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Q92396

- TYRO_PODAS

UniProt

Q92396 - TYRO_PODAS

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Protein

Tyrosinase

Gene

TYR

Organism
Podospora anserina (Pleurage anserina)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

This is a copper-containing oxidase that functions in the formation of pigments such as melanins and other polyphenolic compounds.

Catalytic activityi

2 L-dopa + O2 = 2 dopaquinone + 2 H2O.
L-tyrosine + O2 = dopaquinone + H2O.

Cofactori

Cu2+By similarityNote: Binds 2 copper ions per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi67 – 671Copper ABy similarity
Metal bindingi95 – 951Copper ABy similarity
Metal bindingi104 – 1041Copper ABy similarity
Metal bindingi275 – 2751Copper BBy similarity
Metal bindingi279 – 2791Copper BBy similarity
Metal bindingi304 – 3041Copper BBy similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. monophenol monooxygenase activity Source: UniProtKB-EC

GO - Biological processi

  1. melanin biosynthetic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Biological processi

Melanin biosynthesis

Keywords - Ligandi

Copper, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Tyrosinase (EC:1.14.18.1)
Alternative name(s):
Monophenol monooxygenase
Gene namesi
Name:TYR
OrganismiPodospora anserina (Pleurage anserina)
Taxonomic identifieri5145 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeSordarialesLasiosphaeriaceaePodospora

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 574574TyrosinasePRO_0000186734Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki93 ↔ 952'-(S-cysteinyl)-histidine (Cys-His)By similarity

Keywords - PTMi

Thioether bond

Structurei

3D structure databases

ProteinModelPortaliQ92396.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the tyrosinase family.Curated

Family and domain databases

Gene3Di1.10.1280.10. 1 hit.
InterProiIPR016216. Monophenol_mOase_fun.
IPR002227. Tyrosinase_Cu-bd.
IPR008922. Unchr_di-copper_centre.
[Graphical view]
PfamiPF00264. Tyrosinase. 1 hit.
[Graphical view]
PIRSFiPIRSF000340. MPO_fungal. 1 hit.
PRINTSiPR00092. TYROSINASE.
SUPFAMiSSF48056. SSF48056. 1 hit.
PROSITEiPS00497. TYROSINASE_1. 1 hit.
PS00498. TYROSINASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q92396-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSTTGNIAIT GIPTTAGPDG SFPLRRELRD LQRNYPDHFN LLVLALKDFQ
60 70 80 90 100
ALNESVQTSY YQIAGIHGLP YKPWNNVGSN SDWQSTSGFG GYCTHSSILF
110 120 130 140 150
LTWHRPYLAL FEQALYNSIQ KIANQFPQGP LRTKYVEAAK TFRMPYFDWA
160 170 180 190 200
SQPPSGSSAF PSAFTAPSLQ VVDVDGKTKS TANPIYRFVF HPVNPSPGDF
210 220 230 240 250
PRQWSRFPTT VRYPNPRTGQ SQDNRVAPIL ANELASLRTN VSLLLLSYTN
260 270 280 290 300
FDAFSFNRWD PNMTPGEFGS LEDVHNEIHD RTGGGGHMSS LDVSSFDPLF
310 320 330 340 350
WFHHTNVDRL WAIWQDLNPD NFLTPRPAPY STFNSTEGES QTKDTPLTPF
360 370 380 390 400
WDKSATKFWT SEEIKDTTTT FGYAYPETQE WKYRTGSEYQ TSIRQAVTTL
410 420 430 440 450
YGTNVFANFA AANVQARATE HTELIKSLSL AAPPPSAPIT AEKPLLITQE
460 470 480 490 500
MKASPIPEHL QHLAPNNKYP EWVVNIRAQK HGLHGAFRVI VFLGPIDESD
510 520 530 540 550
PDSWQTEFNT VGRVSVLGRS TQGPTTTKCA KCITDAADEL MISGTVPLTS
560 570
ALLQDIVNEN TASIACSQRK WCRI
Length:574
Mass (Da):64,181
Last modified:February 1, 1997 - v1
Checksum:i7020A9AAF5CDBE8F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U66808 mRNA. Translation: AAB07516.1.
U66807 Genomic DNA. Translation: AAB07484.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U66808 mRNA. Translation: AAB07516.1 .
U66807 Genomic DNA. Translation: AAB07484.1 .

3D structure databases

ProteinModelPortali Q92396.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 1.10.1280.10. 1 hit.
InterProi IPR016216. Monophenol_mOase_fun.
IPR002227. Tyrosinase_Cu-bd.
IPR008922. Unchr_di-copper_centre.
[Graphical view ]
Pfami PF00264. Tyrosinase. 1 hit.
[Graphical view ]
PIRSFi PIRSF000340. MPO_fungal. 1 hit.
PRINTSi PR00092. TYROSINASE.
SUPFAMi SSF48056. SSF48056. 1 hit.
PROSITEi PS00497. TYROSINASE_1. 1 hit.
PS00498. TYROSINASE_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Molecular and functional characterization of the tyrosinase gene of the filamentous fungus Podospora anserina."
    Marbach K., Stahl U.
    Submitted (SEP-1996) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
    Strain: S1.

Entry informationi

Entry nameiTYRO_PODAS
AccessioniPrimary (citable) accession number: Q92396
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 1, 1997
Last modified: November 26, 2014
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3