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Protein

Pleiotropic regulator 1

Gene

Plrg1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing.By similarity

GO - Biological processi

  • mRNA splicing, via spliceosome Source: GO_Central
  • positive regulation of G1/S transition of mitotic cell cycle Source: MGI
  • protein localization to nucleus Source: MGI
Complete GO annotation...

Keywords - Biological processi

mRNA processing, mRNA splicing

Enzyme and pathway databases

ReactomeiR-MMU-72163. mRNA Splicing - Major Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Pleiotropic regulator 1
Gene namesi
Name:Plrg1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:1858197. Plrg1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus, Spliceosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 513513Pleiotropic regulator 1PRO_0000051134Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineBy similarity
Modified residuei119 – 1191PhosphoserineBy similarity
Modified residuei200 – 2001PhosphoserineBy similarity
Modified residuei390 – 3901PhosphoserineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ922V4.
MaxQBiQ922V4.
PaxDbiQ922V4.
PeptideAtlasiQ922V4.
PRIDEiQ922V4.

PTM databases

iPTMnetiQ922V4.
PhosphoSiteiQ922V4.

Expressioni

Gene expression databases

BgeeiQ922V4.
ExpressionAtlasiQ922V4. baseline and differential.
GenevisibleiQ922V4. MM.

Interactioni

Subunit structurei

Component of the PRP19-CDC5L splicing complex composed of a core complex comprising a homotetramer of PRPF19, CDC5L, PLRG1 and BCAS2, and at least three less stably associated proteins CTNNBL1, CWC15 and HSPA8. Interacts (via its WD40 repeat domain) directly with CDC5L (via its C-terminal); the interaction is required for mRNA splicing but not for spliceosome assembly. Also interacts directly in the complex with BCAS2 and PRPF19 (By similarity).By similarity

Protein-protein interaction databases

BioGridi207280. 2 interactions.
IntActiQ922V4. 3 interactions.
MINTiMINT-4107987.
STRINGi10090.ENSMUSP00000114968.

Structurei

3D structure databases

ProteinModelPortaliQ922V4.
SMRiQ922V4. Positions 106-491.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati201 – 24040WD 1Add
BLAST
Repeati243 – 28240WD 2Add
BLAST
Repeati285 – 32440WD 3Add
BLAST
Repeati327 – 36640WD 4Add
BLAST
Repeati369 – 40941WD 5Add
BLAST
Repeati410 – 44839WD 6Add
BLAST
Repeati459 – 49840WD 7Add
BLAST

Sequence similaritiesi

Belongs to the WD repeat PRL1/PRL2 family.Curated
Contains 7 WD repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG0285. Eukaryota.
ENOG410XQV9. LUCA.
GeneTreeiENSGT00520000055597.
HOGENOMiHOG000207595.
HOVERGENiHBG053621.
InParanoidiQ922V4.
KOiK12862.
OMAiWRPELLK.
OrthoDBiEOG7R2BJC.
PhylomeDBiQ922V4.
TreeFamiTF105684.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR020472. G-protein_beta_WD-40_rep.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF00400. WD40. 5 hits.
[Graphical view]
PRINTSiPR00320. GPROTEINBRPT.
SMARTiSM00320. WD40. 7 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS00678. WD_REPEATS_1. 2 hits.
PS50082. WD_REPEATS_2. 5 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q922V4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVEEVQKHSV HTLVFRSLKR THDMFVADNG KPVPLDEESH KRKMAIKLRN
60 70 80 90 100
EYGPVLHMPT SKENLKEKGP QNATDSYPHK QYPANQGQDV EYLVTGTHPY
110 120 130 140 150
PAGPGVALTA DTKIQRMPSE SAAQSLAVAL PSQTRVDANR TGPAGSEYRH
160 170 180 190 200
PGASDRSQPT AMNSIMETGN TKNSALMAKK APTMPKPQWH PPWKLYRVIS
210 220 230 240 250
GHLGWVRCIA VEPGNQWFVT GSADRTIKIW DLASGKLKLS LTGHISTVRG
260 270 280 290 300
VIVSTRSPYL FSCGEDKQVK CWDLEYNKVI RHYHGHLSAV YGLDLHPTLD
310 320 330 340 350
VLVTCSRDST ARIWDVRTKA SVHTLSGHTN AVATVRCQAA EPQIITGSHD
360 370 380 390 400
TTIRLWDLVA GKTRVTLTNH KKSVRAVVLH PLLYTFASGS PDNIKQWKFP
410 420 430 440 450
DGGFIQNLSG HNAIINTLAV NADGVLVSGA DNGTMHLWDW RTGYNFQRVH
460 470 480 490 500
AAVQPGSLDS ESGIFACAFD RSESRLLTAE ADKTIKVYRE DETATEETHP
510
VSWKPEIIKR KRF
Length:513
Mass (Da):56,938
Last modified:December 1, 2001 - v1
Checksum:i8C9A2ED99D84ADEA
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti102 – 1021A → P in AAC04388 (Ref. 1) Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF044334 mRNA. Translation: AAC04388.1.
AK075993 mRNA. Translation: BAC36104.1.
AK076007 mRNA. Translation: BAC36115.1.
AK077197 mRNA. Translation: BAC36675.1.
BC006750 mRNA. Translation: AAH06750.1.
BC052895 mRNA. No translation available.
CCDSiCCDS17433.1.
RefSeqiNP_058064.2. NM_016784.3.
UniGeneiMm.286349.

