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Protein

CUB and sushi domain-containing protein 1

Gene

Csmd1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

  • glucose homeostasis Source: MGI
  • startle response Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
CUB and sushi domain-containing protein 1
Alternative name(s):
CUB and sushi multiple domains protein 1
Gene namesi
Name:Csmd1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:2137383. Csmd1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini30 – 34873458ExtracellularSequence analysisAdd
BLAST
Transmembranei3488 – 350821HelicalSequence analysisAdd
BLAST
Topological domaini3509 – 356456CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2929Sequence analysisAdd
BLAST
Chaini30 – 35643535CUB and sushi domain-containing protein 1PRO_0000021026Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi32 ↔ 58By similarity
Glycosylationi40 – 401N-linked (GlcNAc...)Sequence analysis
Glycosylationi57 – 571N-linked (GlcNAc...)Sequence analysis
Disulfide bondi145 ↔ 185By similarity
Disulfide bondi171 ↔ 202By similarity
Disulfide bondi208 ↔ 234By similarity
Disulfide bondi349 ↔ 389By similarity
Disulfide bondi375 ↔ 406By similarity
Disulfide bondi411 ↔ 437By similarity
Disulfide bondi527 ↔ 567By similarity
Disulfide bondi553 ↔ 580By similarity
Disulfide bondi584 ↔ 610By similarity
Glycosylationi587 – 5871N-linked (GlcNAc...)Sequence analysis
Glycosylationi686 – 6861N-linked (GlcNAc...)Sequence analysis
Disulfide bondi697 ↔ 738By similarity
Disulfide bondi723 ↔ 754By similarity
Disulfide bondi758 ↔ 784By similarity
Disulfide bondi873 ↔ 913By similarity
Disulfide bondi899 ↔ 926By similarity
Disulfide bondi930 ↔ 956By similarity
Glycosylationi955 – 9551N-linked (GlcNAc...)Sequence analysis
Glycosylationi1015 – 10151N-linked (GlcNAc...)Sequence analysis
Glycosylationi1034 – 10341N-linked (GlcNAc...)Sequence analysis
Disulfide bondi1045 ↔ 1085By similarity
Disulfide bondi1071 ↔ 1100By similarity
Disulfide bondi1104 ↔ 1130By similarity
Glycosylationi1184 – 11841N-linked (GlcNAc...)Sequence analysis
Glycosylationi1197 – 11971N-linked (GlcNAc...)Sequence analysis
Disulfide bondi1217 ↔ 1258By similarity
Disulfide bondi1244 ↔ 1273By similarity
Disulfide bondi1277 ↔ 1304By similarity
Disulfide bondi1391 ↔ 1431By similarity
Glycosylationi1399 – 13991N-linked (GlcNAc...)Sequence analysis
Disulfide bondi1417 ↔ 1447By similarity
Disulfide bondi1451 ↔ 1477By similarity
Glycosylationi1454 – 14541N-linked (GlcNAc...)Sequence analysis
Disulfide bondi1564 ↔ 1604By similarity
Glycosylationi1572 – 15721N-linked (GlcNAc...)Sequence analysis
Disulfide bondi1590 ↔ 1621By similarity
Disulfide bondi1625 ↔ 1651By similarity
Glycosylationi1644 – 16441N-linked (GlcNAc...)Sequence analysis
Disulfide bondi1741 ↔ 1781By similarity
Disulfide bondi1767 ↔ 1798By similarity
Glycosylationi1792 – 17921N-linked (GlcNAc...)Sequence analysis
Disulfide bondi1802 ↔ 1828By similarity
Glycosylationi1805 – 18051N-linked (GlcNAc...)Sequence analysis
Glycosylationi1882 – 18821N-linked (GlcNAc...)Sequence analysis
Disulfide bondi1915 ↔ 1955By similarity
