Reviewed,
UniProtKB/Swiss-Prot Q92383 (MAG1_SCHPO)
Last modified
January 19, 2010.
Version 70.
History...
Clusters with 100%,
90%,
50% identity |
Documents (2) |
Third-party data |
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Names and origin
| Protein names | Recommended name: DNA-3-methyladenine glycosylase 1 EC=3.2.2.21 Alternative name(s): 3-methyladenine DNA glycosidase 1 3MEA DNA glycosylase 1 | ||||
| Gene names |
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| Organism | Schizosaccharomyces pombe (Fission yeast) [Complete proteome] | ||||
| Taxonomic identifier | 4896 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Fungi › Dikarya › Ascomycota › Taphrinomycotina › Schizosaccharomycetes › Schizosaccharomycetales › Schizosaccharomycetaceae › Schizosaccharomyces |
Protein attributes
| Sequence length | 228 AA. |
| Sequence status | Complete. |
| Protein existence | Evidence at transcript level. |
General annotation (Comments)
| Function | Hydrolysis of the deoxyribose N-glycosidic bond to excise 3-methyladenine or 7-methyladenine from the damaged DNA polymer formed by alkylation lesions. Can release ethylated and propylated bases from DNA in addition to 3-methyladenine. |
| Catalytic activity | Hydrolysis of alkylated DNA, releasing 3-methyladenine, 3-methylguanine, 7-methylguanine and 7-methyladenine. |
| Sequence similarities | Belongs to the alkylbase DNA glycosidase alkA family. |
Ontologies
| Keywords | |
|---|---|
| Biological process | DNA damage DNA repair |
| Molecular function | Hydrolase |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | DNA dealkylation Inferred from direct assay. Source: GeneDB_SPombe base-excision repair, AP site formationInferred from genetic interaction. Source: GeneDB_SPombe recombinational repairInferred from mutant phenotype. Source: GeneDB_SPombe |
| Cellular component | nucleus Inferred from direct assay. Source: GeneDB_SPombe |
| Molecular function | alkylbase DNA N-glycosylase activity Inferred from direct assay. Source: GeneDB_SPombe damaged DNA bindingInferred from direct assay. Source: GeneDB_SPombe |
| Complete GO annotation... | |
Sequence annotation (Features)
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Cloning and characterization of a cDNA encoding a 3-methyladenine DNA glycosylase from the fission yeast Schizosaccharomyces pombe." Memisoglu A., Samson L. Gene 177:229-235(1996) [PubMed: 8921872] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. |
| [2] | "The genome sequence of Schizosaccharomyces pombe." Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M. Nurse P.Nature 415:871-880(2002) [PubMed: 11859360] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 38366 / 972. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | U76637 mRNA. Translation: AAC49524.1. CU329670 Genomic DNA. Translation: CAC36900.1. |
| PIR | JC5177. |
| RefSeq | NP_593991.1. |
3D structure databases | |
| SMR | Q92383. Positions 21-215. |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | Q92383. |
Genome annotation databases | |
| GeneID | 2543565. |
| GenomeReviews | Gene locus mag1 in contig CU329670_GR. |
| KEGG | spo:SPAPB24D3.04c. |
| NMPDR | fig|4896.1.peg.3961. |
Organism-specific databases | |
| GeneDB_Spombe | SPAPB24D3.04c. |
Phylogenomic databases | |
| eggNOG | fuNOG07498. |
| HOGENOM | HBG544181. |
| OMA | HNTIVEK. |
| OrthoDB | EOG973R7C. |
| PhylomeDB | Q92383. |
Enzyme and pathway databases | |
| BRENDA | 3.2.2.21. 653. |
Gene expression databases | |
| ArrayExpress | Q92383. |
Family and domain databases | |
| InterPro | IPR000035. Alkylbase_DNA_glycsylse_CS. IPR011257. DNA_glycosylase. IPR003265. HhH-GPD_domain. IPR003583. Hlx-hairpin-Hlx_DNA-bd_motif. [Graphical view] |
| Pfam | PF00730. HhH-GPD. 1 hit. [Graphical view] |
| SMART | SM00478. ENDO3c. 1 hit. SM00278. HhH1. 1 hit. [Graphical view] |
| PROSITE | PS00516. ALKYLBASE_DNA_GLYCOS. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | MAG1_SCHPO | ||||||||
| Accession | Primary (citable) accession number: Q92383 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | FPAP (Fungal Proteome Annotation Project) | ||||||||
Relevant documents
| Schizosaccharomyces pombe Schizosaccharomyces pombe: entries and gene names |
| SIMILARITY comments Index of protein domains and families |

Clusters with


