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Protein

Kinesin-like protein 1

Gene

klp1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Microtubule-dependent motor that is involved in microtubule organization in the mitotic spindle.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi575 – 5828ATPPROSITE-ProRule annotation

GO - Molecular functioni

  • ATP binding Source: PomBase
  • ATP-dependent microtubule motor activity, minus-end-directed Source: PomBase
  • gamma-tubulin binding Source: PomBase
  • microtubule binding Source: PomBase
  • microtubule motor activity Source: PomBase

GO - Biological processi

  • cellular protein localization Source: PomBase
  • karyogamy involved in conjugation with cellular fusion Source: PomBase
  • meiotic nuclear division Source: PomBase
  • microtubule anchoring at mitotic spindle pole body Source: PomBase
  • microtubule-based movement Source: PomBase
  • microtubule bundle formation Source: PomBase
  • mitotic sister chromatid segregation Source: PomBase
  • mitotic spindle assembly Source: PomBase
  • protein transport along microtubule to spindle pole body Source: PomBase
Complete GO annotation...

Keywords - Molecular functioni

Motor protein

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Kinesin-like protein 1
Gene namesi
Name:klp1
Synonyms:pkl1
ORF Names:SPAC3A11.14c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:SPAC3A11.14c.
PomBaseiSPAC3A11.14c.

Subcellular locationi

GO - Cellular componenti

  • condensed nuclear chromosome kinetochore Source: PomBase
  • cytoplasm Source: UniProtKB-KW
  • kinesin complex Source: GO_Central
  • microtubule Source: UniProtKB-KW
  • microtubule associated complex Source: PomBase
  • mitotic spindle Source: PomBase
  • mitotic spindle pole body Source: PomBase
  • Msd1-Wdr8-Pkl1 complex Source: PomBase
  • nucleus Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 832832Kinesin-like protein 1PRO_0000125385Add
BLAST

Proteomic databases

MaxQBiQ92376.

Interactioni

GO - Molecular functioni

  • gamma-tubulin binding Source: PomBase
  • microtubule binding Source: PomBase

Protein-protein interaction databases

BioGridi279109. 11 interactions.

Structurei

3D structure databases

ProteinModelPortaliQ92376.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini479 – 822344Kinesin motorPROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili193 – 26674Sequence analysisAdd
BLAST
Coiled coili284 – 30522Sequence analysisAdd
BLAST
Coiled coili344 – 481138Sequence analysisAdd
BLAST

Sequence similaritiesi

Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. NCD subfamily.PROSITE-ProRule annotation
Contains 1 kinesin motor domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

InParanoidiQ92376.
KOiK10405.
OrthoDBiEOG7RRFGF.
PhylomeDBiQ92376.

