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Q923K1 (TS1R3_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 79. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Taste receptor type 1 member 3
Alternative name(s):
Sweet taste receptor T1R3
Gene names
Name:Tas1r3
Synonyms:T1r3, Tr3
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length858 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Putative taste receptor. TAS1R1/TAS1R3 responds to the umami taste stimulus (the taste of monosodium glutamate) and also to most of the 20 standard L-amino acids, but not to their D-enantiomers or other compounds. TAS1R2/TAS1R3 recognizes diverse natural and synthetic sweeteners. TAS1R3 is essential for the recognition and response to the disaccharide trehalose. Sequence differences within and between species can significantly influence the selectivity and specificity of taste responses By similarity.

Subunit structure

Forms homodimers or heterodimers with TAS1R1 and TAS1R2 By similarity.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the G-protein coupled receptor 3 family. TAS1R subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2020 Potential
Chain21 – 858838Taste receptor type 1 member 3
PRO_0000012964

Regions

Topological domain21 – 575555Extracellular Potential
Transmembrane576 – 59621Helical; Name=1; Potential
Topological domain597 – 61014Cytoplasmic Potential
Transmembrane611 – 63121Helical; Name=2; Potential
Topological domain632 – 64413Extracellular Potential
Transmembrane645 – 66521Helical; Name=3; Potential
Topological domain666 – 68722Cytoplasmic Potential
Transmembrane688 – 70821Helical; Name=4; Potential
Topological domain709 – 73527Extracellular Potential
Transmembrane736 – 75621Helical; Name=5; Potential
Topological domain757 – 76711Cytoplasmic Potential
Transmembrane768 – 78821Helical; Name=6; Potential
Topological domain789 – 7968Extracellular Potential
Transmembrane797 – 81721Helical; Name=7; Potential
Topological domain818 – 85841Cytoplasmic Potential

Amino acid modifications

Glycosylation851N-linked (GlcNAc...) Potential
Glycosylation1301N-linked (GlcNAc...) Potential
Glycosylation2031N-linked (GlcNAc...) Potential
Glycosylation2641N-linked (GlcNAc...) Potential
Glycosylation3791N-linked (GlcNAc...) Potential
Glycosylation3871N-linked (GlcNAc...) Potential
Glycosylation4181N-linked (GlcNAc...) Potential
Glycosylation4391N-linked (GlcNAc...) Potential
Glycosylation4821N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
Q923K1 [UniParc].

Last modified December 1, 2001. Version 1.
Checksum: 98890DAF75973B80

FASTA85894,846
        10         20         30         40         50         60 
MPGLAILGLS LAAFLELGMG SSLCLSQQFK AQGDYILGGL FPLGTTEEAT LNQRTQPNGI 

        70         80         90        100        110        120 
LCTRFSPLGL FLAMAMKMAV EEINNGSALL PGLRLGYDLF DTCSEPVVTM KPSLMFMAKV 

       130        140        150        160        170        180 
GSQSIAAYCN YTQYQPRVLA VIGPHSSELA LITGKFFSFF LMPQVSYSAS MDRLSDRETF 

       190        200        210        220        230        240 
PSFFRTVPSD RVQLQAVVTL LQNFSWNWVA ALGSDDDYGR EGLSIFSGLA NSRGICIAHE 

       250        260        270        280        290        300 
GLVPQHDTSG QQLGKVVDVL RQVNQSKVQV VVLFASARAV YSLFSYSILH DLSPKVWVAS 

       310        320        330        340        350        360 
ESWLTSDLVM TLPNIARVGT VLGFLQRGAL LPEFSHYVET RLALAADPTF CASLKAELDL 

       370        380        390        400        410        420 
EERVMGPRCS QCDYIMLQNL SSGLMQNLSA GQLHHQIFAT YAAVYSVAQA LHNTLQCNVS 

       430        440        450        460        470        480 
HCHTSEPVQP WQLLENMYNM SFRARDLTLQ FDAKGSVDME YDLKMWVWQS PTPVLHTVGT 

