Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Prostate androgen-regulated mucin-like protein 1 homolog

Gene

Parm1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May regulate TLP1 expression and telomerase activity, thus enabling certain prostatic cells to resist apoptosis.By similarity

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Prostate androgen-regulated mucin-like protein 1 homolog
Short name:
PARM-1
Gene namesi
Name:Parm1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:2443349. Parm1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini21 – 244224ExtracellularSequence analysisAdd
BLAST
Transmembranei245 – 26521HelicalSequence analysisAdd
BLAST
Topological domaini266 – 29631CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Endosome, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020Sequence analysisAdd
BLAST
Chaini21 – 296276Prostate androgen-regulated mucin-like protein 1 homologPRO_0000045499Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi61 – 611N-linked (GlcNAc...)Sequence analysis
Glycosylationi95 – 951N-linked (GlcNAc...)Sequence analysis
Glycosylationi169 – 1691N-linked (GlcNAc...)Sequence analysis
Modified residuei284 – 2841PhosphoserineBy similarity

Post-translational modificationi

Highly N-glycosylated and O-glycosylated.By similarity

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiQ923D3.
PaxDbiQ923D3.
PRIDEiQ923D3.

PTM databases

iPTMnetiQ923D3.
PhosphoSiteiQ923D3.

Expressioni

Gene expression databases

BgeeiQ923D3.
CleanExiMM_9130213B05RIK.
GenevisibleiQ923D3. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000042844.

Family & Domainsi

Sequence similaritiesi

Belongs to the PARM family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IVTQ. Eukaryota.
ENOG410XTVA. LUCA.
GeneTreeiENSGT00390000014545.
HOGENOMiHOG000280689.
HOVERGENiHBG082108.
InParanoidiQ923D3.
OMAiMQEVEHA.
OrthoDBiEOG7NPFVS.
PhylomeDBiQ923D3.
TreeFamiTF335903.

Family and domain databases

InterProiIPR031431. PARM1.
[Graphical view]
PANTHERiPTHR35453. PTHR35453. 1 hit.
PfamiPF17061. PARM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q923D3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVCKVLIALC IFTAGLRVQG SPTVPLPVSL MTKSSAPVAT WTTSAPHTAR
60 70 80 90 100
ATTPVASATH NASVLRTTAA SLTSQLPTDH REEAVTSPPL KRDVNSTDSS
110 120 130 140 150
PAGFPSTSSD GHLAPTPEEH SLGSPEATVP ATGSQSPMLL SSQAPTSATT
160 170 180 190 200
SPATSLSESL SASVTSSHNS TVANIQPTEA PMAPASPTEE HSSSHTPTSH
210 220 230 240 250
VTAEPVPKEK SPQDTEPGKV ICESETTTPF LIMQEVENAL SSGSIAAITV
260 270 280 290
TVIAVVLLVF GGAAYLKIRH SSYGRLLDDH DYGSWGNYNN PLYDDS
Length:296
Mass (Da):30,667
Last modified:December 1, 2001 - v1
Checksum:i8446AE7E3265936C
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti122 – 1221L → I in BAE28465 (PubMed:16141072).Curated
Sequence conflicti150 – 1501T → I in BAE36224 (PubMed:16141072).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EF564364 mRNA. Translation: ABQ42567.1.
AK078943 mRNA. Translation: BAC37472.1.
AK148300 mRNA. Translation: BAE28465.1.
AK161172 mRNA. Translation: BAE36224.1.
AK167402 mRNA. Translation: BAE39491.1.
CH466617 Genomic DNA. Translation: EDL05291.1.
BC006604 mRNA. Translation: AAH06604.1.
CCDSiCCDS39146.1.
RefSeqiNP_663537.1. NM_145562.2.
UniGeneiMm.5002.

Genome annotation databases

EnsembliENSMUST00000040576; ENSMUSP00000042844; ENSMUSG00000034981.
GeneIDi231440.
KEGGimmu:231440.
UCSCiuc008ybw.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EF564364 mRNA. Translation: ABQ42567.1.
AK078943 mRNA. Translation: BAC37472.1.
AK148300 mRNA. Translation: BAE28465.1.
AK161172 mRNA. Translation: BAE36224.1.
AK167402 mRNA. Translation: BAE39491.1.
CH466617 Genomic DNA. Translation: EDL05291.1.
BC006604 mRNA. Translation: AAH06604.1.
CCDSiCCDS39146.1.
RefSeqiNP_663537.1. NM_145562.2.
UniGeneiMm.5002.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000042844.

PTM databases

iPTMnetiQ923D3.
PhosphoSiteiQ923D3.

Proteomic databases

MaxQBiQ923D3.
PaxDbiQ923D3.
PRIDEiQ923D3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000040576; ENSMUSP00000042844; ENSMUSG00000034981.
GeneIDi231440.
KEGGimmu:231440.
UCSCiuc008ybw.1. mouse.

Organism-specific databases

CTDi25849.
MGIiMGI:2443349. Parm1.

Phylogenomic databases

eggNOGiENOG410IVTQ. Eukaryota.
ENOG410XTVA. LUCA.
GeneTreeiENSGT00390000014545.
HOGENOMiHOG000280689.
HOVERGENiHBG082108.
InParanoidiQ923D3.
OMAiMQEVEHA.
OrthoDBiEOG7NPFVS.
PhylomeDBiQ923D3.
TreeFamiTF335903.

Miscellaneous databases

PROiQ923D3.
SOURCEiSearch...

Gene expression databases

BgeeiQ923D3.
CleanExiMM_9130213B05RIK.
GenevisibleiQ923D3. MM.

Family and domain databases

InterProiIPR031431. PARM1.
[Graphical view]
PANTHERiPTHR35453. PTHR35453. 1 hit.
PfamiPF17061. PARM. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The expression of a mouse homolog of rat prostatic androgen-repressed message-1 (PARM-1), on adipogenesis."
    Roh S., Song S., Sasaki S.
    Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Adipose tissue.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Cecum, Head and Placenta.
  3. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Mammary tumor.
  5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brown adipose tissue, Heart and Pancreas.

Entry informationi

Entry nameiPARM1_MOUSE
AccessioniPrimary (citable) accession number: Q923D3
Secondary accession number(s): A5JSU4, Q3TTV0, Q3UFU4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 10, 2006
Last sequence update: December 1, 2001
Last modified: June 8, 2016
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.