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Q922W5

- P5CR1_MOUSE

UniProt

Q922W5 - P5CR1_MOUSE

Protein

Pyrroline-5-carboxylate reductase 1, mitochondrial

Gene

Pycr1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 98 (01 Oct 2014)
      Sequence version 1 (01 Dec 2001)
      Previous versions | rss
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    Functioni

    Housekeeping enzyme that catalyzes the last step in proline biosynthesis. Can utilize both NAD and NADP, but has higher affinity for NAD. Involved in the cellular response to oxidative stress By similarity.By similarity

    Catalytic activityi

    L-proline + NAD(P)+ = 1-pyrroline-5-carboxylate + NAD(P)H.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei34 – 341NADP; via carbonyl oxygenBy similarity
    Binding sitei56 – 561NADPBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi6 – 116NADPBy similarity
    Nucleotide bindingi69 – 724NADPBy similarity
    Nucleotide bindingi95 – 973NADPBy similarity

    GO - Molecular functioni

    1. pyrroline-5-carboxylate reductase activity Source: UniProtKB

    GO - Biological processi

    1. cellular response to oxidative stress Source: UniProtKB
    2. L-proline biosynthetic process Source: UniProtKB-UniPathway
    3. proline biosynthetic process Source: UniProtKB

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Amino-acid biosynthesis, Proline biosynthesis, Stress response

    Keywords - Ligandi

    NADP

    Enzyme and pathway databases

    UniPathwayiUPA00098; UER00361.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Pyrroline-5-carboxylate reductase 1, mitochondrial (EC:1.5.1.2)
    Short name:
    P5C reductase 1
    Short name:
    P5CR 1
    Gene namesi
    Name:Pycr1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 11

    Organism-specific databases

    MGIiMGI:2384795. Pycr1.

    Subcellular locationi

    GO - Cellular componenti

    1. mitochondrion Source: UniProtKB

    Keywords - Cellular componenti

    Mitochondrion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 309308Pyrroline-5-carboxylate reductase 1, mitochondrialPRO_0000187315Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylserineBy similarity

    Keywords - PTMi

    Acetylation

    Proteomic databases

    MaxQBiQ922W5.
    PaxDbiQ922W5.
    PRIDEiQ922W5.

    PTM databases

    PhosphoSiteiQ922W5.

    Expressioni

    Tissue specificityi

    Highly expressed in osteoblasts and skin.1 Publication

    Gene expression databases

    ArrayExpressiQ922W5.
    BgeeiQ922W5.
    CleanExiMM_PYCR1.
    GenevestigatoriQ922W5.

    Interactioni

    Subunit structurei

    Homodecamer; composed of 5 homodimers.By similarity

    Protein-protein interaction databases

    IntActiQ922W5. 1 interaction.

    Structurei

    3D structure databases

    ProteinModelPortaliQ922W5.
    SMRiQ922W5. Positions 1-275.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0345.
    GeneTreeiENSGT00390000007443.
    HOGENOMiHOG000230247.
    HOVERGENiHBG053399.
    InParanoidiQ922W5.
    KOiK00286.
    OMAiAKMVIEN.
    OrthoDBiEOG7N0C5N.
    PhylomeDBiQ922W5.

    Family and domain databases

    Gene3Di1.10.3730.10. 1 hit.
    3.40.50.720. 1 hit.
    HAMAPiMF_01925. P5C_reductase.
    InterProiIPR008927. 6-PGluconate_DH_C-like.
    IPR016040. NAD(P)-bd_dom.
    IPR029036. P5CR_dimer.
    IPR028939. ProC_N.
    IPR000304. Pyrroline-COOH_reductase.
    [Graphical view]
    PANTHERiPTHR11645. PTHR11645. 1 hit.
    PfamiPF03807. F420_oxidored. 1 hit.
    PF14748. P5CR_dimer. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000193. Pyrrol-5-carb_rd. 1 hit.
    SUPFAMiSSF48179. SSF48179. 1 hit.
    TIGRFAMsiTIGR00112. proC. 1 hit.
    PROSITEiPS00521. P5CR. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q922W5-1 [UniParc]FASTAAdd to Basket

