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Q922U2 (K2C5_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 94. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Keratin, type II cytoskeletal 5
Alternative name(s):
Cytokeratin-5
Short name=CK-5
Keratin-5
Short name=K5
Type-II keratin Kb5
Gene names
Name:Krt5
Synonyms:Krt2-5
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length580 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Subunit structure

Heterotetramer of two type I and two type II keratins. Keratin-5 associates with keratin-14. Interacts with TCHP By similarity. UniProtKB P13647

Tissue specificity

Expressed in epidermis. Ref.1

Miscellaneous

There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa).

Sequence similarities

Belongs to the intermediate filament family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 580580Keratin, type II cytoskeletal 5
PRO_0000063728

Regions

Region1 – 161161Head
Region162 – 471310Rod
Region162 – 19736Coil 1A
Region198 – 21619Linker 1
Region217 – 30993Coil 1B
Region310 – 33223Linker 12
Region333 – 471139Coil 2
Region472 – 580109Tail
Compositional bias2 – 3837Ser-rich
Compositional bias39 – 13395Gly-rich
Compositional bias495 – 56268Gly-rich

Sites

Site4131Stutter

Amino acid modifications

Modified residue211Phosphoserine Ref.4
Modified residue611Phosphoserine Ref.4 UniProtKB P48668
Modified residue721Phosphoserine Ref.4

Experimental info

Sequence conflict1391V → I in AAL16774. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q922U2 [UniParc].

Last modified December 1, 2001. Version 1.
Checksum: 304B341FD4224B41

FASTA58061,767
        10         20         30         40         50         60 
MSRQSSVSFR SGGSRSFSAA SAITPSVSRT SFSSVSRSGG GGGGRISLGG ACGAGGYGSR 

        70         80         90        100        110        120 
SLYNVGGSKR ISYSSGGGSF RNQFGAGGFG FGGGAGSGFG FGGGAGSGFG FGGGAGFGGG 

       130        140        150        160        170        180 
YGGAGFPVCP PGGIQEVTVN QNLLTPLNLQ IDPTIQRVRT EEREQIKTLN NKFASFIDKV 

       190        200        210        220        230        240 
RFLEQQNKVL DTKWALLQEQ GTKTIKQNLD PLFEQYINNL RRQLDGVLGE RGRLDSELRN 

       250        260        270        280        290        300 
MQDLVEDYKN KYEDEINKRT TAENEFVMLK KDVDAAYMNK VELEARVDAL MDEINFMKMF 

       310        320        330        340        350        360 
FDAELSQMQT HVSDTSVVLS MDNNRSLDLD SIIAEVKAQY EDIANRSRTE AESWYQTKYE 

       370        380        390        400        410        420 
ELQQTAGRHG DDLRNTKHEI SEMNRMIQRL RSEIDNVKKQ CANLQNAIAE AEQRGELALK 

       430        440        450        460        470        480 
DARNKLTELE EALQKAKQDM ARLLREYQEL MNTKLALDVE IATYRKLLEG EECRLSGEGV 

       490        500        510        520        530        540 
GPVNISVVTN SVSSGYGGGS SIGVGSGFGG GLGSGFAGGL GPRFTRGGGG LGLGSGLSVG 

       550        560        570        580 
GSGFSAGSSQ GGMSFGSGGG SGSSVKFVST TSSSRRSFKS

« Hide

References

« Hide 'large scale' references
[1]"Complete cytolysis and neonatal lethality in keratin 5 knockout mice reveal its fundamental role in skin integrity and in epidermolysis bullosa simplex."
Peters B., Kirfel J., Bussow H., Vidal M., Magin T.M.
Mol. Biol. Cell 12:1775-1789(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], TISSUE SPECIFICITY.
Strain: 129/Ola.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: Czech II.
Tissue: Mammary gland.
[3]Lubec G., Sunyer B., Chen W.-Q.
Submitted (JAN-2009) to UniProtKB
Cited for: PROTEIN SEQUENCE OF 326-337 AND 455-465, MASS SPECTROMETRY.
Strain: OF1.
Tissue: Hippocampus.
[4]"Solid tumor proteome and phosphoproteome analysis by high resolution mass spectrometry."
Zanivan S., Gnad F., Wickstroem S.A., Geiger T., Macek B., Cox J., Faessler R., Mann M.
J. Proteome Res. 7:5314-5326(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-21; SER-61 AND SER-72, MASS SPECTROMETRY.
Tissue: Melanoma.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AF306785 Genomic DNA. Translation: AAL16774.1.
BC006780 mRNA. Translation: AAH06780.1.
IPIIPI00139301.
RefSeqNP_081287.1. NM_027011.2.
UniGeneMm.451847.

3D structure databases

ProteinModelPortalQ922U2.
SMRQ922U2. Positions 159-298, 328-470.
ModBaseSearch...

Protein-protein interaction databases

IntActQ922U2. 1 interaction.
MINTMINT-218160.

PTM databases

PhosphoSiteQ922U2.

Proteomic databases

PaxDbQ922U2.
PRIDEQ922U2.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000023709; ENSMUSP00000023709; ENSMUSG00000061527.
GeneID110308.
KEGGmmu:110308.

Organism-specific databases

CTD3852.
MGIMGI:96702. Krt5.

Phylogenomic databases

eggNOGNOG146769.
GeneTreeENSGT00610000085801.
HOGENOMHOG000230976.
HOVERGENHBG013015.
InParanoidQ922U2.
KOK07605.
OMACGVGGYG.
OrthoDBEOG4P8FJ6.

Gene expression databases

ArrayExpressQ922U2.
BgeeQ922U2.
CleanExMM_KRT5.
GenevestigatorQ922U2.
GermOnlineENSMUSG00000061527. Mus musculus.

Family and domain databases

InterProIPR016044. F.
IPR001664. IF.
IPR018039. Intermediate_filament_CS.
IPR003054. Keratin_II.
[Graphical view]
PANTHERPTHR23239. PTHR23239. 1 hit.
PTHR23239:SF18. PTHR23239:SF18. 1 hit.
PfamPF00038. Filament. 1 hit.
[Graphical view]
PRINTSPR01276. TYPE2KERATIN.
PROSITEPS00226. IF. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio363739.
SOURCESearch...

Entry information

Entry nameK2C5_MOUSE
AccessionPrimary (citable) accession number: Q922U2
Secondary accession number(s): Q920F2
Entry history
Integrated into UniProtKB/Swiss-Prot: November 8, 2005
Last sequence update: December 1, 2001
Last modified: May 1, 2013
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

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