Disulfide bondi1941 ↔ 1970By similarity
Disulfide bondi1974 ↔ 2000By similarity
Glycosylationi2018 – 20181N-linked (GlcNAc...)Sequence analysis
Disulfide bondi2087 ↔ 2127By similarity
Disulfide bondi2113 ↔ 2142By similarity
Disulfide bondi2146 ↔ 2172By similarity
Glycosylationi2149 – 21491N-linked (GlcNAc...)Sequence analysis
Glycosylationi2154 – 21541N-linked (GlcNAc...)Sequence analysis
Glycosylationi2187 – 21871N-linked (GlcNAc...)Sequence analysis
Disulfide bondi2258 ↔ 2300By similarity
Disulfide bondi2286 ↔ 2315By similarity
Disulfide bondi2319 ↔ 2347By similarity
Glycosylationi2358 – 23581N-linked (GlcNAc...)Sequence analysis
Glycosylationi2394 – 23941N-linked (GlcNAc...)Sequence analysis
Glycosylationi2400 – 24001N-linked (GlcNAc...)Sequence analysis
Disulfide bondi2432 ↔ 2473By similarity
Glycosylationi2445 – 24451N-linked (GlcNAc...)Sequence analysis
Disulfide bondi2459 ↔ 2490By similarity
Glycosylationi2470 – 24701N-linked (GlcNAc...)Sequence analysis
Disulfide bondi2495 ↔ 2537By similarity
Glycosylationi2503 – 25031N-linked (GlcNAc...)Sequence analysis
Disulfide bondi2521 ↔ 2552By similarity
Disulfide bondi2557 ↔ 2602By similarity
Disulfide bondi2588 ↔ 2617By similarity
Glycosylationi2605 – 26051N-linked (GlcNAc...)Sequence analysis
Disulfide bondi2622 ↔ 2662By similarity
Disulfide bondi2648 ↔ 2675By similarity
Disulfide bondi2680 ↔ 2720By similarity
Disulfide bondi2706 ↔ 2733By similarity
Disulfide bondi2738 ↔ 2778By similarity
Glycosylationi2750 – 27501N-linked (GlcNAc...)Sequence analysis
Glycosylationi2761 – 27611N-linked (GlcNAc...)Sequence analysis
Disulfide bondi2764 ↔ 2791By similarity
Glycosylationi2795 – 27951N-linked (GlcNAc...)Sequence analysis
Disulfide bondi2796 ↔ 2841By similarity
Disulfide bondi2827 ↔ 2854By similarity
Disulfide bondi2859 ↔ 2899By similarity
Disulfide bondi2885 ↔ 2912By similarity
Glycosylationi2894 – 28941N-linked (GlcNAc...)Sequence analysis
Disulfide bondi2920 ↔ 2960By similarity
Disulfide bondi2946 ↔ 2973By similarity
Glycosylationi2963 – 29631N-linked (GlcNAc...)Sequence analysis
Disulfide bondi2978 ↔ 3019By similarity
Disulfide bondi3005 ↔ 3032By similarity
Glycosylationi3022 – 30221N-linked (GlcNAc...)Sequence analysis
Disulfide bondi3037 ↔ 3079By similarity
Glycosylationi3056 – 30561N-linked (GlcNAc...)Sequence analysis
Disulfide bondi3063 ↔ 3092By similarity
Glycosylationi3086 – 30861N-linked (GlcNAc...)Sequence analysis
Disulfide bondi3097 ↔ 3137By similarity
Disulfide bondi3123 ↔ 3150By similarity
Disulfide bondi3155 ↔ 3195By similarity
Disulfide bondi3181 ↔ 3208By similarity
Disulfide bondi3216 ↔ 3257By similarity
Glycosylationi3228 – 32281N-linked (GlcNAc...)Sequence analysis
Disulfide bondi3243 ↔ 3270By similarity
Glycosylationi3260 – 32601N-linked (GlcNAc...)Sequence analysis
Disulfide bondi3275 ↔ 3317By similarity
Disulfide bondi3302 ↔ 3330By similarity
Glycosylationi3339 – 33391N-linked (GlcNAc...)Sequence analysis
Glycosylationi3379 – 33791N-linked (GlcNAc...)Sequence analysis
Glycosylationi3386 – 33861N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ923L3.
PaxDbiQ923L3.
PRIDEiQ923L3.

