Q923Q2 (STA13_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
StAR-related lipid transfer protein 13

Alternative name(s):
START domain-containing protein 13
Short name=StARD13

Gene names

Name:

Stard13

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	1113 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	May function as a GTPase-activating protein.
Subunit structure	Homodimer. Interacts with TAX1BP1 By similarity.
Subcellular location	Cytoplasm. Membrane; Peripheral membrane protein; Cytoplasmic side. Mitochondrion membrane; Peripheral membrane protein; Cytoplasmic side. Lipid droplet By similarity.
Sequence similarities	Contains 1 Rho-GAP domain. Contains 1 SAM (sterile alpha motif) domain. Contains 1 START domain.

Ontologies

Keywords
Biological process	Cell cycle
Cellular component	Cytoplasm Lipid droplet Membrane Mitochondrion
Molecular function	GTPase activation
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cell cycle Inferred from electronic annotation. Source: UniProtKB-KW positive regulation of GTPase activity Inferred from electronic annotation. Source: GOC signal transduction Inferred from electronic annotation. Source: InterPro
Cellular_component	lipid particle Inferred from electronic annotation. Source: UniProtKB-SubCell mitochondrial membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	GTPase activator activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1113	1113	StAR-related lipid transfer protein 13		PRO_0000220680
Regions
	Domain	55 – 122	68	SAM
	Domain	663 – 868	206	Rho-GAP
	Domain	899 – 1109	211	START
Amino acid modifications
	Modified residue	133	1	Phosphoserine Ref.3
Experimental info
	Sequence conflict	384	1	M → V in AAH27830. Ref.2
	Sequence conflict	785	1	A → V in AAH27830. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Q923Q2 [UniParc]. Last modified July 27, 2011. Version 5. Checksum: A516D16FFA327E74	FASTA	1,113	125,060
	10 20 30 40 50 60 MFSQVPRTPA AGCYYLNPLT PESQEMYLRF DQTARRSPYR MSRILARHHL VTKIQQEIEA 70 80 90 100 110 120 KEACDWLRAA GFPQYAQLYE DSQFPINIAA VKKDHDFLER DLVEPLCRRL NTLNKCASMR 130 140 150 160 170 180 LDVNFQRKKG DDSDEEDLCI SNKWTFQRTS RRWSRVDDLH TLFPVADRNG SPGGPRMRNT 190 200 210 220 230 240 ASSESVLTDL SEPEVCSIHS ESSGGSDSRS QSGHHSADST HALEATLVSS SLPQSTREGL 250 260 270 280 290 300 NQSFHPKNEK PTRTRAKSFL KRMDTLRVKG ALGRHKGPGR TGGLVISRPV LQQEPESFKT 310 320 330 340 350 360 MQCVQIPNGD LQTSPPAACR KGLPCSSKSS GESSPLENSS TVSTPCMKER KCHHEANKRG 370 380 390 400 410 420 GMYLEDLDVL AGTALPDTSD QNHMHGFHSQ ENLVVHIPKD HKPGTFPKAL SIESLSPTDN 430 440 450 460 470 480 SNGVNWRTGS ISLGRQQGPG MREPRLMSSC HRASRVSIYD NVPSSHLYAS TGDLLDLEKD 490 500 510 520 530 540 GLLPQLDDIL QHVNGIQEVV DDWSKNILPE LQSHSTLAGD PGLSPFPSPN QVTLDFEGNS 550 560 570 580 590 600 VSEGRTTPSD VERDRTSLNE SEATGVRERR DSGVGASLTR PNRRLRWSSF QLSHQPQPSP 610 620 630 640 650 660 ATPHISSQTA AQLNLLQRFS LLRLTAIMEK YSMSNKHGWT WSVPKFMKRI KAPDYRDKAV 670 680 690 700 710 720 FGVPLIVHVQ RTGQPLPQSI QQALRYLRSN CLDQVGLFRK SGVKSRIHAL RQMNENFPDN 730 740 750 760 770 780 VSYEDQSAYD VADMVKQFFR DLPEPLFTNK LSETFLHIYQ YVPKEQRLQA VQAAILLLAD 790 800 810 820 830 840 ENREALQTLL CFLHDVVNLV DENQMTPMNL AVCLAPSLFH LNLLKKESSP KVIQKKYATG 850 860 870 880 890 900 KPDQKDLNEN LAAAQGLAHM ITECNRLFEV PHEMVAQSRD SYLEAEIHVP SLEDLGAQLA 910 920 930 940 950 960 ESGATFHTYL EHLVQGLQKE AKEKFKGWVT CSSPDNTDLA FKKVGDGHPL KLWKASVEVE 970 980 990 1000 1010 1020 APPSVVLNRV LRERHLWDED FVQWKVVERL DKQTEIYQYV LNSMVPHPSR DFLVLRTWKT 1030 1040 1050 1060 1070 1080 DLPKGMCTLV SLSVEYEEAQ LMGGVRAVVM DSQYLIEPCG SGKSRLTHIC RIDLKGHSPE 1090 1100 1110 WYSKGFGHLC AAEVTRIRNS FQPLVAEGPE TKI

References

[1]	"Lineage-specific biology revealed by a finished genome assembly of the mouse." Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P. PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: C57BL/6J.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: FVB/N. Tissue: Mammary tumor.
[3]	"Solid tumor proteome and phosphoproteome analysis by high resolution mass spectrometry." Zanivan S., Gnad F., Wickstroem S.A., Geiger T., Macek B., Cox J., Faessler R., Mann M. J. Proteome Res. 7:5314-5326(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-133, MASS SPECTROMETRY. Tissue: Melanoma.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AC109614 Genomic DNA. No translation available. AC163219 Genomic DNA. No translation available. BC027830 mRNA. Translation: AAH27830.2.
IPI	IPI00230267.
RefSeq	NP_666370.3. NM_146258.2.
UniGene	Mm.209272.
3D structure databases
ProteinModelPortal	Q923Q2.
SMR	Q923Q2. Positions 50-120, 655-863, 907-1104.
ModBase	Search...
Protein-protein interaction databases
MINT	MINT-4135694.
PTM databases
PhosphoSite	Q923Q2.
Proteomic databases
PaxDb	Q923Q2.
PRIDE	Q923Q2.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000110483; ENSMUSP00000106109; ENSMUSG00000016128.
GeneID	243362.
KEGG	mmu:243362.
UCSC	uc009aum.2. mouse.
Organism-specific databases
CTD	90627.
MGI	MGI:2385331. Stard13.
Phylogenomic databases
eggNOG	NOG236923.
GeneTree	ENSGT00700000104233.
HOGENOM	HOG000039960.
HOVERGEN	HBG055955.
Gene expression databases
ArrayExpress	Q923Q2.
Bgee	Q923Q2.
Genevestigator	Q923Q2.
GermOnline	ENSMUSG00000016128. Mus musculus.
Family and domain databases
Gene3D	1.10.555.10. 1 hit. 3.30.530.20. 1 hit.
InterPro	IPR008936. Rho_GTPase_activation_prot. IPR000198. RhoGAP_dom. IPR023393. START-like_dom. IPR002913. START_lipid-bd_dom. [Graphical view]
Pfam	PF00620. RhoGAP. 1 hit. PF01852. START. 1 hit. [Graphical view]
SMART	SM00324. RhoGAP. 1 hit. SM00234. START. 1 hit. [Graphical view]
SUPFAM	SSF48350. Rho_GAP. 1 hit.
PROSITE	PS50238. RHOGAP. 1 hit. PS50105. SAM_DOMAIN. False negative. PS50848. START. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	STARD13. mouse.
NextBio	385731.
SOURCE	Search...

Entry information

Entry name

STA13_MOUSE

Accession

Primary (citable) accession number: Q923Q2
Secondary accession number(s): E9PUB5, Q8K369

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 15, 2002
Last sequence update:	July 27, 2011
Last modified:	May 29, 2013
This is version 95 of the entry and version 5 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program