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Protein

Palmitoyltransferase ZDHHC7

Gene

Zdhhc7

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Palmitoyltransferase with broad specificity. Palmitoylates SNAP25 and DLG4/PSD95. Palmitoylates sex steroid hormone receptors, including ESR1, PGR and AR, thereby regulating their targeting to the plasma membrane and their function in rapid intracellular signaling upon binding of sex hormones (By similarity). May play a role in follicle stimulation hormone (FSH) activation of testicular Sertoli cells (PubMed:11796495).By similarity1 Publication

Catalytic activityi

Palmitoyl-CoA + [protein]-L-cysteine = [protein]-S-palmitoyl-L-cysteine + CoA.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
Palmitoyltransferase ZDHHC7Curated (EC:2.3.1.225By similarity)
Alternative name(s):
Sertoli cell gene with a zinc finger domain protein1 Publication
Zinc finger DHHC domain-containing protein 7Imported
Short name:
DHHC7Imported
Gene namesi
Name:Zdhhc7Imported
Synonyms:Serz1 Publication
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 19

Organism-specific databases

RGDi620205. Zdhhc7.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei51 – 7121HelicalSequence analysisAdd
BLAST
Transmembranei76 – 9621HelicalSequence analysisAdd
BLAST
Transmembranei174 – 19421HelicalSequence analysisAdd
BLAST
Transmembranei218 – 23821HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 308308Palmitoyltransferase ZDHHC7PRO_0000212876Add
BLAST

Post-translational modificationi

Autopalmitoylated.By similarity

Keywords - PTMi

Lipoprotein, Palmitate

Proteomic databases

PaxDbiQ923G5.

Expressioni

Tissue specificityi

Widely expressed. Present in Sertoli cells (at protein level).1 Publication

Gene expression databases

BgeeiENSRNOG00000017342.
GenevisibleiQ923G5. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000023405.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini130 – 18051DHHCPROSITE-ProRule annotationAdd
BLAST

Domaini

The DHHC domain is required for palmitoyltransferase activity.By similarity

Sequence similaritiesi

Belongs to the DHHC palmitoyltransferase family.Curated
Contains 1 DHHC domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1311. Eukaryota.
COG5273. LUCA.
GeneTreeiENSGT00840000129737.
HOGENOMiHOG000234755.
HOVERGENiHBG056583.
InParanoidiQ923G5.
KOiK20029.
OMAiNGVLFNC.
OrthoDBiEOG091G0CME.
PhylomeDBiQ923G5.
TreeFamiTF319798.

Family and domain databases

InterProiIPR001594. Znf_DHHC_palmitoyltrfase.
[Graphical view]
PfamiPF01529. zf-DHHC. 1 hit.
[Graphical view]
PROSITEiPS50216. DHHC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q923G5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQPSGHRLRD IEHHPLLTDN DNYDSASSSS SEADMADRVW FIRDGCGMVC
60 70 80 90 100
AVMTWLLVVY ADFVVTFVML LPSKDFWYSV VNGVLFNCLA VLALSSHLRT
110 120 130 140 150
MLTDPGAVPK GNATKEYMES LQLKPGEVIY KCPKCCCIKP ERAHHCSICK
160 170 180 190 200
RCIRKMDHHC PWVNNCVGEK NQRFFVLFTM YIALSSIHAL ILCGLQFISC
210 220 230 240 250
VRGQWTECSD FSPPITVILL VFLCLEGLLF FTFTAVMFGT QIHSICNDET
260 270 280 290 300
EIERLKSEKP TWERRLRWEG MKSVFGGPPS LLWMNPFVGF RFRRLQMRTR

KGGPEFSV
Length:308
Mass (Da):35,231
Last modified:December 1, 2001 - v1
Checksum:i7943CCA1E52EAF38
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY040615 mRNA. Translation: AAK91508.1.
AY886525 mRNA. Translation: AAX73387.1.
BC061769 mRNA. Translation: AAH61769.1.
RefSeqiNP_596885.1. NM_133394.1.
UniGeneiRn.7790.

Genome annotation databases

EnsembliENSRNOT00000023405; ENSRNOP00000023405; ENSRNOG00000017342.
GeneIDi170906.
KEGGirno:170906.
UCSCiRGD:620205. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY040615 mRNA. Translation: AAK91508.1.
AY886525 mRNA. Translation: AAX73387.1.
BC061769 mRNA. Translation: AAH61769.1.
RefSeqiNP_596885.1. NM_133394.1.
UniGeneiRn.7790.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000023405.

Proteomic databases

PaxDbiQ923G5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000023405; ENSRNOP00000023405; ENSRNOG00000017342.
GeneIDi170906.
KEGGirno:170906.
UCSCiRGD:620205. rat.

Organism-specific databases

CTDi55625.
RGDi620205. Zdhhc7.

Phylogenomic databases

eggNOGiKOG1311. Eukaryota.
COG5273. LUCA.
GeneTreeiENSGT00840000129737.
HOGENOMiHOG000234755.
HOVERGENiHBG056583.
InParanoidiQ923G5.
KOiK20029.
OMAiNGVLFNC.
OrthoDBiEOG091G0CME.
PhylomeDBiQ923G5.
TreeFamiTF319798.

Miscellaneous databases

PROiQ923G5.

Gene expression databases

BgeeiENSRNOG00000017342.
GenevisibleiQ923G5. RN.

Family and domain databases

InterProiIPR001594. Znf_DHHC_palmitoyltrfase.
[Graphical view]
PfamiPF01529. zf-DHHC. 1 hit.
[Graphical view]
PROSITEiPS50216. DHHC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZDHC7_RAT
AccessioniPrimary (citable) accession number: Q923G5
Secondary accession number(s): Q2TGK0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 2003
Last sequence update: December 1, 2001
Last modified: September 7, 2016
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.