Q923K6 (Q923K6_RAT) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Calcium channel isoform alpha1E7 EMBL AAK33009.1

Gene names

Name:	Cacna1e RGD 2246
Synonyms:	CaV2.3 EMBL AAK33009.1

Organism

Rattus norvegicus (Rat) EMBL AAK33009.1

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	2295 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Subcellular location	Membrane; Multi-pass membrane protein By similarity RuleBase RU003808.
Sequence similarities	Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. [View classification] RuleBase RU003808

Ontologies

Keywords
Biological process	Calcium transport Ion transport Transport
Cellular component	Membrane
Domain	Transmembrane RuleBase RU003378
Ligand	Calcium
Molecular function	Calcium channel RuleBase RU003808 Ionic channel Voltage-gated channel RuleBase RU003808
Gene Ontology (GO)
Cellular component	voltage-gated calcium channel complex Inferred from electronic annotation. Source: InterPro
Molecular function	voltage-gated calcium channel activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q923K6 [UniParc]. Last modified December 1, 2001. Version 1. Checksum: 7AED2D2EC30E6E4F	FASTA	2,295	259,230
	10 20 30 40 50 60 MARFGEAVVV GRPGSGDGDS DQSRNRQGTP VPASGPAAAY KQSKAQRATM ALYNPIPVRQ 70 80 90 100 110 120 NCFTVNRSLF IFGEDNIVRK YAKKLIDWPP FEYMILATII ANCIVLALEQ HLPEDDKTPM 130 140 150 160 170 180 SRRLEKTEPY FIGIFCFEAG IKIVALGFIF HKGSYLRNGW NVMDFIVVLS GILATAGTHF 190 200 210 220 230 240 NTHVDLRTLR AVRVLRPLKL VSGIPSLQIV LKSIMKAMVP LLQIGLLLFF AILMFAIIGL 250 260 270 280 290 300 EFYSGKLHRA CFMNNSGILE GFDPPHPCGV QGCPAGYECK DWIGPNDGIT QFDNILFAVL 310 320 330 340 350 360 TVFQCITMEG WTTVLYNTND ALGATWNWLY FIPLIIIGSF FVLNLVLGVL SGEFAKERER 370 380 390 400 410 420 VENRRAFMKL RRQQQIEREL NGYRAWIDKA EEVMLAEENK NSGTSALEVL RRATIKRSRT 430 440 450 460 470 480 EAMTRDSSDE HCVDISSVGT PLARASIKST KVDGASYFRH KERLLRISIR HMVKSQVFYW 490 500 510 520 530 540 IVLSVVALNT ACVAIVHHNQ PQWLTHLLYY AEFLFLGLFL LEMSLKMYGM GPRLYFHSSF 550 560 570 580 590 600 NCFDFGVTVG SIFEVVWAIF RPGTSFGISV LRALRLLRIF KITKYWASLR NLVVSLMSSM 610 620 630 640 650 660 KSIISLLFLL FLFIVVFALL GMQLFGGRFN FNDGTPSANF DTFPAAIMTV FQILTGEDWN 670 680 690 700 710 720 EVLYNGIRSQ GGVSSGMWSA IYFIVLTLFG NYTLLNVFLA IAVDNLANAQ ELTKDEQEEE 730 740 750 760 770 780 EAFNQKHALQ KAKEVSPMSA PNMPSIERER RRRHHMSVWE QRTSQLRRHM QMSSQEALNK 790 800 810 820 830 840 EEAPPMNPLN PLNPLSPLNP LNAHPSLYRR PRPIEGLPLG LGLEKCEEER ISRGGSLKGD 850 860 870 880 890 900 IGGLTSVLDN QRSPLSLGKR EPPWLPRSCH GNCDPTQQET GGGETVVTFE DRARHRQSQR 910 920 930 940 950 960 RSRHRRVRTE GKESASASRS RSASQERSLD EGVSIDGEKE HEPQSSHRSK EPTIHEEERT 970 980 990 1000 1010 1020 QDLRRTNSLM VPRGSGLVGA LDEAETPLVQ PQPELEVGKD AALTEQEAEG SSEQALLADV 1030 1040 1050 1060 1070 1080 QLDVGRGISQ SEPDLSCMTT NMDKATTEST SVTVAIPDVD PLVDSTVVNI SNKTDGEASP 1090 1100 1110 1120 1130 1140 LKEAETKEEE EEVEKKKQKK EKRETGKAMV PHSSMFIFST TNPIRKACHY IVNLRYFEMC 1150 1160 1170 1180 1190 1200 ILLVIAASSI ALAAEDPVLT NSERNKVLRY FDYVFTGVFT FEMVIKMIDQ GLILQDGSYF 1210 1220 1230 1240 1250 1260 RDLWNILDFV VVVGALVAFA LANALGTNKG RDIKTIKSLR VLRVLRPLKT IKRLPKLKAV 1270 1280 1290 1300 1310 1320 FDCVVTSLKN VFNILIVYKL FMFIFAVIAV QLFKGKFFYC TDSSKDTEKE CIGNYVDHEK 1330 1340 1350 1360 1370 1380 NKMEVKGREW KRHEFHYDNI IWALLTLFTV STGEGWPQVL QHSVDVTEED RGPSRSNRME 1390 1400 1410 1420 1430 1440 MSIFYVVYFV VFPFFFVNIF VALIIITFQE QGDKMMEECS LEKNERACID FAISAKPLTR 1450 1460 1470 1480 1490 1500 YMPQNRHTFQ YRVWHFVVSP SFEYTIMAMI ALNTVVLMMK YYSAPWTYEL ALKYLNIAFT 1510 1520 1530 1540 1550 1560 MVFSLECVLK VIAFGFLNYF RDTWNIFDFI TVIGSITEII LTDSKLVNTS GFNMSFLELF 1570 1580 1590 1600 1610 1620 RAARLIKLLR QGYTIRILLW TFVQSFKALP YVCLLIAMLF FIYAIIGMQV FGNIKLDEES 1630 1640 1650 1660 1670 1680 HINRHNNFRS FFGSLMLLFR SATGEAWQEI MLSCLGEKGC EPDTTAPSGQ NESERCGTDL 1690 1700 1710 1720 1730 1740 AYVYFVSFIF FCSFLMLNLF VAVIMDNFEY LTRDSSILGP HHLDEFVRVW AEYDRAACGR 1750 1760 1770 1780 1790 1800 IHYTEMYEML TLMSPPLGLG KRCPSKVAYK RLVLMNMPVA EDMTVHFTST LMALIRTALD 1810 1820 1830 1840 1850 1860 IKIAKGGADR QQLDSELQKE TLAIWPHLSQ KMLDLLVPMP KASDLTVGKI YAAMMIMDYY 1870 1880 1890 1900 1910 1920 KQSKVKKQRQ QLEEQKNAPM FQRMEPSSLP QEIISNAKAL PYLQQDPVSG LSGRSGYPSM 1930 1940 1950 1960 1970 1980 SPLSPQEIFQ LACMDPADDG QFQEQQSLEP EVSELKSVQS SNHGIYLPPD TQEHAGSGRA 1990 2000 2010 2020 2030 2040 SSMPRLTMDP QVVTDPSSMR RSFSTIRDKR SNSSWLEEFS MERSSENTYK SRRRSYHSSL 2050 2060 2070 2080 2090 2100 RLSAHRLNSD SGHKSDTHRS GGRERGRSKE RKHLLSPDVS RCNSEERGTQ ADWESPERRQ 2110 2120 2130 2140 2150 2160 SRSPSEGRSQ TPNRQGTGSL SESSIPSISD TSTPRRSRRQ LPPVPPKPRP LLSYSSLMRH 2170 2180 2190 2200 2210 2220 TGGISPPPDG SEGGSPLASQ ALESNSACLT ESSNSLHPQQ GQHPSPQHYI SEPYLALHED 2230 2240 2250 2260 2270 2280 SHASDCGEEE TLTFEAAVAT SLGRSNTIGS APPLRHSWQM PNGHYRRRRL GGLGLAMMCG 2290 AVSDLLSDTE EDDKC

References

[1]	"Identification of the Calcium Channel alpha1E (Ca2.3) Isoform Expressed in Atrial Myocytes." Mitchell J.W., Larsen J.K., Best P.M. Submitted (APR-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: Sprague-Dawley EMBL AAK33009.1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY029412 mRNA. Translation: AAK33009.1.
IPI	IPI00198751.
RefSeq	NP_062167.2. NM_019294.2.
UniGene	Rn.10742.
3D structure databases
ProteinModelPortal	Q923K6.
ModBase	Search...
Protein-protein interaction databases
STRING	Q923K6.
Proteomic databases
PRIDE	Q923K6.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	54234.
KEGG	rno:54234.
Organism-specific databases
CTD	777.
Phylogenomic databases
HOVERGEN	HBG050763.
InParanoid	Q923K6.
Gene expression databases
ArrayExpress	Q923K6.
Genevestigator	Q923K6.
Family and domain databases
InterPro	IPR018249. EF_HAND_2. IPR005821. Ion_trans. IPR014873. VDCC_a1su_IQ. IPR005449. VDCC_R_a1su. IPR002077. VDCCAlpha1. [Graphical view]
KO	K04852.
PANTHER	PTHR10037:SF57. RVDCCAlpha1. 1 hit.
Pfam	PF08763. Ca_chan_IQ. 1 hit. PF00520. Ion_trans. 4 hits. [Graphical view]
PRINTS	PR00167. CACHANNEL. PR01633. RVDCCALPHA1.
SMART	SM01062. Ca_chan_IQ. 1 hit. [Graphical view]
PROSITE	PS50222. EF_HAND_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	610674.

Entry information

Entry name

Q923K6_RAT

Accession

Primary (citable) accession number: Q923K6

Entry history

Integrated into UniProtKB/TrEMBL:	December 1, 2001
Last sequence update:	December 1, 2001
Last modified:	January 25, 2012
This is version 69 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)