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Protein

Palmitoyltransferase ZDHHC7

Gene

Zdhhc7

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Palmitoyltransferase with broad specificity. Palmitoylates SNAP25 and DLG4/PSD95. Palmitoylates sex steroid hormone receptors, including ESR1, PGR and AR, thereby regulating their targeting to the plasma membrane and their function in rapid intracellular signaling upon binding of sex hormones (By similarity). May play a role in follicle stimulation hormone (FSH) activation of testicular Sertoli cells (PubMed:11796495).By similarity1 Publication

Catalytic activityi

Palmitoyl-CoA + [protein]-L-cysteine = [protein]-S-palmitoyl-L-cysteine + CoA.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAcyltransferase, Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
Palmitoyltransferase ZDHHC7Curated (EC:2.3.1.225By similarity)
Alternative name(s):
Sertoli cell gene with a zinc finger domain protein1 Publication
Zinc finger DHHC domain-containing protein 7Imported
Short name:
DHHC7Imported
Gene namesi
Name:Zdhhc7Imported
Synonyms:Serz1 Publication
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 19

Organism-specific databases

RGDi620205 Zdhhc7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei51 – 71HelicalSequence analysisAdd BLAST21
Transmembranei76 – 96HelicalSequence analysisAdd BLAST21
Transmembranei174 – 194HelicalSequence analysisAdd BLAST21
Transmembranei218 – 238HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002128761 – 308Palmitoyltransferase ZDHHC7Add BLAST308

Post-translational modificationi

Autopalmitoylated.By similarity

Keywords - PTMi

Lipoprotein, Palmitate

Proteomic databases

PaxDbiQ923G5

Expressioni

Tissue specificityi

Widely expressed. Present in Sertoli cells (at protein level).1 Publication

Gene expression databases

BgeeiENSRNOG00000017342
GenevisibleiQ923G5 RN

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000023405

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini130 – 180DHHCPROSITE-ProRule annotationAdd BLAST51

Domaini

The DHHC domain is required for palmitoyltransferase activity.By similarity

Sequence similaritiesi

Belongs to the DHHC palmitoyltransferase family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1311 Eukaryota
COG5273 LUCA
GeneTreeiENSGT00880000137864
HOGENOMiHOG000234755
HOVERGENiHBG056583
InParanoidiQ923G5
KOiK20029
OMAiNGVLFNC
OrthoDBiEOG091G0CME
PhylomeDBiQ923G5
TreeFamiTF319798

Family and domain databases

InterProiView protein in InterPro
IPR001594 Palmitoyltrfase_DHHC
PfamiView protein in Pfam
PF01529 DHHC, 1 hit
PROSITEiView protein in PROSITE
PS50216 DHHC, 1 hit

Sequencei

Sequence statusi: Complete.

Q923G5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQPSGHRLRD IEHHPLLTDN DNYDSASSSS SEADMADRVW FIRDGCGMVC
60 70 80 90 100
AVMTWLLVVY ADFVVTFVML LPSKDFWYSV VNGVLFNCLA VLALSSHLRT
110 120 130 140 150
MLTDPGAVPK GNATKEYMES LQLKPGEVIY KCPKCCCIKP ERAHHCSICK
160 170 180 190 200
RCIRKMDHHC PWVNNCVGEK NQRFFVLFTM YIALSSIHAL ILCGLQFISC
210 220 230 240 250
VRGQWTECSD FSPPITVILL VFLCLEGLLF FTFTAVMFGT QIHSICNDET
260 270 280 290 300
EIERLKSEKP TWERRLRWEG MKSVFGGPPS LLWMNPFVGF RFRRLQMRTR

KGGPEFSV
Length:308
Mass (Da):35,231
Last modified:December 1, 2001 - v1
Checksum:i7943CCA1E52EAF38
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY040615 mRNA Translation: AAK91508.1
AY886525 mRNA Translation: AAX73387.1
BC061769 mRNA Translation: AAH61769.1
RefSeqiNP_596885.1, NM_133394.1
UniGeneiRn.7790

Genome annotation databases

EnsembliENSRNOT00000023405; ENSRNOP00000023405; ENSRNOG00000017342
GeneIDi170906
KEGGirno:170906
UCSCiRGD:620205 rat

Similar proteinsi

Entry informationi

Entry nameiZDHC7_RAT
AccessioniPrimary (citable) accession number: Q923G5
Secondary accession number(s): Q2TGK0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 2003
Last sequence update: December 1, 2001
Last modified: May 23, 2018
This is version 96 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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