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Protein

Keratin, type II cytoskeletal 5

Gene

Krt5

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei413 – 4131StutterSequence Analysis

GO - Molecular functioni

  1. scaffold protein binding Source: MGI
  2. structural molecule activity Source: InterPro
Complete GO annotation...

Enzyme and pathway databases

ReactomeiREACT_346453. Type I hemidesmosome assembly.

Names & Taxonomyi

Protein namesi
Recommended name:
Keratin, type II cytoskeletal 5
Alternative name(s):
Cytokeratin-5
Short name:
CK-5
Keratin-5
Short name:
K5
Type-II keratin Kb5
Gene namesi
Name:Krt5By similarity
Synonyms:Krt2-5Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:96702. Krt5.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: MGI
  2. extracellular vesicular exosome Source: MGI
  3. intermediate filament Source: MGI
  4. keratin filament Source: MGI
  5. membrane Source: MGI
  6. mitochondrion Source: MGI
  7. nucleus Source: MGI
  8. plasma membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Intermediate filament, Keratin

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 580580Keratin, type II cytoskeletal 5PRO_0000063728Add
BLAST

Proteomic databases

MaxQBiQ922U2.
PaxDbiQ922U2.
PRIDEiQ922U2.

PTM databases

PhosphoSiteiQ922U2.

Expressioni

Tissue specificityi

Expressed in epidermis.1 Publication

Gene expression databases

BgeeiQ922U2.
CleanExiMM_KRT5.
ExpressionAtlasiQ922U2. baseline and differential.
GenevestigatoriQ922U2.

Interactioni

Subunit structurei

Heterotetramer of two type I and two type II keratins. Keratin-5 associates with keratin-14. Interacts with TCHP (By similarity).By similarity

Protein-protein interaction databases

BioGridi225482. 9 interactions.
IntActiQ922U2. 1 interaction.
MINTiMINT-218160.

Structurei

3D structure databases

ProteinModelPortaliQ922U2.
SMRiQ922U2. Positions 159-298, 328-470.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 161161HeadSequence AnalysisAdd
BLAST
Regioni162 – 471310RodSequence AnalysisAdd
BLAST
Regioni162 – 19736Coil 1ASequence AnalysisAdd
BLAST
Regioni198 – 21619Linker 1Sequence AnalysisAdd
BLAST
Regioni217 – 30993Coil 1BSequence AnalysisAdd
BLAST
Regioni310 – 33223Linker 12Sequence AnalysisAdd
BLAST
Regioni333 – 471139Coil 2Sequence AnalysisAdd
BLAST
Regioni472 – 580109TailSequence AnalysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi2 – 3837Ser-richSequence AnalysisAdd
BLAST
Compositional biasi39 – 13395Gly-richSequence AnalysisAdd
BLAST
Compositional biasi495 – 56268Gly-richSequence AnalysisAdd
BLAST

Sequence similaritiesi

Belongs to the intermediate filament family.Sequence Analysis

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiNOG146769.
GeneTreeiENSGT00760000118796.
HOGENOMiHOG000230976.
HOVERGENiHBG013015.
InParanoidiQ922U2.
KOiK07605.
OMAiCGVGGYG.
OrthoDBiEOG7FV3Q8.
PhylomeDBiQ922U2.
TreeFamiTF317854.

Family and domain databases

InterProiIPR001664. IF.
IPR018039. Intermediate_filament_CS.
IPR003054. Keratin_II.
[Graphical view]
PANTHERiPTHR23239. PTHR23239. 1 hit.
PfamiPF00038. Filament. 1 hit.
[Graphical view]
PRINTSiPR01276. TYPE2KERATIN.
PROSITEiPS00226. IF. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q922U2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSRQSSVSFR SGGSRSFSAA SAITPSVSRT SFSSVSRSGG GGGGRISLGG
60 70 80 90 100
ACGAGGYGSR SLYNVGGSKR ISYSSGGGSF RNQFGAGGFG FGGGAGSGFG
110 120 130 140 150
FGGGAGSGFG FGGGAGFGGG YGGAGFPVCP PGGIQEVTVN QNLLTPLNLQ
160 170 180 190 200
IDPTIQRVRT EEREQIKTLN NKFASFIDKV RFLEQQNKVL DTKWALLQEQ
210 220 230 240 250
GTKTIKQNLD PLFEQYINNL RRQLDGVLGE RGRLDSELRN MQDLVEDYKN
260 270 280 290 300
KYEDEINKRT TAENEFVMLK KDVDAAYMNK VELEARVDAL MDEINFMKMF
310 320 330 340 350
FDAELSQMQT HVSDTSVVLS MDNNRSLDLD SIIAEVKAQY EDIANRSRTE
360 370 380 390 400
AESWYQTKYE ELQQTAGRHG DDLRNTKHEI SEMNRMIQRL RSEIDNVKKQ
410 420 430 440 450
CANLQNAIAE AEQRGELALK DARNKLTELE EALQKAKQDM ARLLREYQEL
460 470 480 490 500
MNTKLALDVE IATYRKLLEG EECRLSGEGV GPVNISVVTN SVSSGYGGGS
510 520 530 540 550
SIGVGSGFGG GLGSGFAGGL GPRFTRGGGG LGLGSGLSVG GSGFSAGSSQ
560 570 580
GGMSFGSGGG SGSSVKFVST TSSSRRSFKS
Length:580
Mass (Da):61,767
Last modified:November 30, 2001 - v1
Checksum:i304B341FD4224B41
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti139 – 1391V → I in AAL16774 (PubMed:11408584).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF306785 Genomic DNA. Translation: AAL16774.1.
BC006780 mRNA. Translation: AAH06780.1.
CCDSiCCDS27861.1.
RefSeqiNP_081287.1. NM_027011.2.
UniGeneiMm.451847.

Genome annotation databases

EnsembliENSMUST00000023709; ENSMUSP00000023709; ENSMUSG00000061527.
GeneIDi110308.
KEGGimmu:110308.
UCSCiuc007xtw.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF306785 Genomic DNA. Translation: AAL16774.1.
BC006780 mRNA. Translation: AAH06780.1.
CCDSiCCDS27861.1.
RefSeqiNP_081287.1. NM_027011.2.
UniGeneiMm.451847.

3D structure databases

ProteinModelPortaliQ922U2.
SMRiQ922U2. Positions 159-298, 328-470.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi225482. 9 interactions.
IntActiQ922U2. 1 interaction.
MINTiMINT-218160.

PTM databases

PhosphoSiteiQ922U2.

Proteomic databases

MaxQBiQ922U2.
PaxDbiQ922U2.
PRIDEiQ922U2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000023709; ENSMUSP00000023709; ENSMUSG00000061527.
GeneIDi110308.
KEGGimmu:110308.
UCSCiuc007xtw.1. mouse.

Organism-specific databases

CTDi3852.
MGIiMGI:96702. Krt5.

Phylogenomic databases

eggNOGiNOG146769.
GeneTreeiENSGT00760000118796.
HOGENOMiHOG000230976.
HOVERGENiHBG013015.
InParanoidiQ922U2.
KOiK07605.
OMAiCGVGGYG.
OrthoDBiEOG7FV3Q8.
PhylomeDBiQ922U2.
TreeFamiTF317854.

Enzyme and pathway databases

ReactomeiREACT_346453. Type I hemidesmosome assembly.

Miscellaneous databases

NextBioi363739.
PROiQ922U2.
SOURCEiSearch...

Gene expression databases

BgeeiQ922U2.
CleanExiMM_KRT5.
ExpressionAtlasiQ922U2. baseline and differential.
GenevestigatoriQ922U2.

Family and domain databases

InterProiIPR001664. IF.
IPR018039. Intermediate_filament_CS.
IPR003054. Keratin_II.
[Graphical view]
PANTHERiPTHR23239. PTHR23239. 1 hit.
PfamiPF00038. Filament. 1 hit.
[Graphical view]
PRINTSiPR01276. TYPE2KERATIN.
PROSITEiPS00226. IF. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Complete cytolysis and neonatal lethality in keratin 5 knockout mice reveal its fundamental role in skin integrity and in epidermolysis bullosa simplex."
    Peters B., Kirfel J., Bussow H., Vidal M., Magin T.M.
    Mol. Biol. Cell 12:1775-1789(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], TISSUE SPECIFICITY.
    Strain: 129/OlaImported.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Czech IIImported.
    Tissue: Mammary glandImported.
  3. Lubec G., Sunyer B., Chen W.-Q.
    Submitted (DEC-2008) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 326-337 AND 455-465, IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: OF1.
    Tissue: Hippocampus.

Entry informationi

Entry nameiK2C5_MOUSE
AccessioniPrimary (citable) accession number: Q922U2
Secondary accession number(s): Q920F2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 7, 2005
Last sequence update: November 30, 2001
Last modified: March 31, 2015
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa).

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.