron transport, Transport

Keywords - Ligandi

Iron

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 40 member 1
Alternative name(s):
CAR1
Cell adhesion regulator
Ferroportin-1
Gene namesi
Name:Slc40a1
Synonyms:Fpn1, Fpt1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi620180. Slc40a1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei12 – 3423HelicalSequence analysisAdd
BLAST
Transmembranei54 – 7623HelicalSequence analysisAdd
BLAST
Transmembranei96 – 11520HelicalSequence analysisAdd
BLAST
Transmembranei125 – 14723HelicalSequence analysisAdd
BLAST
Transmembranei302 – 32423HelicalSequence analysisAdd
BLAST
Transmembranei339 – 36123HelicalSequence analysisAdd
BLAST
Transmembranei373 – 39523HelicalSequence analysisAdd
BLAST
Transmembranei449 – 47123HelicalSequence analysisAdd
BLAST
Transmembranei491 – 51323HelicalSequence analysisAdd
BLAST
Transmembranei518 – 54023HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 570570Solute carrier family 40 member 1PRO_0000191312Add
BLAST

Proteomic databases

PaxDbiQ923U9.
PRIDEiQ923U9.

Interactioni

Subunit structurei

Identified in a complex with STOM.By similarity

Protein-protein interaction databases

BioGridi250996. 5 interactions.
STRINGi10116.ENSRNOP00000005228.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2601. Eukaryota.
ENOG410XS3F. LUCA.
HOGENOMiHOG000234273.
HOVERGENiHBG055582.
InParanoidiQ923U9.
KOiK14685.
PhylomeDBiQ923U9.

Family and domain databases

InterProiIPR009716. Ferroportin-1.
IPR020846. MFS_dom.
[Graphical view]
PfamiPF06963. FPN1. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 3 hits.

Sequencei

Sequence statusi: Complete.

Q923U9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTKSRDQTHQ EGCCGSLANY LTSAKFLLYL GHSLSTWGDR MWHFAVSVFL
60 70 80 90 100
VELYGNGLLL TAVYGLVVAG SVLVLGAIIG DWVDKNARLK VAQTSLVVQN
110 120 130 140 150
VSVILCGIIL MMVFLHKNEL LNMYHGWVLT VCYILIITIA NIANLASTAT
160 170 180 190 200
AITIQRDWIV VVAGENRSRL ADMNATIRRI DQLTNILAPM AVGQIMTFGS
210 220 230 240 250
PVIGCGFISG WNLVSMCVEY FLLWKVYQKT PALAVKAALK VEESELKQLT
260 270 280 290 300
SPKDTEPKPL EGTHLMGEKD SNIRELECEQ EPTCASQIAE PFRTFRDGWV
310 320 330 340 350
SYYNQPVFLA GMGLAFLYMT VLGFDCITTG YAYTQGLSGS ILSVLMGASA
360 370 380 390 400
ITGIMGTVAF TWLRRKCGLV RTGLFSGLAQ LSCLILCVIS VFMPGSPLDL
410 420 430 440 450
SVSPFEDIRS RFIHEEAVSS TTKIPETEML MSNVSNVVNT VHEMSTKSVP
460 470 480 490 500
IISVSLLFAG VIAARIGLWS FDLTVTQLLQ ENVIESERGI INGVQNSMNY
510 520 530 540 550
LLDLLHFIMV ILAPNPEAFG LLVLISVSFV AMGHLMYFRF AQKTLGNQIF
560 570
VCAPDEKEVT DESQPNTSVV
Length:570
Mass (Da):62,586
Last modified:June 1, 2002 - v2
Checksum:i766786F22F054E94
GO

Sequence cautioni

The sequence AAD00260.1 differs from that shown. Reason: Frameshift at position 310. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti57 – 571G → S in AAD00260 (Ref. 2) Curated
Sequence conflicti328 – 3303TTG → ATV (Ref. 2) Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF394785 mRNA. Translation: AAK77858.2.
U76714 mRNA. Translation: AAD00260.1. Frameshift.
RefSeqiNP_579849.2. NM_133315.2.
UniGeneiRn.15324.

Genome annotation databases

GeneIDi170840.
KEGGirno:170840.
UCSCiRGD:620180. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF394785 mRNA. Translation: AAK77858.2.
U76714 mRNA. Translation: AAD00260.1. Frameshift.
RefSeqiNP_579849.2. NM_133315.2.
UniGeneiRn.15324.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi250996. 5 interactions.
STRINGi10116.ENSRNOP00000005228.

Proteomic databases

PaxDbiQ923U9.
PRIDEiQ923U9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi170840.
KEGGirno:170840.
UCSCiRGD:620180. rat.

Organism-specific databases

CTDi30061.
RGDi620180. Slc40a1.

Phylogenomic databases

eggNOGiKOG2601. Eukaryota.
ENOG410XS3F. LUCA.
HOGENOMiHOG000234273.
HOVERGENiHBG055582.
InParanoidiQ923U9.
KOiK14685.
PhylomeDBiQ923U9.

Miscellaneous databases

NextBioi621253.
PROiQ923U9.

Family and domain databases

InterProiIPR009716. Ferroportin-1.
IPR020846. MFS_dom.
[Graphical view]
PfamiPF06963. FPN1. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 3 hits.
ProtoNetiSearch...

Publicationsi

  1. "Iron induces ferroportin 1 (FPT1) clustering and redistribution in rat intestinal epithelial cells."
    Yeh K.-Y., Yeh M., Glass J.
    Submitted (FEB-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Sprague-Dawley.
  2. Yang X.Z.
    Submitted (OCT-1996) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiS40A1_RAT
AccessioniPrimary (citable) accession number: Q923U9
Secondary accession number(s): Q9Z1C9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 7, 2004
Last sequence update: June 1, 2002
Last modified: November 11, 2015
This is version 94 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.