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Protein

Nascent polypeptide-associated complex subunit beta

Gene

btf3

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Component of the nascent polypeptide-associated complex (NAC), a dynamic component of the ribosomal exit tunnel, protecting the emerging polypeptides from interaction with other cytoplasmic proteins to ensure appropriate nascent protein targeting. The NAC complex also promotes mitochondrial protein import by enhancing productive ribosome interactions with the outer mitochondrial membrane and blocks the inappropriate interaction of ribosomes translating non-secretory nascent polypeptides with translocation sites in the membrane of the endoplasmic reticulum. EGD1 may act as a transcription factor that exert a negative effect on the expression of several genes that are transcribed by RNA polymerase II.By similarity

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Nascent polypeptide-associated complex subunit beta
Short name:
NAC-beta
Alternative name(s):
Beta-NAC
Gene namesi
Name:btf3
Synonyms:egd1
ORF Names:SPAC4F10.14c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:SPAC4F10.14c.
PomBaseiSPAC4F10.14c. btf3.

Subcellular locationi

  • Cytoplasm By similarity
  • Nucleus By similarity

  • Note: Predominantly cytoplasmic, may also transiently localize to the nucleus.By similarity

GO - Cellular componenti

  • cytosol Source: PomBase
  • nascent polypeptide-associated complex Source: PomBase
  • nucleus Source: UniProtKB-SubCell
  • polysomal ribosome Source: PomBase

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002135531 – 151Nascent polypeptide-associated complex subunit betaAdd BLAST151

Proteomic databases

MaxQBiQ92371.
PRIDEiQ92371.

Interactioni

Subunit structurei

Part of the nascent polypeptide-associated complex (NAC), consisting of ucp15 and btf3. NAC associates with ribosomes via btf3 (By similarity).By similarity

Protein-protein interaction databases

BioGridi279933. 30 interactors.
MINTiMINT-4701409.

Structurei

3D structure databases

SMRiQ92371.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini35 – 100NAC-A/BPROSITE-ProRule annotationAdd BLAST66

Sequence similaritiesi

Belongs to the NAC-beta family.Curated

Phylogenomic databases

HOGENOMiHOG000261245.
InParanoidiQ92371.
KOiK01527.
OMAiFAAPKVH.
OrthoDBiEOG092C58TX.
PhylomeDBiQ92371.

Family and domain databases

InterProiView protein in InterPro
IPR002715. Nas_poly-pep-assoc_cplx_dom.
PfamiView protein in Pfam
PF01849. NAC. 1 hit.
SMARTiView protein in SMART
SM01407. NAC. 1 hit.
PROSITEiView protein in PROSITE
PS51151. NAC_AB. 1 hit.

Sequencei

Sequence statusi: Complete.

Q92371-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDPSKLAKLQ AGARIGGKGT PRRKVKKPSK SAMSAADDKK VQGALKKLNM
60 70 80 90 100
QNLAGIQEVN MFKEDGGVIN FRAPTVHSSL PNETTAIYGK AEEKTLSEIL
110 120 130 140 150
PGILNNLGPE SLTALRQMAE QLKVSEGEKG ADAQADDGEI PDLVEKFDEQ

D
Length:151
Mass (Da):16,202
Last modified:July 15, 1999 - v2
Checksum:iE1250863AB09FDCC
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti103I → N in AAB40599 (PubMed:8809106).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U49084 mRNA. Translation: AAB40599.1.
CU329670 Genomic DNA. Translation: CAB11717.1.
PIRiS71926.
T38818.
RefSeqiNP_594757.1. NM_001020184.2.

Genome annotation databases

EnsemblFungiiSPAC4F10.14c.1; SPAC4F10.14c.1:pep; SPAC4F10.14c.
GeneIDi2543515.
KEGGispo:SPAC4F10.14c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U49084 mRNA. Translation: AAB40599.1.
CU329670 Genomic DNA. Translation: CAB11717.1.
PIRiS71926.
T38818.
RefSeqiNP_594757.1. NM_001020184.2.

3D structure databases

SMRiQ92371.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi279933. 30 interactors.
MINTiMINT-4701409.

Proteomic databases

MaxQBiQ92371.
PRIDEiQ92371.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPAC4F10.14c.1; SPAC4F10.14c.1:pep; SPAC4F10.14c.
GeneIDi2543515.
KEGGispo:SPAC4F10.14c.

Organism-specific databases

EuPathDBiFungiDB:SPAC4F10.14c.
PomBaseiSPAC4F10.14c. btf3.

Phylogenomic databases

HOGENOMiHOG000261245.
InParanoidiQ92371.
KOiK01527.
OMAiFAAPKVH.
OrthoDBiEOG092C58TX.
PhylomeDBiQ92371.

Miscellaneous databases

PROiPR:Q92371.

Family and domain databases

InterProiView protein in InterPro
IPR002715. Nas_poly-pep-assoc_cplx_dom.
PfamiView protein in Pfam
PF01849. NAC. 1 hit.
SMARTiView protein in SMART
SM01407. NAC. 1 hit.
PROSITEiView protein in PROSITE
PS51151. NAC_AB. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiNACB_SCHPO
AccessioniPrimary (citable) accession number: Q92371
Secondary accession number(s): O36026
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: July 15, 1999
Last modified: June 7, 2017
This is version 105 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.