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Protein

Putative cell agglutination protein pfl8

Gene

pfl8

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be involved in agglutination during conjugation or other aspects of colony formation (By similarity). Induces flocculation when overexpressed (PubMed:23236291).By similarity1 Publication

Caution

Was originally thought to be a kinetochore protein, but co-localization has not been confirmed (PubMed:16079914). A more recent study identified it as a secreted protein (PubMed:16823372).2 Publications

GO - Biological processi

  • cell-cell adhesion involved in flocculation Source: PomBase

Names & Taxonomyi

Protein namesi
Recommended name:
Putative cell agglutination protein pfl8Curated
Alternative name(s):
Adhesin pfl81 Publication
Pombe flocculin 81 Publication
Sim4-mal2-associated protein 51 Publication
Gene namesi
Name:pfl81 Publication
Synonyms:fta51 Publication, sma5
ORF Names:SPAC1F8.06Imported
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:SPAC1F8.06
PomBaseiSPAC1F8.06 pfl8

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_000011663321 – 385Putative cell agglutination protein pfl8Sequence analysisAdd BLAST365

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi72N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi270N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi346N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ92344
PaxDbiQ92344
PRIDEiQ92344

Interactioni

Protein-protein interaction databases

BioGridi278345, 6 interactors
STRINGi4896.SPAC1F8.06.1

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini196 – 360PA14PROSITE-ProRule annotationAdd BLAST165

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi16 – 155Ser-richPROSITE-ProRule annotationAdd BLAST140

Keywords - Domaini

Signal

Phylogenomic databases

HOGENOMiHOG000112665
InParanoidiQ92344
OrthoDBiEOG092C6H7G
PhylomeDBiQ92344

Family and domain databases

InterProiView protein in InterPro
IPR018871 GLEYA_adhesin_domain
IPR037524 PA14/GLEYA
PfamiView protein in Pfam
PF10528 GLEYA, 1 hit
PROSITEiView protein in PROSITE
PS51820 PA14, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q92344-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNSYISLIFT LLFFTSAARS SSVSVETGSC VRYTTIYSSG SSEFTSTITP
60 70 80 90 100
ETPSSSSSTF VPISTHTSSA TNTTSGQLSI SSSSSTSSEY SSSSIPITTV
110 120 130 140 150
SSSDSFIPSS SQTISASSST TDNVIVSSSI SSTVSSTPVS TIYSGTSGTT
160 170 180 190 200
FVSSSTTYQV IPTQICDGVR GLEYAVYNYD LPSESTFCHP SNGYTEVSTF
210 220 230 240 250
NKPAYFGSKD LKQSAPLFTG IFSSLDDIPT YSASDYLPAY PPNPEGMSST
260 270 280 290 300
SSSCKTIVYQ FFFRVPATDN WSLFVKNVDD AFFGWFGDKA ISGWSNVNYD
310 320 330 340 350
AYAHWRIGAY GMGTFDLGYL EQDSFVPVRF VLANGAYIGG FDFAFNSSST
360 370 380
GPVRTTSYSY TSTCDKSFLP FGKGNGGLDE GTANV
Length:385
Mass (Da):41,001
Last modified:February 1, 1997 - v1
Checksum:i88A58F377701F5C4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA Translation: CAB03600.1
PIRiT38113
RefSeqiNP_592795.1, NM_001018195.2

Genome annotation databases

EnsemblFungiiSPAC1F8.06.1; SPAC1F8.06.1:pep; SPAC1F8.06
GeneIDi2541854
KEGGispo:SPAC1F8.06

Similar proteinsi

Entry informationi

Entry nameiPFL8_SCHPO
AccessioniPrimary (citable) accession number: Q92344
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 1, 1997
Last modified: April 25, 2018
This is version 93 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health