Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Actin-related protein 2/3 complex subunit 4

Gene

arc4

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the mother actin filament (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

Actin-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Actin-related protein 2/3 complex subunit 4
Alternative name(s):
Arp2/3 complex 20 kDa
Short name:
p20-ARC
Gene namesi
Name:arc4
Synonyms:arp20
ORF Names:SPAC6G9.07c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:SPAC6G9.07c.
PomBaseiSPAC6G9.07c. arc4.

Subcellular locationi

GO - Cellular componenti

  • actin cortical patch Source: PomBase
  • Arp2/3 protein complex Source: PomBase
  • cytosol Source: PomBase
  • nucleus Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001240521 – 168Actin-related protein 2/3 complex subunit 4Add BLAST168

Proteomic databases

MaxQBiQ92352.
PRIDEiQ92352.

Interactioni

Subunit structurei

Component of the Arp2/3 complex composed of arp2, act2, arc1/p41-ARC, arc2/p34-ARC, arc3/p21-ARC, arc4/p20-ARC and arc5/p16-ARC.1 Publication

Protein-protein interaction databases

BioGridi278261. 2 interactors.
IntActiQ92352. 3 interactors.
MINTiMINT-4701225.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3DWLX-ray3.78F/K1-168[»]
ProteinModelPortaliQ92352.
SMRiQ92352.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ92352.

Family & Domainsi

Sequence similaritiesi

Belongs to the ARPC4 family.Curated

Phylogenomic databases

HOGENOMiHOG000202303.
InParanoidiQ92352.
KOiK05755.
OMAiLITNNHT.
OrthoDBiEOG092C5HW8.
PhylomeDBiQ92352.

Family and domain databases

InterProiIPR008384. ARPC4.
[Graphical view]
PANTHERiPTHR22629. PTHR22629. 1 hit.
PfamiPF05856. ARPC4. 1 hit.
[Graphical view]
PIRSFiPIRSF039100. ARPC4. 1 hit.

Sequencei

Sequence statusi: Complete.

Q92352-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSNTLRPYLN AVRSTLTASL ALEEFSSEIV ERQSQPEVEV GRSPEILLKP
60 70 80 90 100
LVVSRNEQEQ CLIESSVNSV RFSIRIKQVD EIERILVRKF MQFLMGRAES
110 120 130 140 150
FFILRRKPVQ GYDISFLITN YHTEEMLKHK LVDFIIEFME EVDAEISEMK
160
LFLNGRARLV AETYLSCF
Length:168
Mass (Da):19,615
Last modified:February 1, 1997 - v1
Checksum:i93E7D63F3907820E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA. Translation: CAB03609.1.
AB010050 mRNA. Translation: BAA24183.1.
PIRiT39069.
T43309.
RefSeqiNP_594116.1. NM_001019540.2.

Genome annotation databases

EnsemblFungiiSPAC6G9.07c.1; SPAC6G9.07c.1:pep; SPAC6G9.07c.
GeneIDi2541767.
KEGGispo:SPAC6G9.07c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA. Translation: CAB03609.1.
AB010050 mRNA. Translation: BAA24183.1.
PIRiT39069.
T43309.
RefSeqiNP_594116.1. NM_001019540.2.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3DWLX-ray3.78F/K1-168[»]
ProteinModelPortaliQ92352.
SMRiQ92352.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi278261. 2 interactors.
IntActiQ92352. 3 interactors.
MINTiMINT-4701225.

Proteomic databases

MaxQBiQ92352.
PRIDEiQ92352.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPAC6G9.07c.1; SPAC6G9.07c.1:pep; SPAC6G9.07c.
GeneIDi2541767.
KEGGispo:SPAC6G9.07c.

Organism-specific databases

EuPathDBiFungiDB:SPAC6G9.07c.
PomBaseiSPAC6G9.07c. arc4.

Phylogenomic databases

HOGENOMiHOG000202303.
InParanoidiQ92352.
KOiK05755.
OMAiLITNNHT.
OrthoDBiEOG092C5HW8.
PhylomeDBiQ92352.

Miscellaneous databases

EvolutionaryTraceiQ92352.
PROiQ92352.

Family and domain databases

InterProiIPR008384. ARPC4.
[Graphical view]
PANTHERiPTHR22629. PTHR22629. 1 hit.
PfamiPF05856. ARPC4. 1 hit.
[Graphical view]
PIRSFiPIRSF039100. ARPC4. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiARPC4_SCHPO
AccessioniPrimary (citable) accession number: Q92352
Secondary accession number(s): Q9URL0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 1, 1997
Last modified: November 2, 2016
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.