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Protein

Keratin, type II cytoskeletal 5

Gene

Krt5

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei413StutterSequence analysis1

GO - Molecular functioni

Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-MMU-446107. Type I hemidesmosome assembly.
R-MMU-6805567. Keratinization.
R-MMU-6809371. Formation of the cornified envelope.

Names & Taxonomyi

Protein namesi
Recommended name:
Keratin, type II cytoskeletal 5
Alternative name(s):
Cytokeratin-5
Short name:
CK-5
Keratin-5
Short name:
K5
Type-II keratin Kb5
Gene namesi
Name:Krt5By similarity
Synonyms:Krt2-5Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:96702. Krt5.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: MGI
  • extracellular exosome Source: MGI
  • intermediate filament Source: MGI
  • keratin filament Source: MGI
  • membrane Source: MGI
  • mitochondrion Source: MGI
  • nucleus Source: MGI
  • plasma membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Intermediate filament, Keratin

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000637281 – 580Keratin, type II cytoskeletal 5Add BLAST580

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei5PhosphoserineBy similarity1
Modified residuei8PhosphoserineBy similarity1
Modified residuei16PhosphoserineCombined sources1
Modified residuei21PhosphoserineCombined sources1
Modified residuei26PhosphoserineCombined sources1
Modified residuei36PhosphoserineBy similarity1
Modified residuei47PhosphoserineCombined sources1
Modified residuei61PhosphoserineCombined sources1
Modified residuei68PhosphoserineBy similarity1
Modified residuei72PhosphoserineBy similarity1
Modified residuei79PhosphoserineBy similarity1
Cross-linki270Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)By similarity
Modified residuei526Omega-N-methylarginineCombined sources1

Keywords - PTMi

Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiQ922U2.
PRIDEiQ922U2.

PTM databases

iPTMnetiQ922U2.
PhosphoSitePlusiQ922U2.

Expressioni

Tissue specificityi

Expressed in epidermis.1 Publication

Gene expression databases

BgeeiENSMUSG00000061527.
CleanExiMM_KRT5.
ExpressionAtlasiQ922U2. baseline and differential.
GenevisibleiQ922U2. MM.

Interactioni

Subunit structurei

Heterotetramer of two type I and two type II keratins. Keratin-5 associates with keratin-14. Interacts with TCHP (By similarity). Interacts with KEPPK1 (PubMed:18285451).By similarity1 Publication

GO - Molecular functioni

Protein-protein interaction databases

BioGridi225482. 9 interactors.
IntActiQ922U2. 1 interactor.
MINTiMINT-218160.
STRINGi10090.ENSMUSP00000023709.

Structurei

3D structure databases

ProteinModelPortaliQ922U2.
SMRiQ922U2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 161HeadSequence analysisAdd BLAST161
Regioni162 – 471RodSequence analysisAdd BLAST310
Regioni162 – 197Coil 1ASequence analysisAdd BLAST36
Regioni198 – 216Linker 1Sequence analysisAdd BLAST19
Regioni217 – 309Coil 1BSequence analysisAdd BLAST93
Regioni310 – 332Linker 12Sequence analysisAdd BLAST23
Regioni333 – 471Coil 2Sequence analysisAdd BLAST139
Regioni472 – 580TailSequence analysisAdd BLAST109

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi2 – 38Ser-richSequence analysisAdd BLAST37
Compositional biasi39 – 133Gly-richSequence analysisAdd BLAST95
Compositional biasi495 – 562Gly-richSequence analysisAdd BLAST68

Sequence similaritiesi

Belongs to the intermediate filament family.Sequence analysis

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IG4R. Eukaryota.
ENOG410YY6B. LUCA.
GeneTreeiENSGT00760000118796.
HOGENOMiHOG000230976.
HOVERGENiHBG013015.
InParanoidiQ922U2.
KOiK07605.
OMAiMHTHISD.
OrthoDBiEOG091G09KR.
PhylomeDBiQ922U2.
TreeFamiTF317854.

