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Protein

Sodium/glucose cotransporter 2

Gene

Slc5a2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Efficient substrate transport in mammalian kidney is provided by the concerted action of a low affinity high capacity and a high affinity low capacity Na+/glucose cotransporter arranged in series along kidney proximal tubules.By similarity

GO - Molecular functioni

  1. symporter activity Source: UniProtKB-KW

GO - Biological processi

  1. carbohydrate transport Source: UniProtKB-KW
  2. sodium ion transport Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Ion transport, Sodium transport, Sugar transport, Symport, Transport

Keywords - Ligandi

Sodium

Enzyme and pathway databases

ReactomeiREACT_210308. Na+-dependent glucose transporters.
REACT_268398. Orphan transporters.

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium/glucose cotransporter 2
Short name:
Na(+)/glucose cotransporter 2
Alternative name(s):
Low affinity sodium-glucose cotransporter
Solute carrier family 5 member 2
Gene namesi
Name:Slc5a2
Synonyms:Sglt2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 7

Organism-specific databases

MGIiMGI:2181411. Slc5a2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2323CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei24 – 4219HelicalSequence AnalysisAdd
BLAST
Topological domaini43 – 5917ExtracellularSequence AnalysisAdd
BLAST
Transmembranei60 – 8021HelicalSequence AnalysisAdd
BLAST
Topological domaini81 – 10020CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei101 – 12121HelicalSequence AnalysisAdd
BLAST
Topological domaini122 – 16645ExtracellularSequence AnalysisAdd
BLAST
Transmembranei167 – 18721HelicalSequence AnalysisAdd
BLAST
Topological domaini188 – 20316CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei204 – 22421HelicalSequence AnalysisAdd
BLAST
Topological domaini225 – 26844ExtracellularSequence AnalysisAdd
BLAST
Transmembranei269 – 28921HelicalSequence AnalysisAdd
BLAST
Topological domaini290 – 31223CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei313 – 33220HelicalSequence AnalysisAdd
BLAST
Topological domaini333 – 42189ExtracellularSequence AnalysisAdd
BLAST
Transmembranei422 – 44120HelicalSequence AnalysisAdd
BLAST
Topological domaini442 – 45312CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei454 – 47421HelicalSequence AnalysisAdd
BLAST
Topological domaini475 – 52450ExtracellularSequence AnalysisAdd
BLAST
Transmembranei525 – 54521HelicalSequence AnalysisAdd
BLAST
Topological domaini546 – 648103CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei649 – 66921HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. extracellular vesicular exosome Source: MGI
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 670670Sodium/glucose cotransporter 2PRO_0000105373Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi248 – 2481N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ923I7.
PaxDbiQ923I7.
PRIDEiQ923I7.

PTM databases

PhosphoSiteiQ923I7.

Expressioni

Gene expression databases

BgeeiQ923I7.
ExpressionAtlasiQ923I7. baseline and differential.
GenevestigatoriQ923I7.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000112597.

Structurei

3D structure databases

ProteinModelPortaliQ923I7.
SMRiQ923I7. Positions 23-495.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG4146.
GeneTreeiENSGT00760000118955.
HOGENOMiHOG000025422.
HOVERGENiHBG052859.
InParanoidiQ923I7.
KOiK14382.
OMAiFFWGFYA.
OrthoDBiEOG77126J.
PhylomeDBiQ923I7.
TreeFamiTF352855.

