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Q923I7 (SC5A2_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 91. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Sodium/glucose cotransporter 2

Short name=Na(+)/glucose cotransporter 2
Alternative name(s):
Low affinity sodium-glucose cotransporter
Solute carrier family 5 member 2
Gene names
Name:Slc5a2
Synonyms:Sglt2
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length670 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Efficient substrate transport in mammalian kidney is provided by the concerted action of a low affinity high capacity and a high affinity low capacity Na+/glucose cotransporter arranged in series along kidney proximal tubules By similarity.

Subcellular location

Membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family. [View classification]

Ontologies

Keywords
   Biological processIon transport
Sodium transport
Sugar transport
Symport
Transport
   Cellular componentMembrane
   DomainTransmembrane
Transmembrane helix
   LigandSodium
   PTMGlycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processcarbohydrate transport

Inferred from electronic annotation. Source: UniProtKB-KW

sodium ion transport

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionsymporter activity

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 670670Sodium/glucose cotransporter 2
PRO_0000105373

Regions

Topological domain1 – 2323Cytoplasmic Potential
Transmembrane24 – 4219Helical; Potential
Topological domain43 – 5917Extracellular Potential
Transmembrane60 – 8021Helical; Potential
Topological domain81 – 10020Cytoplasmic Potential
Transmembrane101 – 12121Helical; Potential
Topological domain122 – 16645Extracellular Potential
Transmembrane167 – 18721Helical; Potential
Topological domain188 – 20316Cytoplasmic Potential
Transmembrane204 – 22421Helical; Potential
Topological domain225 – 26844Extracellular Potential
Transmembrane269 – 28921Helical; Potential
Topological domain290 – 31223Cytoplasmic Potential
Transmembrane313 – 33220Helical; Potential
Topological domain333 – 42189Extracellular Potential
Transmembrane422 – 44120Helical; Potential
Topological domain442 – 45312Cytoplasmic Potential
Transmembrane454 – 47421Helical; Potential
Topological domain475 – 52450Extracellular Potential
Transmembrane525 – 54521Helical; Potential
Topological domain546 – 648103Cytoplasmic Potential
Transmembrane649 – 66921Helical; Potential

Amino acid modifications

Glycosylation2481N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
Q923I7 [UniParc].

Last modified December 1, 2001. Version 1.
Checksum: 66BD6E48889E15DF

FASTA67073,008
        10         20         30         40         50         60 
MEQHVEAGSE LGEQKVLIDN PADILVIAAY FLLVIGVGLW SMFRTNRGTV GGYFLAGRSM 

        70         80         90        100        110        120 
VWWPVGASLF ASNIGSGHFV GLAGTGAASG LAVAGFEWNA LFVVLLLGWL FVPVYLTAGV 

       130        140        150        160        170        180 
ITMPQYLRKR FGGHRIRLYL SVLSLFLYIF TKISVDMFSG AVFIQQALGW NIYASVIALL 

       190        200        210        220        230        240 
GITMIYTVTG GLAALMYTDT VQTFVILAGA FILTGYAFHE VGGYSGLFDK YLGAMTSLTV 

       250        260        270        280        290        300 
SKDPSVGNIS STCYQPRPDS YHLLRDPVTG DLPWPALLLG LTIVSGWYWC SDQVIVQRCL 

       310        320        330        340        350        360 
AGKNLTHIKA GCILCGYLKL MPMFLMVMPG MISRILYPDE VACVVPEVCK RVCGTEVGCS 

       370        380        390        400        410        420 
NIAYPRLVVK LMPNGLRGLM LAVMLAALMS SLASIFNSSS TLFTMDIYTR LRPRAGDKEL 

       430        440        450        460        470        480 
LLVGRLWVVF IVAVSVAWLP VVQAAQGGQL FDYIQSVSSY LAPPVSAVFV LALFVPRVNE 

       490        500        510        520        530        540 
KGAFWGLVGG LLMGLARLIP EFFFGSGSCV RPSACPALFC RVHYLYFAII LFICSGILTL 

       550        560        570        580        590        600 
GISLCTAPIP QKHLHRLVFS LRHSKEERED LDADELEGPA PAPVQNGGQE CAMEMEEVQS 

       610        620        630        640        650        660 
PAPGLLRRCL LWFCGMSKSG SGSPPPTTEE VAATTRRLED ISEDPRWARV VNLNALLMMT 

       670 
VAVFLWGFYA 

« Hide

References

« Hide 'large scale' references
[1]"Differential regulation of mouse kidney sodium-dependent transporters mRNA by cadmium."
Tabatabai N.M., Blumenthal S.S., Lewand D.L., Petering D.H.
Toxicol. Appl. Pharmacol. 177:163-173(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: C57BL/6.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: FVB/N.
Tissue: Kidney.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY033886 mRNA. Translation: AAK61606.1.
BC022226 mRNA. Translation: AAH22226.1.
RefSeqNP_573517.1. NM_133254.3.
UniGeneMm.38870.

3D structure databases

ProteinModelPortalQ923I7.
SMRQ923I7. Positions 21-551.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10090.ENSMUSP00000112597.

Chemistry

BindingDBQ923I7.
ChEMBLCHEMBL1075302.

PTM databases

PhosphoSiteQ923I7.

Proteomic databases

PaxDbQ923I7.
PRIDEQ923I7.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000118169; ENSMUSP00000112597; ENSMUSG00000030781.
GeneID246787.
KEGGmmu:246787.
UCSCuc009jyu.1. mouse.

Organism-specific databases

CTD6524.
MGIMGI:2181411. Slc5a2.

Phylogenomic databases

eggNOGCOG4146.
GeneTreeENSGT00550000074313.
HOGENOMHOG000025422.
HOVERGENHBG052859.
InParanoidQ923I7.
KOK14382.
OMAFFWGFYA.
OrthoDBEOG77126J.
TreeFamTF352855.

Gene expression databases

ArrayExpressQ923I7.
BgeeQ923I7.
GenevestigatorQ923I7.

Family and domain databases

InterProIPR001734. Na/solute_symporter.
IPR018212. Na/solute_symporter_CS.
IPR019900. Na/solute_symporter_subgr.
[Graphical view]
PANTHERPTHR11819. PTHR11819. 1 hit.
PfamPF00474. SSF. 1 hit.
[Graphical view]
TIGRFAMsTIGR00813. sss. 1 hit.
PROSITEPS00456. NA_SOLUT_SYMP_1. 1 hit.
PS00457. NA_SOLUT_SYMP_2. 1 hit.
PS50283. NA_SOLUT_SYMP_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSSLC5A2. mouse.
NextBio387316.
PROQ923I7.
SOURCESearch...

Entry information

Entry nameSC5A2_MOUSE
AccessionPrimary (citable) accession number: Q923I7
Entry history
Integrated into UniProtKB/Swiss-Prot: December 7, 2004
Last sequence update: December 1, 2001
Last modified: March 19, 2014
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot