Reviewed, UniProtKB/Swiss-Prot Q923D2 (BLVRB_MOUSE)

Names and origin

Protein names

Recommended name:
    Flavin reductase
      Short name=FR
    EC=1.5.1.30
Alternative name(s):
    NADPH-dependent diaphorase
    NADPH-flavin reductase
      Short name=FLR
    Biliverdin reductase B
      Short name=BVR-B
    EC=1.3.1.24
    Biliverdin-IX beta-reductase

Gene names

Name:

Blvrb

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

Protein attributes

Sequence length	206 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Catalyzes electron transfer from reduced pyridine nucleotides to flavins as well as methylene blue, pyrroloquinoline quinone, riboflavin, or methemoglobin. Possible role in protecting cells from oxidative damage or in regulating iron metabolism. In the liver, converts biliverdin to bilirubin By similarity.
Catalytic activity	Reduced riboflavin + NADP(+) = riboflavin + NADPH. Bilirubin + NAD(P)(+) = biliverdin + NAD(P)H.
Subunit structure	Monomer By similarity.
Subcellular location	CytoplasmPotential.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	NADP
Molecular function	Oxidoreductase
Technical term	Multifunctional enzyme
Gene Ontology (GO)
Biological process	cellular metabolic process Inferred from electronic annotation. Source: InterPro oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	biliverdin reductase activity Inferred from electronic annotation. Source: EC coenzyme binding Inferred from electronic annotation. Source: InterPro flavin reductase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed By similarity
	Chain	2 – 206	205	Flavin reductase		PRO_0000064949
Regions
	Nucleotide binding	5 – 36	32	NAD or NADP Potential

Sequences

	Sequence		Length	Mass (Da)
	Q923D2-1 [UniParc]. Last modified January 23, 2007. Version 3. Checksum: EDAEE91F5F39F629	FASTA	206	22,197
	10 20 30 40 50 60 MTVKKIAIFG ATGRTGLTTL AQAVQAGYEV TVLVRDSSRL PSEGPQPAHV VVGDVRQAAD 70 80 90 100 110 120 VDKTVAGQEA VIVLLGTGND LSPTTVMSEG TRNIVTAMKA HGVDKVVACT SAFLLWDPTK 130 140 150 160 170 180 VPPRLQDVTD DHIRMHKILQ ESGLKYVAVM PPHIGDQPLT GAYTVTLDGR GPSRVISKHD 190 200 LGHFMLRCLT TNEYDGHTTY PSHQYD

References

[1]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: Czech II and FVB/N. Tissue: Mammary tumor.

Cross-references

Sequence databases
EMBLGenBankDDBJ	BC006617 mRNA. Translation: AAH06617.1. BC027279 mRNA. Translation: AAH27279.1.
RefSeq	NP_659172.1.
UniGene	Mm.24021
3D structure databases
HSSP	HSSP built from PDB template 1HDO based on UniProtKB P30043.
SMR	Q923D2. Positions 1-205.
ModBase	Search...
PTM databases
PhosphoSite	Q923D2.
Genome annotation databases
Ensembl	ENSMUSG00000040466. Mus musculus. [Contig view]
GeneID	233016.
KEGG	mmu:233016.
Organism-specific databases
MGI	MGI:2385271. Blvrb.
Phylogenomic databases
HOGENOM	Q923D2.
HOVERGEN	Q923D2.
Gene expression databases
ArrayExpress	Q923D2.
CleanEx	MM_BLVRB.
GermOnline	ENSMUSG00000040466. Mus musculus.
Family and domain databases
InterPro	IPR001509. Epimerase_deHydtase. IPR016040. NAD(P)-bd. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
Pfam	PF01370. Epimerase. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	381462.
SOURCE	Search...

Entry information

Entry name

BLVRB_MOUSE

Accession

Primary (citable) accession number: Q923D2

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 10, 2005
Last sequence update:	January 23, 2007
Last modified:	November 25, 2008
This is version 49 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)