PTM databases

PhosphoSiteiQ923L3.

Expressioni

Gene expression databases

BgeeiQ923L3.
CleanExiMM_CSMD1.
GenevisibleiQ923L3. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000080751.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini32 – 140109CUB 1PROSITE-ProRule annotationAdd
BLAST
Domaini143 – 20462Sushi 1PROSITE-ProRule annotationAdd
BLAST
Domaini208 – 312105CUB 2PROSITE-ProRule annotationAdd
BLAST
Domaini347 – 40862Sushi 2PROSITE-ProRule annotationAdd
BLAST
Domaini411 – 522112CUB 3PROSITE-ProRule annotationAdd
BLAST
Domaini525 – 58258Sushi 3PROSITE-ProRule annotationAdd
BLAST
Domaini584 – 692109CUB 4PROSITE-ProRule annotationAdd
BLAST
Domaini695 – 75662Sushi 4PROSITE-ProRule annotationAdd
BLAST
Domaini758 – 866109CUB 5PROSITE-ProRule annotationAdd
BLAST
Domaini871 – 92858Sushi 5PROSITE-ProRule annotationAdd
BLAST
Domaini930 – 1040111CUB 6PROSITE-ProRule annotationAdd
BLAST
Domaini1043 – 110260Sushi 6PROSITE-ProRule annotationAdd
BLAST
Domaini1104 – 1212109CUB 7PROSITE-ProRule annotationAdd
BLAST
Domaini1215 – 127561Sushi 7PROSITE-ProRule annotationAdd
BLAST
Domaini1277 – 1386110CUB 8PROSITE-ProRule annotationAdd
BLAST
Domaini1389 – 144961Sushi 8PROSITE-ProRule annotationAdd
BLAST
Domaini1451 – 1559109CUB 9PROSITE-ProRule annotationAdd
BLAST
Domaini1562 – 162362Sushi 9PROSITE-ProRule annotationAdd
BLAST
Domaini1625 – 1733109CUB 10PROSITE-ProRule annotationAdd
BLAST
Domaini1739 – 180062Sushi 10PROSITE-ProRule annotationAdd
BLAST
Domaini1802 – 1910109CUB 11PROSITE-ProRule annotationAdd
BLAST
Domaini1913 – 197260Sushi 11PROSITE-ProRule annotationAdd
BLAST
Domaini1974 – 2082109CUB 12PROSITE-ProRule annotationAdd
BLAST
Domaini2085 – 214460Sushi 12PROSITE-ProRule annotationAdd
BLAST
Domaini2146 – 2257112CUB 13PROSITE-ProRule annotationAdd
BLAST
Domaini2256 – 231762Sushi 13PROSITE-ProRule annotationAdd
BLAST
Domaini2319 – 2430112CUB 14PROSITE-ProRule annotationAdd
BLAST
Domaini2430 – 249263Sushi 14PROSITE-ProRule annotationAdd
BLAST
Domaini2493 – 255462Sushi 15PROSITE-ProRule annotationAdd
BLAST
Domaini2555 – 261965Sushi 16PROSITE-ProRule annotationAdd
BLAST
Domaini2620 – 267758Sushi 17PROSITE-ProRule annotationAdd
BLAST
Domaini2678 – 273558Sushi 18PROSITE-ProRule annotationAdd
BLAST
Domaini2736 – 279358Sushi 19PROSITE-ProRule annotationAdd
BLAST
Domaini2794 – 285663Sushi 20PROSITE-ProRule annotationAdd
BLAST
Domaini2857 – 291458Sushi 21PROSITE-ProRule annotationAdd
BLAST
Domaini2918 – 297558Sushi 22PROSITE-ProRule annotationAdd
BLAST
Domaini2976 – 303459Sushi 23PROSITE-ProRule annotationAdd
BLAST
Domaini3035 – 309460Sushi 24PROSITE-ProRule annotationAdd
BLAST
Domaini3095 – 315258Sushi 25PROSITE-ProRule annotationAdd
BLAST
Domaini3153 – 321058Sushi 26PROSITE-ProRule annotationAdd
BLAST
Domaini3214 – 327259Sushi 27PROSITE-ProRule annotationAdd
BLAST
Domaini3273 – 333260Sushi 28PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the CSMD family.Curated
Contains 14 CUB domains.PROSITE-ProRule annotation
Contains 28 Sushi (CCP/SCR) domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Sushi, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4297. Eukaryota.
ENOG410XPJ1. LUCA.
GeneTreeiENSGT00760000118803.
HOGENOMiHOG000112015.
HOVERGENiHBG051134.
InParanoidiQ923L3.
KOiK17495.
OMAiSCVAECG.
OrthoDBiEOG7FNC6J.
TreeFamiTF316872.

Family and domain databases

Gene3Di2.60.120.290. 14 hits.
InterProiIPR000859. CUB_dom.
IPR000436. Sushi_SCR_CCP_dom.
[Graphical view]
PfamiPF00431. CUB. 14 hits.
PF00084. Sushi. 28 hits.
[Graphical view]
SMARTiSM00032. CCP. 28 hits.
SM00042. CUB. 14 hits.
[Graphical view]
SUPFAMiSSF49854. SSF49854. 14 hits.
SSF57535. SSF57535. 28 hits.
PROSITEiPS01180. CUB. 14 hits.
PS50923. SUSHI. 28 hits.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q923L3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTAWRKFKSL LLPLVLAVLC AGLLTAAKGQ NCGGLVQGPN GTIESPGFPH
60 70 80 90 100
GYPNYANCTW IIITGERNRI QLSFHTFALE EDFDILSVYD GQPQQGNLKV
110 120 130 140 150
RLSGFQLPSS IVSTGSLLTL WFTTDFAVSA QGFKAMYEVL PSHTCGNPGE
160 170 180 190 200
ILKGVLHGTR FNIGDKIRYS CLSGYILEGH AILTCIVSPG NGASWDFPAP
210 220 230 240 250
FCRAEGACGG TLRGTSGSIS SPHFPSEYDN NADCTWTILA EPGDTIALVF
260 270 280 290 300
TDFQLEEGYD FLEISGTEAP SIWLTGMNLP SPVISSKNWL RLHFTSDSNH
310 320 330 340 350
RRKGFNAQFQ VKKAIELKSR GVKMLPSKDS SHKNSVLTQG GVSLISDMCP
360 370 380 390 400
DPGIPDNGRR AGSDFRVGAN VQFSCEDNYV LQGAKGITCQ RVTETLAAWN
410 420 430 440 450
DHRPICRART CGSNLRGPSG VITSPNYPVQ YEDNAHCVWV ITTTDPDKVI
460 470 480 490 500
KLAFEEFELE RGYDTLTVGD AGKVGDTRSV LYVLTGSSVP DLIVSMSNQM
510 520 530 540 550
WLHLQSDDSI GSPGFKAVYQ EIEKGGCGDP GIPAYGKRTG SSFLHGDTLT
560 570 580 590 600
FECQAAFELV GERVITCQKN NQWSGNKPSC VFSCFFNFTA PSGIILSPNY
610 620 630 640 650
PEEYGNNMNC VWLIISEPGS RIHLIFNDFD VEPQFDFLAV KDDGISDITV
660 670 680 690 700
LGTFSGNEVP AQLASSGHIV RLEFQSDHST TGRGFNITYT TFGQNECHDP
710 720 730 740 750
GIPVNGRRFG DRFLLGSSVS FHCDDGFVKT QGSESITCIL QDGNVVWSST
760 770 780 790 800
VPRCEAPCGG HLTASSGVIL PPGWPGYYKD SLNCEWVIEA KPGHSIKITF
810 820 830 840 850
DRFQTEVNYD TLEVRDGPTS SSPLIGEYHG TQAPQFLIST GNYMYLLFTT
860 870 880 890 900
DSSRASVGFL IHYESVTLES DSCLDPGIPV NGQRHGSNFG IRSTVTFSCD
910 920 930 940 950
PGYTLSDDEP LVCEKNHQWN HALPSCDALC GGYIHGKSGT VLSPGFPDFY
960 970 980 990 1000
PNSLNCTWTI EVSHGKGVQM NFHTFHLESS HDYLLITEDG SFSEPVARLT
1010 1020 1030 1040 1050
GSVLPHTIKA GLFGNFTAQL RFISDFSISY EGFNITFAEY DLEPCDDPGV
1060 1070 1080 1090 1100
