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Q92396 (TYRO_PODAS) Reviewed, UniProtKB/Swiss-Prot

Last modified October 16, 2013. Version 56. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Tyrosinase

EC=1.14.18.1
Alternative name(s):
Monophenol monooxygenase
Gene names
Name:TYR
OrganismPodospora anserina (Pleurage anserina)
Taxonomic identifier5145 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeSordarialesLasiosphaeriaceaePodospora

Protein attributes

Sequence length574 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

This is a copper-containing oxidase that functions in the formation of pigments such as melanins and other polyphenolic compounds.

Catalytic activity

2 L-dopa + O2 = 2 dopaquinone + 2 H2O.

L-tyrosine + O2 = dopaquinone + H2O.

Cofactor

Binds 2 copper ions per subunit By similarity.

Sequence similarities

Belongs to the tyrosinase family.

Ontologies

Keywords
   Biological processMelanin biosynthesis
   LigandCopper
Metal-binding
   Molecular functionMonooxygenase
Oxidoreductase
   PTMThioether bond
Gene Ontology (GO)
   Biological_processmelanin biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionmetal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

monophenol monooxygenase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 574574Tyrosinase
PRO_0000186734

Sites

Metal binding671Copper A By similarity
Metal binding951Copper A By similarity
Metal binding1041Copper A By similarity
Metal binding2751Copper B By similarity
Metal binding2791Copper B By similarity
Metal binding3041Copper B By similarity

Amino acid modifications

Cross-link93 ↔ 952'-(S-cysteinyl)-histidine (Cys-His) By similarity

Sequences

Sequence LengthMass (Da)Tools
Q92396 [UniParc].

Last modified February 1, 1997. Version 1.
Checksum: 7020A9AAF5CDBE8F

FASTA57464,181
        10         20         30         40         50         60 
MSTTGNIAIT GIPTTAGPDG SFPLRRELRD LQRNYPDHFN LLVLALKDFQ ALNESVQTSY 

        70         80         90        100        110        120 
YQIAGIHGLP YKPWNNVGSN SDWQSTSGFG GYCTHSSILF LTWHRPYLAL FEQALYNSIQ 

       130        140        150        160        170        180 
KIANQFPQGP LRTKYVEAAK TFRMPYFDWA SQPPSGSSAF PSAFTAPSLQ VVDVDGKTKS 

       190        200        210        220        230        240 
TANPIYRFVF HPVNPSPGDF PRQWSRFPTT VRYPNPRTGQ SQDNRVAPIL ANELASLRTN 

       250        260        270        280        290        300 
VSLLLLSYTN FDAFSFNRWD PNMTPGEFGS LEDVHNEIHD RTGGGGHMSS LDVSSFDPLF 

       310        320        330        340        350        360 
WFHHTNVDRL WAIWQDLNPD NFLTPRPAPY STFNSTEGES QTKDTPLTPF WDKSATKFWT 

       370        380        390        400        410        420 
SEEIKDTTTT FGYAYPETQE WKYRTGSEYQ TSIRQAVTTL YGTNVFANFA AANVQARATE 

       430        440        450        460        470        480 
HTELIKSLSL AAPPPSAPIT AEKPLLITQE MKASPIPEHL QHLAPNNKYP EWVVNIRAQK 

       490        500        510        520        530        540 
HGLHGAFRVI VFLGPIDESD PDSWQTEFNT VGRVSVLGRS TQGPTTTKCA KCITDAADEL 

       550        560        570 
MISGTVPLTS ALLQDIVNEN TASIACSQRK WCRI 

« Hide

References

[1]"Molecular and functional characterization of the tyrosinase gene of the filamentous fungus Podospora anserina."
Marbach K., Stahl U.
Submitted (SEP-1996) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
Strain: S1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U66808 mRNA. Translation: AAB07516.1.
U66807 Genomic DNA. Translation: AAB07484.1.

3D structure databases

ProteinModelPortalQ92396.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D1.10.1280.10. 1 hit.
InterProIPR016216. Monophenol_mOase_fun.
IPR002227. Tyrosinase.
IPR008922. Unchr_di-copper_centre.
[Graphical view]
PfamPF00264. Tyrosinase. 1 hit.
[Graphical view]
PIRSFPIRSF000340. MPO_fungal. 1 hit.
PRINTSPR00092. TYROSINASE.
SUPFAMSSF48056. SSF48056. 1 hit.
PROSITEPS00497. TYROSINASE_1. 1 hit.
PS00498. TYROSINASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameTYRO_PODAS
AccessionPrimary (citable) accession number: Q92396
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 1, 1997
Last modified: October 16, 2013
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families