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Q923Q2 (STA13_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 103. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
StAR-related lipid transfer protein 13
Alternative name(s):
START domain-containing protein 13
Short name=StARD13
Gene names
Name:Stard13
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length1113 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

May function as a GTPase-activating protein.

Subunit structure

Homodimer. Interacts with TAX1BP1 By similarity.

Subcellular location

Cytoplasm. Membrane; Peripheral membrane protein; Cytoplasmic side. Mitochondrion membrane; Peripheral membrane protein; Cytoplasmic side. Lipid droplet By similarity.

Sequence similarities

Contains 1 Rho-GAP domain.

Contains 1 SAM (sterile alpha motif) domain.

Contains 1 START domain.

Ontologies

Keywords
   Biological processCell cycle
   Cellular componentCytoplasm
Lipid droplet
Membrane
Mitochondrion
   Molecular functionGTPase activation
   PTMAcetylation
Phosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processcell cycle

Inferred from electronic annotation. Source: UniProtKB-KW

signal transduction

Inferred from electronic annotation. Source: InterPro

   Cellular_componentlipid particle

Inferred from electronic annotation. Source: UniProtKB-SubCell

mitochondrial membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionGTPase activator activity

Inferred from electronic annotation. Source: UniProtKB-KW

lipid binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 11131113StAR-related lipid transfer protein 13
PRO_0000220680

Regions

Domain55 – 12268SAM
Domain663 – 868206Rho-GAP
Domain899 – 1109211START

Amino acid modifications

Modified residue11N-acetylmethionine By similarity
Modified residue1331Phosphoserine Ref.3

Experimental info

Sequence conflict3841M → V in AAH27830. Ref.2
Sequence conflict7851A → V in AAH27830. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Q923Q2 [UniParc].

Last modified July 27, 2011. Version 5.
Checksum: A516D16FFA327E74

FASTA1,113125,060
        10         20         30         40         50         60 
MFSQVPRTPA AGCYYLNPLT PESQEMYLRF DQTARRSPYR MSRILARHHL VTKIQQEIEA 

        70         80         90        100        110        120 
KEACDWLRAA GFPQYAQLYE DSQFPINIAA VKKDHDFLER DLVEPLCRRL NTLNKCASMR 

       130        140        150        160        170        180 
LDVNFQRKKG DDSDEEDLCI SNKWTFQRTS RRWSRVDDLH TLFPVADRNG SPGGPRMRNT 

       190        200        210        220        230        240 
ASSESVLTDL SEPEVCSIHS ESSGGSDSRS QSGHHSADST HALEATLVSS SLPQSTREGL 

       250        260        270        280        290        300 
NQSFHPKNEK PTRTRAKSFL KRMDTLRVKG ALGRHKGPGR TGGLVISRPV LQQEPESFKT 

       310        320        330        340        350        360 
MQCVQIPNGD LQTSPPAACR KGLPCSSKSS GESSPLENSS TVSTPCMKER KCHHEANKRG 

       370        380        390        400        410        420 
GMYLEDLDVL AGTALPDTSD QNHMHGFHSQ ENLVVHIPKD HKPGTFPKAL SIESLSPTDN 

       430        440        450        460        470        480 
SNGVNWRTGS ISLGRQQGPG MREPRLMSSC HRASRVSIYD NVPSSHLYAS TGDLLDLEKD 

       490        500        510        520        530        540 
GLLPQLDDIL QHVNGIQEVV DDWSKNILPE LQSHSTLAGD PGLSPFPSPN QVTLDFEGNS 

       550        560        570        580        590        600 
VSEGRTTPSD VERDRTSLNE SEATGVRERR DSGVGASLTR PNRRLRWSSF QLSHQPQPSP 

       610        620        630        640        650        660 
ATPHISSQTA AQLNLLQRFS LLRLTAIMEK YSMSNKHGWT WSVPKFMKRI KAPDYRDKAV 

       670        680        690        700        710        720 
FGVPLIVHVQ RTGQPLPQSI QQALRYLRSN CLDQVGLFRK SGVKSRIHAL RQMNENFPDN 

