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Q922U1

- PRPF3_MOUSE

UniProt

Q922U1 - PRPF3_MOUSE

Protein

U4/U6 small nuclear ribonucleoprotein Prp3

Gene

Prpf3

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 103 (01 Oct 2014)
      Sequence version 1 (01 Dec 2001)
      Previous versions | rss
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    Functioni

    Participates in pre-mRNA splicing. Part of the U4/U5/U6 tri-snRNP complex, one of the building blocks of the spliceosome By similarity.By similarity

    GO - Biological processi

    1. mRNA splicing, via spliceosome Source: InterPro

    Keywords - Biological processi

    mRNA processing, mRNA splicing

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    U4/U6 small nuclear ribonucleoprotein Prp3
    Alternative name(s):
    Pre-mRNA-splicing factor 3
    Gene namesi
    Name:Prpf3
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 3

    Organism-specific databases

    MGIiMGI:1918017. Prpf3.

    Subcellular locationi

    Nucleus speckle PROSITE-ProRule annotation
    Note: Colocalizes with spliceosomal snRNPs.By similarity

    GO - Cellular componenti

    1. Cajal body Source: Ensembl
    2. cytoplasm Source: Ensembl
    3. nuclear speck Source: UniProtKB-SubCell
    4. spliceosomal complex Source: UniProtKB-KW
    5. U4/U6 x U5 tri-snRNP complex Source: InterPro

    Keywords - Cellular componenti

    Nucleus, Spliceosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 683683U4/U6 small nuclear ribonucleoprotein Prp3PRO_0000097045Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei164 – 1641PhosphoserineBy similarity
    Modified residuei619 – 6191PhosphoserineBy similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ922U1.
    PaxDbiQ922U1.
    PRIDEiQ922U1.

    PTM databases

    PhosphoSiteiQ922U1.

    Expressioni

    Gene expression databases

    ArrayExpressiQ922U1.
    BgeeiQ922U1.
    CleanExiMM_PRPF3.
    GenevestigatoriQ922U1.

    Interactioni

    Subunit structurei

    Interacts directly with PRPF4. Part of a heteromeric complex containing PPIH, PRPF3 and PRPF4 that is stable in the absence of RNA. Component of the U4/U6-U5 tri-snRNP complex composed of the U4, U6 and U5 snRNAs and at least PRPF3, PRPF4, PRPF6, PRPF8, PRPF31, SNRNP200, TXNL4A, SNRNP40, DDX23, CD2BP2, PPIH, NHP2L1, EFTUD2, SART1 and USP39 By similarity.By similarity

    Protein-protein interaction databases

    IntActiQ922U1. 2 interactions.
    MINTiMINT-4108680.
    STRINGi10090.ENSMUSP00000015892.

    Structurei

    3D structure databases

    ProteinModelPortaliQ922U1.
    SMRiQ922U1. Positions 1-73.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini1 – 8787PWIPROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi579 – 5846Poly-Val

    Sequence similaritiesi

    Contains 1 PWI domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG268901.
    GeneTreeiENSGT00390000011497.
    HOGENOMiHOG000205412.
    HOVERGENiHBG053699.
    InParanoidiQ922U1.
    KOiK12843.
    OMAiPWVERTV.
    OrthoDBiEOG789C9P.
    PhylomeDBiQ922U1.
    TreeFamiTF313082.

