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Q923K1

- TS1R3_RAT

UniProt

Q923K1 - TS1R3_RAT

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Protein

Taste receptor type 1 member 3

Gene
Tas1r3, T1r3, Tr3
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Putative taste receptor. TAS1R1/TAS1R3 responds to the umami taste stimulus (the taste of monosodium glutamate) and also to most of the 20 standard L-amino acids, but not to their D-enantiomers or other compounds. TAS1R2/TAS1R3 recognizes diverse natural and synthetic sweeteners. TAS1R3 is essential for the recognition and response to the disaccharide trehalose. Sequence differences within and between species can significantly influence the selectivity and specificity of taste responses By similarity.

GO - Molecular functioni

  1. sweet taste receptor activity Source: Ensembl
  2. taste receptor activity Source: UniProtKB

GO - Biological processi

  1. detection of chemical stimulus involved in sensory perception of sweet taste Source: RGD
  2. sensory perception of sweet taste Source: UniProtKB
  3. sensory perception of umami taste Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Sensory transduction, Taste

Names & Taxonomyi

Protein namesi
Recommended name:
Taste receptor type 1 member 3
Alternative name(s):
Sweet taste receptor T1R3
Gene namesi
Name:Tas1r3
Synonyms:T1r3, Tr3
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 5

Organism-specific databases

RGDi620539. Tas1r3.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini21 – 575555Extracellular Reviewed predictionAdd
BLAST
Transmembranei576 – 59621Helical; Name=1; Reviewed predictionAdd
BLAST
Topological domaini597 – 61014Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei611 – 63121Helical; Name=2; Reviewed predictionAdd
BLAST
Topological domaini632 – 64413Extracellular Reviewed predictionAdd
BLAST
Transmembranei645 – 66521Helical; Name=3; Reviewed predictionAdd
BLAST
Topological domaini666 – 68722Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei688 – 70821Helical; Name=4; Reviewed predictionAdd
BLAST
Topological domaini709 – 73527Extracellular Reviewed predictionAdd
BLAST
Transmembranei736 – 75621Helical; Name=5; Reviewed predictionAdd
BLAST
Topological domaini757 – 76711Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei768 – 78821Helical; Name=6; Reviewed predictionAdd
BLAST
Topological domaini789 – 7968Extracellular Reviewed prediction
Transmembranei797 – 81721Helical; Name=7; Reviewed predictionAdd
BLAST
Topological domaini818 – 85841Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020 Reviewed predictionAdd
BLAST
Chaini21 – 858838Taste receptor type 1 member 3PRO_0000012964Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi85 – 851N-linked (GlcNAc...) Reviewed prediction
Glycosylationi130 – 1301N-linked (GlcNAc...) Reviewed prediction
Glycosylationi203 – 2031N-linked (GlcNAc...) Reviewed prediction
Glycosylationi264 – 2641N-linked (GlcNAc...) Reviewed prediction
Glycosylationi379 – 3791N-linked (GlcNAc...) Reviewed prediction
Glycosylationi387 – 3871N-linked (GlcNAc...) Reviewed prediction
Glycosylationi418 – 4181N-linked (GlcNAc...) Reviewed prediction
Glycosylationi439 – 4391N-linked (GlcNAc...) Reviewed prediction
Glycosylationi482 – 4821N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ923K1.
PRIDEiQ923K1.

Expressioni

Gene expression databases

GenevestigatoriQ923K1.

Interactioni

Subunit structurei

Forms homodimers or heterodimers with TAS1R1 and TAS1R2 By similarity.

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000026671.

Structurei

3D structure databases

ProteinModelPortaliQ923K1.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG303330.
GeneTreeiENSGT00740000115154.
HOGENOMiHOG000231293.
HOVERGENiHBG098572.
InParanoidiQ923K1.
KOiK04626.
OMAiQLLENMY.
OrthoDBiEOG7K0ZBJ.
PhylomeDBiQ923K1.
TreeFamiTF331269.

Family and domain databases

InterProiIPR001828. ANF_lig-bd_rcpt.
IPR000337. GPCR_3.
IPR011500. GPCR_3_9-Cys_dom.
IPR017978. GPCR_3_C.
IPR017979. GPCR_3_CS.
IPR028082. Peripla_BP_I.
[Graphical view]
PfamiPF00003. 7tm_3. 1 hit.
PF01094. ANF_receptor. 1 hit.
PF07562. NCD3G. 1 hit.
[Graphical view]
PRINTSiPR00248. GPCRMGR.
SUPFAMiSSF53822. SSF53822. 1 hit.
PROSITEiPS00980. G_PROTEIN_RECEP_F3_2. 1 hit.
PS50259. G_PROTEIN_RECEP_F3_4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q923K1-1 [UniParc]FASTAAdd to Basket

