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Protein

D-aspartate oxidase

Gene

Ddo

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Selectively catalyzes the oxidative deamination of D-aspartate and its N-methylated derivative, N-methyl D-aspartate.By similarity

Catalytic activityi

D-aspartate + H2O + O2 = oxaloacetate + NH3 + H2O2.

Cofactori

FADBy similarity, 6-hydroxy-FADBy similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei166FAD; via amide nitrogen and carbonyl oxygenBy similarity1
Binding sitei183FADBy similarity1
Binding sitei223SubstrateBy similarity1
Binding sitei278SubstrateBy similarity1
Binding sitei312FADBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi6 – 20FADBy similarityAdd BLAST15
Nucleotide bindingi36 – 37FADBy similarity2
Nucleotide bindingi43 – 44FADBy similarity2
Nucleotide bindingi48 – 50FADBy similarity3
Nucleotide bindingi307 – 311FADBy similarity5

GO - Molecular functioni

  • cofactor binding Source: UniProtKB
  • D-aspartate oxidase activity Source: UniProtKB
  • FAD binding Source: InterPro
  • receptor binding Source: MGI

GO - Biological processi

  • aspartate metabolic process Source: MGI
  • D-amino acid catabolic process Source: UniProtKB
  • grooming behavior Source: MGI
  • hormone metabolic process Source: MGI
  • insemination Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

FAD, Flavoprotein

Enzyme and pathway databases

ReactomeiR-MMU-389661. Glyoxylate metabolism and glycine degradation.

Names & Taxonomyi

Protein namesi
Recommended name:
D-aspartate oxidase (EC:1.4.3.1)
Short name:
DASOX
Short name:
DDO
Gene namesi
Name:Ddo
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:1925528. Ddo.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Peroxisome

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL3616357.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001627711 – 341D-aspartate oxidaseAdd BLAST341

Proteomic databases

MaxQBiQ922Z0.
PaxDbiQ922Z0.
PRIDEiQ922Z0.

PTM databases

iPTMnetiQ922Z0.
PhosphoSitePlusiQ922Z0.

Expressioni

Gene expression databases

BgeeiENSMUSG00000063428.
CleanExiMM_DDO.
GenevisibleiQ922Z0. MM.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000019977.

Structurei

3D structure databases

ProteinModelPortaliQ922Z0.
SMRiQ922Z0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi339 – 341Microbody targeting signalSequence analysis3

Sequence similaritiesi

Belongs to the DAMOX/DASOX family.Curated

Phylogenomic databases

eggNOGiKOG3923. Eukaryota.
COG0665. LUCA.
GeneTreeiENSGT00390000018635.
HOGENOMiHOG000046303.
HOVERGENiHBG003493.
InParanoidiQ922Z0.
KOiK00272.
OMAiHVFGHAF.
OrthoDBiEOG091G0G0Y.
PhylomeDBiQ922Z0.
TreeFamiTF313887.

Family and domain databases

Gene3Di3.50.50.60. 3 hits.
InterProiIPR006181. D-amino_acid_oxidase_CS.
IPR023209. DAO.
IPR006076. FAD-dep_OxRdtase.
IPR023753. FAD/NAD-binding_dom.
[Graphical view]
PANTHERiPTHR11530. PTHR11530. 1 hit.
PfamiPF01266. DAO. 1 hit.
[Graphical view]
PIRSFiPIRSF000189. D-aa_oxidase. 1 hit.
PROSITEiPS00677. DAO. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q922Z0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDTVCIAVVG AGVIGLSTAA CISQLVPGCT VTVISDRFTP DTTSNVAAGM
60 70 80 90 100
LIPHTCADTP VPTQKRWFRE TFEHLSEIAK SAEAADAGVH LVSGWQIFRS
110 120 130 140 150
VPAEEVPFWA DVVLGFRKMT EAELKRFPQY VFGQAFTTLK CETSAYLPWL
160 170 180 190 200
ERRIKGSGGL LLTRRIEDLW ELQPSFDIVV NCSGLGSRRL VGDPMISPVR
210 220 230 240 250
GQVLQARAPW VKHFIRDGGG LTYVYPGMSY VTLGGTRQKG DWNRSPDAEL
260 270 280 290 300
SREIFSRCCT LEPSLHRAYD IKEKVGLRPS RPGVRLQKEI LVRGQQTLPV
310 320 330 340
VHNYGHGSGG ISVHWGSALE ATRLVMECIH TLRTPASLSK L
Length:341
Mass (Da):37,546
Last modified:December 1, 2001 - v1
Checksum:iA80BC74CC44A601D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti56C → Y in AAH27312 (PubMed:15489334).Curated1
Sequence conflicti67W → C in AAH27312 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK033375 mRNA. Translation: BAC28253.1.
AK085947 mRNA. Translation: BAC39577.1.
AK161548 mRNA. Translation: BAE36456.1.
BC006690 mRNA. Translation: AAH06690.1.
BC027312 mRNA. Translation: AAH27312.1.
CCDSiCCDS23798.1.
RefSeqiNP_001303645.1. NM_001316716.1.
NP_001303646.1. NM_001316717.1.
NP_001303647.1. NM_001316718.1.
NP_001303648.1. NM_001316719.1.
NP_081718.2. NM_027442.5.
UniGeneiMm.252862.