Genome annotation databases

EnsembliENSMUST00000150268; ENSMUSP00000114968; ENSMUSG00000027998.
GeneIDi53317.
KEGGimmu:53317.
UCSCiuc008ppi.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF044334 mRNA. Translation: AAC04388.1.
AK075993 mRNA. Translation: BAC36104.1.
AK076007 mRNA. Translation: BAC36115.1.
AK077197 mRNA. Translation: BAC36675.1.
BC006750 mRNA. Translation: AAH06750.1.
BC052895 mRNA. No translation available.
CCDSiCCDS17433.1.
RefSeqiNP_058064.2. NM_016784.3.
UniGeneiMm.286349.

3D structure databases

ProteinModelPortaliQ922V4.
SMRiQ922V4. Positions 106-491.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi207280. 2 interactions.
IntActiQ922V4. 3 interactions.
MINTiMINT-4107987.
STRINGi10090.ENSMUSP00000114968.

PTM databases

iPTMnetiQ922V4.
PhosphoSiteiQ922V4.

Proteomic databases

EPDiQ922V4.
MaxQBiQ922V4.
PaxDbiQ922V4.
PeptideAtlasiQ922V4.
PRIDEiQ922V4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000150268; ENSMUSP00000114968; ENSMUSG00000027998.
GeneIDi53317.
KEGGimmu:53317.
UCSCiuc008ppi.1. mouse.

Organism-specific databases

CTDi5356.
MGIiMGI:1858197. Plrg1.

Phylogenomic databases

eggNOGiKOG0285. Eukaryota.
ENOG410XQV9. LUCA.
GeneTreeiENSGT00520000055597.
HOGENOMiHOG000207595.
HOVERGENiHBG053621.
InParanoidiQ922V4.
KOiK12862.
OMAiWRPELLK.
OrthoDBiEOG7R2BJC.
PhylomeDBiQ922V4.
TreeFamiTF105684.

Enzyme and pathway databases

ReactomeiR-MMU-72163. mRNA Splicing - Major Pathway.

Miscellaneous databases

PROiQ922V4.
SOURCEiSearch...

Gene expression databases

BgeeiQ922V4.
ExpressionAtlasiQ922V4. baseline and differential.
GenevisibleiQ922V4. MM.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR020472. G-protein_beta_WD-40_rep.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF00400. WD40. 5 hits.
[Graphical view]
PRINTSiPR00320. GPROTEINBRPT.
SMARTiSM00320. WD40. 7 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS00678. WD_REPEATS_1. 2 hits.
PS50082. WD_REPEATS_2. 5 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Okresz L.
    Submitted (JAN-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Embryo and Testis.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C3H/He.
    Tissue: Mammary tumor and Mesenchymal cell.
  4. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Spleen and Testis.

Entry informationi

Entry nameiPLRG1_MOUSE
AccessioniPrimary (citable) accession number: Q922V4
Secondary accession number(s): O55039
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 7, 2003
Last sequence update: December 1, 2001
Last modified: July 6, 2016
This is version 123 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.