Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q922U2

- K2C5_MOUSE

UniProt

Q922U2 - K2C5_MOUSE

Protein

Keratin, type II cytoskeletal 5

Gene

Krt5

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 106 (01 Oct 2014)
      Sequence version 1 (01 Dec 2001)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei413 – 4131StutterSequence Analysis

    GO - Molecular functioni

    1. protein binding Source: MGI
    2. structural molecule activity Source: InterPro

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Keratin, type II cytoskeletal 5
    Alternative name(s):
    Cytokeratin-5
    Short name:
    CK-5
    Keratin-5
    Short name:
    K5
    Type-II keratin Kb5
    Gene namesi
    Name:Krt5By similarity
    Synonyms:Krt2-5Imported
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 15

    Organism-specific databases

    MGIiMGI:96702. Krt5.

    Subcellular locationi

    GO - Cellular componenti

    1. keratin filament Source: MGI
    2. mitochondrion Source: MGI
    3. plasma membrane Source: MGI

    Keywords - Cellular componenti

    Intermediate filament, Keratin

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 580580Keratin, type II cytoskeletal 5PRO_0000063728Add
    BLAST

    Proteomic databases

    MaxQBiQ922U2.
    PaxDbiQ922U2.
    PRIDEiQ922U2.

    PTM databases

    PhosphoSiteiQ922U2.

    Expressioni

    Tissue specificityi

    Expressed in epidermis.1 Publication

    Gene expression databases

    ArrayExpressiQ922U2.
    BgeeiQ922U2.
    CleanExiMM_KRT5.
    GenevestigatoriQ922U2.

    Interactioni

    Subunit structurei

    Heterotetramer of two type I and two type II keratins. Keratin-5 associates with keratin-14. Interacts with TCHP By similarity.By similarity

    Protein-protein interaction databases

    BioGridi225482. 9 interactions.
    IntActiQ922U2. 1 interaction.
    MINTiMINT-218160.

    Structurei

    3D structure databases

    ProteinModelPortaliQ922U2.
    SMRiQ922U2. Positions 159-298, 328-470.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1 – 161161HeadSequence AnalysisAdd
    BLAST
    Regioni162 – 471310RodSequence AnalysisAdd
    BLAST
    Regioni162 – 19736Coil 1ASequence AnalysisAdd
    BLAST
    Regioni198 – 21619Linker 1Sequence AnalysisAdd
    BLAST
    Regioni217 – 30993Coil 1BSequence AnalysisAdd
    BLAST
    Regioni310 – 33223Linker 12Sequence AnalysisAdd
    BLAST
    Regioni333 – 471139Coil 2Sequence AnalysisAdd
    BLAST
    Regioni472 – 580109TailSequence AnalysisAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi2 – 3837Ser-richSequence AnalysisAdd
    BLAST
    Compositional biasi39 – 13395Gly-richSequence AnalysisAdd
    BLAST
    Compositional biasi495 – 56268Gly-richSequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Belongs to the intermediate filament family.Sequence Analysis

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    eggNOGiNOG146769.
    GeneTreeiENSGT00610000085801.
    HOGENOMiHOG000230976.
    HOVERGENiHBG013015.
    InParanoidiQ922U2.
    KOiK07605.
    OMAiCGVGGYG.
    OrthoDBiEOG7FV3Q8.
    PhylomeDBiQ922U2.
    TreeFamiTF317854.