Genome annotation databases

EnsembliENSMUST00000019977; ENSMUSP00000019977; ENSMUSG00000063428.
GeneIDi70503.
KEGGimmu:70503.
UCSCiuc007exa.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK033375 mRNA. Translation: BAC28253.1.
AK085947 mRNA. Translation: BAC39577.1.
AK161548 mRNA. Translation: BAE36456.1.
BC006690 mRNA. Translation: AAH06690.1.
BC027312 mRNA. Translation: AAH27312.1.
CCDSiCCDS23798.1.
RefSeqiNP_001303645.1. NM_001316716.1.
NP_001303646.1. NM_001316717.1.
NP_001303647.1. NM_001316718.1.
NP_001303648.1. NM_001316719.1.
NP_081718.2. NM_027442.5.
UniGeneiMm.252862.

3D structure databases

ProteinModelPortaliQ922Z0.
SMRiQ922Z0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000019977.

Chemistry databases

ChEMBLiCHEMBL3616357.

PTM databases

iPTMnetiQ922Z0.
PhosphoSitePlusiQ922Z0.

Proteomic databases

MaxQBiQ922Z0.
PaxDbiQ922Z0.
PRIDEiQ922Z0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000019977; ENSMUSP00000019977; ENSMUSG00000063428.
GeneIDi70503.
KEGGimmu:70503.
UCSCiuc007exa.2. mouse.

Organism-specific databases

CTDi8528.
MGIiMGI:1925528. Ddo.

Phylogenomic databases

eggNOGiKOG3923. Eukaryota.
COG0665. LUCA.
GeneTreeiENSGT00390000018635.
HOGENOMiHOG000046303.
HOVERGENiHBG003493.
InParanoidiQ922Z0.
KOiK00272.
OMAiHVFGHAF.
OrthoDBiEOG091G0G0Y.
PhylomeDBiQ922Z0.
TreeFamiTF313887.

Enzyme and pathway databases

ReactomeiR-MMU-389661. Glyoxylate metabolism and glycine degradation.

Miscellaneous databases

PROiQ922Z0.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000063428.
CleanExiMM_DDO.
GenevisibleiQ922Z0. MM.

Family and domain databases

Gene3Di3.50.50.60. 3 hits.
InterProiIPR006181. D-amino_acid_oxidase_CS.
IPR023209. DAO.
IPR006076. FAD-dep_OxRdtase.
IPR023753. FAD/NAD-binding_dom.
[Graphical view]
PANTHERiPTHR11530. PTHR11530. 1 hit.
PfamiPF01266. DAO. 1 hit.
[Graphical view]
PIRSFiPIRSF000189. D-aa_oxidase. 1 hit.
PROSITEiPS00677. DAO. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiOXDD_MOUSE
AccessioniPrimary (citable) accession number: Q922Z0
Secondary accession number(s): Q3TT69, Q8R2R2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 27, 2005
Last sequence update: December 1, 2001
Last modified: November 30, 2016
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.