Family and domain databases

Gene3Di3.40.850.10. 1 hit.
InterProiIPR027640. Kinesin-like_fam.
IPR019821. Kinesin_motor_CS.
IPR001752. Kinesin_motor_dom.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR24115. PTHR24115. 1 hit.
PfamiPF00225. Kinesin. 1 hit.
[Graphical view]
PRINTSiPR00380. KINESINHEAVY.
SMARTiSM00129. KISc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00411. KINESIN_MOTOR_1. 1 hit.
PS50067. KINESIN_MOTOR_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q92376-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVIENTKDIS INTGYKRQED ALNTDSEDLI YRPKKIIKTN QEDAVHDLKY
60 70 80 90 100
ENFVSKNHVL QSDINGKKRD SNRDKAAVVT APIASTHESN YEESVSKFKE
110 120 130 140 150
SWLPQLKDLI ESHKTICEST LAYESDQAMA SSNTLKRIKD LKSKPKNIIQ
160 170 180 190 200
LERLHMLSNG EHRLLSKDET DDIESAYLNL RSHLQVQEQV YAEKDHEYSL
210 220 230 240 250
QLQSYREAAE KAKQDILETK ENLSSELSIS NIQLKEAKER LEAANASYQK
260 270 280 290 300
LRREHKELAL YHEKKTHSLV CNLNGERKSF GDFVENEVKS YKHEYANICE
310 320 330 340 350
SLRRALVLIQ GSCTEKILRF KEKILDLLEM KQQEENDRIS HIEYENDLTV
360 370 380 390 400
KKLKRRISEL EMAVKEYESE KSYSEKEYEE KISSLRIELE DKLAEIDMLR
410 420 430 440 450
NKLLKEEHKH HSTSEKLEEL SKYVASIQDK ERNNGQNALE LQARIQQLER
460 470 480 490 500
RNEDMYNKLL AEEIIRRKLH NDIQELKGNI RVFCRVRPLL PSEESEYCIA
510 520 530 540 550
DVLQFPDKDA LEPQKLILKG PNVESSLGHT YDRNYEFSFD RVFAPESDNS
560 570 580 590 600
SVFEEISQLI QSAIDGYNVS IFAYGQTGSG KTYTMSSQDG MIAMSIKHIF
610 620 630 640 650
NYLSTLREKG WVYKLRGQFL EIYNETIYDL LNKAEMLKNP KHDIHHDEKE
660 670 680 690 700
RRTTVDNVSI IDFNEEDTVY KMLNRAGENR FIAATKANER SSRSHTVFML
710 720 730 740 750
YIDGENSRTK QICKGTLNLV DLAGSERLSY SQAVGDRLRE TQAINKSLSC
760 770 780 790 800
LGDVIHALGN ASNSTTKEKS HIPYRNSKLT YLLKYSLGKG AKTLMFVNVS
810 820 830
PLKSQFMDTL NSLRFATKVN DTKVGSIKHY KR
Length:832
Mass (Da):96,337
Last modified:December 15, 1998 - v2
Checksum:i870CF74224B9F3E4
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti343 – 3431E → D in AAB88235 (PubMed:8898367).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U63916 mRNA. Translation: AAB88235.1.
CU329670 Genomic DNA. Translation: CAB16597.1.
PIRiT38749.
RefSeqiNP_594189.1. NM_001019613.2.

Genome annotation databases

EnsemblFungiiSPAC3A11.14c.1; SPAC3A11.14c.1:pep; SPAC3A11.14c.
GeneIDi2542655.
KEGGispo:SPAC3A11.14c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U63916 mRNA. Translation: AAB88235.1.
CU329670 Genomic DNA. Translation: CAB16597.1.
PIRiT38749.
RefSeqiNP_594189.1. NM_001019613.2.

3D structure databases

ProteinModelPortaliQ92376.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi279109. 11 interactions.

Proteomic databases

MaxQBiQ92376.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPAC3A11.14c.1; SPAC3A11.14c.1:pep; SPAC3A11.14c.
GeneIDi2542655.
KEGGispo:SPAC3A11.14c.

Organism-specific databases

EuPathDBiFungiDB:SPAC3A11.14c.
PomBaseiSPAC3A11.14c.

Phylogenomic databases

InParanoidiQ92376.
KOiK10405.
OrthoDBiEOG7RRFGF.
PhylomeDBiQ92376.

Miscellaneous databases

PROiQ92376.

Family and domain databases

Gene3Di3.40.850.10. 1 hit.
InterProiIPR027640. Kinesin-like_fam.
IPR019821. Kinesin_motor_CS.
IPR001752. Kinesin_motor_dom.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR24115. PTHR24115. 1 hit.
PfamiPF00225. Kinesin. 1 hit.
[Graphical view]
PRINTSiPR00380. KINESINHEAVY.
SMARTiSM00129. KISc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00411. KINESIN_MOTOR_1. 1 hit.
PS50067. KINESIN_MOTOR_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Fission yeast pkl1 is a kinesin-related protein involved in mitotic spindle function."
    Pidoux A.L., Ledizet M., Cande W.Z.
    Mol. Biol. Cell 7:1639-1655(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION.
    Strain: 972 / ATCC 24843.
  2. "pkl1(+)and klp2(+): two kinesins of the Kar3 subfamily in fission yeast perform different functions in both mitosis and meiosis."
    Troxell C.L., Sweezy M.A., West R.R., Reed K.D., Carson B.D., Pidoux A.L., Cande W.Z., McIntosh J.R.
    Mol. Biol. Cell 12:3476-3488(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], SUBCELLULAR LOCATION.
  3. "The genome sequence of Schizosaccharomyces pombe."
    Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
    , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
    Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 972 / ATCC 24843.

Entry informationi

Entry nameiKLP1_SCHPO
AccessioniPrimary (citable) accession number: Q92376
Secondary accession number(s): O42669
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: December 15, 1998
Last modified: July 6, 2016
This is version 115 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.