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Q92370

- TRPG_SCHPO

UniProt

Q92370 - TRPG_SCHPO

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Protein
Multifunctional tryptophan biosynthesis protein
Gene
trp1, SPBC1539.09c
Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Trifunctional enzyme bearing the Gln amidotransferase (GATase) domain of anthranilate synthase, indole-glycerolphosphate synthase, and phosphoribosylanthranilate isomerase activities.UniRule annotation

Catalytic activityi

N-(5-phospho-beta-D-ribosyl)anthranilate = 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate.UniRule annotation
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate = 1-C-(3-indolyl)-glycerol 3-phosphate + CO2 + H2O.UniRule annotation
Chorismate + L-glutamine = anthranilate + pyruvate + L-glutamate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei108 – 1081For GATase activity By similarity
Active sitei197 – 1971For GATase activity By similarity
Active sitei199 – 1991For GATase activity By similarity

GO - Molecular functioni

  1. anthranilate synthase activity Source: PomBase
  2. indole-3-glycerol-phosphate lyase activity Source: PomBase
  3. indole-3-glycerol-phosphate synthase activity Source: UniProtKB-EC
  4. phosphoribosylanthranilate isomerase activity Source: PomBase
  5. transferase activity Source: UniProtKB-KW
Complete GO annotation...

GO - Biological processi

  1. glutamine metabolic process Source: UniProtKB-KW
  2. tryptophan biosynthetic process Source: PomBase
Complete GO annotation...

Keywords - Molecular functioni

Decarboxylase, Isomerase, Lyase, Transferase

Keywords - Biological processi

Amino-acid biosynthesis, Aromatic amino acid biosynthesis, Tryptophan biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00035; UER00040.
UPA00035; UER00042.
UPA00035; UER00043.

Protein family/group databases

MEROPSiC26.A25.

Names & Taxonomyi

Protein namesi
Recommended name:
Multifunctional tryptophan biosynthesis protein
Including the following 3 domains:
Anthranilate synthase component 2 (EC:4.1.3.27)
Short name:
AS
Alternative name(s):
Anthranilate synthase, glutamine amidotransferase component
Indole-3-glycerol phosphate synthase (EC:4.1.1.48)
Short name:
IGPS
N-(5'-phosphoribosyl)anthranilate isomerase (EC:5.3.1.24)
Short name:
PRAI
Gene namesi
Name:trp1
ORF Names:SPBC1539.09c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
ProteomesiUP000002485: Chromosome II

Organism-specific databases

PomBaseiSPBC1539.09c.

Subcellular locationi

GO - Cellular componenti

  1. anthranilate synthase complex Source: PomBase
  2. cytosol Source: PomBase
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 759759Multifunctional tryptophan biosynthesis proteinUniRule annotation
PRO_0000056865Add
BLAST

Proteomic databases

MaxQBiQ92370.
PaxDbiQ92370.

Interactioni

Protein-protein interaction databases

BioGridi276517. 3 interactions.
MINTiMINT-4701389.
STRINGi4896.SPBC1539.09c-1.

Structurei

3D structure databases

ProteinModelPortaliQ92370.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini27 – 223197Glutamine amidotransferase type-1
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni257 – 519263Indole-3-glycerol phosphate synthaseUniRule annotation
Add
BLAST
Regioni536 – 759224N-(5'-phosphoribosyl)anthranilate isomeraseUniRule annotation
Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Glutamine amidotransferase

Phylogenomic databases

eggNOGiCOG0134.
HOGENOMiHOG000280459.
KOiK13501.
OMAiPVLGVCM.
OrthoDBiEOG78WM1Q.
PhylomeDBiQ92370.

Family and domain databases

Gene3Di3.20.20.70. 2 hits.
3.40.50.880. 1 hit.
HAMAPiMF_00134_B. IGPS_B.
MF_00135. PRAI.
InterProiIPR013785. Aldolase_TIM.
IPR016302. Anthranilate_synth_II.
IPR029062. Class_I_gatase-like.
IPR017926. GATASE.
IPR013798. Indole-3-glycerol_P_synth.
IPR001468. Indole-3-GlycerolPSynthase_CS.
IPR001240. PRAI_dom.
IPR011060. RibuloseP-bd_barrel.
IPR006221. TrpG/PapA_dom.
[Graphical view]
PfamiPF00117. GATase. 1 hit.
PF00218. IGPS. 1 hit.
PF00697. PRAI. 1 hit.
[Graphical view]
PIRSFiPIRSF001382. TrpG-trpC-trpF. 1 hit.
SUPFAMiSSF51366. SSF51366. 3 hits.
SSF52317. SSF52317. 1 hit.
TIGRFAMsiTIGR00566. trpG_papA. 1 hit.
PROSITEiPS51273. GATASE_TYPE_1. 1 hit.
PS00614. IGPS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q92370-1 [UniParc]FASTAAdd to Basket

« Hide

MSEKVDVGES VKGDASENAV KEVAERPIVM IDNYDSFTWN VVQYLSNLEK    50
RYPIMVFRND EITVDELEKL NPLKLVLSPG PGHPARDGGI CNEAISRFAG 100
KIPILGVCMG LQCIFETMGG KVDSAGEIIH GKVSKINHDG LGFYQGIPQN 150
ISVTRYHSLA GKISSLPDCL DVTSWTENGV IMGARHKKYA IEGVQYHPES 200
ILSEYGKEYI QNFLNLTAGT WEENGIVMPT KNNAFNAAMR ENSNSVSSTK 250
IRKQESILEK IHAQRLIDIA ESKRKPGLSV GDLQTYLNLN IAPPCINFYE 300
RLKQSKPALM AEVKRASPSK GDIKLDANAA IQALTYAQVG ASVISVLTEP 350
KWFKGSLNDL FVARKAVEHV ANRPAILRKD FIIDPYQIME ARLNGADSVL 400
LIVAMLSREQ LESLYKFSKS LGMEPLVEVN CAEEMKTAIE LGAKVIGVNN 450
RNLHSFEVDL STTSKLAEMV PDDVILAALS GISSPADVAH YSSQGVSAVL 500
VGESLMRASD PAAFARELLN LSSSEISNGK KTSTPLVKVC GTRSLLAAKT 550
IVESGGDLIG LIFVEKSKRK VDLSVAKEIS HFVHTTNRKH ISPKKAVTGQ 600
SWFDHQYENL ASSPHPLLVG VFQNQPLEYI RSIIAEVNLD IVQLHGQEPF 650
EWIHMLDRPV IKVFPLNSSE ISRPNYHIVP LIDAYVGGES GGLGKKVDWE 700
AASFIPVSYV LAGGLTPKNV QDAISVSRPA VVDVSSGVET DGKQDLEKIK 750
AFINAVKEL 759
Length:759
Mass (Da):83,040
Last modified:April 27, 2001 - v2
Checksum:i519E2EA55CB9B212
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti387 – 3871Q → E in CAA70348. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Y09137 mRNA. Translation: CAA70348.1.
CU329671 Genomic DNA. Translation: CAB51341.1.
PIRiT39468.
T46566.
RefSeqiNP_596823.1. NM_001023843.1.

Genome annotation databases

EnsemblFungiiSPBC1539.09c.1; SPBC1539.09c.1:pep; SPBC1539.09c.
GeneIDi2539973.
KEGGispo:SPBC1539.09c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Y09137 mRNA. Translation: CAA70348.1 .
CU329671 Genomic DNA. Translation: CAB51341.1 .
PIRi T39468.
T46566.
RefSeqi NP_596823.1. NM_001023843.1.

3D structure databases

ProteinModelPortali Q92370.
ModBasei Search...

Protein-protein interaction databases

BioGridi 276517. 3 interactions.
MINTi MINT-4701389.
STRINGi 4896.SPBC1539.09c-1.

Protein family/group databases

MEROPSi C26.A25.

Proteomic databases

MaxQBi Q92370.
PaxDbi Q92370.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii SPBC1539.09c.1 ; SPBC1539.09c.1:pep ; SPBC1539.09c .
GeneIDi 2539973.
KEGGi spo:SPBC1539.09c.

Organism-specific databases

PomBasei SPBC1539.09c.

Phylogenomic databases

eggNOGi COG0134.
HOGENOMi HOG000280459.
KOi K13501.
OMAi PVLGVCM.
OrthoDBi EOG78WM1Q.
PhylomeDBi Q92370.

Enzyme and pathway databases

UniPathwayi UPA00035 ; UER00040 .
UPA00035 ; UER00042 .
UPA00035 ; UER00043 .

Miscellaneous databases

NextBioi 20801116.

Family and domain databases

Gene3Di 3.20.20.70. 2 hits.
3.40.50.880. 1 hit.
HAMAPi MF_00134_B. IGPS_B.
MF_00135. PRAI.
InterProi IPR013785. Aldolase_TIM.
IPR016302. Anthranilate_synth_II.
IPR029062. Class_I_gatase-like.
IPR017926. GATASE.
IPR013798. Indole-3-glycerol_P_synth.
IPR001468. Indole-3-GlycerolPSynthase_CS.
IPR001240. PRAI_dom.
IPR011060. RibuloseP-bd_barrel.
IPR006221. TrpG/PapA_dom.
[Graphical view ]
Pfami PF00117. GATase. 1 hit.
PF00218. IGPS. 1 hit.
PF00697. PRAI. 1 hit.
[Graphical view ]
PIRSFi PIRSF001382. TrpG-trpC-trpF. 1 hit.
SUPFAMi SSF51366. SSF51366. 3 hits.
SSF52317. SSF52317. 1 hit.
TIGRFAMsi TIGR00566. trpG_papA. 1 hit.
PROSITEi PS51273. GATASE_TYPE_1. 1 hit.
PS00614. IGPS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. David C., Couzin N., Lauquin G.J.-M.
    Submitted (NOV-1996) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: 972 / ATCC 24843.
  2. "The genome sequence of Schizosaccharomyces pombe."
    Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
    , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
    Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 972 / ATCC 24843.

Entry informationi

Entry nameiTRPG_SCHPO
AccessioniPrimary (citable) accession number: Q92370
Secondary accession number(s): Q9UUF5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: April 27, 2001
Last modified: July 9, 2014
This is version 114 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Multifunctional enzyme, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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