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Q923K1

- TS1R3_RAT

UniProt

Q923K1 - TS1R3_RAT

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Protein

Taste receptor type 1 member 3

Gene

Tas1r3

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Putative taste receptor. TAS1R1/TAS1R3 responds to the umami taste stimulus (the taste of monosodium glutamate) and also to most of the 20 standard L-amino acids, but not to their D-enantiomers or other compounds. TAS1R2/TAS1R3 recognizes diverse natural and synthetic sweeteners. TAS1R3 is essential for the recognition and response to the disaccharide trehalose. Sequence differences within and between species can significantly influence the selectivity and specificity of taste responses (By similarity).By similarity

GO - Molecular functioni

  1. sweet taste receptor activity Source: Ensembl
  2. taste receptor activity Source: UniProtKB

GO - Biological processi

  1. detection of chemical stimulus involved in sensory perception of sweet taste Source: RGD
  2. sensory perception of sweet taste Source: UniProtKB
  3. sensory perception of umami taste Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Sensory transduction, Taste

Names & Taxonomyi

Protein namesi
Recommended name:
Taste receptor type 1 member 3
Alternative name(s):
Sweet taste receptor T1R3
Gene namesi
Name:Tas1r3
Synonyms:T1r3, Tr3
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 5

Organism-specific databases

RGDi620539. Tas1r3.

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB
  2. plasma membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020Sequence AnalysisAdd
BLAST
Chaini21 – 858838Taste receptor type 1 member 3PRO_0000012964Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi85 – 851N-linked (GlcNAc...)Sequence Analysis
Glycosylationi130 – 1301N-linked (GlcNAc...)Sequence Analysis
Glycosylationi203 – 2031N-linked (GlcNAc...)Sequence Analysis
Glycosylationi264 – 2641N-linked (GlcNAc...)Sequence Analysis
Glycosylationi379 – 3791N-linked (GlcNAc...)Sequence Analysis
Glycosylationi387 – 3871N-linked (GlcNAc...)Sequence Analysis
Glycosylationi418 – 4181N-linked (GlcNAc...)Sequence Analysis
Glycosylationi439 – 4391N-linked (GlcNAc...)Sequence Analysis
Glycosylationi482 – 4821N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ923K1.
PRIDEiQ923K1.

Expressioni

Gene expression databases

GenevestigatoriQ923K1.

Interactioni

Subunit structurei

Forms homodimers or heterodimers with TAS1R1 and TAS1R2.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000026671.

Structurei

3D structure databases

ProteinModelPortaliQ923K1.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini21 – 575555ExtracellularSequence AnalysisAdd
BLAST
Topological domaini597 – 61014CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini632 – 64413ExtracellularSequence AnalysisAdd
BLAST
Topological domaini666 – 68722CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini709 – 73527ExtracellularSequence AnalysisAdd
BLAST
Topological domaini757 – 76711CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini789 – 7968ExtracellularSequence Analysis
Topological domaini818 – 85841CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei576 – 59621Helical; Name=1Sequence AnalysisAdd
BLAST
Transmembranei611 – 63121Helical; Name=2Sequence AnalysisAdd
BLAST
Transmembranei645 – 66521Helical; Name=3Sequence AnalysisAdd
BLAST
Transmembranei688 – 70821Helical; Name=4Sequence AnalysisAdd
BLAST
Transmembranei736 – 75621Helical; Name=5Sequence AnalysisAdd
BLAST
Transmembranei768 – 78821Helical; Name=6Sequence AnalysisAdd
BLAST
Transmembranei797 – 81721Helical; Name=7Sequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG303330.
GeneTreeiENSGT00760000118884.
HOGENOMiHOG000231293.
HOVERGENiHBG098572.
InParanoidiQ923K1.
KOiK04626.
OMAiQLLENMY.
OrthoDBiEOG7K0ZBJ.
PhylomeDBiQ923K1.
TreeFamiTF331269.