       490        500        510        520        530        540 
FNGTLQLQHS KMYWPGNQVP VSQCSRQCKD GQVRRVKGFH SCCYDCVDCK AGSYRKHPDD 

       550        560        570        580        590        600 
FTCTPCGKDQ WSPEKSTTCL PRRPKFLAWG EPAVLSLLLL LCLVLGLTLA ALGLFVHYWD 

       610        620        630        640        650        660 
SPLVQASGGS LFCFGLICLG LFCLSVLLFP GRPRSASCLA QQPMAHLPLT GCLSTLFLQA 

       670        680        690        700        710        720 
AEIFVESELP LSWANWLCSY LRGPWAWLVV LLATLVEAAL CAWYLMAFPP EVVTDWQVLP 

       730        740        750        760        770        780 
TEVLEHCRMR SWVSLGLVHI TNAVLAFLCF LGTFLVQSQP GRYNRARGLT FAMLAYFIIW 

       790        800        810        820        830        840 
VSFVPLLANV QVAYQPAVQM GAILFCALGI LATFHLPKCY VLLWLPELNT QEFFLGRSPK 

       850 
EASDGNSGSS EATRGHSE

« Hide

References

[1]"Mammalian sweet taste receptors."
Nelson G., Hoon M.A., Chandrashekar J., Zhang Y., Ryba N.J.P., Zuker C.S.
Cell 106:381-390(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: Wistar.
Tissue: Circumvallate papilla.
[2]"Human receptors for sweet and umami taste."
Li X., Staszewski L., Xu H., Durick K., Zoller M., Adler E.
Proc. Natl. Acad. Sci. U.S.A. 99:4692-4696(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: Wistar.
Tissue: Circumvallate papilla.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AY032620 mRNA. Translation: AAK51601.1.
AF456324 mRNA. Translation: AAM10636.1.
IPIIPI00203696.
RefSeqNP_570831.1. NM_130818.1.
UniGeneRn.81025.

3D structure databases

ProteinModelPortalQ923K1.
ModBaseSearch...

Protein-protein interaction databases

STRING10116.ENSRNOP00000026671.

Protein family/group databases

GPCRDBSearch...

Proteomic databases

PaxDbQ923K1.
PRIDEQ923K1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000026671; ENSRNOP00000026671; ENSRNOG00000019589.
GeneID170634.
KEGGrno:170634.

Organism-specific databases

CTD83756.
RGD620539. Tas1r3.

Phylogenomic databases

eggNOGNOG303330.
GeneTreeENSGT00690000101951.
HOGENOMHOG000231293.
HOVERGENHBG098572.
InParanoidQ923K1.
KOK04626.
OMASPKVWVA.
OrthoDBEOG44XJG8.

Gene expression databases

GenevestigatorQ923K1.
GermOnlineENSRNOG00000019589. Rattus norvegicus.

Family and domain databases

InterProIPR001828. ANF_lig-bd_rcpt.
IPR000337. GPCR_3.
IPR011500. GPCR_3_9-Cys_dom.
IPR017978. GPCR_3_C.
IPR017979. GPCR_3_CS.
[Graphical view]
PfamPF00003. 7tm_3. 1 hit.
PF01094. ANF_receptor. 1 hit.
PF07562. NCD3G. 1 hit.
[Graphical view]
PRINTSPR00248. GPCRMGR.
PROSITEPS00979. G_PROTEIN_RECEP_F3_1. False negative.
PS00980. G_PROTEIN_RECEP_F3_2. 1 hit.
PS00981. G_PROTEIN_RECEP_F3_3. False negative.
PS50259. G_PROTEIN_RECEP_F3_4. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio621131.

Entry information

Entry nameTS1R3_RAT
AccessionPrimary (citable) accession number: Q923K1
Entry history
Integrated into UniProtKB/Swiss-Prot: January 4, 2005
Last sequence update: December 1, 2001
Last modified: April 3, 2013
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries

SIMILARITY comments

Index of protein domains and families

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