Reviewed,
UniProtKB/Swiss-Prot Q922W5 (P5CR1_MOUSE)
Last modified
June 16, 2009.
Version 51.
History...
Clusters with 100%,
90%,
50% identity |
Documents (3) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Pyrroline-5-carboxylate reductase 1, mitochondrial Short name=P5C reductase 1 Short name=P5CR 1 EC=1.5.1.2 | ||
| Gene names |
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| Organism | Mus musculus (Mouse) | ||
| Taxonomic identifier | 10090 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus |
Protein attributes
| Sequence length | 309 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Catalytic activity | L-proline + NAD(P)+ = 1-pyrroline-5-carboxylate + NAD(P)H. |
| Pathway | |
| Subunit structure | Homodecamer; composed of 5 homodimers By similarity. |
| Subcellular location | |
| Sequence similarities | Belongs to the pyrroline-5-carboxylate reductase family. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Amino-acid biosynthesis Proline biosynthesis |
| Cellular component | Mitochondrion |
| Ligand | NADP |
| Molecular function | Oxidoreductase |
| PTM | Acetylation |
| Gene Ontology (GO) | |
| Biological process | oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW proline biosynthetic processInferred from electronic annotation. Source: UniProtKB-KW |
| Cellular component | mitochondrion Ref.2 Inferred from direct assay. Source: MGI |
| Molecular function | binding Inferred from electronic annotation. Source: InterPro pyrroline-5-carboxylate reductase activityInferred from electronic annotation. Source: EC |
| Complete GO annotation... | |
Sequence annotation (Features)
Sequences
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References
| [1] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: FVB/N. Tissue: Mammary tumor. |
| [2] | "Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria." Mootha V.K., Bunkenborg J., Olsen J.V., Hjerrild M., Wisniewski J.R., Stahl E., Bolouri M.S., Ray H.N., Sihag S., Kamal M., Patterson N., Lander E.S., Mann M. Cell 115:629-640(2003) [PubMed: 14651853] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], SUBCELLULAR LOCATION. |
Cross-references
Sequence databases | |
|---|---|
| BC006727 mRNA. Translation: AAH06727.1. | |
| IPI | IPI00123510. |
| RefSeq | NP_659044.1. |
| UniGene | Mm.127731 |
3D structure databases | |
| SMR | Q922W5. Positions 1-275. |
| ModBase | Search... |
Proteomic databases | |
| PRIDE | Q922W5. |
Genome annotation databases | |
| Ensembl | ENSMUSG00000025140. Mus musculus. [Contig view] |
| GeneID | 209027. |
| KEGG | mmu:209027. |
| NMPDR | fig|10090.3.peg.25811. |
Organism-specific databases | |
| MGI | MGI:2384795. Pycr1. |
Phylogenomic databases | |
| HOGENOM | Q922W5. |
| HOVERGEN | Q922W5. |
| OMA | Q922W5. APSGHSK. |
Enzyme and pathway databases | |
| BRENDA | 1.5.1.2. 244. |
Gene expression databases | |
| ArrayExpress | Q922W5. |
| Bgee | Q922W5. |
| CleanEx | MM_PYCR1. |
| GermOnline | ENSMUSG00000025140. Mus musculus. |
Family and domain databases | |
| InterPro | IPR016040. NAD(P)-bd_dom. IPR004455. NADP_OxRdtase_F420. IPR000304. P5CR. [Graphical view] |
| Gene3D | G3DSA:3.40.50.720. NAD(P)-bd. 1 hit. |
| PANTHER | PTHR11645. P5CR. 1 hit. |
| Pfam | PF03807. F420_oxidored. 1 hit. [Graphical view] |
| PIRSF | PIRSF000193. Pyrrol-5-carb_rd. 1 hit. |
| TIGRFAMs | TIGR00112. proC. 1 hit. |
| PROSITE | PS00521. P5CR. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 372532. |
| SOURCE | Search... |
Entry information
| Entry name | P5CR1_MOUSE | ||||||||
| Accession | Primary (citable) accession number: Q922W5 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| MGD cross-references Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot |
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

Clusters with