Family and domain databases

InterProiIPR001664. IF.
IPR018039. Intermediate_filament_CS.
IPR032444. Keratin_2_head.
IPR003054. Keratin_II.
[Graphical view]
PANTHERiPTHR23239. PTHR23239. 2 hits.
PfamiPF00038. Filament. 1 hit.
PF16208. Keratin_2_head. 1 hit.
[Graphical view]
PRINTSiPR01276. TYPE2KERATIN.
SMARTiSM01391. Filament. 1 hit.
[Graphical view]
PROSITEiPS00226. IF. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q922U2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSRQSSVSFR SGGSRSFSAA SAITPSVSRT SFSSVSRSGG GGGGRISLGG
60 70 80 90 100
ACGAGGYGSR SLYNVGGSKR ISYSSGGGSF RNQFGAGGFG FGGGAGSGFG
110 120 130 140 150
FGGGAGSGFG FGGGAGFGGG YGGAGFPVCP PGGIQEVTVN QNLLTPLNLQ
160 170 180 190 200
IDPTIQRVRT EEREQIKTLN NKFASFIDKV RFLEQQNKVL DTKWALLQEQ
210 220 230 240 250
GTKTIKQNLD PLFEQYINNL RRQLDGVLGE RGRLDSELRN MQDLVEDYKN
260 270 280 290 300
KYEDEINKRT TAENEFVMLK KDVDAAYMNK VELEARVDAL MDEINFMKMF
310 320 330 340 350
FDAELSQMQT HVSDTSVVLS MDNNRSLDLD SIIAEVKAQY EDIANRSRTE
360 370 380 390 400
AESWYQTKYE ELQQTAGRHG DDLRNTKHEI SEMNRMIQRL RSEIDNVKKQ
410 420 430 440 450
CANLQNAIAE AEQRGELALK DARNKLTELE EALQKAKQDM ARLLREYQEL
460 470 480 490 500
MNTKLALDVE IATYRKLLEG EECRLSGEGV GPVNISVVTN SVSSGYGGGS
510 520 530 540 550
SIGVGSGFGG GLGSGFAGGL GPRFTRGGGG LGLGSGLSVG GSGFSAGSSQ
560 570 580
GGMSFGSGGG SGSSVKFVST TSSSRRSFKS
Length:580
Mass (Da):61,767
Last modified:December 1, 2001 - v1
Checksum:i304B341FD4224B41
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti139V → I in AAL16774 (PubMed:11408584).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF306785 Genomic DNA. Translation: AAL16774.1.
BC006780 mRNA. Translation: AAH06780.1.
CCDSiCCDS27861.1.
RefSeqiNP_081287.1. NM_027011.2.
UniGeneiMm.451847.

Genome annotation databases

EnsembliENSMUST00000023709; ENSMUSP00000023709; ENSMUSG00000061527.
GeneIDi110308.
KEGGimmu:110308.
UCSCiuc007xtw.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF306785 Genomic DNA. Translation: AAL16774.1.
BC006780 mRNA. Translation: AAH06780.1.
CCDSiCCDS27861.1.
RefSeqiNP_081287.1. NM_027011.2.
UniGeneiMm.451847.

3D structure databases

ProteinModelPortaliQ922U2.
SMRiQ922U2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi225482. 9 interactors.
IntActiQ922U2. 1 interactor.
MINTiMINT-218160.
STRINGi10090.ENSMUSP00000023709.

PTM databases

iPTMnetiQ922U2.
PhosphoSitePlusiQ922U2.

Proteomic databases

PaxDbiQ922U2.
PRIDEiQ922U2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000023709; ENSMUSP00000023709; ENSMUSG00000061527.
GeneIDi110308.
KEGGimmu:110308.
UCSCiuc007xtw.1. mouse.

Organism-specific databases

CTDi3852.
MGIiMGI:96702. Krt5.

Phylogenomic databases

eggNOGiENOG410IG4R. Eukaryota.
ENOG410YY6B. LUCA.
GeneTreeiENSGT00760000118796.
HOGENOMiHOG000230976.
HOVERGENiHBG013015.
InParanoidiQ922U2.
KOiK07605.
OMAiMHTHISD.
OrthoDBiEOG091G09KR.
PhylomeDBiQ922U2.
TreeFamiTF317854.

Enzyme and pathway databases

ReactomeiR-MMU-446107. Type I hemidesmosome assembly.
R-MMU-6805567. Keratinization.
R-MMU-6809371. Formation of the cornified envelope.

Miscellaneous databases

PROiQ922U2.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000061527.
CleanExiMM_KRT5.
ExpressionAtlasiQ922U2. baseline and differential.
GenevisibleiQ922U2. MM.

Family and domain databases

InterProiIPR001664. IF.
IPR018039. Intermediate_filament_CS.
IPR032444. Keratin_2_head.
IPR003054. Keratin_II.
[Graphical view]
PANTHERiPTHR23239. PTHR23239. 2 hits.
PfamiPF00038. Filament. 1 hit.
PF16208. Keratin_2_head. 1 hit.
[Graphical view]
PRINTSiPR01276. TYPE2KERATIN.
SMARTiSM01391. Filament. 1 hit.
[Graphical view]
PROSITEiPS00226. IF. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiK2C5_MOUSE
AccessioniPrimary (citable) accession number: Q922U2
Secondary accession number(s): Q920F2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 8, 2005
Last sequence update: December 1, 2001
Last modified: November 30, 2016
This is version 126 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa).

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.