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Q923I7

- SC5A2_MOUSE

UniProt

Q923I7 - SC5A2_MOUSE

Protein

Sodium/glucose cotransporter 2

Gene

Slc5a2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 97 (01 Oct 2014)
      Sequence version 1 (01 Dec 2001)
      Previous versions | rss
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    Functioni

    Efficient substrate transport in mammalian kidney is provided by the concerted action of a low affinity high capacity and a high affinity low capacity Na+/glucose cotransporter arranged in series along kidney proximal tubules.By similarity

    GO - Molecular functioni

    1. protein binding Source: UniProtKB
    2. symporter activity Source: UniProtKB-KW

    GO - Biological processi

    1. carbohydrate transport Source: UniProtKB-KW
    2. sodium ion transport Source: UniProtKB-KW

    Keywords - Biological processi

    Ion transport, Sodium transport, Sugar transport, Symport, Transport

    Keywords - Ligandi

    Sodium

    Enzyme and pathway databases

    ReactomeiREACT_210308. Na+-dependent glucose transporters.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Sodium/glucose cotransporter 2
    Short name:
    Na(+)/glucose cotransporter 2
    Alternative name(s):
    Low affinity sodium-glucose cotransporter
    Solute carrier family 5 member 2
    Gene namesi
    Name:Slc5a2
    Synonyms:Sglt2
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 7

    Organism-specific databases

    MGIiMGI:2181411. Slc5a2.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 670670Sodium/glucose cotransporter 2PRO_0000105373Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi248 – 2481N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    MaxQBiQ923I7.
    PaxDbiQ923I7.
    PRIDEiQ923I7.

    PTM databases

    PhosphoSiteiQ923I7.

    Expressioni

    Gene expression databases

    BgeeiQ923I7.
    GenevestigatoriQ923I7.

    Interactioni

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000112597.

    Structurei

    3D structure databases

    ProteinModelPortaliQ923I7.
    SMRiQ923I7. Positions 23-495.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 2323CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini43 – 5917ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini81 – 10020CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini122 – 16645ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini188 – 20316CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini225 – 26844ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini290 – 31223CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini333 – 42189ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini442 – 45312CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini475 – 52450ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini546 – 648103CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei24 – 4219HelicalSequence AnalysisAdd
    BLAST
    Transmembranei60 – 8021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei101 – 12121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei167 – 18721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei204 – 22421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei269 – 28921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei313 – 33220HelicalSequence AnalysisAdd
    BLAST
    Transmembranei422 – 44120HelicalSequence AnalysisAdd
    BLAST
    Transmembranei454 – 47421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei525 – 54521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei649 – 66921HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG4146.
    GeneTreeiENSGT00550000074313.
    HOGENOMiHOG000025422.
    HOVERGENiHBG052859.
    InParanoidiQ923I7.
    KOiK14382.
    OMAiFFWGFYA.
    OrthoDBiEOG77126J.
    PhylomeDBiQ923I7.
    TreeFamiTF352855.