Family and domain databases

InterProiIPR001828. ANF_lig-bd_rcpt.
IPR000337. GPCR_3.
IPR011500. GPCR_3_9-Cys_dom.
IPR017978. GPCR_3_C.
IPR017979. GPCR_3_CS.
IPR028082. Peripla_BP_I.
[Graphical view]
PfamiPF00003. 7tm_3. 1 hit.
PF01094. ANF_receptor. 1 hit.
PF07562. NCD3G. 1 hit.
[Graphical view]
PRINTSiPR00248. GPCRMGR.
SUPFAMiSSF53822. SSF53822. 1 hit.
PROSITEiPS00980. G_PROTEIN_RECEP_F3_2. 1 hit.
PS50259. G_PROTEIN_RECEP_F3_4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q923K1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPGLAILGLS LAAFLELGMG SSLCLSQQFK AQGDYILGGL FPLGTTEEAT
60 70 80 90 100
LNQRTQPNGI LCTRFSPLGL FLAMAMKMAV EEINNGSALL PGLRLGYDLF
110 120 130 140 150
DTCSEPVVTM KPSLMFMAKV GSQSIAAYCN YTQYQPRVLA VIGPHSSELA
160 170 180 190 200
LITGKFFSFF LMPQVSYSAS MDRLSDRETF PSFFRTVPSD RVQLQAVVTL
210 220 230 240 250
LQNFSWNWVA ALGSDDDYGR EGLSIFSGLA NSRGICIAHE GLVPQHDTSG
260 270 280 290 300
QQLGKVVDVL RQVNQSKVQV VVLFASARAV YSLFSYSILH DLSPKVWVAS
310 320 330 340 350
ESWLTSDLVM TLPNIARVGT VLGFLQRGAL LPEFSHYVET RLALAADPTF
360 370 380 390 400
CASLKAELDL EERVMGPRCS QCDYIMLQNL SSGLMQNLSA GQLHHQIFAT
410 420 430 440 450
YAAVYSVAQA LHNTLQCNVS HCHTSEPVQP WQLLENMYNM SFRARDLTLQ
460 470 480 490 500
FDAKGSVDME YDLKMWVWQS PTPVLHTVGT FNGTLQLQHS KMYWPGNQVP
510 520 530 540 550
VSQCSRQCKD GQVRRVKGFH SCCYDCVDCK AGSYRKHPDD FTCTPCGKDQ
560 570 580 590 600
WSPEKSTTCL PRRPKFLAWG EPAVLSLLLL LCLVLGLTLA ALGLFVHYWD
610 620 630 640 650
SPLVQASGGS LFCFGLICLG LFCLSVLLFP GRPRSASCLA QQPMAHLPLT
660 670 680 690 700
GCLSTLFLQA AEIFVESELP LSWANWLCSY LRGPWAWLVV LLATLVEAAL
710 720 730 740 750
CAWYLMAFPP EVVTDWQVLP TEVLEHCRMR SWVSLGLVHI TNAVLAFLCF
760 770 780 790 800
LGTFLVQSQP GRYNRARGLT FAMLAYFIIW VSFVPLLANV QVAYQPAVQM
810 820 830 840 850
GAILFCALGI LATFHLPKCY VLLWLPELNT QEFFLGRSPK EASDGNSGSS

EATRGHSE
Length:858
Mass (Da):94,846
Last modified:December 1, 2001 - v1
Checksum:i98890DAF75973B80
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY032620 mRNA. Translation: AAK51601.1.
AF456324 mRNA. Translation: AAM10636.1.
RefSeqiNP_570831.1. NM_130818.1.
UniGeneiRn.81025.

Genome annotation databases

EnsembliENSRNOT00000026671; ENSRNOP00000026671; ENSRNOG00000019589.
GeneIDi170634.
KEGGirno:170634.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY032620 mRNA. Translation: AAK51601.1 .
AF456324 mRNA. Translation: AAM10636.1 .
RefSeqi NP_570831.1. NM_130818.1.
UniGenei Rn.81025.

3D structure databases

ProteinModelPortali Q923K1.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000026671.

Protein family/group databases

GPCRDBi Search...

Proteomic databases

PaxDbi Q923K1.
PRIDEi Q923K1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000026671 ; ENSRNOP00000026671 ; ENSRNOG00000019589 .
GeneIDi 170634.
KEGGi rno:170634.

Organism-specific databases

CTDi 83756.
RGDi 620539. Tas1r3.

Phylogenomic databases

eggNOGi NOG303330.
GeneTreei ENSGT00760000118884.
HOGENOMi HOG000231293.
HOVERGENi HBG098572.
InParanoidi Q923K1.
KOi K04626.
OMAi QLLENMY.
OrthoDBi EOG7K0ZBJ.
PhylomeDBi Q923K1.
TreeFami TF331269.

Miscellaneous databases

NextBioi 621131.
PROi Q923K1.

Gene expression databases

Genevestigatori Q923K1.

Family and domain databases

InterProi IPR001828. ANF_lig-bd_rcpt.
IPR000337. GPCR_3.
IPR011500. GPCR_3_9-Cys_dom.
IPR017978. GPCR_3_C.
IPR017979. GPCR_3_CS.
IPR028082. Peripla_BP_I.
[Graphical view ]
Pfami PF00003. 7tm_3. 1 hit.
PF01094. ANF_receptor. 1 hit.
PF07562. NCD3G. 1 hit.
[Graphical view ]
PRINTSi PR00248. GPCRMGR.
SUPFAMi SSF53822. SSF53822. 1 hit.
PROSITEi PS00980. G_PROTEIN_RECEP_F3_2. 1 hit.
PS50259. G_PROTEIN_RECEP_F3_4. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Wistar.
    Tissue: Circumvallate papilla.
  2. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Wistar.
    Tissue: Circumvallate papilla.

Entry informationi

Entry nameiTS1R3_RAT
AccessioniPrimary (citable) accession number: Q923K1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 4, 2005
Last sequence update: December 1, 2001
Last modified: October 29, 2014
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3