Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q923K1

- TS1R3_RAT

UniProt

Q923K1 - TS1R3_RAT

Protein

Taste receptor type 1 member 3

Gene

Tas1r3

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 86 (01 Oct 2014)
      Sequence version 1 (01 Dec 2001)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Putative taste receptor. TAS1R1/TAS1R3 responds to the umami taste stimulus (the taste of monosodium glutamate) and also to most of the 20 standard L-amino acids, but not to their D-enantiomers or other compounds. TAS1R2/TAS1R3 recognizes diverse natural and synthetic sweeteners. TAS1R3 is essential for the recognition and response to the disaccharide trehalose. Sequence differences within and between species can significantly influence the selectivity and specificity of taste responses By similarity.By similarity

    GO - Molecular functioni

    1. sweet taste receptor activity Source: Ensembl
    2. taste receptor activity Source: UniProtKB

    GO - Biological processi

    1. detection of chemical stimulus involved in sensory perception of sweet taste Source: RGD
    2. sensory perception of sweet taste Source: UniProtKB
    3. sensory perception of umami taste Source: UniProtKB

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Keywords - Biological processi

    Sensory transduction, Taste

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Taste receptor type 1 member 3
    Alternative name(s):
    Sweet taste receptor T1R3
    Gene namesi
    Name:Tas1r3
    Synonyms:T1r3, Tr3
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 5

    Organism-specific databases

    RGDi620539. Tas1r3.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2020Sequence AnalysisAdd
    BLAST
    Chaini21 – 858838Taste receptor type 1 member 3PRO_0000012964Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi85 – 851N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi130 – 1301N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi203 – 2031N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi264 – 2641N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi379 – 3791N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi387 – 3871N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi418 – 4181N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi439 – 4391N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi482 – 4821N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiQ923K1.
    PRIDEiQ923K1.

    Expressioni

    Gene expression databases

    GenevestigatoriQ923K1.

    Interactioni

    Subunit structurei

    Forms homodimers or heterodimers with TAS1R1 and TAS1R2.By similarity

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000026671.

    Structurei

    3D structure databases

    ProteinModelPortaliQ923K1.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini21 – 575555ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini597 – 61014CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini632 – 64413ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini666 – 68722CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini709 – 73527ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini757 – 76711CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini789 – 7968ExtracellularSequence Analysis
    Topological domaini818 – 85841CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei576 – 59621Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei611 – 63121Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei645 – 66521Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei688 – 70821Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei736 – 75621Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei768 – 78821Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei797 – 81721Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG303330.
    GeneTreeiENSGT00740000115154.
    HOGENOMiHOG000231293.
    HOVERGENiHBG098572.
    InParanoidiQ923K1.
    KOiK04626.
    OMAiQLLENMY.
    OrthoDBiEOG7K0ZBJ.
    PhylomeDBiQ923K1.
    TreeFamiTF331269.