PAFSRRIGFQ FGVGDTLAFT CFQGYRLEGA TKLTCLGGGR RVWSAPLPRC
1110 1120 1130 1140 1150
VAECGASVKG NEGTLLSPNF PSHYDNNHEC IYKIETEAGK GIHLRARTFQ
1160 1170 1180 1190 1200
LFEGDTLKVY DGKDSSSRSL GVFTRSEFMG LVLNSTSNHL RLEFNTNGSD
1210 1220 1230 1240 1250
TAQGFQLTYT SFDLVKCEDP GIPNYGYRIR DDGHFTDTVV LYSCNPGYAM
1260 1270 1280 1290 1300
HGSSTLTCLS GDRRVWDKPM PSCVAECGGL VHAATSGRIL SPGYPAPYDN
1310 1320 1330 1340 1350
NLHCTWTIEA DPGKTISLHF IVFDTETAHD ILKVWDGPVD SNILLKEWSG
1360 1370 1380 1390 1400
SALPEDIHST FNSLTLQFDS DFFISKSGFS IQFSTSIAST CNDPGMPQNG
1410 1420 1430 1440 1450
TRYGDSREPG DTITFQCDPG YQLQGPAKIT CVQLNNRFFW QPDPPSCIAA
1460 1470 1480 1490 1500
CGGNLTGPAG VILSPNYPQP YPPGKECDWR IKVNPDFVIA LIFKSFSMEP
1510 1520 1530 1540 1550
SYDFLHIYEG EDSNSPLIGS FQGSQAPERI ESSGNSLFLA FRSDASVGLS
1560 1570 1580 1590 1600
GFAIEFKEKP REACFDPGNI MNGTRIGTDF KLGSTVTYQC DSGYKIVDPS
1610 1620 1630 1640 1650
SIECVTGADG KPSWDRALPA CQAPCGGQYT GSEGVVLSPN YPHNYTAGQM
1660 1670 1680 1690 1700
CIYSITVPKE FVVFGQFAYF QTALNDLAEL FDGTHPQARL LSSLSGSHSG
1710 1720 1730 1740 1750
ETLPLATSNQ ILLRFSAKSG ASARGFHFVY QAVPRTSDTQ CSSVPEPRYG
1760 1770 1780 1790 1800
RRIGSEFSAG SIVRFECNPG YLLQGSTAIR CQSVPNALAQ WNDTIPSCVV
1810 1820 1830 1840 1850
PCSGNFTQRR GTILSPGYPE PYGNNLNCVW KIIVSEGSGI QIQVISFATE
1860 1870 1880 1890 1900
QNWDSLEIHD GGDMTAPRLG SFSGTTVPAL LNSTSNQLCL HFQSDISVAA
1910 1920 1930 1940 1950
AGFHLEYKTV GLAACQEPAL PSNGIKIGDR YMVNDVLSFQ CEPGYTLQGR
1960 1970 1980 1990 2000
SHISCMPGTV RRWNYPSPLC IATCGGTLTS MSGVILSPGF PGSYPNNLDC
2010 2020 2030 2040 2050
TWKISLPIGY GAHIQFLNFS TEANHDYLEI QNGPYHSSPM MGQFSGPDLP
2060 2070 2080 2090 2100
TSLLSTTHET LIRFYSDHSQ NRQGFKLSYQ AYELQNCPDP PAFQNGFMIN
2110 2120 2130 2140 2150
SDYSVGQSIS FECYPGYILL GHPVLTCQHG TDRNWNYPFP RCDAPCGYNV
2160 2170 2180 2190 2200
TSQNGTIYSP GFPDEYPILK DCLWLVTVPP GHGVYINFTL LQTEAVNDYI
2210 2220 2230 2240 2250
AVWDGPDQNS PQLGVFSGNT ALETAYSSTN QVLLKFHSDF SNGGFFVLNF
2260 2270 2280 2290 2300
HAFQLKRCPP PPAVPQADLL TEDEDFEIGD FVKYQCHPGY TLLGSDTLTC
2310 2320 2330 2340 2350
KLSSQLLFQG SPPTCEAQCP ANEVRTESSG VILSPGYPGN YFNSQTCAWS
2360 2370 2380 2390 2400
IKVEPNFNIT LFVDTFQSEK QFDALEVFDG SSGQSPLLVV LSGNHTEQSN
2410 2420 2430 2440 2450
FTSRSNHLYL RWSTDHATSK KGFKIRYAAP YCSLTSTLRN GGILNKTAGA
2460 2470 2480 2490 2500
VGSKVHYFCK PGYRMIGHSN ATCRRNPVGV YQWDSMAPLC QAVSCGIPEA
2510 2520 2530 2540 2550
PGNGSFTGNE FTLDSKVTYE CNEGFKLDAS QEATTVCQED GLWSNRGKPP
2560 2570 2580 2590 2600
TCKPVPCPSI EGQLSEHVLW RLVSGSLNEY GAQVLLSCSP GYFLQGQRLL
2610 2620 2630 2640 2650
QCQANGTWST EEDRPRCKVI SCGSLSFPPN GNKIGTLTIY GATAIFTCNT
2660 2670 2680 2690 2700
GYTLVGSHVR ECLANGLWSG SETRCLAGHC GSPDPIVNGH ISGDGFSYRD
2710 2720 2730 2740 2750
TVVYQCNPGF RLVGTSVRIC LQDHKWSGQT PVCVPITCGH PGNPAHGLTN
2760 2770 2780 2790 2800
GTEFNLNDLV NFTCHTGYRL QGASRAQCRS NGQWSSPLPI CRVVNCSDPG
2810 2820 2830 2840 2850
SVENAVRHGQ QNFPESFEYG TSVMYHCKTG FYLLGSSALT CMASGLWDRS
2860 2870 2880 2890 2900
LPKCLAISCG HPGVPANAVL TGELFTYGAT VQYSCKGGQI LTGNSTRVCQ
2910 2920 2930 2940 2950
EDSHWSGSLP HCSGNSPGFC GDPGTPAHGS RLGDEFKTKS LLRFSCEMGH
2960 2970 2980 2990 3000
QLRGSAERTC LVNGSWSGVQ PVCEAVSCGN PGTPTNGMIL SSDGILFSSS
3010 3020 3030 3040 3050
VIYACWEGYK TSGLMTRHCT ANGTWTGTAP DCTIISCGDP GTLPNGIQFG
3060 3070 3080 3090 3100
TDFTFNKTVS YQCNPGYLME PPTSPTIRCT KDGTWNQSRP LCKAVLCNQP
3110 3120 3130 3140 3150
PPVPNGKVEG SDFRWGASIS YSCVDGYQLS HSAILSCEGR GVWKGEVPQC
3160 3170 3180 3190 3200
LPVFCGDPGT PAEGRLSGKS FTFKSEVFIQ CKPPFVLVGS SRRTCQADGI
3210 3220 3230 3240 3250
WSGIQPTCID PAHTACPDPG TPHFGIQNSS KGYEVGSTVF FRCRKGYHIQ
3260 3270 3280 3290 3300
GSTTRTCLAN LTWSGIQTEC IPHACRQPET PAHADVRAID LPAFGYTLVY
3310 3320 3330 3340 3350
TCHPGFFLAG GSEHRTCKAD MKWTGKSPVC KSKGVREVNE TVTKTPVPSD
3360 3370 3380 3390 3400
VFFINSVWKG YYEYLGKRQP ATLTVDWFNA TSSKVNATFT AASRVQLELT
3410 3420 3430 3440 3450
GVYKKEEAHL LLKAFHIKGP ADIFVSKFEN DNWGLDGYVS SGLERGGFSF
3460 3470 3480 3490 3500
QGDIHGKDFG KFKLERQDPS NSDADSSNHY QGTSSGSVAA AILVPFFALI
3510 3520 3530 3540 3550
LSGFAFYLYK HRTRPKVQYN GYAGHENSNG QASFENPMYD TNLKPTEAKA
3560
VRFDTTLNTV CTVV
Length:3,564
Mass (Da):387,862
Last modified:July 27, 2011 - v2
Checksum:iBCBC9BB488908858
GO
Isoform 2 (identifier: Q923L3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     3332-3347: SKGVREVNETVTKTPV → I

Note: No experimental confirmation available.
Show »
Length:3,549
Mass (Da):386,249
Checksum:i578A1577BCC5DD6E
GO
Isoform 3 (identifier: Q923L3-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     102-3564: Missing.

Note: No experimental confirmation available.
Show »
Length:101
Mass (Da):11,092
Checksum:i9A3E87014C04D290
GO

Sequence cautioni

The sequence BAC30095.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti627 – 6271N → K in AAG54083 (PubMed:11472063).Curated
Sequence conflicti1189 – 11891H → Y in AAG54083 (PubMed:11472063).Curated
Sequence conflicti1652 – 16521I → V in AAG54083 (PubMed:11472063).Curated
Sequence conflicti2222 – 22221L → P in AAG54083 (PubMed:11472063).Curated
Sequence conflicti2354 – 23541E → K in AAG54083 (PubMed:11472063).Curated
Sequence conflicti2384 – 23841Q → R in AAG54083 (PubMed:11472063).Curated
Sequence conflicti2721 – 273111LQDHKWSGQTP → CRTTSGRGRLT in AAG54083 (PubMed:11472063).CuratedAdd
BLAST
Sequence conflicti2955 – 29551S → F in AAG54083 (PubMed:11472063).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei102 – 35643463Missing in isoform 3. 1 PublicationVSP_009036Add
BLAST
Alternative sequencei3332 – 334716SKGVR…TKTPV → I in isoform 2. 1 PublicationVSP_009037Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY017475 mRNA. Translation: AAG54083.1.
AK038679 mRNA. Translation: BAC30095.1. Different initiation.
AK082377 mRNA. Translation: BAC38482.1.
AC101229 Genomic DNA. No translation available.
AC122323 Genomic DNA. No translation available.
AC122839 Genomic DNA. No translation available.
AC122911 Genomic DNA. No translation available.
AC123819 Genomic DNA. No translation available.
AC123866 Genomic DNA. No translation available.
AC123984 Genomic DNA. No translation available.
AC124351 Genomic DNA. No translation available.
AC125132 Genomic DNA. No translation available.
AC125354 Genomic DNA. No translation available.
AC132578 Genomic DNA. No translation available.
AC144939 Genomic DNA. No translation available.
AC154107 Genomic DNA. No translation available.
CCDSiCCDS40244.1. [Q923L3-1]
RefSeqiNP_444401.2. NM_053171.2. [Q923L3-1]
UniGeneiMm.436988.

Genome annotation databases

EnsembliENSMUST00000082104; ENSMUSP00000080751; ENSMUSG00000060924. [Q923L3-1]
GeneIDi94109.
KEGGimmu:94109.
UCSCiuc009kzp.1. mouse. [Q923L3-1]
uc009kzr.1. mouse. [Q923L3-3]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY017475 mRNA. Translation: AAG54083.1.
AK038679 mRNA. Translation: BAC30095.1. Different initiation.
AK082377 mRNA. Translation: BAC38482.1.
AC101229 Genomic DNA. No translation available.
AC122323 Genomic DNA. No translation available.
AC122839 Genomic DNA. No translation available.
AC122911 Genomic DNA. No translation available.
AC123819 Genomic DNA. No translation available.
AC123866 Genomic DNA. No translation available.
AC123984 Genomic DNA. No translation available.
AC124351 Genomic DNA. No translation available.
AC125132 Genomic DNA. No translation available.
AC125354 Genomic DNA. No translation available.
AC132578 Genomic DNA. No translation available.
AC144939 Genomic DNA. No translation available.
AC154107 Genomic DNA. No translation available.
CCDSiCCDS40244.1. [Q923L3-1]
RefSeqiNP_444401.2. NM_053171.2. [Q923L3-1]
UniGeneiMm.436988.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000080751.

PTM databases

PhosphoSiteiQ923L3.

Proteomic databases

MaxQBiQ923L3.
PaxDbiQ923L3.
PRIDEiQ923L3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000082104; ENSMUSP00000080751; ENSMUSG00000060924. [Q923L3-1]
GeneIDi94109.
KEGGimmu:94109.
UCSCiuc009kzp.1. mouse. [Q923L3-1]
uc009kzr.1. mouse. [Q923L3-3]

Organism-specific databases

CTDi64478.
MGIiMGI:2137383. Csmd1.

Phylogenomic databases

eggNOGiKOG4297. Eukaryota.
ENOG410XPJ1. LUCA.
GeneTreeiENSGT00760000118803.
HOGENOMiHOG000112015.
HOVERGENiHBG051134.
InParanoidiQ923L3.
KOiK17495.
OMAiSCVAECG.
OrthoDBiEOG7FNC6J.
TreeFamiTF316872.

Miscellaneous databases

NextBioi352095.
PROiQ923L3.
SOURCEiSearch...

Gene expression databases

BgeeiQ923L3.
CleanExiMM_CSMD1.
GenevisibleiQ923L3. MM.

Family and domain databases

Gene3Di2.60.120.290. 14 hits.
InterProiIPR000859. CUB_dom.
IPR000436. Sushi_SCR_CCP_dom.
[Graphical view]
PfamiPF00431. CUB. 14 hits.
PF00084. Sushi. 28 hits.
[Graphical view]
SMARTiSM00032. CCP. 28 hits.
SM00042. CUB. 14 hits.
[Graphical view]
SUPFAMiSSF49854. SSF49854. 14 hits.
SSF57535. SSF57535. 28 hits.
PROSITEiPS01180. CUB. 14 hits.
PS50923. SUSHI. 28 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Strain: C57BL/6J.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 3250-3564 (ISOFORM 2).
    Strain: C57BL/6J.
    Tissue: Cerebellum and Hypothalamus.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  4. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain.

Entry informationi

Entry nameiCSMD1_MOUSE
AccessioniPrimary (citable) accession number: Q923L3
Secondary accession number(s): E9QK23, Q8BUV1, Q8BYQ3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 28, 2003
Last sequence update: July 27, 2011
Last modified: November 11, 2015
This is version 105 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.