Family and domain databases

InterProiIPR001734. Na/solute_symporter.
IPR018212. Na/solute_symporter_CS.
IPR019900. Na/solute_symporter_subgr.
[Graphical view]
PANTHERiPTHR11819. PTHR11819. 1 hit.
PfamiPF00474. SSF. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00813. sss. 1 hit.
PROSITEiPS00456. NA_SOLUT_SYMP_1. 1 hit.
PS00457. NA_SOLUT_SYMP_2. 1 hit.
PS50283. NA_SOLUT_SYMP_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q923I7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEQHVEAGSE LGEQKVLIDN PADILVIAAY FLLVIGVGLW SMFRTNRGTV
60 70 80 90 100
GGYFLAGRSM VWWPVGASLF ASNIGSGHFV GLAGTGAASG LAVAGFEWNA
110 120 130 140 150
LFVVLLLGWL FVPVYLTAGV ITMPQYLRKR FGGHRIRLYL SVLSLFLYIF
160 170 180 190 200
TKISVDMFSG AVFIQQALGW NIYASVIALL GITMIYTVTG GLAALMYTDT
210 220 230 240 250
VQTFVILAGA FILTGYAFHE VGGYSGLFDK YLGAMTSLTV SKDPSVGNIS
260 270 280 290 300
STCYQPRPDS YHLLRDPVTG DLPWPALLLG LTIVSGWYWC SDQVIVQRCL
310 320 330 340 350
AGKNLTHIKA GCILCGYLKL MPMFLMVMPG MISRILYPDE VACVVPEVCK
360 370 380 390 400
RVCGTEVGCS NIAYPRLVVK LMPNGLRGLM LAVMLAALMS SLASIFNSSS
410 420 430 440 450
TLFTMDIYTR LRPRAGDKEL LLVGRLWVVF IVAVSVAWLP VVQAAQGGQL
460 470 480 490 500
FDYIQSVSSY LAPPVSAVFV LALFVPRVNE KGAFWGLVGG LLMGLARLIP
510 520 530 540 550
EFFFGSGSCV RPSACPALFC RVHYLYFAII LFICSGILTL GISLCTAPIP
560 570 580 590 600
QKHLHRLVFS LRHSKEERED LDADELEGPA PAPVQNGGQE CAMEMEEVQS
610 620 630 640 650
PAPGLLRRCL LWFCGMSKSG SGSPPPTTEE VAATTRRLED ISEDPRWARV
660 670
VNLNALLMMT VAVFLWGFYA
Length:670
Mass (Da):73,008
Last modified:December 1, 2001 - v1
Checksum:i66BD6E48889E15DF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY033886 mRNA. Translation: AAK61606.1.
BC022226 mRNA. Translation: AAH22226.1.
CCDSiCCDS21894.1.
RefSeqiNP_573517.1. NM_133254.3.
UniGeneiMm.38870.

Genome annotation databases

EnsembliENSMUST00000118169; ENSMUSP00000112597; ENSMUSG00000030781.
GeneIDi246787.
KEGGimmu:246787.
UCSCiuc009jyu.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY033886 mRNA. Translation: AAK61606.1.
BC022226 mRNA. Translation: AAH22226.1.
CCDSiCCDS21894.1.
RefSeqiNP_573517.1. NM_133254.3.
UniGeneiMm.38870.

3D structure databases

ProteinModelPortaliQ923I7.
SMRiQ923I7. Positions 23-495.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000112597.

Chemistry

BindingDBiQ923I7.
ChEMBLiCHEMBL1075302.

PTM databases

PhosphoSiteiQ923I7.

Proteomic databases

MaxQBiQ923I7.
PaxDbiQ923I7.
PRIDEiQ923I7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000118169; ENSMUSP00000112597; ENSMUSG00000030781.
GeneIDi246787.
KEGGimmu:246787.
UCSCiuc009jyu.1. mouse.

Organism-specific databases

CTDi6524.
MGIiMGI:2181411. Slc5a2.

Phylogenomic databases

eggNOGiCOG4146.
GeneTreeiENSGT00760000118955.
HOGENOMiHOG000025422.
HOVERGENiHBG052859.
InParanoidiQ923I7.
KOiK14382.
OMAiFFWGFYA.
OrthoDBiEOG77126J.
PhylomeDBiQ923I7.
TreeFamiTF352855.

Enzyme and pathway databases

ReactomeiREACT_210308. Na+-dependent glucose transporters.
REACT_268398. Orphan transporters.

Miscellaneous databases

NextBioi387316.
PROiQ923I7.
SOURCEiSearch...

Gene expression databases

BgeeiQ923I7.
ExpressionAtlasiQ923I7. baseline and differential.
GenevestigatoriQ923I7.

Family and domain databases

InterProiIPR001734. Na/solute_symporter.
IPR018212. Na/solute_symporter_CS.
IPR019900. Na/solute_symporter_subgr.
[Graphical view]
PANTHERiPTHR11819. PTHR11819. 1 hit.
PfamiPF00474. SSF. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00813. sss. 1 hit.
PROSITEiPS00456. NA_SOLUT_SYMP_1. 1 hit.
PS00457. NA_SOLUT_SYMP_2. 1 hit.
PS50283. NA_SOLUT_SYMP_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Differential regulation of mouse kidney sodium-dependent transporters mRNA by cadmium."
    Tabatabai N.M., Blumenthal S.S., Lewand D.L., Petering D.H.
    Toxicol. Appl. Pharmacol. 177:163-173(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C57BL/6.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Kidney.

Entry informationi

Entry nameiSC5A2_MOUSE
AccessioniPrimary (citable) accession number: Q923I7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 7, 2004
Last sequence update: December 1, 2001
Last modified: February 4, 2015
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.