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Protein

WW domain-binding protein 11

Gene

Wbp11

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Activates pre-mRNA splicing. May inhibit PP1 phosphatase activity.2 Publications

GO - Molecular functioni

  • protein phosphatase regulator activity Source: MGI
  • RNA binding Source: MGI
  • WW domain binding Source: MGI

GO - Biological processi

Keywordsi

Biological processmRNA processing, mRNA splicing, rRNA processing

Enzyme and pathway databases

ReactomeiR-MMU-72163. mRNA Splicing - Major Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
WW domain-binding protein 11
Short name:
WBP-11
Alternative name(s):
Splicing factor that interacts with PQBP-1 and PP1
Gene namesi
Name:Wbp11
Synonyms:Sipp1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:1891823. Wbp11.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi219V → A: Impairs interaction with PP1; when associated with A-221. 1 Publication1
Mutagenesisi221F → A: Impairs interaction with PP1; when associated with A-219. 1 Publication1
Mutagenesisi308V → A: Impairs interaction with PP1; when associated with A-310. 1 Publication1
Mutagenesisi310F → A: Impairs interaction with PP1; when associated with A-308. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000659461 – 641WW domain-binding protein 11Add BLAST641

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei13N6-acetyllysineCombined sources1
Modified residuei181PhosphoserineCombined sources1
Modified residuei192Omega-N-methylarginineBy similarity1
Modified residuei236PhosphotyrosineCombined sources1
Modified residuei237PhosphoserineCombined sources1
Modified residuei279PhosphoserineBy similarity1
Modified residuei283PhosphoserineBy similarity1
Modified residuei353PhosphoserineCombined sources1
Modified residuei361PhosphoserineCombined sources1
Modified residuei364PhosphoserineCombined sources1
Cross-linki557Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei565N6-acetyllysineCombined sources1
Cross-linki572Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei600PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ923D5.
MaxQBiQ923D5.
PaxDbiQ923D5.
PRIDEiQ923D5.

PTM databases

iPTMnetiQ923D5.
PhosphoSitePlusiQ923D5.

Expressioni

Tissue specificityi

Ubiquitously expressed, with highest levels in testis.1 Publication

Gene expression databases

BgeeiENSMUSG00000030216.
CleanExiMM_WBP11.
ExpressionAtlasiQ923D5. baseline and differential.
GenevisibleiQ923D5. MM.

Interactioni

Subunit structurei

Interacts via the PGR motif with PQBP1 in the nucleus. Interacts with the WW domains of WBP4 (By similarity). Interacts with PPP1CA, PPP1CB and PPP1CC.By similarity1 Publication

GO - Molecular functioni

Protein-protein interaction databases

BioGridi208550. 14 interactors.
ELMiQ923D5.
IntActiQ923D5. 11 interactors.
MINTiMINT-125895.
STRINGi10090.ENSMUSP00000112213.

Structurei

3D structure databases

SMRiQ923D5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 45Required for nuclear importAdd BLAST45
Regioni217 – 221Interaction with PP15
Regioni306 – 310Interaction with PP15
Regioni633 – 641Required for nuclear export9

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili75 – 133Sequence analysisAdd BLAST59

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi455 – 466PGRAdd BLAST12

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi140 – 209Pro-richAdd BLAST70
Compositional biasi246 – 297Asp-richAdd BLAST52
Compositional biasi319 – 322Poly-Lys4
Compositional biasi393 – 538Pro-richAdd BLAST146

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG4672. Eukaryota.
ENOG41115S5. LUCA.
GeneTreeiENSGT00730000111015.
HOGENOMiHOG000154840.
HOVERGENiHBG056793.
InParanoidiQ923D5.
KOiK12866.
OMAiNKKQRQM.
OrthoDBiEOG091G0BKC.
PhylomeDBiQ923D5.
TreeFamiTF323226.

Family and domain databases

InterProiView protein in InterPro
IPR019007. WW_dom-bd_prot_11.
PfamiView protein in Pfam
PF09429. Wbp11. 1 hit.

Sequencei

Sequence statusi: Complete.

Q923D5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGRRSTSSTK SGKFMNPTDQ ARKEARKREL KKNKKQRMMV RAAVLKMKDP
60 70 80 90 100
KQIIRDMEKL DEMEFNPVQQ PQLNEKVLKD KRKKLRETFE RILRLYEKEN
110 120 130 140 150
PDIYKELRKL EVEYEQKRAQ LSQYFDAVKN AQHVEVESIP LPDMPHAPSN
160 170 180 190 200
ILIQDIPLPG AQPPSILKKT SAYGPPARAV SILPLLGHGV PRLPPGRKPP
210 220 230 240 250
GPPPGPPPPQ VLQMYGRKVG FALDLPPRRR DEDMLYSPEL AQRGHDDDMS
260 270 280 290 300
STSEDDGYPE DMDQDKHDDS TEDSDTDRSD AESDGDEFGH REDSERDNTE
310 320 330 340 350
EKKSGLSVRF ADMPGKSRKK KKNMKELTPL QAMMLRMAGQ EIPEEGREVE
360 370 380 390 400
EFSEEEDADD SDDSEAEKQS QKQHKDDGHS DSTAAASSQQ QAPPQSAPAS
410 420 430 440 450
QIQAPPMPGP PPLGPPPAPP LRPPGPPTGL PPGPPPGAPP FLRPPGMPGI
460 470 480 490 500
RGPLPRLLPP GPPPGRPPGP PPGPPPGLPP GPPPRGPPPR LPPPAPPGIP
510 520 530 540 550
PPRPGMMRPP LVPPLGPAPP GLFPPAPLPN PGVLSAPPSL IQRPKADDAS
560 570 580 590 600
AATIEKKATA TISAKPQITN PKAEVTRFVP TALRVRRENK GATAVPQRRS
610 620 630 640
EDDSAVPVAK AAPRSGPSVA VSVQTKDDVY EAFMKEMEGL L
Length:641
Mass (Da):69,875
Last modified:September 13, 2005 - v2
Checksum:i9C97281B4257B1F6
GO

Sequence cautioni

The sequence AAC34812 differs from that shown. Reason: Frameshift at position 598.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti378G → A in AAH06600 (PubMed:15489334).Curated1
Sequence conflicti378G → A in AAC34812 (PubMed:9724750).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK031678 mRNA. Translation: BAC27508.1.
AK041079 mRNA. Translation: BAC30812.1.
AK144968 mRNA. Translation: BAE26160.1.
BC006600 mRNA. Translation: AAH06600.1.
BC021823 mRNA. Translation: AAH21823.1.
AF071186 mRNA. Translation: AAC34812.1. Sequence problems.
CCDSiCCDS20655.1.
RefSeqiNP_068360.4. NM_021714.4.
XP_017177182.1. XM_017321693.1.
UniGeneiMm.141197.
Mm.440103.

Genome annotation databases

EnsembliENSMUST00000116514; ENSMUSP00000112213; ENSMUSG00000030216.
GeneIDi60321.
KEGGimmu:60321.
UCSCiuc009emf.2. mouse.

Similar proteinsi

Entry informationi

Entry nameiWBP11_MOUSE
AccessioniPrimary (citable) accession number: Q923D5
Secondary accession number(s): O88539, Q3UMD8, Q8VDI0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 13, 2005
Last sequence update: September 13, 2005
Last modified: November 22, 2017
This is version 131 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot