Sodium/glucose cotransporter 2 - Mus musculus (Mouse)

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Q923I7 (SC5A2_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 83. History...

Clusters with 100%, 90%, 50% identity |

Documents (2) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Sodium/glucose cotransporter 2
Short name=Na(+)/glucose cotransporter 2

Alternative name(s):
Low affinity sodium-glucose cotransporter
Solute carrier family 5 member 2

Gene names

Name:	Slc5a2
Synonyms:	Sglt2

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	670 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Efficient substrate transport in mammalian kidney is provided by the concerted action of a low affinity high capacity and a high affinity low capacity Na⁺/glucose cotransporter arranged in series along kidney proximal tubules By similarity.
Subcellular location	Membrane; Multi-pass membrane protein.
Sequence similarities	Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family. [View classification]

Ontologies

Keywords
Biological process	Ion transport Sodium transport Sugar transport Symport Transport
Cellular component	Membrane
Domain	Transmembrane Transmembrane helix
Ligand	Sodium
PTM	Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	carbohydrate transport Inferred from electronic annotation. Source: UniProtKB-KW sodium ion transport Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	symporter activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 670

670

Sodium/glucose cotransporter 2

PRO_0000105373

Regions

Topological domain

1 – 23

Cytoplasmic Potential

Transmembrane

24 – 42

Helical; Potential

Topological domain

43 – 59

Extracellular Potential

Transmembrane

60 – 80

Helical; Potential

Topological domain

81 – 100

Cytoplasmic Potential

Transmembrane

101 – 121

Helical; Potential

Topological domain

122 – 166

Extracellular Potential

Transmembrane

167 – 187

Helical; Potential

Topological domain

188 – 203

Cytoplasmic Potential

Transmembrane

204 – 224

Helical; Potential

Topological domain

225 – 268

Extracellular Potential

Transmembrane

269 – 289

Helical; Potential

Topological domain

290 – 312

Cytoplasmic Potential

Transmembrane

313 – 332

Helical; Potential

Topological domain

333 – 421

Extracellular Potential

Transmembrane

422 – 441

Helical; Potential

Topological domain

442 – 453

Cytoplasmic Potential

Transmembrane

454 – 474

Helical; Potential

Topological domain

475 – 524

Extracellular Potential

Transmembrane

525 – 545

Helical; Potential

Topological domain

546 – 648

103

Cytoplasmic Potential

Transmembrane

649 – 669

Helical; Potential

Amino acid modifications

Glycosylation

248

N-linked (GlcNAc...) Potential

Sequences

Sequence

Length

Mass (Da)

Tools

Q923I7 [UniParc].

Last modified December 1, 2001. Version 1.
Checksum: 66BD6E48889E15DF
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FASTA

670

73,008

        10         20         30         40         50         60 
MEQHVEAGSE LGEQKVLIDN PADILVIAAY FLLVIGVGLW SMFRTNRGTV GGYFLAGRSM 

        70         80         90        100        110        120 
VWWPVGASLF ASNIGSGHFV GLAGTGAASG LAVAGFEWNA LFVVLLLGWL FVPVYLTAGV 

       130        140        150        160        170        180 
ITMPQYLRKR FGGHRIRLYL SVLSLFLYIF TKISVDMFSG AVFIQQALGW NIYASVIALL 

       190        200        210        220        230        240 
GITMIYTVTG GLAALMYTDT VQTFVILAGA FILTGYAFHE VGGYSGLFDK YLGAMTSLTV 

       250        260        270        280        290        300 
SKDPSVGNIS STCYQPRPDS YHLLRDPVTG DLPWPALLLG LTIVSGWYWC SDQVIVQRCL 

       310        320        330        340        350        360 
AGKNLTHIKA GCILCGYLKL MPMFLMVMPG MISRILYPDE VACVVPEVCK RVCGTEVGCS 

       370        380        390        400        410        420 
NIAYPRLVVK LMPNGLRGLM LAVMLAALMS SLASIFNSSS TLFTMDIYTR LRPRAGDKEL 

       430        440        450        460        470        480 
LLVGRLWVVF IVAVSVAWLP VVQAAQGGQL FDYIQSVSSY LAPPVSAVFV LALFVPRVNE 

       490        500        510        520        530        540 
KGAFWGLVGG LLMGLARLIP EFFFGSGSCV RPSACPALFC RVHYLYFAII LFICSGILTL 

       550        560        570        580        590        600 
GISLCTAPIP QKHLHRLVFS LRHSKEERED LDADELEGPA PAPVQNGGQE CAMEMEEVQS 

       610        620        630        640        650        660 
PAPGLLRRCL LWFCGMSKSG SGSPPPTTEE VAATTRRLED ISEDPRWARV VNLNALLMMT 

       670 
VAVFLWGFYA

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Differential regulation of mouse kidney sodium-dependent transporters mRNA by cadmium." Tabatabai N.M., Blumenthal S.S., Lewand D.L., Petering D.H. Toxicol. Appl. Pharmacol. 177:163-173(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: C57BL/6.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: FVB/N. Tissue: Kidney.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY033886 mRNA. Translation: AAK61606.1. BC022226 mRNA. Translation: AAH22226.1.
IPI	IPI00124340.
RefSeq	NP_573517.1. NM_133254.3.
UniGene	Mm.38870.
3D structure databases
ProteinModelPortal	Q923I7.
SMR	Q923I7. Positions 23-495.
ModBase	Search...
Protein-protein interaction databases
STRING	10090.ENSMUSP00000112597.
PTM databases
PhosphoSite	Q923I7.
Proteomic databases
PaxDb	Q923I7.
PRIDE	Q923I7.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000118169; ENSMUSP00000112597; ENSMUSG00000030781.
GeneID	246787.
KEGG	mmu:246787.
UCSC	uc009jyu.1. mouse.
Organism-specific databases
CTD	6524.
MGI	MGI:2181411. Slc5a2.
Phylogenomic databases
eggNOG	COG4146.
GeneTree	ENSGT00550000074313.
HOGENOM	HOG000025422.
HOVERGEN	HBG052859.
InParanoid	Q923I7.
KO	K14382.
OMA	FFWGFYA.
OrthoDB	EOG4C2H9F.
Gene expression databases
ArrayExpress	Q923I7.
Bgee	Q923I7.
Genevestigator	Q923I7.
GermOnline	ENSMUSG00000030781. Mus musculus.
Family and domain databases
InterPro	IPR001734. Na/solute_symporter. IPR018212. Na/solute_symporter_CS. IPR019900. Na/solute_symporter_subgr. [Graphical view]
PANTHER	PTHR11819. PTHR11819. 1 hit.
Pfam	PF00474. SSF. 1 hit. [Graphical view]
TIGRFAMs	TIGR00813. sss. 1 hit.
PROSITE	PS00456. NA_SOLUT_SYMP_1. 1 hit. PS00457. NA_SOLUT_SYMP_2. 1 hit. PS50283. NA_SOLUT_SYMP_3. 1 hit. [Graphical view]
ProtoNet	Search...
Other
BindingDB	Q923I7.
ChEMBL	CHEMBL1075302.
ChiTaRS	SLC5A2. mouse.
NextBio	387316.
SOURCE	Search...

Entry information

Entry name

SC5A2_MOUSE

Accession

Primary (citable) accession number: Q923I7

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 7, 2004
Last sequence update:	December 1, 2001
Last modified:	May 1, 2013
This is version 83 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Amino acid modifications

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other

Entry information

Relevant documents