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Protein

Kinesin-like protein 1

Gene

klp1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Microtubule-dependent motor that is involved in microtubule organization in the mitotic spindle.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi575 – 582ATPPROSITE-ProRule annotation8

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • ATP-dependent microtubule motor activity, minus-end-directed Source: PomBase
  • gamma-tubulin binding Source: PomBase
  • microtubule binding Source: PomBase
  • microtubule motor activity Source: PomBase

GO - Biological processi

  • cellular protein localization Source: PomBase
  • karyogamy involved in conjugation with cellular fusion Source: PomBase
  • microtubule anchoring at mitotic spindle pole body Source: PomBase
  • microtubule bundle formation Source: PomBase
  • mitotic sister chromatid segregation Source: PomBase
  • mitotic spindle assembly Source: PomBase
  • protein transport along microtubule to spindle pole body Source: PomBase
  • transport along microtubule Source: PomBase

Keywordsi

Molecular functionMotor protein
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Kinesin-like protein 1
Gene namesi
Name:klp1
Synonyms:pkl1
ORF Names:SPAC3A11.14c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:SPAC3A11.14c
PomBaseiSPAC3A11.14c

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001253851 – 832Kinesin-like protein 1Add BLAST832

Proteomic databases

MaxQBiQ92376
PaxDbiQ92376
PRIDEiQ92376

PTM databases

iPTMnetiQ92376

Interactioni

GO - Molecular functioni

  • gamma-tubulin binding Source: PomBase
  • microtubule binding Source: PomBase

Protein-protein interaction databases

BioGridi279109, 11 interactors
STRINGi4896.SPAC3A11.14c.1

Structurei

3D structure databases

ProteinModelPortaliQ92376
SMRiQ92376
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini479 – 822Kinesin motorPROSITE-ProRule annotationAdd BLAST344

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili193 – 266Sequence analysisAdd BLAST74
Coiled coili284 – 305Sequence analysisAdd BLAST22
Coiled coili344 – 481Sequence analysisAdd BLAST138

Sequence similaritiesi

Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. NCD subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

InParanoidiQ92376
KOiK10405
OrthoDBiEOG092C2D4G
PhylomeDBiQ92376

Family and domain databases

Gene3Di3.40.850.10, 1 hit
InterProiView protein in InterPro
IPR027640 Kinesin-like_fam
IPR019821 Kinesin_motor_CS
IPR001752 Kinesin_motor_dom
IPR036961 Kinesin_motor_dom_sf
IPR027417 P-loop_NTPase
PANTHERiPTHR24115 PTHR24115, 2 hits
PfamiView protein in Pfam
PF00225 Kinesin, 1 hit
PRINTSiPR00380 KINESINHEAVY
SMARTiView protein in SMART
SM00129 KISc, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS00411 KINESIN_MOTOR_1, 1 hit
PS50067 KINESIN_MOTOR_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q92376-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVIENTKDIS INTGYKRQED ALNTDSEDLI YRPKKIIKTN QEDAVHDLKY
60 70 80 90 100
ENFVSKNHVL QSDINGKKRD SNRDKAAVVT APIASTHESN YEESVSKFKE
110 120 130 140 150
SWLPQLKDLI ESHKTICEST LAYESDQAMA SSNTLKRIKD LKSKPKNIIQ
160 170 180 190 200
LERLHMLSNG EHRLLSKDET DDIESAYLNL RSHLQVQEQV YAEKDHEYSL
210 220 230 240 250
QLQSYREAAE KAKQDILETK ENLSSELSIS NIQLKEAKER LEAANASYQK
260 270 280 290 300
LRREHKELAL YHEKKTHSLV CNLNGERKSF GDFVENEVKS YKHEYANICE
310 320 330 340 350
SLRRALVLIQ GSCTEKILRF KEKILDLLEM KQQEENDRIS HIEYENDLTV
360 370 380 390 400
KKLKRRISEL EMAVKEYESE KSYSEKEYEE KISSLRIELE DKLAEIDMLR
410 420 430 440 450
NKLLKEEHKH HSTSEKLEEL SKYVASIQDK ERNNGQNALE LQARIQQLER
460 470 480 490 500
RNEDMYNKLL AEEIIRRKLH NDIQELKGNI RVFCRVRPLL PSEESEYCIA
510 520 530 540 550
DVLQFPDKDA LEPQKLILKG PNVESSLGHT YDRNYEFSFD RVFAPESDNS
560 570 580 590 600
SVFEEISQLI QSAIDGYNVS IFAYGQTGSG KTYTMSSQDG MIAMSIKHIF
610 620 630 640 650
NYLSTLREKG WVYKLRGQFL EIYNETIYDL LNKAEMLKNP KHDIHHDEKE
660 670 680 690 700
RRTTVDNVSI IDFNEEDTVY KMLNRAGENR FIAATKANER SSRSHTVFML
710 720 730 740 750
YIDGENSRTK QICKGTLNLV DLAGSERLSY SQAVGDRLRE TQAINKSLSC
760 770 780 790 800
LGDVIHALGN ASNSTTKEKS HIPYRNSKLT YLLKYSLGKG AKTLMFVNVS
810 820 830
PLKSQFMDTL NSLRFATKVN DTKVGSIKHY KR
Length:832
Mass (Da):96,337
Last modified:December 15, 1998 - v2
Checksum:i870CF74224B9F3E4
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti343E → D in AAB88235 (PubMed:8898367).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U63916 mRNA Translation: AAB88235.1
CU329670 Genomic DNA Translation: CAB16597.1
PIRiT38749
RefSeqiNP_594189.1, NM_001019613.2

Genome annotation databases

EnsemblFungiiSPAC3A11.14c.1; SPAC3A11.14c.1:pep; SPAC3A11.14c
GeneIDi2542655
KEGGispo:SPAC3A11.14c

Entry informationi

Entry nameiKLP1_SCHPO
AccessioniPrimary (citable) accession number: Q92376
Secondary accession number(s): O42669
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: December 15, 1998
Last modified: April 25, 2018
This is version 125 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

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