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Protein

TOM1-like protein 1

Gene

Tom1l1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Probable adapter protein involved in signaling pathways. Interacts with the SH2 and SH3 domains of various signaling proteins when it is phosphorylated. May promote FYN activation, possibly by disrupting intramolecular SH3-dependent interactions.1 Publication

GO - Molecular functioni

  • clathrin binding Source: MGI
  • protein kinase activator activity Source: MGI
  • protein kinase binding Source: MGI

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
TOM1-like protein 1
Alternative name(s):
Src-activating and signaling molecule protein
Target of Myb-like protein 1
Gene namesi
Name:Tom1l1
Synonyms:Srcasm
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1919193. Tom1l1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Endosome, Golgi apparatus, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi392Y → F: Specifically abolishes interaction with GRB2; mild decrease in phosphorylation. 1 Publication1
Mutagenesisi440 – 441YY → FF: Specifically abolishes interaction with PIK3R1; mild decrease in phosphorylation. 1 Publication2
Mutagenesisi457Y → F: Abolishes phosphorylation by FYN and interaction with FYN. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000725671 – 474TOM1-like protein 1Add BLAST474

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei170PhosphoserineCombined sources1
Modified residuei313PhosphoserineBy similarity1
Modified residuei320PhosphoserineBy similarity1
Modified residuei457Phosphotyrosine1 Publication1

Post-translational modificationi

Phosphorylated on tyrosines by LYN (By similarity). Phosphorylated on tyrosines by FYN.By similarity1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ923U0.
PeptideAtlasiQ923U0.
PRIDEiQ923U0.

PTM databases

iPTMnetiQ923U0.
PhosphoSitePlusiQ923U0.

Expressioni

Tissue specificityi

Strongly expressed in brain and kidney, expressed at intermediate levels skin and heart, and weakly expressed in thymus. Not expressed in liver and spleen.

Gene expression databases

BgeeiENSMUSG00000020541.
CleanExiMM_TOM1L1.
ExpressionAtlasiQ923U0. baseline and differential.
GenevisibleiQ923U0. MM.

Interactioni

Subunit structurei

Interacts with LYN (By similarity). Interacts with the SH2 and SH3 domains of FYN when phosphorylated. Also interacts with GRB2 and PIK3R1 when phosphorylated.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi215046. 1 interactor.
IntActiQ923U0. 1 interactor.
MINTiMINT-221864.
STRINGi10090.ENSMUSP00000103500.

Structurei

3D structure databases

ProteinModelPortaliQ923U0.
SMRiQ923U0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini22 – 154VHSPROSITE-ProRule annotationAdd BLAST133
Domaini199 – 287GATPROSITE-ProRule annotationAdd BLAST89

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni392 – 395Interaction with GRB24
Regioni441 – 444Interaction with PIK3R14

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi420 – 424SH3-binding5
Motifi457 – 460SH2-binding4

Sequence similaritiesi

Belongs to the TOM1 family.Curated
Contains 1 GAT domain.PROSITE-ProRule annotation
Contains 1 VHS domain.PROSITE-ProRule annotation

Keywords - Domaini

SH3-binding

Phylogenomic databases

eggNOGiKOG1087. Eukaryota.
ENOG410Y26G. LUCA.
GeneTreeiENSGT00860000133703.
HOGENOMiHOG000285970.
HOVERGENiHBG025068.
InParanoidiQ923U0.
OMAiTMNNQLS.
OrthoDBiEOG091G08M1.
PhylomeDBiQ923U0.

Family and domain databases

Gene3Di1.20.58.160. 1 hit.
1.25.40.90. 1 hit.
InterProiIPR008942. ENTH_VHS.
IPR004152. GAT_dom.
IPR014645. TOM1.
IPR027428. TOM1L1.
IPR002014. VHS_dom.
[Graphical view]
PANTHERiPTHR13856:SF28. PTHR13856:SF28. 1 hit.
PfamiPF03127. GAT. 1 hit.
PF00790. VHS. 1 hit.
[Graphical view]
PIRSFiPIRSF036948. TOM1. 1 hit.
SMARTiSM00288. VHS. 1 hit.
[Graphical view]
SUPFAMiSSF48464. SSF48464. 1 hit.
PROSITEiPS50909. GAT. 1 hit.
PS50179. VHS. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q923U0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAFGKSHRDP YATSVGHLIE KATFAGVLTE DWGQFLHICD IINTTQDGPK
60 70 80 90 100
DAVKALKKRI SKNYNHKEIQ LSLSLIDMCV QNCGPSFQSL IVKKEFIKDT
110 120 130 140 150
LVKLLNPRYT LPLETQNRIL NFIKTWSQGF PGGVDVSEVK EVYLDLLKKG
160 170 180 190 200
VQFPPSDGEP ETRQEAGQIS PNRPTSVPTA PALSSIIAPK NPTISLVPEQ
210 220 230 240 250
IGKLHSELDM VKMNVKVMTA ILMENTPGSE NHEDIELLRK LYKTGREMQE
260 270 280 290 300
RIMDLLVVVE NEDVTMELIQ VNEDLNNAVL GYERFTRNQQ RLLEQKRNRT
310 320 330 340 350
EATRTSSEPS APSCDLLDLS PIVPVPTPNE GALNSVNAQL SGLSVSSLSP
360 370 380 390 400
VITNNLYPSL QPQRDLLASE DIEIPTLFPQ RTSQNLASSH TYDNFHSNSV
410 420 430 440 450
LLQPVSLHTA TAAAAANQRL PPLPSSHPVL KDGDLQPPNY YEVMEFDPLA
460 470
PTTEAVYEEI DGYHQKEAQS HSDC
Length:474
Mass (Da):52,695
Last modified:December 1, 2001 - v1
Checksum:i4663AD9C0E6C292C
GO
Isoform 2 (identifier: Q923U0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-247: Missing.

