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Protein

Taste receptor type 1 member 3

Gene

Tas1r3

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Putative taste receptor. TAS1R1/TAS1R3 responds to the umami taste stimulus (the taste of monosodium glutamate) and also to most of the 20 standard L-amino acids, but not to their D-enantiomers or other compounds. TAS1R2/TAS1R3 recognizes diverse natural and synthetic sweeteners. TAS1R3 is essential for the recognition and response to the disaccharide trehalose. Sequence differences within and between species can significantly influence the selectivity and specificity of taste responses (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

  • detection of chemical stimulus involved in sensory perception of sweet taste Source: RGD
  • sensory perception of sweet taste Source: UniProtKB
  • sensory perception of umami taste Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Sensory transduction, Taste

Enzyme and pathway databases

ReactomeiR-RNO-420499. Class C/3 (Metabotropic glutamate/pheromone receptors).

Names & Taxonomyi

Protein namesi
Recommended name:
Taste receptor type 1 member 3
Alternative name(s):
Sweet taste receptor T1R3
Gene namesi
Name:Tas1r3
Synonyms:T1r3, Tr3
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 5

Organism-specific databases

RGDi620539. Tas1r3.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini21 – 575ExtracellularSequence analysisAdd BLAST555
Transmembranei576 – 596Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini597 – 610CytoplasmicSequence analysisAdd BLAST14
Transmembranei611 – 631Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini632 – 644ExtracellularSequence analysisAdd BLAST13
Transmembranei645 – 665Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini666 – 687CytoplasmicSequence analysisAdd BLAST22
Transmembranei688 – 708Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini709 – 735ExtracellularSequence analysisAdd BLAST27
Transmembranei736 – 756Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini757 – 767CytoplasmicSequence analysisAdd BLAST11
Transmembranei768 – 788Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini789 – 796ExtracellularSequence analysis8
Transmembranei797 – 817Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini818 – 858CytoplasmicSequence analysisAdd BLAST41

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB
  • plasma membrane Source: UniProtKB-SubCell
  • sweet taste receptor complex Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_000001296421 – 858Taste receptor type 1 member 3Add BLAST838

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi85N-linked (GlcNAc...)Sequence analysis1
Glycosylationi130N-linked (GlcNAc...)Sequence analysis1
Glycosylationi203N-linked (GlcNAc...)Sequence analysis1
Glycosylationi264N-linked (GlcNAc...)Sequence analysis1
Glycosylationi379N-linked (GlcNAc...)Sequence analysis1
Glycosylationi387N-linked (GlcNAc...)Sequence analysis1
Glycosylationi418N-linked (GlcNAc...)Sequence analysis1
Glycosylationi439N-linked (GlcNAc...)Sequence analysis1
Glycosylationi482N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ923K1.
PRIDEiQ923K1.

Expressioni

Gene expression databases

GenevisibleiQ923K1. RN.

Interactioni

Subunit structurei

Forms homodimers or heterodimers with TAS1R1 and TAS1R2.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000026671.

Structurei

3D structure databases

ProteinModelPortaliQ923K1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1056. Eukaryota.
ENOG410XR6W. LUCA.
GeneTreeiENSGT00760000118884.
HOGENOMiHOG000231293.
HOVERGENiHBG098572.
InParanoidiQ923K1.
KOiK04626.
OMAiCFGLACL.
OrthoDBiEOG091G01UW.
PhylomeDBiQ923K1.
TreeFamiTF331269.

Family and domain databases

InterProiIPR001828. ANF_lig-bd_rcpt.
IPR000337. GPCR_3.
IPR011500. GPCR_3_9-Cys_dom.
IPR017978. GPCR_3_C.
IPR017979. GPCR_3_CS.
IPR028082. Peripla_BP_I.
[Graphical view]
PfamiPF00003. 7tm_3. 1 hit.
PF01094. ANF_receptor. 1 hit.
PF07562. NCD3G. 1 hit.
[Graphical view]
PRINTSiPR00248. GPCRMGR.
SUPFAMiSSF53822. SSF53822. 1 hit.
PROSITEiPS00980. G_PROTEIN_RECEP_F3_2. 1 hit.
PS50259. G_PROTEIN_RECEP_F3_4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q923K1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPGLAILGLS LAAFLELGMG SSLCLSQQFK AQGDYILGGL FPLGTTEEAT
60 70 80 90 100
LNQRTQPNGI LCTRFSPLGL FLAMAMKMAV EEINNGSALL PGLRLGYDLF
110 120 130 140 150
DTCSEPVVTM KPSLMFMAKV GSQSIAAYCN YTQYQPRVLA VIGPHSSELA
160 170 180 190 200
LITGKFFSFF LMPQVSYSAS MDRLSDRETF PSFFRTVPSD RVQLQAVVTL
210 220 230 240 250
LQNFSWNWVA ALGSDDDYGR EGLSIFSGLA NSRGICIAHE GLVPQHDTSG
260 270 280 290 300
QQLGKVVDVL RQVNQSKVQV VVLFASARAV YSLFSYSILH DLSPKVWVAS
310 320 330 340 350
ESWLTSDLVM TLPNIARVGT VLGFLQRGAL LPEFSHYVET RLALAADPTF
360 370 380 390 400
CASLKAELDL EERVMGPRCS QCDYIMLQNL SSGLMQNLSA GQLHHQIFAT
410 420 430 440 450
YAAVYSVAQA LHNTLQCNVS HCHTSEPVQP WQLLENMYNM SFRARDLTLQ
460 470 480 490 500
FDAKGSVDME YDLKMWVWQS PTPVLHTVGT FNGTLQLQHS KMYWPGNQVP
510 520 530 540 550
VSQCSRQCKD GQVRRVKGFH SCCYDCVDCK AGSYRKHPDD FTCTPCGKDQ
560 570 580 590 600
WSPEKSTTCL PRRPKFLAWG EPAVLSLLLL LCLVLGLTLA ALGLFVHYWD
610 620 630 640 650
SPLVQASGGS LFCFGLICLG LFCLSVLLFP GRPRSASCLA QQPMAHLPLT
660 670 680 690 700
GCLSTLFLQA AEIFVESELP LSWANWLCSY LRGPWAWLVV LLATLVEAAL
710 720 730 740 750
CAWYLMAFPP EVVTDWQVLP TEVLEHCRMR SWVSLGLVHI TNAVLAFLCF
760 770 780 790 800
LGTFLVQSQP GRYNRARGLT FAMLAYFIIW VSFVPLLANV QVAYQPAVQM
810 820 830 840 850
GAILFCALGI LATFHLPKCY VLLWLPELNT QEFFLGRSPK EASDGNSGSS

EATRGHSE
Length:858
Mass (Da):94,846
Last modified:December 1, 2001 - v1
Checksum:i98890DAF75973B80
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY032620 mRNA. Translation: AAK51601.1.
AF456324 mRNA. Translation: AAM10636.1.
RefSeqiNP_570831.1. NM_130818.1.
XP_008762556.1. XM_008764334.1.
UniGeneiRn.81025.

Genome annotation databases

EnsembliENSRNOT00000026671; ENSRNOP00000026671; ENSRNOG00000019589.
GeneIDi170634.
KEGGirno:170634.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY032620 mRNA. Translation: AAK51601.1.
AF456324 mRNA. Translation: AAM10636.1.
RefSeqiNP_570831.1. NM_130818.1.
XP_008762556.1. XM_008764334.1.
UniGeneiRn.81025.

3D structure databases

ProteinModelPortaliQ923K1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000026671.

Protein family/group databases

GPCRDBiSearch...

Proteomic databases

PaxDbiQ923K1.
PRIDEiQ923K1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000026671; ENSRNOP00000026671; ENSRNOG00000019589.
GeneIDi170634.
KEGGirno:170634.

Organism-specific databases

CTDi83756.
RGDi620539. Tas1r3.

Phylogenomic databases

eggNOGiKOG1056. Eukaryota.
ENOG410XR6W. LUCA.
GeneTreeiENSGT00760000118884.
HOGENOMiHOG000231293.
HOVERGENiHBG098572.
InParanoidiQ923K1.
KOiK04626.
OMAiCFGLACL.
OrthoDBiEOG091G01UW.
PhylomeDBiQ923K1.
TreeFamiTF331269.

Enzyme and pathway databases

ReactomeiR-RNO-420499. Class C/3 (Metabotropic glutamate/pheromone receptors).

Miscellaneous databases

PROiQ923K1.

Gene expression databases

GenevisibleiQ923K1. RN.

Family and domain databases

InterProiIPR001828. ANF_lig-bd_rcpt.
IPR000337. GPCR_3.
IPR011500. GPCR_3_9-Cys_dom.
IPR017978. GPCR_3_C.
IPR017979. GPCR_3_CS.
IPR028082. Peripla_BP_I.
[Graphical view]
PfamiPF00003. 7tm_3. 1 hit.
PF01094. ANF_receptor. 1 hit.
PF07562. NCD3G. 1 hit.
[Graphical view]
PRINTSiPR00248. GPCRMGR.
SUPFAMiSSF53822. SSF53822. 1 hit.
PROSITEiPS00980. G_PROTEIN_RECEP_F3_2. 1 hit.
PS50259. G_PROTEIN_RECEP_F3_4. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTS1R3_RAT
AccessioniPrimary (citable) accession number: Q923K1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 4, 2005
Last sequence update: December 1, 2001
Last modified: September 7, 2016
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.