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Q922U1 (PRPF3_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 102. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
U4/U6 small nuclear ribonucleoprotein Prp3
Alternative name(s):
Pre-mRNA-splicing factor 3
Gene names
Name:Prpf3
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length683 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Participates in pre-mRNA splicing. Part of the U4/U5/U6 tri-snRNP complex, one of the building blocks of the spliceosome By similarity.

Subunit structure

Interacts directly with PRPF4. Part of a heteromeric complex containing PPIH, PRPF3 and PRPF4 that is stable in the absence of RNA. Component of the U4/U6-U5 tri-snRNP complex composed of the U4, U6 and U5 snRNAs and at least PRPF3, PRPF4, PRPF6, PRPF8, PRPF31, SNRNP200, TXNL4A, SNRNP40, DDX23, CD2BP2, PPIH, NHP2L1, EFTUD2, SART1 and USP39 By similarity.

Subcellular location

Nucleus speckle By similarity. Note: Colocalizes with spliceosomal snRNPs By similarity.

Sequence similarities

Contains 1 PWI domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 683683U4/U6 small nuclear ribonucleoprotein Prp3
PRO_0000097045

Regions

Domain1 – 8787PWI
Compositional bias579 – 5846Poly-Val

Amino acid modifications

Modified residue1641Phosphoserine By similarity
Modified residue6191Phosphoserine By similarity

Experimental info

Sequence conflict781H → L in BAB29324. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q922U1 [UniParc].

Last modified December 1, 2001. Version 1.
Checksum: 988219CF88E0EC4A

FASTA68377,455
        10         20         30         40         50         60 
MALSKRELDE LKPWIEKTVK RVLGFSEPTV VTAALNCVGK GMDKKKAADH LKPFLDDSTL 

        70         80         90        100        110        120 
RFVDKLFEAV EEGRSSRHSK SSSDRSRKRE LKEVFGDDSE ISKESSGVKK RRIPRFEEVE 

       130        140        150        160        170        180 
EEPEVIPGPP SESPGMLTKL QIKQMMEAAT RQIEERKKQL SFISPPAPQP KTPSSSQPER 

       190        200        210        220        230        240 
LPIGNTIQPS QAATFMNDAI EKARKAAELQ ARIQAQLALK PGLIGNANMV GLANLHAMGI 

       250        260        270        280        290        300 
APPKVELKDQ TKPTPLILDE QGRTVDATGK EVELTHRMPT LKANIRAVKR EQFKQQLKEK 

       310        320        330        340        350        360 
PSEDMESNTF FDPRVSIAPS QRQRRTFKFH DKGKFEKIAQ RLRTKAQLEK LQAEISQAAR 

       370        380        390        400        410        420 
KTGIHTSTRL ALIAPKKELK EGDIPEIEWW DSYIIPNGFD LTEENPKRED YFGITNLVEH 

       430        440        450        460        470        480 
PAQLNPPVDN DTPVTLGVYL TKKEQKKLRR QTRREAQKEL QEKVRLGLTP PPEPKVRISN 

       490        500        510        520        530        540 
LMRVLGTEAV QDPTKVEAHV RAQMAKRQKA HEEANAARKL TAEQRKVKKI KKLKEDISQG 

       550        560        570        580        590        600 
VHISVYRVRN LSNPAKKFKI EANAGQLYLT GVVVLHKDVN VVVVEGGPKA QKKFKRLMLH 

       610        620        630        640        650        660 
RIKWDEQTSN TKGDDDEESD EEAVKKTNKC VLVWEGTAKD RSFGEMKFKQ CPTENMAREH 

       670        680 
FKKHGAEHYW DLALSESVLE STD 

« Hide

References

[1]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J and NOD.
Tissue: Placenta and Thymus.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Mammary tumor.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK014398 mRNA. Translation: BAB29324.1.
AK088194 mRNA. Translation: BAC40202.1.
AK167435 mRNA. Translation: BAE39521.1.
BC006782 mRNA. Translation: AAH06782.1.
CCDSCCDS17621.1.
RefSeqNP_081817.2. NM_027541.4.
XP_006502142.1. XM_006502079.1.
UniGeneMm.279872.

3D structure databases

ProteinModelPortalQ922U1.
SMRQ922U1. Positions 1-73.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActQ922U1. 2 interactions.
MINTMINT-4108680.
STRING10090.ENSMUSP00000015892.

PTM databases

PhosphoSiteQ922U1.

Proteomic databases

MaxQBQ922U1.
PaxDbQ922U1.
PRIDEQ922U1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000015892; ENSMUSP00000015892; ENSMUSG00000015748.
ENSMUST00000161476; ENSMUSP00000124950; ENSMUSG00000015748.
GeneID70767.
KEGGmmu:70767.
UCSCuc008qlf.1. mouse.

Organism-specific databases

CTD9129.
MGIMGI:1918017. Prpf3.

Phylogenomic databases

eggNOGNOG268901.
GeneTreeENSGT00390000011497.
HOGENOMHOG000205412.
HOVERGENHBG053699.
InParanoidQ922U1.
KOK12843.
OMAPWVERTV.
OrthoDBEOG789C9P.
PhylomeDBQ922U1.
TreeFamTF313082.

Gene expression databases

ArrayExpressQ922U1.
BgeeQ922U1.
CleanExMM_PRPF3.
GenevestigatorQ922U1.

Family and domain databases

Gene3D1.20.1390.10. 1 hit.
InterProIPR010541. DUF1115.
IPR013881. Pre-mRNA_splic_Prp3.
IPR027104. Prp3.
IPR002483. PWI_dom.
[Graphical view]
PANTHERPTHR14212. PTHR14212. 1 hit.
PfamPF06544. DUF1115. 1 hit.
PF08572. PRP3. 1 hit.
PF01480. PWI. 1 hit.
[Graphical view]
SMARTSM00311. PWI. 1 hit.
[Graphical view]
SUPFAMSSF101233. SSF101233. 1 hit.
PROSITEPS51025. PWI. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio332211.
PROQ922U1.
SOURCESearch...

Entry information

Entry namePRPF3_MOUSE
AccessionPrimary (citable) accession number: Q922U1
Secondary accession number(s): Q3TJH4, Q9D6C6
Entry history
Integrated into UniProtKB/Swiss-Prot: September 26, 2003
Last sequence update: December 1, 2001
Last modified: July 9, 2014
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot