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Protein

Tripartite motif-containing protein 7

Gene

Trim7

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri29 – 8153RING-typePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri124 – 16542B box-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Tripartite motif-containing protein 7
Alternative name(s):
Glycogenin-interacting protein
Gene namesi
Name:Trim7
Synonyms:Gnip
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:2137353. Trim7.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: MGI
  • nucleus Source: MGI
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 510510Tripartite motif-containing protein 7PRO_0000056205Add
BLAST

Proteomic databases

MaxQBiQ923T7.
PaxDbiQ923T7.
PRIDEiQ923T7.

PTM databases

iPTMnetiQ923T7.
PhosphoSiteiQ923T7.

Expressioni

Gene expression databases

BgeeiENSMUSG00000040350.
CleanExiMM_TRIM7.
ExpressionAtlasiQ923T7. baseline and differential.
GenevisibleiQ923T7. MM.

Interactioni

Subunit structurei

Forms homodimers and heterodimers. Interacts with GYG and DES (By similarity).By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000104836.

Structurei

3D structure databases

ProteinModelPortaliQ923T7.
SMRiQ923T7. Positions 17-106, 129-498.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini323 – 510188B30.2/SPRYPROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili165 – 275111Sequence analysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi122 – 1276Poly-Ala

Domaini

The B30.2 domain mediates interaction with GYG. The coiled-coil region mediates homodimerization and heterodimerization.

Sequence similaritiesi

Belongs to the TRIM/RBCC family.Curated
Contains 1 B box-type zinc finger.PROSITE-ProRule annotation
Contains 1 B30.2/SPRY domain.PROSITE-ProRule annotation
Contains 1 RING-type zinc finger.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri29 – 8153RING-typePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri124 – 16542B box-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Coiled coil, Zinc-finger

Phylogenomic databases

eggNOGiKOG2177. Eukaryota.
ENOG4111G04. LUCA.
GeneTreeiENSGT00760000118893.
HOGENOMiHOG000234133.
HOVERGENiHBG001357.
InParanoidiQ923T7.
KOiK12000.
PhylomeDBiQ923T7.
TreeFamiTF317532.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
4.10.45.10. 1 hit.
InterProiIPR001870. B30.2/SPRY.
IPR003879. Butyrophylin.
IPR013320. ConA-like_dom.
IPR006574. PRY.
IPR003877. SPRY_dom.
IPR000315. Znf_B-box.
IPR020457. Znf_B-box_chordata.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR017907. Znf_RING_CS.
[Graphical view]
PfamiPF13765. PRY. 1 hit.
PF00622. SPRY. 1 hit.
PF00643. zf-B_box. 1 hit.
[Graphical view]
PRINTSiPR01406. BBOXZNFINGER.
PR01407. BUTYPHLNCDUF.
SMARTiSM00336. BBOX. 1 hit.
SM00589. PRY. 1 hit.
SM00184. RING. 1 hit.
SM00449. SPRY. 1 hit.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 1 hit.
PROSITEiPS50188. B302_SPRY. 1 hit.
PS50119. ZF_BBOX. 1 hit.
PS00518. ZF_RING_1. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q923T7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MATVGPRTGP NAGAEALALA AELQGEATCS ICLEFFREPV SVECGHSFCR
60 70 80 90 100
ACIMRCWERP GAGTGTATRT LPCPLPCPQC REPARPSQLR PNRQLAAVVS
110 120 130 140 150
LLRRFSLPPT APGERGTPAV PARAAAARCS QHGEQLKLYC QDDGRAICVV
160 170 180 190 200
CDRAREHRSH AVLPLEEAVQ EAKELLDSRL RALKKVLEDY EAFRSTEERE
210 220 230 240 250
SKELLKQMAA EKEKVGAEFQ ALRAFLVEQE GRLLSRLEVL SREVTQKQNE
260 270 280 290 300
NLAQLEGEIT QLSKLSGQIQ ETAQKPDLDF LQEFKSTLSK CSSVPSSKPT
310 320 330 340 350
TVSSEMKNKV WNVSLKSFVL KGLLKKFKED LQGELEKEEK VELTLDPDTA
360 370 380 390 400
NPRLILSLDL KSVRLGQRAQ DLPNHPRRFD TNTRVLASCG FSSGRHHWEV
410 420 430 440 450
EVGSKDGWAF GVARESVRRK GLTPFTPEEG VWAMQLNNGQ YWAVTSPERT
460 470 480 490 500
QLNCGHLSRV RVALDLEVGA VSFYAVEDMR HLYTFRVNFQ ERVFPLFSVC
510
STGTYLRIWP
Note: No experimental confirmation available.
Length:510
Mass (Da):57,021
Last modified:December 21, 2004 - v2
Checksum:i01335C644BFFA4E3
GO
Isoform 2 (identifier: Q923T7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-207: Missing.

Show »
Length:303
Mass (Da):34,377
Checksum:i8BD6447853ACA8A7
GO
Isoform 3 (identifier: Q923T7-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     206-243: KQMAAEKEKV...LSRLEVLSRE → VSPSVRSIGL...RERERIWLKQ
     244-510: Missing.

Note: No experimental confirmation available.
Show »
Length:243
Mass (Da):27,256
Checksum:i284F3D48E8EEC781
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 207207Missing in isoform 2. 1 PublicationVSP_012289Add
BLAST
Alternative sequencei206 – 24338KQMAA…VLSRE → VSPSVRSIGLWMTKAERERE RERERERERERERIWLKQ in isoform 3. 1 PublicationVSP_012290Add
BLAST
Alternative sequencei244 – 510267Missing in isoform 3. 1 PublicationVSP_012291Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF220033 mRNA. Translation: AAG53487.1.
AF396656 mRNA. Translation: AAK85382.1.
AL645849 Genomic DNA. Translation: CAI35115.1.
CCDSiCCDS48779.1. [Q923T7-2]
RefSeqiNP_444396.2. NM_053166.2. [Q923T7-2]
XP_006534638.1. XM_006534575.2. [Q923T7-2]
UniGeneiMm.390335.

Genome annotation databases

EnsembliENSMUST00000109213; ENSMUSP00000104836; ENSMUSG00000040350. [Q923T7-2]
GeneIDi94089.
KEGGimmu:94089.
UCSCiuc007ipd.2. mouse. [Q923T7-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF220033 mRNA. Translation: AAG53487.1.
AF396656 mRNA. Translation: AAK85382.1.
AL645849 Genomic DNA. Translation: CAI35115.1.
CCDSiCCDS48779.1. [Q923T7-2]
RefSeqiNP_444396.2. NM_053166.2. [Q923T7-2]
XP_006534638.1. XM_006534575.2. [Q923T7-2]
UniGeneiMm.390335.

3D structure databases

ProteinModelPortaliQ923T7.
SMRiQ923T7. Positions 17-106, 129-498.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000104836.

PTM databases

iPTMnetiQ923T7.
PhosphoSiteiQ923T7.

Proteomic databases

MaxQBiQ923T7.
PaxDbiQ923T7.
PRIDEiQ923T7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000109213; ENSMUSP00000104836; ENSMUSG00000040350. [Q923T7-2]
GeneIDi94089.
KEGGimmu:94089.
UCSCiuc007ipd.2. mouse. [Q923T7-1]

Organism-specific databases

CTDi81786.
MGIiMGI:2137353. Trim7.

Phylogenomic databases

eggNOGiKOG2177. Eukaryota.
ENOG4111G04. LUCA.
GeneTreeiENSGT00760000118893.
HOGENOMiHOG000234133.
HOVERGENiHBG001357.
InParanoidiQ923T7.
KOiK12000.
PhylomeDBiQ923T7.
TreeFamiTF317532.

Miscellaneous databases

PROiQ923T7.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000040350.
CleanExiMM_TRIM7.
ExpressionAtlasiQ923T7. baseline and differential.
GenevisibleiQ923T7. MM.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
4.10.45.10. 1 hit.
InterProiIPR001870. B30.2/SPRY.
IPR003879. Butyrophylin.
IPR013320. ConA-like_dom.
IPR006574. PRY.
IPR003877. SPRY_dom.
IPR000315. Znf_B-box.
IPR020457. Znf_B-box_chordata.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR017907. Znf_RING_CS.
[Graphical view]
PfamiPF13765. PRY. 1 hit.
PF00622. SPRY. 1 hit.
PF00643. zf-B_box. 1 hit.
[Graphical view]
PRINTSiPR01406. BBOXZNFINGER.
PR01407. BUTYPHLNCDUF.
SMARTiSM00336. BBOX. 1 hit.
SM00589. PRY. 1 hit.
SM00184. RING. 1 hit.
SM00449. SPRY. 1 hit.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 1 hit.
PROSITEiPS50188. B302_SPRY. 1 hit.
PS50119. ZF_BBOX. 1 hit.
PS00518. ZF_RING_1. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTRIM7_MOUSE
AccessioniPrimary (citable) accession number: Q923T7
Secondary accession number(s): Q5NCB6, Q99PQ5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 21, 2004
Last sequence update: December 21, 2004
Last modified: September 7, 2016
This is version 111 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.