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Q922U1

- PRPF3_MOUSE

UniProt

Q922U1 - PRPF3_MOUSE

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Protein
U4/U6 small nuclear ribonucleoprotein Prp3
Gene
Prpf3
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Participates in pre-mRNA splicing. Part of the U4/U5/U6 tri-snRNP complex, one of the building blocks of the spliceosome By similarity.

GO - Biological processi

  1. mRNA splicing, via spliceosome Source: InterPro
Complete GO annotation...

Keywords - Biological processi

mRNA processing, mRNA splicing

Names & Taxonomyi

Protein namesi
Recommended name:
U4/U6 small nuclear ribonucleoprotein Prp3
Alternative name(s):
Pre-mRNA-splicing factor 3
Gene namesi
Name:Prpf3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 3

Organism-specific databases

MGIiMGI:1918017. Prpf3.

Subcellular locationi

Nucleus speckle By similarity
Note: Colocalizes with spliceosomal snRNPs By similarity.

GO - Cellular componenti

  1. Cajal body Source: Ensembl
  2. U4/U6 x U5 tri-snRNP complex Source: InterPro
  3. cytoplasm Source: Ensembl
  4. nuclear speck Source: UniProtKB-SubCell
  5. spliceosomal complex Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Nucleus, Spliceosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 683683U4/U6 small nuclear ribonucleoprotein Prp3
PRO_0000097045Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei164 – 1641Phosphoserine By similarity
Modified residuei619 – 6191Phosphoserine By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ922U1.
PaxDbiQ922U1.
PRIDEiQ922U1.

PTM databases

PhosphoSiteiQ922U1.

Expressioni

Gene expression databases

ArrayExpressiQ922U1.
BgeeiQ922U1.
CleanExiMM_PRPF3.
GenevestigatoriQ922U1.

Interactioni

Subunit structurei

Interacts directly with PRPF4. Part of a heteromeric complex containing PPIH, PRPF3 and PRPF4 that is stable in the absence of RNA. Component of the U4/U6-U5 tri-snRNP complex composed of the U4, U6 and U5 snRNAs and at least PRPF3, PRPF4, PRPF6, PRPF8, PRPF31, SNRNP200, TXNL4A, SNRNP40, DDX23, CD2BP2, PPIH, NHP2L1, EFTUD2, SART1 and USP39 By similarity.

Protein-protein interaction databases

IntActiQ922U1. 2 interactions.
MINTiMINT-4108680.
STRINGi10090.ENSMUSP00000015892.

Structurei

3D structure databases

ProteinModelPortaliQ922U1.
SMRiQ922U1. Positions 1-73.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 8787PWI
Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi579 – 5846Poly-Val

Sequence similaritiesi

Contains 1 PWI domain.

Phylogenomic databases

eggNOGiNOG268901.
GeneTreeiENSGT00390000011497.
HOGENOMiHOG000205412.
HOVERGENiHBG053699.
InParanoidiQ922U1.
KOiK12843.
OMAiPWVERTV.
OrthoDBiEOG789C9P.
PhylomeDBiQ922U1.
TreeFamiTF313082.

Family and domain databases

Gene3Di1.20.1390.10. 1 hit.
InterProiIPR010541. DUF1115.
IPR013881. Pre-mRNA_splic_Prp3.
IPR027104. Prp3.
IPR002483. PWI_dom.
[Graphical view]
PANTHERiPTHR14212. PTHR14212. 1 hit.
PfamiPF06544. DUF1115. 1 hit.
PF08572. PRP3. 1 hit.
PF01480. PWI. 1 hit.
[Graphical view]
SMARTiSM00311. PWI. 1 hit.
[Graphical view]
SUPFAMiSSF101233. SSF101233. 1 hit.
PROSITEiPS51025. PWI. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q922U1-1 [UniParc]FASTAAdd to Basket

« Hide

MALSKRELDE LKPWIEKTVK RVLGFSEPTV VTAALNCVGK GMDKKKAADH    50
LKPFLDDSTL RFVDKLFEAV EEGRSSRHSK SSSDRSRKRE LKEVFGDDSE 100
ISKESSGVKK RRIPRFEEVE EEPEVIPGPP SESPGMLTKL QIKQMMEAAT 150
RQIEERKKQL SFISPPAPQP KTPSSSQPER LPIGNTIQPS QAATFMNDAI 200
EKARKAAELQ ARIQAQLALK PGLIGNANMV GLANLHAMGI APPKVELKDQ 250
TKPTPLILDE QGRTVDATGK EVELTHRMPT LKANIRAVKR EQFKQQLKEK 300
PSEDMESNTF FDPRVSIAPS QRQRRTFKFH DKGKFEKIAQ RLRTKAQLEK 350
LQAEISQAAR KTGIHTSTRL ALIAPKKELK EGDIPEIEWW DSYIIPNGFD 400
LTEENPKRED YFGITNLVEH PAQLNPPVDN DTPVTLGVYL TKKEQKKLRR 450
QTRREAQKEL QEKVRLGLTP PPEPKVRISN LMRVLGTEAV QDPTKVEAHV 500
RAQMAKRQKA HEEANAARKL TAEQRKVKKI KKLKEDISQG VHISVYRVRN 550
LSNPAKKFKI EANAGQLYLT GVVVLHKDVN VVVVEGGPKA QKKFKRLMLH 600
RIKWDEQTSN TKGDDDEESD EEAVKKTNKC VLVWEGTAKD RSFGEMKFKQ 650
CPTENMAREH FKKHGAEHYW DLALSESVLE STD 683
Length:683
Mass (Da):77,455
Last modified:December 1, 2001 - v1
Checksum:i988219CF88E0EC4A
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti78 – 781H → L in BAB29324. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK014398 mRNA. Translation: BAB29324.1.
AK088194 mRNA. Translation: BAC40202.1.
AK167435 mRNA. Translation: BAE39521.1.
BC006782 mRNA. Translation: AAH06782.1.
CCDSiCCDS17621.1.
RefSeqiNP_081817.2. NM_027541.4.
XP_006502142.1. XM_006502079.1.
UniGeneiMm.279872.

Genome annotation databases

EnsembliENSMUST00000015892; ENSMUSP00000015892; ENSMUSG00000015748.
ENSMUST00000161476; ENSMUSP00000124950; ENSMUSG00000015748.
GeneIDi70767.
KEGGimmu:70767.
UCSCiuc008qlf.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK014398 mRNA. Translation: BAB29324.1 .
AK088194 mRNA. Translation: BAC40202.1 .
AK167435 mRNA. Translation: BAE39521.1 .
BC006782 mRNA. Translation: AAH06782.1 .
CCDSi CCDS17621.1.
RefSeqi NP_081817.2. NM_027541.4.
XP_006502142.1. XM_006502079.1.
UniGenei Mm.279872.

3D structure databases

ProteinModelPortali Q922U1.
SMRi Q922U1. Positions 1-73.
ModBasei Search...

Protein-protein interaction databases

IntActi Q922U1. 2 interactions.
MINTi MINT-4108680.
STRINGi 10090.ENSMUSP00000015892.

PTM databases

PhosphoSitei Q922U1.

Proteomic databases

MaxQBi Q922U1.
PaxDbi Q922U1.
PRIDEi Q922U1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000015892 ; ENSMUSP00000015892 ; ENSMUSG00000015748 .
ENSMUST00000161476 ; ENSMUSP00000124950 ; ENSMUSG00000015748 .
GeneIDi 70767.
KEGGi mmu:70767.
UCSCi uc008qlf.1. mouse.

Organism-specific databases

CTDi 9129.
MGIi MGI:1918017. Prpf3.

Phylogenomic databases

eggNOGi NOG268901.
GeneTreei ENSGT00390000011497.
HOGENOMi HOG000205412.
HOVERGENi HBG053699.
InParanoidi Q922U1.
KOi K12843.
OMAi PWVERTV.
OrthoDBi EOG789C9P.
PhylomeDBi Q922U1.
TreeFami TF313082.

Miscellaneous databases

NextBioi 332211.
PROi Q922U1.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q922U1.
Bgeei Q922U1.
CleanExi MM_PRPF3.
Genevestigatori Q922U1.

Family and domain databases

Gene3Di 1.20.1390.10. 1 hit.
InterProi IPR010541. DUF1115.
IPR013881. Pre-mRNA_splic_Prp3.
IPR027104. Prp3.
IPR002483. PWI_dom.
[Graphical view ]
PANTHERi PTHR14212. PTHR14212. 1 hit.
Pfami PF06544. DUF1115. 1 hit.
PF08572. PRP3. 1 hit.
PF01480. PWI. 1 hit.
[Graphical view ]
SMARTi SM00311. PWI. 1 hit.
[Graphical view ]
SUPFAMi SSF101233. SSF101233. 1 hit.
PROSITEi PS51025. PWI. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J and NOD.
    Tissue: Placenta and Thymus.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Mammary tumor.

Entry informationi

Entry nameiPRPF3_MOUSE
AccessioniPrimary (citable) accession number: Q922U1
Secondary accession number(s): Q3TJH4, Q9D6C6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 26, 2003
Last sequence update: December 1, 2001
Last modified: July 9, 2014
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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