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Q923Q2

- STA13_MOUSE

UniProt

Q923Q2 - STA13_MOUSE

Protein

StAR-related lipid transfer protein 13

Gene

Stard13

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 106 (01 Oct 2014)
      Sequence version 5 (27 Jul 2011)
      Previous versions | rss
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    Functioni

    May function as a GTPase-activating protein.

    GO - Molecular functioni

    1. GTPase activator activity Source: UniProtKB-KW
    2. lipid binding Source: InterPro

    GO - Biological processi

    1. cell cycle Source: UniProtKB-KW
    2. signal transduction Source: InterPro

    Keywords - Molecular functioni

    GTPase activation

    Keywords - Biological processi

    Cell cycle

    Enzyme and pathway databases

    ReactomeiREACT_210090. Rho GTPase cycle.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    StAR-related lipid transfer protein 13
    Alternative name(s):
    START domain-containing protein 13
    Short name:
    StARD13
    Gene namesi
    Name:Stard13
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 5

    Organism-specific databases

    MGIiMGI:2385331. Stard13.

    Subcellular locationi

    GO - Cellular componenti

    1. lipid particle Source: UniProtKB-SubCell
    2. mitochondrial membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm, Lipid droplet, Membrane, Mitochondrion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 11131113StAR-related lipid transfer protein 13PRO_0000220680Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei1 – 11N-acetylmethionineBy similarity
    Modified residuei133 – 1331Phosphoserine1 Publication

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    PaxDbiQ923Q2.
    PRIDEiQ923Q2.

    PTM databases

    PhosphoSiteiQ923Q2.

    Expressioni

    Gene expression databases

    ArrayExpressiQ923Q2.
    BgeeiQ923Q2.
    GenevestigatoriQ923Q2.

    Interactioni

    Subunit structurei

    Homodimer. Interacts with TAX1BP1 By similarity.By similarity

    Protein-protein interaction databases

    IntActiQ923Q2. 1 interaction.
    MINTiMINT-4135694.

    Structurei

    3D structure databases

    ProteinModelPortaliQ923Q2.
    SMRiQ923Q2. Positions 50-120, 655-863, 907-1104.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini55 – 12268SAMAdd
    BLAST
    Domaini663 – 868206Rho-GAPPROSITE-ProRule annotationAdd
    BLAST
    Domaini899 – 1109211STARTPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 Rho-GAP domain.PROSITE-ProRule annotation
    Contains 1 START domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG236923.
    GeneTreeiENSGT00740000115136.
    HOGENOMiHOG000039960.
    HOVERGENiHBG055955.
    OrthoDBiEOG7CG6Z8.
    PhylomeDBiQ923Q2.

    Family and domain databases

    Gene3Di1.10.555.10. 1 hit.
    3.30.530.20. 1 hit.
    InterProiIPR008936. Rho_GTPase_activation_prot.
    IPR000198. RhoGAP_dom.
    IPR013761. SAM/pointed.
    IPR023393. START-like_dom.
    IPR002913. START_lipid-bd_dom.
    [Graphical view]
    PfamiPF00620. RhoGAP. 1 hit.
    PF01852. START. 1 hit.
    [Graphical view]
    SMARTiSM00324. RhoGAP. 1 hit.
    SM00234. START. 1 hit.
    [Graphical view]
    SUPFAMiSSF47769. SSF47769. 1 hit.
    SSF48350. SSF48350. 1 hit.
    PROSITEiPS50238. RHOGAP. 1 hit.
    PS50848. START. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q923Q2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MFSQVPRTPA AGCYYLNPLT PESQEMYLRF DQTARRSPYR MSRILARHHL     50
    VTKIQQEIEA KEACDWLRAA GFPQYAQLYE DSQFPINIAA VKKDHDFLER 100
    DLVEPLCRRL NTLNKCASMR LDVNFQRKKG DDSDEEDLCI SNKWTFQRTS 150
    RRWSRVDDLH TLFPVADRNG SPGGPRMRNT ASSESVLTDL SEPEVCSIHS 200
    ESSGGSDSRS QSGHHSADST HALEATLVSS SLPQSTREGL NQSFHPKNEK 250
    PTRTRAKSFL KRMDTLRVKG ALGRHKGPGR TGGLVISRPV LQQEPESFKT 300
    MQCVQIPNGD LQTSPPAACR KGLPCSSKSS GESSPLENSS TVSTPCMKER 350
    KCHHEANKRG GMYLEDLDVL AGTALPDTSD QNHMHGFHSQ ENLVVHIPKD 400
    HKPGTFPKAL SIESLSPTDN SNGVNWRTGS ISLGRQQGPG MREPRLMSSC 450
    HRASRVSIYD NVPSSHLYAS TGDLLDLEKD GLLPQLDDIL QHVNGIQEVV 500
    DDWSKNILPE LQSHSTLAGD PGLSPFPSPN QVTLDFEGNS VSEGRTTPSD 550
    VERDRTSLNE SEATGVRERR DSGVGASLTR PNRRLRWSSF QLSHQPQPSP 600
    ATPHISSQTA AQLNLLQRFS LLRLTAIMEK YSMSNKHGWT WSVPKFMKRI 650
    KAPDYRDKAV FGVPLIVHVQ RTGQPLPQSI QQALRYLRSN CLDQVGLFRK 700
    SGVKSRIHAL RQMNENFPDN VSYEDQSAYD VADMVKQFFR DLPEPLFTNK 750
    LSETFLHIYQ YVPKEQRLQA VQAAILLLAD ENREALQTLL CFLHDVVNLV 800
    DENQMTPMNL AVCLAPSLFH LNLLKKESSP KVIQKKYATG KPDQKDLNEN 850
    LAAAQGLAHM ITECNRLFEV PHEMVAQSRD SYLEAEIHVP SLEDLGAQLA 900
    ESGATFHTYL EHLVQGLQKE AKEKFKGWVT CSSPDNTDLA FKKVGDGHPL 950
    KLWKASVEVE APPSVVLNRV LRERHLWDED FVQWKVVERL DKQTEIYQYV 1000
    LNSMVPHPSR DFLVLRTWKT DLPKGMCTLV SLSVEYEEAQ LMGGVRAVVM 1050
    DSQYLIEPCG SGKSRLTHIC RIDLKGHSPE WYSKGFGHLC AAEVTRIRNS 1100
    FQPLVAEGPE TKI 1113
    Length:1,113
    Mass (Da):125,060
    Last modified:July 27, 2011 - v5
    Checksum:iA516D16FFA327E74
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti384 – 3841M → V in AAH27830. (PubMed:15489334)Curated
    Sequence conflicti785 – 7851A → V in AAH27830. (PubMed:15489334)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC109614 Genomic DNA. No translation available.
    AC163219 Genomic DNA. No translation available.
    BC027830 mRNA. Translation: AAH27830.2.
    CCDSiCCDS19890.1.
    RefSeqiNP_666370.3. NM_146258.2.
    UniGeneiMm.209272.

    Genome annotation databases

    EnsembliENSMUST00000110483; ENSMUSP00000106109; ENSMUSG00000016128.
    GeneIDi243362.
    KEGGimmu:243362.
    UCSCiuc009aum.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC109614 Genomic DNA. No translation available.
    AC163219 Genomic DNA. No translation available.
    BC027830 mRNA. Translation: AAH27830.2 .
    CCDSi CCDS19890.1.
    RefSeqi NP_666370.3. NM_146258.2.
    UniGenei Mm.209272.

    3D structure databases

    ProteinModelPortali Q923Q2.
    SMRi Q923Q2. Positions 50-120, 655-863, 907-1104.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q923Q2. 1 interaction.
    MINTi MINT-4135694.

    PTM databases

    PhosphoSitei Q923Q2.

    Proteomic databases

    PaxDbi Q923Q2.
    PRIDEi Q923Q2.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000110483 ; ENSMUSP00000106109 ; ENSMUSG00000016128 .
    GeneIDi 243362.
    KEGGi mmu:243362.
    UCSCi uc009aum.2. mouse.

    Organism-specific databases

    CTDi 90627.
    MGIi MGI:2385331. Stard13.

    Phylogenomic databases

    eggNOGi NOG236923.
    GeneTreei ENSGT00740000115136.
    HOGENOMi HOG000039960.
    HOVERGENi HBG055955.
    OrthoDBi EOG7CG6Z8.
    PhylomeDBi Q923Q2.

    Enzyme and pathway databases

    Reactomei REACT_210090. Rho GTPase cycle.

    Miscellaneous databases

    ChiTaRSi STARD13. mouse.
    NextBioi 385731.
    PROi Q923Q2.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q923Q2.
    Bgeei Q923Q2.
    Genevestigatori Q923Q2.

    Family and domain databases

    Gene3Di 1.10.555.10. 1 hit.
    3.30.530.20. 1 hit.
    InterProi IPR008936. Rho_GTPase_activation_prot.
    IPR000198. RhoGAP_dom.
    IPR013761. SAM/pointed.
    IPR023393. START-like_dom.
    IPR002913. START_lipid-bd_dom.
    [Graphical view ]
    Pfami PF00620. RhoGAP. 1 hit.
    PF01852. START. 1 hit.
    [Graphical view ]
    SMARTi SM00324. RhoGAP. 1 hit.
    SM00234. START. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47769. SSF47769. 1 hit.
    SSF48350. SSF48350. 1 hit.
    PROSITEi PS50238. RHOGAP. 1 hit.
    PS50848. START. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: FVB/N.
      Tissue: Mammary tumor.
    3. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-133, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Liver.

    Entry informationi

    Entry nameiSTA13_MOUSE
    AccessioniPrimary (citable) accession number: Q923Q2
    Secondary accession number(s): E9PUB5, Q8K369
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 15, 2002
    Last sequence update: July 27, 2011
    Last modified: October 1, 2014
    This is version 106 of the entry and version 5 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3