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Q92396

- TYRO_PODAS

UniProt

Q92396 - TYRO_PODAS

Protein

Tyrosinase

Gene

TYR

Organism
Podospora anserina (Pleurage anserina)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 58 (01 Oct 2014)
      Sequence version 1 (01 Feb 1997)
      Previous versions | rss
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    Functioni

    This is a copper-containing oxidase that functions in the formation of pigments such as melanins and other polyphenolic compounds.

    Catalytic activityi

    2 L-dopa + O2 = 2 dopaquinone + 2 H2O.
    L-tyrosine + O2 = dopaquinone + H2O.

    Cofactori

    Binds 2 copper ions per subunit.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi67 – 671Copper ABy similarity
    Metal bindingi95 – 951Copper ABy similarity
    Metal bindingi104 – 1041Copper ABy similarity
    Metal bindingi275 – 2751Copper BBy similarity
    Metal bindingi279 – 2791Copper BBy similarity
    Metal bindingi304 – 3041Copper BBy similarity

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. monophenol monooxygenase activity Source: UniProtKB-EC

    GO - Biological processi

    1. melanin biosynthetic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Monooxygenase, Oxidoreductase

    Keywords - Biological processi

    Melanin biosynthesis

    Keywords - Ligandi

    Copper, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Tyrosinase (EC:1.14.18.1)
    Alternative name(s):
    Monophenol monooxygenase
    Gene namesi
    Name:TYR
    OrganismiPodospora anserina (Pleurage anserina)
    Taxonomic identifieri5145 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeSordarialesLasiosphaeriaceaePodospora

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 574574TyrosinasePRO_0000186734Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Cross-linki93 ↔ 952'-(S-cysteinyl)-histidine (Cys-His)By similarity

    Keywords - PTMi

    Thioether bond

    Structurei

    3D structure databases

    ProteinModelPortaliQ92396.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the tyrosinase family.Curated

    Family and domain databases

    Gene3Di1.10.1280.10. 1 hit.
    InterProiIPR016216. Monophenol_mOase_fun.
    IPR002227. Tyrosinase_Cu-bd.
    IPR008922. Unchr_di-copper_centre.
    [Graphical view]
    PfamiPF00264. Tyrosinase. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000340. MPO_fungal. 1 hit.
    PRINTSiPR00092. TYROSINASE.
    SUPFAMiSSF48056. SSF48056. 1 hit.
    PROSITEiPS00497. TYROSINASE_1. 1 hit.
    PS00498. TYROSINASE_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q92396-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSTTGNIAIT GIPTTAGPDG SFPLRRELRD LQRNYPDHFN LLVLALKDFQ    50
    ALNESVQTSY YQIAGIHGLP YKPWNNVGSN SDWQSTSGFG GYCTHSSILF 100
    LTWHRPYLAL FEQALYNSIQ KIANQFPQGP LRTKYVEAAK TFRMPYFDWA 150
    SQPPSGSSAF PSAFTAPSLQ VVDVDGKTKS TANPIYRFVF HPVNPSPGDF 200
    PRQWSRFPTT VRYPNPRTGQ SQDNRVAPIL ANELASLRTN VSLLLLSYTN 250
    FDAFSFNRWD PNMTPGEFGS LEDVHNEIHD RTGGGGHMSS LDVSSFDPLF 300
    WFHHTNVDRL WAIWQDLNPD NFLTPRPAPY STFNSTEGES QTKDTPLTPF 350
    WDKSATKFWT SEEIKDTTTT FGYAYPETQE WKYRTGSEYQ TSIRQAVTTL 400
    YGTNVFANFA AANVQARATE HTELIKSLSL AAPPPSAPIT AEKPLLITQE 450
    MKASPIPEHL QHLAPNNKYP EWVVNIRAQK HGLHGAFRVI VFLGPIDESD 500
    PDSWQTEFNT VGRVSVLGRS TQGPTTTKCA KCITDAADEL MISGTVPLTS 550
    ALLQDIVNEN TASIACSQRK WCRI 574
    Length:574
    Mass (Da):64,181
    Last modified:February 1, 1997 - v1
    Checksum:i7020A9AAF5CDBE8F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U66808 mRNA. Translation: AAB07516.1.
    U66807 Genomic DNA. Translation: AAB07484.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U66808 mRNA. Translation: AAB07516.1 .
    U66807 Genomic DNA. Translation: AAB07484.1 .

    3D structure databases

    ProteinModelPortali Q92396.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    Gene3Di 1.10.1280.10. 1 hit.
    InterProi IPR016216. Monophenol_mOase_fun.
    IPR002227. Tyrosinase_Cu-bd.
    IPR008922. Unchr_di-copper_centre.
    [Graphical view ]
    Pfami PF00264. Tyrosinase. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000340. MPO_fungal. 1 hit.
    PRINTSi PR00092. TYROSINASE.
    SUPFAMi SSF48056. SSF48056. 1 hit.
    PROSITEi PS00497. TYROSINASE_1. 1 hit.
    PS00498. TYROSINASE_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular and functional characterization of the tyrosinase gene of the filamentous fungus Podospora anserina."
      Marbach K., Stahl U.
      Submitted (SEP-1996) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
      Strain: S1.

    Entry informationi

    Entry nameiTYRO_PODAS
    AccessioniPrimary (citable) accession number: Q92396
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: February 1, 1997
    Last modified: October 1, 2014
    This is version 58 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3