       730        740        750        760        770        780 
VSYEDQSAYD VADMVKQFFR DLPEPLFTNK LSETFLHIYQ YVPKEQRLQA VQAAILLLAD 

       790        800        810        820        830        840 
ENREALQTLL CFLHDVVNLV DENQMTPMNL AVCLAPSLFH LNLLKKESSP KVIQKKYATG 

       850        860        870        880        890        900 
KPDQKDLNEN LAAAQGLAHM ITECNRLFEV PHEMVAQSRD SYLEAEIHVP SLEDLGAQLA 

       910        920        930        940        950        960 
ESGATFHTYL EHLVQGLQKE AKEKFKGWVT CSSPDNTDLA FKKVGDGHPL KLWKASVEVE 

       970        980        990       1000       1010       1020 
APPSVVLNRV LRERHLWDED FVQWKVVERL DKQTEIYQYV LNSMVPHPSR DFLVLRTWKT 

      1030       1040       1050       1060       1070       1080 
DLPKGMCTLV SLSVEYEEAQ LMGGVRAVVM DSQYLIEPCG SGKSRLTHIC RIDLKGHSPE 

      1090       1100       1110 
WYSKGFGHLC AAEVTRIRNS FQPLVAEGPE TKI 

« Hide

References

[1]"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. expand/collapse author list , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.
PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: C57BL/6J.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: FVB/N.
Tissue: Mammary tumor.
[3]"Large-scale phosphorylation analysis of mouse liver."
Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-133, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Liver.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AC109614 Genomic DNA. No translation available.
AC163219 Genomic DNA. No translation available.
BC027830 mRNA. Translation: AAH27830.2.
RefSeqNP_666370.3. NM_146258.2.
UniGeneMm.209272.

3D structure databases

ProteinModelPortalQ923Q2.
SMRQ923Q2. Positions 50-120, 655-863, 907-1104.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActQ923Q2. 1 interaction.
MINTMINT-4135694.

PTM databases

PhosphoSiteQ923Q2.

Proteomic databases

PaxDbQ923Q2.
PRIDEQ923Q2.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000110483; ENSMUSP00000106109; ENSMUSG00000016128.
GeneID243362.
KEGGmmu:243362.
UCSCuc009aum.2. mouse.

Organism-specific databases

CTD90627.
MGIMGI:2385331. Stard13.

Phylogenomic databases

eggNOGNOG236923.
GeneTreeENSGT00740000115136.
HOGENOMHOG000039960.
HOVERGENHBG055955.
OrthoDBEOG7CG6Z8.
PhylomeDBQ923Q2.

Gene expression databases

ArrayExpressQ923Q2.
BgeeQ923Q2.
GenevestigatorQ923Q2.

Family and domain databases

Gene3D1.10.555.10. 1 hit.
3.30.530.20. 1 hit.
InterProIPR008936. Rho_GTPase_activation_prot.
IPR000198. RhoGAP_dom.
IPR013761. SAM/pointed.
IPR023393. START-like_dom.
IPR002913. START_lipid-bd_dom.
[Graphical view]
PfamPF00620. RhoGAP. 1 hit.
PF01852. START. 1 hit.
[Graphical view]
SMARTSM00324. RhoGAP. 1 hit.
SM00234. START. 1 hit.
[Graphical view]
SUPFAMSSF47769. SSF47769. 1 hit.
SSF48350. SSF48350. 1 hit.
PROSITEPS50238. RHOGAP. 1 hit.
PS50848. START. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSSTARD13. mouse.
NextBio385731.
PROQ923Q2.
SOURCESearch...

Entry information

Entry nameSTA13_MOUSE
AccessionPrimary (citable) accession number: Q923Q2
Secondary accession number(s): E9PUB5, Q8K369
Entry history
Integrated into UniProtKB/Swiss-Prot: November 15, 2002
Last sequence update: July 27, 2011
Last modified: April 16, 2014
This is version 103 of the entry and version 5 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot