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Protein

TOM1-like protein 1

Gene

Tom1l1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Probable adapter protein involved in signaling pathways. Interacts with the SH2 and SH3 domains of various signaling proteins when it is phosphorylated. May promote FYN activation, possibly by disrupting intramolecular SH3-dependent interactions.1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processProtein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
TOM1-like protein 1
Alternative name(s):
Src-activating and signaling molecule protein
Target of Myb-like protein 1
Gene namesi
Name:Tom1l1
Synonyms:Srcasm
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1919193 Tom1l1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Endosome, Golgi apparatus, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi392Y → F: Specifically abolishes interaction with GRB2; mild decrease in phosphorylation. 1 Publication1
Mutagenesisi440 – 441YY → FF: Specifically abolishes interaction with PIK3R1; mild decrease in phosphorylation. 1 Publication2
Mutagenesisi457Y → F: Abolishes phosphorylation by FYN and interaction with FYN. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000725671 – 474TOM1-like protein 1Add BLAST474

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei170PhosphoserineCombined sources1
Modified residuei313PhosphoserineBy similarity1
Modified residuei320PhosphoserineBy similarity1
Modified residuei457Phosphotyrosine1 Publication1

Post-translational modificationi

Phosphorylated on tyrosines by LYN (By similarity). Phosphorylated on tyrosines by FYN.By similarity1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ923U0
PeptideAtlasiQ923U0
PRIDEiQ923U0

PTM databases

iPTMnetiQ923U0
PhosphoSitePlusiQ923U0

Expressioni

Tissue specificityi

Strongly expressed in brain and kidney, expressed at intermediate levels skin and heart, and weakly expressed in thymus. Not expressed in liver and spleen.

Gene expression databases

BgeeiENSMUSG00000020541
CleanExiMM_TOM1L1
ExpressionAtlasiQ923U0 baseline and differential
GenevisibleiQ923U0 MM

Interactioni

Subunit structurei

Interacts with LYN (By similarity). Interacts with the SH2 and SH3 domains of FYN when phosphorylated. Also interacts with GRB2 and PIK3R1 when phosphorylated.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi215046, 2 interactors
IntActiQ923U0, 1 interactor
MINTiQ923U0
STRINGi10090.ENSMUSP00000103500

Structurei

3D structure databases

ProteinModelPortaliQ923U0
SMRiQ923U0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini22 – 154VHSPROSITE-ProRule annotationAdd BLAST133
Domaini199 – 287GATPROSITE-ProRule annotationAdd BLAST89

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni392 – 395Interaction with GRB24
Regioni441 – 444Interaction with PIK3R14

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi420 – 424SH3-binding5
Motifi457 – 460SH2-binding4

Sequence similaritiesi

Belongs to the TOM1 family.Curated

Keywords - Domaini

SH3-binding

Phylogenomic databases

eggNOGiKOG1087 Eukaryota
ENOG410Y26G LUCA
GeneTreeiENSGT00920000148990
HOGENOMiHOG000285970
HOVERGENiHBG025068
InParanoidiQ923U0
OMAiYERFTRN
OrthoDBiEOG091G08M1
PhylomeDBiQ923U0

Family and domain databases

Gene3Di1.20.58.160, 1 hit
1.25.40.90, 1 hit
InterProiView protein in InterPro
IPR008942 ENTH_VHS
IPR004152 GAT_dom
IPR038425 GAT_sf
IPR014645 TOM1
IPR027428 TOM1L1
IPR002014 VHS_dom
PANTHERiPTHR13856:SF28 PTHR13856:SF28, 1 hit
PfamiView protein in Pfam
PF03127 GAT, 1 hit
PF00790 VHS, 1 hit
PIRSFiPIRSF036948 TOM1, 1 hit
SMARTiView protein in SMART
SM00288 VHS, 1 hit
SUPFAMiSSF48464 SSF48464, 1 hit
PROSITEiView protein in PROSITE
PS50909 GAT, 1 hit
PS50179 VHS, 1 hit

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q923U0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAFGKSHRDP YATSVGHLIE KATFAGVLTE DWGQFLHICD IINTTQDGPK
60 70 80 90 100
DAVKALKKRI SKNYNHKEIQ LSLSLIDMCV QNCGPSFQSL IVKKEFIKDT
110 120 130 140 150
LVKLLNPRYT LPLETQNRIL NFIKTWSQGF PGGVDVSEVK EVYLDLLKKG
160 170 180 190 200
VQFPPSDGEP ETRQEAGQIS PNRPTSVPTA PALSSIIAPK NPTISLVPEQ
210 220 230 240 250
IGKLHSELDM VKMNVKVMTA ILMENTPGSE NHEDIELLRK LYKTGREMQE
260 270 280 290 300
RIMDLLVVVE NEDVTMELIQ VNEDLNNAVL GYERFTRNQQ RLLEQKRNRT
310 320 330 340 350
EATRTSSEPS APSCDLLDLS PIVPVPTPNE GALNSVNAQL SGLSVSSLSP
360 370 380 390 400
VITNNLYPSL QPQRDLLASE DIEIPTLFPQ RTSQNLASSH TYDNFHSNSV
410 420 430 440 450
LLQPVSLHTA TAAAAANQRL PPLPSSHPVL KDGDLQPPNY YEVMEFDPLA
460 470
PTTEAVYEEI DGYHQKEAQS HSDC
Length:474
Mass (Da):52,695
Last modified:December 1, 2001 - v1
Checksum:i4663AD9C0E6C292C
GO
Isoform 2 (identifier: Q923U0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-247: Missing.

Note: No experimental confirmation available.
Show »
Length:227
Mass (Da):25,147
Checksum:i8D3070961389431A
GO
Isoform 3 (identifier: Q923U0-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     125-200: Missing.

Note: No experimental confirmation available.
Show »
Length:398
Mass (Da):44,628
Checksum:i348EB71A44498423
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti414A → V in BAB26526 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0039961 – 247Missing in isoform 2. 1 PublicationAdd BLAST247
Alternative sequenceiVSP_003997125 – 200Missing in isoform 3. 1 PublicationAdd BLAST76

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF395837 mRNA Translation: AAK83377.1
AK009826 mRNA Translation: BAB26526.1
AK083630 mRNA Translation: BAC38972.1
AL672199 Genomic DNA No translation available.
BC004710 mRNA Translation: AAH04710.1
RefSeqiXP_006534331.1, XM_006534268.3
UniGeneiMm.167868

Genome annotation databases

EnsembliENSMUST00000020849; ENSMUSP00000020849; ENSMUSG00000020541 [Q923U0-1]
ENSMUST00000107867; ENSMUSP00000103499; ENSMUSG00000020541 [Q923U0-2]
ENSMUST00000107869; ENSMUSP00000103501; ENSMUSG00000020541 [Q923U0-3]
GeneIDi71943
UCSCiuc007kxa.1 mouse [Q923U0-2]
uc007kxb.1 mouse [Q923U0-1]
uc011ycr.1 mouse [Q923U0-3]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiTM1L1_MOUSE
AccessioniPrimary (citable) accession number: Q923U0
Secondary accession number(s): B0QZV4
, Q5SRC7, Q5SRC9, Q99KE0, Q9D6Y5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 15, 2002
Last sequence update: December 1, 2001
Last modified: June 20, 2018
This is version 134 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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