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    MSVGFIGAGQ LAFALAKGFT AAGVLAAHKI MASSPDMDQA TVSALRKIGV    50
    NLTPHNKETV RHSDVLFLAV KPHIIPFILD EIGANIEDRH IVVSCAAGVT 100
    INSIEKKLTA FQPAPKVIRC MTNTPVVVRE GVTVYATGTH AQVEDGRLVE 150
    QLMGSVGFCT EVEEDLIDAV TGLSGSGPAY AFTALDALAD GGVKMGLPRR 200
    LAVRLGAQAL LGAAKMLLDS EQHPSQLKDN VCSPGGATIH ALHVLESGGF 250
    RSLLINAVEA SCIRTRELQT MADQETISPA AIKKTVLDKV KLDSSAGASL 300
    SSDHVKPLP 309
    Length:309
    Mass (Da):32,373
    Last modified:December 1, 2001 - v1
    Checksum:iA3CD24AACDD53DEF
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC006727 mRNA. Translation: AAH06727.1.
    CCDSiCCDS25749.1.
    RefSeqiNP_659044.1. NM_144795.3.
    XP_006532798.1. XM_006532735.1.
    UniGeneiMm.127731.

    Genome annotation databases

    EnsembliENSMUST00000026133; ENSMUSP00000026133; ENSMUSG00000025140.
    ENSMUST00000170556; ENSMUSP00000131199; ENSMUSG00000025140.
    GeneIDi209027.
    KEGGimmu:209027.
    UCSCiuc007mtv.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC006727 mRNA. Translation: AAH06727.1 .
    CCDSi CCDS25749.1.
    RefSeqi NP_659044.1. NM_144795.3.
    XP_006532798.1. XM_006532735.1.
    UniGenei Mm.127731.

    3D structure databases

    ProteinModelPortali Q922W5.
    SMRi Q922W5. Positions 1-275.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q922W5. 1 interaction.

    PTM databases

    PhosphoSitei Q922W5.

    Proteomic databases

    MaxQBi Q922W5.
    PaxDbi Q922W5.
    PRIDEi Q922W5.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000026133 ; ENSMUSP00000026133 ; ENSMUSG00000025140 .
    ENSMUST00000170556 ; ENSMUSP00000131199 ; ENSMUSG00000025140 .
    GeneIDi 209027.
    KEGGi mmu:209027.
    UCSCi uc007mtv.1. mouse.

    Organism-specific databases

    CTDi 5831.
    MGIi MGI:2384795. Pycr1.

    Phylogenomic databases

    eggNOGi COG0345.
    GeneTreei ENSGT00390000007443.
    HOGENOMi HOG000230247.
    HOVERGENi HBG053399.
    InParanoidi Q922W5.
    KOi K00286.
    OMAi AKMVIEN.
    OrthoDBi EOG7N0C5N.
    PhylomeDBi Q922W5.

    Enzyme and pathway databases

    UniPathwayi UPA00098 ; UER00361 .

    Miscellaneous databases

    NextBioi 372532.
    PROi Q922W5.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q922W5.
    Bgeei Q922W5.
    CleanExi MM_PYCR1.
    Genevestigatori Q922W5.

    Family and domain databases

    Gene3Di 1.10.3730.10. 1 hit.
    3.40.50.720. 1 hit.
    HAMAPi MF_01925. P5C_reductase.
    InterProi IPR008927. 6-PGluconate_DH_C-like.
    IPR016040. NAD(P)-bd_dom.
    IPR029036. P5CR_dimer.
    IPR028939. ProC_N.
    IPR000304. Pyrroline-COOH_reductase.
    [Graphical view ]
    PANTHERi PTHR11645. PTHR11645. 1 hit.
    Pfami PF03807. F420_oxidored. 1 hit.
    PF14748. P5CR_dimer. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000193. Pyrrol-5-carb_rd. 1 hit.
    SUPFAMi SSF48179. SSF48179. 1 hit.
    TIGRFAMsi TIGR00112. proC. 1 hit.
    PROSITEi PS00521. P5CR. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: FVB/N.
      Tissue: Mammary tumor.
    2. Cited for: TISSUE SPECIFICITY.

    Entry informationi

    Entry nameiP5CR1_MOUSE
    AccessioniPrimary (citable) accession number: Q922W5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 1, 2005
    Last sequence update: December 1, 2001
    Last modified: October 1, 2014
    This is version 98 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3