    Family and domain databases

    InterProiIPR001828. ANF_lig-bd_rcpt.
    IPR000337. GPCR_3.
    IPR011500. GPCR_3_9-Cys_dom.
    IPR017978. GPCR_3_C.
    IPR017979. GPCR_3_CS.
    IPR028082. Peripla_BP_I.
    [Graphical view]
    PfamiPF00003. 7tm_3. 1 hit.
    PF01094. ANF_receptor. 1 hit.
    PF07562. NCD3G. 1 hit.
    [Graphical view]
    PRINTSiPR00248. GPCRMGR.
    SUPFAMiSSF53822. SSF53822. 1 hit.
    PROSITEiPS00980. G_PROTEIN_RECEP_F3_2. 1 hit.
    PS50259. G_PROTEIN_RECEP_F3_4. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q923K1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPGLAILGLS LAAFLELGMG SSLCLSQQFK AQGDYILGGL FPLGTTEEAT    50
    LNQRTQPNGI LCTRFSPLGL FLAMAMKMAV EEINNGSALL PGLRLGYDLF 100
    DTCSEPVVTM KPSLMFMAKV GSQSIAAYCN YTQYQPRVLA VIGPHSSELA 150
    LITGKFFSFF LMPQVSYSAS MDRLSDRETF PSFFRTVPSD RVQLQAVVTL 200
    LQNFSWNWVA ALGSDDDYGR EGLSIFSGLA NSRGICIAHE GLVPQHDTSG 250
    QQLGKVVDVL RQVNQSKVQV VVLFASARAV YSLFSYSILH DLSPKVWVAS 300
    ESWLTSDLVM TLPNIARVGT VLGFLQRGAL LPEFSHYVET RLALAADPTF 350
    CASLKAELDL EERVMGPRCS QCDYIMLQNL SSGLMQNLSA GQLHHQIFAT 400
    YAAVYSVAQA LHNTLQCNVS HCHTSEPVQP WQLLENMYNM SFRARDLTLQ 450
    FDAKGSVDME YDLKMWVWQS PTPVLHTVGT FNGTLQLQHS KMYWPGNQVP 500
    VSQCSRQCKD GQVRRVKGFH SCCYDCVDCK AGSYRKHPDD FTCTPCGKDQ 550
    WSPEKSTTCL PRRPKFLAWG EPAVLSLLLL LCLVLGLTLA ALGLFVHYWD 600
    SPLVQASGGS LFCFGLICLG LFCLSVLLFP GRPRSASCLA QQPMAHLPLT 650
    GCLSTLFLQA AEIFVESELP LSWANWLCSY LRGPWAWLVV LLATLVEAAL 700
    CAWYLMAFPP EVVTDWQVLP TEVLEHCRMR SWVSLGLVHI TNAVLAFLCF 750
    LGTFLVQSQP GRYNRARGLT FAMLAYFIIW VSFVPLLANV QVAYQPAVQM 800
    GAILFCALGI LATFHLPKCY VLLWLPELNT QEFFLGRSPK EASDGNSGSS 850
    EATRGHSE 858
    Length:858
    Mass (Da):94,846
    Last modified:December 1, 2001 - v1
    Checksum:i98890DAF75973B80
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY032620 mRNA. Translation: AAK51601.1.
    AF456324 mRNA. Translation: AAM10636.1.
    RefSeqiNP_570831.1. NM_130818.1.
    UniGeneiRn.81025.

    Genome annotation databases

    EnsembliENSRNOT00000026671; ENSRNOP00000026671; ENSRNOG00000019589.
    GeneIDi170634.
    KEGGirno:170634.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY032620 mRNA. Translation: AAK51601.1 .
    AF456324 mRNA. Translation: AAM10636.1 .
    RefSeqi NP_570831.1. NM_130818.1.
    UniGenei Rn.81025.

    3D structure databases

    ProteinModelPortali Q923K1.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000026671.

    Protein family/group databases

    GPCRDBi Search...

    Proteomic databases

    PaxDbi Q923K1.
    PRIDEi Q923K1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000026671 ; ENSRNOP00000026671 ; ENSRNOG00000019589 .
    GeneIDi 170634.
    KEGGi rno:170634.

    Organism-specific databases

    CTDi 83756.
    RGDi 620539. Tas1r3.

    Phylogenomic databases

    eggNOGi NOG303330.
    GeneTreei ENSGT00740000115154.
    HOGENOMi HOG000231293.
    HOVERGENi HBG098572.
    InParanoidi Q923K1.
    KOi K04626.
    OMAi QLLENMY.
    OrthoDBi EOG7K0ZBJ.
    PhylomeDBi Q923K1.
    TreeFami TF331269.

    Miscellaneous databases

    NextBioi 621131.
    PROi Q923K1.

    Gene expression databases

    Genevestigatori Q923K1.

    Family and domain databases

    InterProi IPR001828. ANF_lig-bd_rcpt.
    IPR000337. GPCR_3.
    IPR011500. GPCR_3_9-Cys_dom.
    IPR017978. GPCR_3_C.
    IPR017979. GPCR_3_CS.
    IPR028082. Peripla_BP_I.
    [Graphical view ]
    Pfami PF00003. 7tm_3. 1 hit.
    PF01094. ANF_receptor. 1 hit.
    PF07562. NCD3G. 1 hit.
    [Graphical view ]
    PRINTSi PR00248. GPCRMGR.
    SUPFAMi SSF53822. SSF53822. 1 hit.
    PROSITEi PS00980. G_PROTEIN_RECEP_F3_2. 1 hit.
    PS50259. G_PROTEIN_RECEP_F3_4. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: Wistar.
      Tissue: Circumvallate papilla.
    2. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: Wistar.
      Tissue: Circumvallate papilla.

    Entry informationi

    Entry nameiTS1R3_RAT
    AccessioniPrimary (citable) accession number: Q923K1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 4, 2005
    Last sequence update: December 1, 2001
    Last modified: October 1, 2014
    This is version 86 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3