Note: No experimental confirmation available.
Show »
Length:227
Mass (Da):25,147
Checksum:i8D3070961389431A
GO
Isoform 3 (identifier: Q923U0-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     125-200: Missing.

Note: No experimental confirmation available.
Show »
Length:398
Mass (Da):44,628
Checksum:i348EB71A44498423
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti414A → V in BAB26526 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0039961 – 247Missing in isoform 2. 1 PublicationAdd BLAST247
Alternative sequenceiVSP_003997125 – 200Missing in isoform 3. 1 PublicationAdd BLAST76

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF395837 mRNA. Translation: AAK83377.1.
AK009826 mRNA. Translation: BAB26526.1.
AK083630 mRNA. Translation: BAC38972.1.
AL672199 Genomic DNA. Translation: CAI24236.1.
AL672199 Genomic DNA. Translation: CAI24238.1.
AL672199 Genomic DNA. Translation: CAQ12613.1.
BC004710 mRNA. Translation: AAH04710.1.
RefSeqiXP_006534331.1. XM_006534268.3. [Q923U0-1]
UniGeneiMm.167868.

Genome annotation databases

EnsembliENSMUST00000020849; ENSMUSP00000020849; ENSMUSG00000020541. [Q923U0-1]
ENSMUST00000107867; ENSMUSP00000103499; ENSMUSG00000020541. [Q923U0-2]
ENSMUST00000107869; ENSMUSP00000103501; ENSMUSG00000020541. [Q923U0-3]
GeneIDi71943.
UCSCiuc007kxa.1. mouse. [Q923U0-2]
uc007kxb.1. mouse. [Q923U0-1]
uc011ycr.1. mouse. [Q923U0-3]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF395837 mRNA. Translation: AAK83377.1.
AK009826 mRNA. Translation: BAB26526.1.
AK083630 mRNA. Translation: BAC38972.1.
AL672199 Genomic DNA. Translation: CAI24236.1.
AL672199 Genomic DNA. Translation: CAI24238.1.
AL672199 Genomic DNA. Translation: CAQ12613.1.
BC004710 mRNA. Translation: AAH04710.1.
RefSeqiXP_006534331.1. XM_006534268.3. [Q923U0-1]
UniGeneiMm.167868.

3D structure databases

ProteinModelPortaliQ923U0.
SMRiQ923U0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi215046. 1 interactor.
IntActiQ923U0. 1 interactor.
MINTiMINT-221864.
STRINGi10090.ENSMUSP00000103500.

PTM databases

iPTMnetiQ923U0.
PhosphoSitePlusiQ923U0.

Proteomic databases

PaxDbiQ923U0.
PeptideAtlasiQ923U0.
PRIDEiQ923U0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000020849; ENSMUSP00000020849; ENSMUSG00000020541. [Q923U0-1]
ENSMUST00000107867; ENSMUSP00000103499; ENSMUSG00000020541. [Q923U0-2]
ENSMUST00000107869; ENSMUSP00000103501; ENSMUSG00000020541. [Q923U0-3]
GeneIDi71943.
UCSCiuc007kxa.1. mouse. [Q923U0-2]
uc007kxb.1. mouse. [Q923U0-1]
uc011ycr.1. mouse. [Q923U0-3]

Organism-specific databases

CTDi10040.
MGIiMGI:1919193. Tom1l1.

Phylogenomic databases

eggNOGiKOG1087. Eukaryota.
ENOG410Y26G. LUCA.
GeneTreeiENSGT00860000133703.
HOGENOMiHOG000285970.
HOVERGENiHBG025068.
InParanoidiQ923U0.
OMAiTMNNQLS.
OrthoDBiEOG091G08M1.
PhylomeDBiQ923U0.

Miscellaneous databases

PROiQ923U0.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000020541.
CleanExiMM_TOM1L1.
ExpressionAtlasiQ923U0. baseline and differential.
GenevisibleiQ923U0. MM.

Family and domain databases

Gene3Di1.20.58.160. 1 hit.
1.25.40.90. 1 hit.
InterProiIPR008942. ENTH_VHS.
IPR004152. GAT_dom.
IPR014645. TOM1.
IPR027428. TOM1L1.
IPR002014. VHS_dom.
[Graphical view]
PANTHERiPTHR13856:SF28. PTHR13856:SF28. 1 hit.
PfamiPF03127. GAT. 1 hit.
PF00790. VHS. 1 hit.
[Graphical view]
PIRSFiPIRSF036948. TOM1. 1 hit.
SMARTiSM00288. VHS. 1 hit.
[Graphical view]
SUPFAMiSSF48464. SSF48464. 1 hit.
PROSITEiPS50909. GAT. 1 hit.
PS50179. VHS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTM1L1_MOUSE
AccessioniPrimary (citable) accession number: Q923U0
Secondary accession number(s): B0QZV4
, Q5SRC7, Q5SRC9, Q99KE0, Q9D6Y5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 15, 2002
Last sequence update: December 1, 2001
Last modified: November 30, 2016
This is version 124 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.