    Family and domain databases

    InterProiIPR001664. IF.
    IPR018039. Intermediate_filament_CS.
    IPR003054. Keratin_II.
    [Graphical view]
    PANTHERiPTHR23239. PTHR23239. 1 hit.
    PfamiPF00038. Filament. 1 hit.
    [Graphical view]
    PRINTSiPR01276. TYPE2KERATIN.
    PROSITEiPS00226. IF. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q922U2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSRQSSVSFR SGGSRSFSAA SAITPSVSRT SFSSVSRSGG GGGGRISLGG    50
    ACGAGGYGSR SLYNVGGSKR ISYSSGGGSF RNQFGAGGFG FGGGAGSGFG 100
    FGGGAGSGFG FGGGAGFGGG YGGAGFPVCP PGGIQEVTVN QNLLTPLNLQ 150
    IDPTIQRVRT EEREQIKTLN NKFASFIDKV RFLEQQNKVL DTKWALLQEQ 200
    GTKTIKQNLD PLFEQYINNL RRQLDGVLGE RGRLDSELRN MQDLVEDYKN 250
    KYEDEINKRT TAENEFVMLK KDVDAAYMNK VELEARVDAL MDEINFMKMF 300
    FDAELSQMQT HVSDTSVVLS MDNNRSLDLD SIIAEVKAQY EDIANRSRTE 350
    AESWYQTKYE ELQQTAGRHG DDLRNTKHEI SEMNRMIQRL RSEIDNVKKQ 400
    CANLQNAIAE AEQRGELALK DARNKLTELE EALQKAKQDM ARLLREYQEL 450
    MNTKLALDVE IATYRKLLEG EECRLSGEGV GPVNISVVTN SVSSGYGGGS 500
    SIGVGSGFGG GLGSGFAGGL GPRFTRGGGG LGLGSGLSVG GSGFSAGSSQ 550
    GGMSFGSGGG SGSSVKFVST TSSSRRSFKS 580
    Length:580
    Mass (Da):61,767
    Last modified:December 1, 2001 - v1
    Checksum:i304B341FD4224B41
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti139 – 1391V → I in AAL16774. (PubMed:11408584)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF306785 Genomic DNA. Translation: AAL16774.1.
    BC006780 mRNA. Translation: AAH06780.1.
    CCDSiCCDS27861.1.
    RefSeqiNP_081287.1. NM_027011.2.
    UniGeneiMm.451847.

    Genome annotation databases

    EnsembliENSMUST00000023709; ENSMUSP00000023709; ENSMUSG00000061527.
    GeneIDi110308.
    KEGGimmu:110308.
    UCSCiuc007xtw.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF306785 Genomic DNA. Translation: AAL16774.1 .
    BC006780 mRNA. Translation: AAH06780.1 .
    CCDSi CCDS27861.1.
    RefSeqi NP_081287.1. NM_027011.2.
    UniGenei Mm.451847.

    3D structure databases

    ProteinModelPortali Q922U2.
    SMRi Q922U2. Positions 159-298, 328-470.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 225482. 9 interactions.
    IntActi Q922U2. 1 interaction.
    MINTi MINT-218160.

    PTM databases

    PhosphoSitei Q922U2.

    Proteomic databases

    MaxQBi Q922U2.
    PaxDbi Q922U2.
    PRIDEi Q922U2.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000023709 ; ENSMUSP00000023709 ; ENSMUSG00000061527 .
    GeneIDi 110308.
    KEGGi mmu:110308.
    UCSCi uc007xtw.1. mouse.

    Organism-specific databases

    CTDi 3852.
    MGIi MGI:96702. Krt5.

    Phylogenomic databases

    eggNOGi NOG146769.
    GeneTreei ENSGT00610000085801.
    HOGENOMi HOG000230976.
    HOVERGENi HBG013015.
    InParanoidi Q922U2.
    KOi K07605.
    OMAi CGVGGYG.
    OrthoDBi EOG7FV3Q8.
    PhylomeDBi Q922U2.
    TreeFami TF317854.

    Miscellaneous databases

    NextBioi 363739.
    PROi Q922U2.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q922U2.
    Bgeei Q922U2.
    CleanExi MM_KRT5.
    Genevestigatori Q922U2.

    Family and domain databases

    InterProi IPR001664. IF.
    IPR018039. Intermediate_filament_CS.
    IPR003054. Keratin_II.
    [Graphical view ]
    PANTHERi PTHR23239. PTHR23239. 1 hit.
    Pfami PF00038. Filament. 1 hit.
    [Graphical view ]
    PRINTSi PR01276. TYPE2KERATIN.
    PROSITEi PS00226. IF. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete cytolysis and neonatal lethality in keratin 5 knockout mice reveal its fundamental role in skin integrity and in epidermolysis bullosa simplex."
      Peters B., Kirfel J., Bussow H., Vidal M., Magin T.M.
      Mol. Biol. Cell 12:1775-1789(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], TISSUE SPECIFICITY.
      Strain: 129/OlaImported.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: Czech IIImported.
      Tissue: Mammary glandImported.
    3. Lubec G., Sunyer B., Chen W.-Q.
      Submitted (JAN-2009) to UniProtKB
      Cited for: PROTEIN SEQUENCE OF 326-337 AND 455-465, IDENTIFICATION BY MASS SPECTROMETRY.
      Strain: OF1.
      Tissue: Hippocampus.

    Entry informationi

    Entry nameiK2C5_MOUSE
    AccessioniPrimary (citable) accession number: Q922U2
    Secondary accession number(s): Q920F2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 8, 2005
    Last sequence update: December 1, 2001
    Last modified: October 1, 2014
    This is version 106 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa).

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3