    Family and domain databases

    Gene3Di1.20.1390.10. 1 hit.
    InterProiIPR010541. DUF1115.
    IPR013881. Pre-mRNA_splic_Prp3.
    IPR027104. Prp3.
    IPR002483. PWI_dom.
    [Graphical view]
    PANTHERiPTHR14212. PTHR14212. 1 hit.
    PfamiPF06544. DUF1115. 1 hit.
    PF08572. PRP3. 1 hit.
    PF01480. PWI. 1 hit.
    [Graphical view]
    SMARTiSM00311. PWI. 1 hit.
    [Graphical view]
    SUPFAMiSSF101233. SSF101233. 1 hit.
    PROSITEiPS51025. PWI. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q922U1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MALSKRELDE LKPWIEKTVK RVLGFSEPTV VTAALNCVGK GMDKKKAADH    50
    LKPFLDDSTL RFVDKLFEAV EEGRSSRHSK SSSDRSRKRE LKEVFGDDSE 100
    ISKESSGVKK RRIPRFEEVE EEPEVIPGPP SESPGMLTKL QIKQMMEAAT 150
    RQIEERKKQL SFISPPAPQP KTPSSSQPER LPIGNTIQPS QAATFMNDAI 200
    EKARKAAELQ ARIQAQLALK PGLIGNANMV GLANLHAMGI APPKVELKDQ 250
    TKPTPLILDE QGRTVDATGK EVELTHRMPT LKANIRAVKR EQFKQQLKEK 300
    PSEDMESNTF FDPRVSIAPS QRQRRTFKFH DKGKFEKIAQ RLRTKAQLEK 350
    LQAEISQAAR KTGIHTSTRL ALIAPKKELK EGDIPEIEWW DSYIIPNGFD 400
    LTEENPKRED YFGITNLVEH PAQLNPPVDN DTPVTLGVYL TKKEQKKLRR 450
    QTRREAQKEL QEKVRLGLTP PPEPKVRISN LMRVLGTEAV QDPTKVEAHV 500
    RAQMAKRQKA HEEANAARKL TAEQRKVKKI KKLKEDISQG VHISVYRVRN 550
    LSNPAKKFKI EANAGQLYLT GVVVLHKDVN VVVVEGGPKA QKKFKRLMLH 600
    RIKWDEQTSN TKGDDDEESD EEAVKKTNKC VLVWEGTAKD RSFGEMKFKQ 650
    CPTENMAREH FKKHGAEHYW DLALSESVLE STD 683
    Length:683
    Mass (Da):77,455
    Last modified:December 1, 2001 - v1
    Checksum:i988219CF88E0EC4A
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti78 – 781H → L in BAB29324. (PubMed:16141072)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK014398 mRNA. Translation: BAB29324.1.
    AK088194 mRNA. Translation: BAC40202.1.
    AK167435 mRNA. Translation: BAE39521.1.
    BC006782 mRNA. Translation: AAH06782.1.
    CCDSiCCDS17621.1.
    RefSeqiNP_081817.2. NM_027541.4.
    XP_006502142.1. XM_006502079.1.
    UniGeneiMm.279872.

    Genome annotation databases

    EnsembliENSMUST00000015892; ENSMUSP00000015892; ENSMUSG00000015748.
    ENSMUST00000161476; ENSMUSP00000124950; ENSMUSG00000015748.
    GeneIDi70767.
    KEGGimmu:70767.
    UCSCiuc008qlf.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK014398 mRNA. Translation: BAB29324.1 .
    AK088194 mRNA. Translation: BAC40202.1 .
    AK167435 mRNA. Translation: BAE39521.1 .
    BC006782 mRNA. Translation: AAH06782.1 .
    CCDSi CCDS17621.1.
    RefSeqi NP_081817.2. NM_027541.4.
    XP_006502142.1. XM_006502079.1.
    UniGenei Mm.279872.

    3D structure databases

    ProteinModelPortali Q922U1.
    SMRi Q922U1. Positions 1-73.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q922U1. 2 interactions.
    MINTi MINT-4108680.
    STRINGi 10090.ENSMUSP00000015892.

    PTM databases

    PhosphoSitei Q922U1.

    Proteomic databases

    MaxQBi Q922U1.
    PaxDbi Q922U1.
    PRIDEi Q922U1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000015892 ; ENSMUSP00000015892 ; ENSMUSG00000015748 .
    ENSMUST00000161476 ; ENSMUSP00000124950 ; ENSMUSG00000015748 .
    GeneIDi 70767.
    KEGGi mmu:70767.
    UCSCi uc008qlf.1. mouse.

    Organism-specific databases

    CTDi 9129.
    MGIi MGI:1918017. Prpf3.

    Phylogenomic databases

    eggNOGi NOG268901.
    GeneTreei ENSGT00390000011497.
    HOGENOMi HOG000205412.
    HOVERGENi HBG053699.
    InParanoidi Q922U1.
    KOi K12843.
    OMAi PWVERTV.
    OrthoDBi EOG789C9P.
    PhylomeDBi Q922U1.
    TreeFami TF313082.

    Miscellaneous databases

    NextBioi 332211.
    PROi Q922U1.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q922U1.
    Bgeei Q922U1.
    CleanExi MM_PRPF3.
    Genevestigatori Q922U1.

    Family and domain databases

    Gene3Di 1.20.1390.10. 1 hit.
    InterProi IPR010541. DUF1115.
    IPR013881. Pre-mRNA_splic_Prp3.
    IPR027104. Prp3.
    IPR002483. PWI_dom.
    [Graphical view ]
    PANTHERi PTHR14212. PTHR14212. 1 hit.
    Pfami PF06544. DUF1115. 1 hit.
    PF08572. PRP3. 1 hit.
    PF01480. PWI. 1 hit.
    [Graphical view ]
    SMARTi SM00311. PWI. 1 hit.
    [Graphical view ]
    SUPFAMi SSF101233. SSF101233. 1 hit.
    PROSITEi PS51025. PWI. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J and NOD.
      Tissue: Placenta and Thymus.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Mammary tumor.

    Entry informationi

    Entry nameiPRPF3_MOUSE
    AccessioniPrimary (citable) accession number: Q922U1
    Secondary accession number(s): Q3TJH4, Q9D6C6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 26, 2003
    Last sequence update: December 1, 2001
    Last modified: October 1, 2014
    This is version 103 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3