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Q922W5

- P5CR1_MOUSE

UniProt

Q922W5 - P5CR1_MOUSE

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Protein
Pyrroline-5-carboxylate reductase 1, mitochondrial
Gene
Pycr1
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Housekeeping enzyme that catalyzes the last step in proline biosynthesis. Can utilize both NAD and NADP, but has higher affinity for NAD. Involved in the cellular response to oxidative stress By similarity.

Catalytic activityi

L-proline + NAD(P)+ = 1-pyrroline-5-carboxylate + NAD(P)H.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei34 – 341NADP; via carbonyl oxygen By similarity
Binding sitei56 – 561NADP By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi6 – 116NADP By similarity
Nucleotide bindingi69 – 724NADP By similarity
Nucleotide bindingi95 – 973NADP By similarity

GO - Molecular functioni

  1. pyrroline-5-carboxylate reductase activity Source: UniProtKB

GO - Biological processi

  1. L-proline biosynthetic process Source: UniProtKB-UniPathway
  2. cellular response to oxidative stress Source: UniProtKB
  3. proline biosynthetic process Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Amino-acid biosynthesis, Proline biosynthesis, Stress response

Keywords - Ligandi

NADP

Enzyme and pathway databases

UniPathwayiUPA00098; UER00361.

Names & Taxonomyi

Protein namesi
Recommended name:
Pyrroline-5-carboxylate reductase 1, mitochondrial (EC:1.5.1.2)
Short name:
P5C reductase 1
Short name:
P5CR 1
Gene namesi
Name:Pycr1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 11

Organism-specific databases

MGIiMGI:2384795. Pycr1.

Subcellular locationi

GO - Cellular componenti

  1. mitochondrion Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed By similarity
Chaini2 – 309308Pyrroline-5-carboxylate reductase 1, mitochondrial
PRO_0000187315Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylserine By similarity

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiQ922W5.
PaxDbiQ922W5.
PRIDEiQ922W5.

PTM databases

PhosphoSiteiQ922W5.

Expressioni

Tissue specificityi

Gene expression databases

ArrayExpressiQ922W5.
BgeeiQ922W5.
CleanExiMM_PYCR1.
GenevestigatoriQ922W5.

Interactioni

Subunit structurei

Homodecamer; composed of 5 homodimers By similarity.

Protein-protein interaction databases

IntActiQ922W5. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ922W5.
SMRiQ922W5. Positions 1-275.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0345.
GeneTreeiENSGT00390000007443.
HOGENOMiHOG000230247.
HOVERGENiHBG053399.
InParanoidiQ922W5.
KOiK00286.
OMAiAKMVIEN.
OrthoDBiEOG7N0C5N.
PhylomeDBiQ922W5.

Family and domain databases

Gene3Di1.10.3730.10. 1 hit.
3.40.50.720. 1 hit.
HAMAPiMF_01925. P5C_reductase.
InterProiIPR008927. 6-PGluconate_DH_C-like.
IPR016040. NAD(P)-bd_dom.
IPR029036. P5CR_dimer.
IPR028939. ProC_N.
IPR000304. Pyrroline-COOH_reductase.
[Graphical view]
PANTHERiPTHR11645. PTHR11645. 1 hit.
PfamiPF03807. F420_oxidored. 1 hit.
PF14748. P5CR_dimer. 1 hit.
[Graphical view]
PIRSFiPIRSF000193. Pyrrol-5-carb_rd. 1 hit.
SUPFAMiSSF48179. SSF48179. 1 hit.
TIGRFAMsiTIGR00112. proC. 1 hit.
PROSITEiPS00521. P5CR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q922W5-1 [UniParc]FASTAAdd to Basket

« Hide

MSVGFIGAGQ LAFALAKGFT AAGVLAAHKI MASSPDMDQA TVSALRKIGV    50
NLTPHNKETV RHSDVLFLAV KPHIIPFILD EIGANIEDRH IVVSCAAGVT 100
INSIEKKLTA FQPAPKVIRC MTNTPVVVRE GVTVYATGTH AQVEDGRLVE 150
QLMGSVGFCT EVEEDLIDAV TGLSGSGPAY AFTALDALAD GGVKMGLPRR 200
LAVRLGAQAL LGAAKMLLDS EQHPSQLKDN VCSPGGATIH ALHVLESGGF 250
RSLLINAVEA SCIRTRELQT MADQETISPA AIKKTVLDKV KLDSSAGASL 300
SSDHVKPLP 309
Length:309
Mass (Da):32,373
Last modified:December 1, 2001 - v1
Checksum:iA3CD24AACDD53DEF
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC006727 mRNA. Translation: AAH06727.1.
CCDSiCCDS25749.1.
RefSeqiNP_659044.1. NM_144795.3.
XP_006532798.1. XM_006532735.1.
UniGeneiMm.127731.

Genome annotation databases

EnsembliENSMUST00000026133; ENSMUSP00000026133; ENSMUSG00000025140.
ENSMUST00000170556; ENSMUSP00000131199; ENSMUSG00000025140.
GeneIDi209027.
KEGGimmu:209027.
UCSCiuc007mtv.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC006727 mRNA. Translation: AAH06727.1 .
CCDSi CCDS25749.1.
RefSeqi NP_659044.1. NM_144795.3.
XP_006532798.1. XM_006532735.1.
UniGenei Mm.127731.

3D structure databases

ProteinModelPortali Q922W5.
SMRi Q922W5. Positions 1-275.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q922W5. 1 interaction.

PTM databases

PhosphoSitei Q922W5.

Proteomic databases

MaxQBi Q922W5.
PaxDbi Q922W5.
PRIDEi Q922W5.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000026133 ; ENSMUSP00000026133 ; ENSMUSG00000025140 .
ENSMUST00000170556 ; ENSMUSP00000131199 ; ENSMUSG00000025140 .
GeneIDi 209027.
KEGGi mmu:209027.
UCSCi uc007mtv.1. mouse.

Organism-specific databases

CTDi 5831.
MGIi MGI:2384795. Pycr1.

Phylogenomic databases

eggNOGi COG0345.
GeneTreei ENSGT00390000007443.
HOGENOMi HOG000230247.
HOVERGENi HBG053399.
InParanoidi Q922W5.
KOi K00286.
OMAi AKMVIEN.
OrthoDBi EOG7N0C5N.
PhylomeDBi Q922W5.

Enzyme and pathway databases

UniPathwayi UPA00098 ; UER00361 .

Miscellaneous databases

NextBioi 372532.
PROi Q922W5.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q922W5.
Bgeei Q922W5.
CleanExi MM_PYCR1.
Genevestigatori Q922W5.

Family and domain databases

Gene3Di 1.10.3730.10. 1 hit.
3.40.50.720. 1 hit.
HAMAPi MF_01925. P5C_reductase.
InterProi IPR008927. 6-PGluconate_DH_C-like.
IPR016040. NAD(P)-bd_dom.
IPR029036. P5CR_dimer.
IPR028939. ProC_N.
IPR000304. Pyrroline-COOH_reductase.
[Graphical view ]
PANTHERi PTHR11645. PTHR11645. 1 hit.
Pfami PF03807. F420_oxidored. 1 hit.
PF14748. P5CR_dimer. 1 hit.
[Graphical view ]
PIRSFi PIRSF000193. Pyrrol-5-carb_rd. 1 hit.
SUPFAMi SSF48179. SSF48179. 1 hit.
TIGRFAMsi TIGR00112. proC. 1 hit.
PROSITEi PS00521. P5CR. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Mammary tumor.
  2. Cited for: TISSUE SPECIFICITY.

Entry informationi

Entry nameiP5CR1_MOUSE
AccessioniPrimary (citable) accession number: Q922W5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 1, 2005
Last sequence update: December 1, 2001
Last modified: September 3, 2014
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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