    Family and domain databases

    InterProiIPR001734. Na/solute_symporter.
    IPR018212. Na/solute_symporter_CS.
    IPR019900. Na/solute_symporter_subgr.
    [Graphical view]
    PANTHERiPTHR11819. PTHR11819. 1 hit.
    PfamiPF00474. SSF. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00813. sss. 1 hit.
    PROSITEiPS00456. NA_SOLUT_SYMP_1. 1 hit.
    PS00457. NA_SOLUT_SYMP_2. 1 hit.
    PS50283. NA_SOLUT_SYMP_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q923I7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEQHVEAGSE LGEQKVLIDN PADILVIAAY FLLVIGVGLW SMFRTNRGTV    50
    GGYFLAGRSM VWWPVGASLF ASNIGSGHFV GLAGTGAASG LAVAGFEWNA 100
    LFVVLLLGWL FVPVYLTAGV ITMPQYLRKR FGGHRIRLYL SVLSLFLYIF 150
    TKISVDMFSG AVFIQQALGW NIYASVIALL GITMIYTVTG GLAALMYTDT 200
    VQTFVILAGA FILTGYAFHE VGGYSGLFDK YLGAMTSLTV SKDPSVGNIS 250
    STCYQPRPDS YHLLRDPVTG DLPWPALLLG LTIVSGWYWC SDQVIVQRCL 300
    AGKNLTHIKA GCILCGYLKL MPMFLMVMPG MISRILYPDE VACVVPEVCK 350
    RVCGTEVGCS NIAYPRLVVK LMPNGLRGLM LAVMLAALMS SLASIFNSSS 400
    TLFTMDIYTR LRPRAGDKEL LLVGRLWVVF IVAVSVAWLP VVQAAQGGQL 450
    FDYIQSVSSY LAPPVSAVFV LALFVPRVNE KGAFWGLVGG LLMGLARLIP 500
    EFFFGSGSCV RPSACPALFC RVHYLYFAII LFICSGILTL GISLCTAPIP 550
    QKHLHRLVFS LRHSKEERED LDADELEGPA PAPVQNGGQE CAMEMEEVQS 600
    PAPGLLRRCL LWFCGMSKSG SGSPPPTTEE VAATTRRLED ISEDPRWARV 650
    VNLNALLMMT VAVFLWGFYA 670
    Length:670
    Mass (Da):73,008
    Last modified:December 1, 2001 - v1
    Checksum:i66BD6E48889E15DF
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY033886 mRNA. Translation: AAK61606.1.
    BC022226 mRNA. Translation: AAH22226.1.
    CCDSiCCDS21894.1.
    RefSeqiNP_573517.1. NM_133254.3.
    UniGeneiMm.38870.

    Genome annotation databases

    EnsembliENSMUST00000118169; ENSMUSP00000112597; ENSMUSG00000030781.
    GeneIDi246787.
    KEGGimmu:246787.
    UCSCiuc009jyu.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY033886 mRNA. Translation: AAK61606.1 .
    BC022226 mRNA. Translation: AAH22226.1 .
    CCDSi CCDS21894.1.
    RefSeqi NP_573517.1. NM_133254.3.
    UniGenei Mm.38870.

    3D structure databases

    ProteinModelPortali Q923I7.
    SMRi Q923I7. Positions 23-495.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000112597.

    Chemistry

    BindingDBi Q923I7.
    ChEMBLi CHEMBL1075302.

    PTM databases

    PhosphoSitei Q923I7.

    Proteomic databases

    MaxQBi Q923I7.
    PaxDbi Q923I7.
    PRIDEi Q923I7.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000118169 ; ENSMUSP00000112597 ; ENSMUSG00000030781 .
    GeneIDi 246787.
    KEGGi mmu:246787.
    UCSCi uc009jyu.1. mouse.

    Organism-specific databases

    CTDi 6524.
    MGIi MGI:2181411. Slc5a2.

    Phylogenomic databases

    eggNOGi COG4146.
    GeneTreei ENSGT00550000074313.
    HOGENOMi HOG000025422.
    HOVERGENi HBG052859.
    InParanoidi Q923I7.
    KOi K14382.
    OMAi FFWGFYA.
    OrthoDBi EOG77126J.
    PhylomeDBi Q923I7.
    TreeFami TF352855.

    Enzyme and pathway databases

    Reactomei REACT_210308. Na+-dependent glucose transporters.

    Miscellaneous databases

    ChiTaRSi SLC5A2. mouse.
    NextBioi 387316.
    PROi Q923I7.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q923I7.
    Genevestigatori Q923I7.

    Family and domain databases

    InterProi IPR001734. Na/solute_symporter.
    IPR018212. Na/solute_symporter_CS.
    IPR019900. Na/solute_symporter_subgr.
    [Graphical view ]
    PANTHERi PTHR11819. PTHR11819. 1 hit.
    Pfami PF00474. SSF. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00813. sss. 1 hit.
    PROSITEi PS00456. NA_SOLUT_SYMP_1. 1 hit.
    PS00457. NA_SOLUT_SYMP_2. 1 hit.
    PS50283. NA_SOLUT_SYMP_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Differential regulation of mouse kidney sodium-dependent transporters mRNA by cadmium."
      Tabatabai N.M., Blumenthal S.S., Lewand D.L., Petering D.H.
      Toxicol. Appl. Pharmacol. 177:163-173(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: C57BL/6.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: FVB/N.
      Tissue: Kidney.

    Entry informationi

    Entry nameiSC5A2_MOUSE
    AccessioniPrimary (citable) accession number: Q923I7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 7, 2004
    Last sequence update: December 1, 2001
    Last modified: October 1, 2014
    This is version 97 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3