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Protein

D-aspartate oxidase

Gene

Ddo

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Selectively catalyzes the oxidative deamination of D-aspartate and its N-methylated derivative, N-methyl D-aspartate.By similarity

Catalytic activityi

D-aspartate + H2O + O2 = oxaloacetate + NH3 + H2O2.

Cofactori

FADBy similarity, 6-hydroxy-FADBy similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei166FAD; via amide nitrogen and carbonyl oxygenBy similarity1
Binding sitei183FADBy similarity1
Binding sitei223SubstrateBy similarity1
Binding sitei278SubstrateBy similarity1
Binding sitei312FADBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi6 – 20FADBy similarityAdd BLAST15
Nucleotide bindingi36 – 37FADBy similarity2
Nucleotide bindingi43 – 44FADBy similarity2
Nucleotide bindingi48 – 50FADBy similarity3
Nucleotide bindingi307 – 311FADBy similarity5

GO - Molecular functioni

  • cofactor binding Source: UniProtKB
  • D-aspartate oxidase activity Source: UniProtKB
  • FAD binding Source: InterPro
  • signaling receptor binding Source: MGI

GO - Biological processi

  • aspartate catabolic process Source: MGI
  • aspartate metabolic process Source: MGI
  • D-amino acid catabolic process Source: UniProtKB
  • grooming behavior Source: MGI
  • hormone metabolic process Source: MGI
  • insemination Source: MGI

Keywordsi

Molecular functionOxidoreductase
LigandFAD, Flavoprotein

Enzyme and pathway databases

ReactomeiR-MMU-389661 Glyoxylate metabolism and glycine degradation
R-MMU-9033241 Peroxisomal protein import

Names & Taxonomyi

Protein namesi
Recommended name:
D-aspartate oxidase (EC:1.4.3.1)
Short name:
DASOX
Short name:
DDO
Gene namesi
Name:Ddo
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:1925528 Ddo

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Peroxisome

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL3616357

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001627711 – 341D-aspartate oxidaseAdd BLAST341

Proteomic databases

MaxQBiQ922Z0
PaxDbiQ922Z0
PRIDEiQ922Z0

PTM databases

iPTMnetiQ922Z0
PhosphoSitePlusiQ922Z0

Expressioni

Gene expression databases

BgeeiENSMUSG00000063428
CleanExiMM_DDO
ExpressionAtlasiQ922Z0 baseline and differential
GenevisibleiQ922Z0 MM

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000019977

Chemistry databases

BindingDBiQ922Z0

Structurei

3D structure databases

ProteinModelPortaliQ922Z0
SMRiQ922Z0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi339 – 341Microbody targeting signalSequence analysis3

Sequence similaritiesi

Belongs to the DAMOX/DASOX family.Curated

Phylogenomic databases

eggNOGiKOG3923 Eukaryota
COG0665 LUCA
GeneTreeiENSGT00390000018635
HOGENOMiHOG000046303
HOVERGENiHBG003493
InParanoidiQ922Z0
KOiK00272
OMAiHLVSGWQ
OrthoDBiEOG091G0G0Y
PhylomeDBiQ922Z0
TreeFamiTF313887

Family and domain databases

InterProiView protein in InterPro
IPR006181 D-amino_acid_oxidase_CS
IPR023209 DAO
IPR006076 FAD-dep_OxRdtase
PANTHERiPTHR11530 PTHR11530, 1 hit
PfamiView protein in Pfam
PF01266 DAO, 1 hit
PIRSFiPIRSF000189 D-aa_oxidase, 1 hit
PROSITEiView protein in PROSITE
PS00677 DAO, 1 hit

Sequencei

Sequence statusi: Complete.

Q922Z0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDTVCIAVVG AGVIGLSTAA CISQLVPGCT VTVISDRFTP DTTSNVAAGM
60 70 80 90 100
LIPHTCADTP VPTQKRWFRE TFEHLSEIAK SAEAADAGVH LVSGWQIFRS
110 120 130 140 150
VPAEEVPFWA DVVLGFRKMT EAELKRFPQY VFGQAFTTLK CETSAYLPWL
160 170 180 190 200
ERRIKGSGGL LLTRRIEDLW ELQPSFDIVV NCSGLGSRRL VGDPMISPVR
210 220 230 240 250
GQVLQARAPW VKHFIRDGGG LTYVYPGMSY VTLGGTRQKG DWNRSPDAEL
260 270 280 290 300
SREIFSRCCT LEPSLHRAYD IKEKVGLRPS RPGVRLQKEI LVRGQQTLPV
310 320 330 340
VHNYGHGSGG ISVHWGSALE ATRLVMECIH TLRTPASLSK L
Length:341
Mass (Da):37,546
Last modified:December 1, 2001 - v1
Checksum:iA80BC74CC44A601D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti56C → Y in AAH27312 (PubMed:15489334).Curated1
Sequence conflicti67W → C in AAH27312 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK033375 mRNA Translation: BAC28253.1
AK085947 mRNA Translation: BAC39577.1
AK161548 mRNA Translation: BAE36456.1
BC006690 mRNA Translation: AAH06690.1
BC027312 mRNA Translation: AAH27312.1
CCDSiCCDS23798.1
RefSeqiNP_001303645.1, NM_001316716.1
NP_001303646.1, NM_001316717.1
NP_001303647.1, NM_001316718.1
NP_001303648.1, NM_001316719.1
NP_081718.2, NM_027442.5
UniGeneiMm.252862

Genome annotation databases

EnsembliENSMUST00000019977; ENSMUSP00000019977; ENSMUSG00000063428
GeneIDi70503
KEGGimmu:70503
UCSCiuc007exa.2 mouse

Similar proteinsi

Entry informationi

Entry nameiOXDD_MOUSE
AccessioniPrimary (citable) accession number: Q922Z0
Secondary accession number(s): Q3TT69, Q8R2R2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 27, 2005
Last sequence update: December 1, 2001
Last modified: May 23, 2018
This is version 114 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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