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MPGLAILGLS LAAFLELGMG SSLCLSQQFK AQGDYILGGL FPLGTTEEAT    50
LNQRTQPNGI LCTRFSPLGL FLAMAMKMAV EEINNGSALL PGLRLGYDLF 100
DTCSEPVVTM KPSLMFMAKV GSQSIAAYCN YTQYQPRVLA VIGPHSSELA 150
LITGKFFSFF LMPQVSYSAS MDRLSDRETF PSFFRTVPSD RVQLQAVVTL 200
LQNFSWNWVA ALGSDDDYGR EGLSIFSGLA NSRGICIAHE GLVPQHDTSG 250
QQLGKVVDVL RQVNQSKVQV VVLFASARAV YSLFSYSILH DLSPKVWVAS 300
ESWLTSDLVM TLPNIARVGT VLGFLQRGAL LPEFSHYVET RLALAADPTF 350
CASLKAELDL EERVMGPRCS QCDYIMLQNL SSGLMQNLSA GQLHHQIFAT 400
YAAVYSVAQA LHNTLQCNVS HCHTSEPVQP WQLLENMYNM SFRARDLTLQ 450
FDAKGSVDME YDLKMWVWQS PTPVLHTVGT FNGTLQLQHS KMYWPGNQVP 500
VSQCSRQCKD GQVRRVKGFH SCCYDCVDCK AGSYRKHPDD FTCTPCGKDQ 550
WSPEKSTTCL PRRPKFLAWG EPAVLSLLLL LCLVLGLTLA ALGLFVHYWD 600
SPLVQASGGS LFCFGLICLG LFCLSVLLFP GRPRSASCLA QQPMAHLPLT 650
GCLSTLFLQA AEIFVESELP LSWANWLCSY LRGPWAWLVV LLATLVEAAL 700
CAWYLMAFPP EVVTDWQVLP TEVLEHCRMR SWVSLGLVHI TNAVLAFLCF 750
LGTFLVQSQP GRYNRARGLT FAMLAYFIIW VSFVPLLANV QVAYQPAVQM 800
GAILFCALGI LATFHLPKCY VLLWLPELNT QEFFLGRSPK EASDGNSGSS 850
EATRGHSE 858
Length:858
Mass (Da):94,846
Last modified:December 1, 2001 - v1
Checksum:i98890DAF75973B80
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY032620 mRNA. Translation: AAK51601.1.
AF456324 mRNA. Translation: AAM10636.1.
RefSeqiNP_570831.1. NM_130818.1.
UniGeneiRn.81025.

Genome annotation databases

EnsembliENSRNOT00000026671; ENSRNOP00000026671; ENSRNOG00000019589.
GeneIDi170634.
KEGGirno:170634.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY032620 mRNA. Translation: AAK51601.1 .
AF456324 mRNA. Translation: AAM10636.1 .
RefSeqi NP_570831.1. NM_130818.1.
UniGenei Rn.81025.

3D structure databases

ProteinModelPortali Q923K1.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000026671.

Protein family/group databases

GPCRDBi Search...

Proteomic databases

PaxDbi Q923K1.
PRIDEi Q923K1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000026671 ; ENSRNOP00000026671 ; ENSRNOG00000019589 .
GeneIDi 170634.
KEGGi rno:170634.

Organism-specific databases

CTDi 83756.
RGDi 620539. Tas1r3.

Phylogenomic databases

eggNOGi NOG303330.
GeneTreei ENSGT00740000115154.
HOGENOMi HOG000231293.
HOVERGENi HBG098572.
InParanoidi Q923K1.
KOi K04626.
OMAi QLLENMY.
OrthoDBi EOG7K0ZBJ.
PhylomeDBi Q923K1.
TreeFami TF331269.

Miscellaneous databases

NextBioi 621131.
PROi Q923K1.

Gene expression databases

Genevestigatori Q923K1.

Family and domain databases

InterProi IPR001828. ANF_lig-bd_rcpt.
IPR000337. GPCR_3.
IPR011500. GPCR_3_9-Cys_dom.
IPR017978. GPCR_3_C.
IPR017979. GPCR_3_CS.
IPR028082. Peripla_BP_I.
[Graphical view ]
Pfami PF00003. 7tm_3. 1 hit.
PF01094. ANF_receptor. 1 hit.
PF07562. NCD3G. 1 hit.
[Graphical view ]
PRINTSi PR00248. GPCRMGR.
SUPFAMi SSF53822. SSF53822. 1 hit.
PROSITEi PS00980. G_PROTEIN_RECEP_F3_2. 1 hit.
PS50259. G_PROTEIN_RECEP_F3_4. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Wistar.
    Tissue: Circumvallate papilla.
  2. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Wistar.
    Tissue: Circumvallate papilla.

Entry informationi

Entry nameiTS1R3_RAT
AccessioniPrimary (citable) accession number: Q923K1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 4, 2005
Last sequence update: December 1, 2001
Last modified: April 16, 2014
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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