Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Nascent polypeptide-associated complex subunit beta

Gene

btf3

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Component of the nascent polypeptide-associated complex (NAC), a dynamic component of the ribosomal exit tunnel, protecting the emerging polypeptides from interaction with other cytoplasmic proteins to ensure appropriate nascent protein targeting. The NAC complex also promotes mitochondrial protein import by enhancing productive ribosome interactions with the outer mitochondrial membrane and blocks the inappropriate interaction of ribosomes translating non-secretory nascent polypeptides with translocation sites in the membrane of the endoplasmic reticulum. EGD1 may act as a transcription factor that exert a negative effect on the expression of several genes that are transcribed by RNA polymerase II.By similarity

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Nascent polypeptide-associated complex subunit beta
Short name:
NAC-beta
Alternative name(s):
Beta-NAC
Gene namesi
Name:btf3
Synonyms:egd1
ORF Names:SPAC4F10.14c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:SPAC4F10.14c
PomBaseiSPAC4F10.14c btf3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002135531 – 151Nascent polypeptide-associated complex subunit betaAdd BLAST151

Proteomic databases

MaxQBiQ92371
PaxDbiQ92371
PRIDEiQ92371

PTM databases

iPTMnetiQ92371

Interactioni

Subunit structurei

Part of the nascent polypeptide-associated complex (NAC), consisting of ucp15 and btf3. NAC associates with ribosomes via btf3 (By similarity).By similarity

Protein-protein interaction databases

BioGridi279933, 30 interactors
STRINGi4896.SPAC4F10.14c.1

Structurei

3D structure databases

SMRiQ92371
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini35 – 100NAC-A/BPROSITE-ProRule annotationAdd BLAST66

Sequence similaritiesi

Belongs to the NAC-beta family.Curated

Phylogenomic databases

HOGENOMiHOG000261245
InParanoidiQ92371
KOiK01527
OMAiFAAPKVH
OrthoDBiEOG092C58TX
PhylomeDBiQ92371

Family and domain databases

Gene3Di2.20.70.30, 1 hit
InterProiView protein in InterPro
IPR038187 NAC_A/B_dom_sf
IPR002715 Nas_poly-pep-assoc_cplx_dom
PfamiView protein in Pfam
PF01849 NAC, 1 hit
SMARTiView protein in SMART
SM01407 NAC, 1 hit
PROSITEiView protein in PROSITE
PS51151 NAC_AB, 1 hit

Sequencei

Sequence statusi: Complete.

Q92371-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDPSKLAKLQ AGARIGGKGT PRRKVKKPSK SAMSAADDKK VQGALKKLNM
60 70 80 90 100
QNLAGIQEVN MFKEDGGVIN FRAPTVHSSL PNETTAIYGK AEEKTLSEIL
110 120 130 140 150
PGILNNLGPE SLTALRQMAE QLKVSEGEKG ADAQADDGEI PDLVEKFDEQ

D
Length:151
Mass (Da):16,202
Last modified:July 15, 1999 - v2
Checksum:iE1250863AB09FDCC
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti103I → N in AAB40599 (PubMed:8809106).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U49084 mRNA Translation: AAB40599.1
CU329670 Genomic DNA Translation: CAB11717.1
PIRiS71926
T38818
RefSeqiNP_594757.1, NM_001020184.2

Genome annotation databases

EnsemblFungiiSPAC4F10.14c.1; SPAC4F10.14c.1:pep; SPAC4F10.14c
GeneIDi2543515
KEGGispo:SPAC4F10.14c

Similar proteinsi

Entry informationi

Entry nameiNACB_SCHPO
AccessioniPrimary (citable) accession number: Q92371
Secondary accession number(s): O36026
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: July 15, 1999
Last modified: March 28, 2018
This is version 110 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health