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Protein

Serine/threonine-protein phosphatase 4 regulatory subunit 3B

Gene

Ppp4r3b

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Regulatory subunit of serine/threonine-protein phosphatase 4 (PP4). May regulate the activity of PPP4C at centrosomal microtubule organizing centers (By similarity).By similarity

GO - Biological processi

  • positive regulation of gluconeogenesis Source: MGI
  • protein dephosphorylation Source: MGI
  • regulation of lipid metabolic process Source: Ensembl
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein phosphatase 4 regulatory subunit 3BBy similarity
Alternative name(s):
SMEK homolog 2
Gene namesi
Name:Ppp4r3bBy similarity
Synonyms:Kiaa1387, Pp4r3b, Smek2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:2144474. Smek2.

Subcellular locationi

GO - Cellular componenti

  • centrosome Source: MGI
  • cytoplasm Source: MGI
  • nucleoplasm Source: MGI
  • nucleus Source: MGI
  • protein phosphatase 4 complex Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002546041 – 820Serine/threonine-protein phosphatase 4 regulatory subunit 3BAdd BLAST820

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei117PhosphoserineCombined sources1
Modified residuei663PhosphoserineBy similarity1
Modified residuei811PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ922R5.
PaxDbiQ922R5.
PeptideAtlasiQ922R5.
PRIDEiQ922R5.

PTM databases

iPTMnetiQ922R5.
PhosphoSitePlusiQ922R5.

Expressioni

Gene expression databases

BgeeiENSMUSG00000020463.
ExpressionAtlasiQ922R5. baseline and differential.
GenevisibleiQ922R5. MM.

Interactioni

Subunit structurei

Serine/threonine-protein phosphatase 4 (PP4) occurs in different assemblies of the catalytic and one or more regulatory subunits. Component of the PP4 complex PPP4C-PPP4R2-PPP4R3B.

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000020755.

Structurei

3D structure databases

ProteinModelPortaliQ922R5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 100WH1Add BLAST100

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi802 – 809Poly-Glu8

Sequence similaritiesi

Belongs to the SMEK family.Curated
Contains 1 WH1 domain.Curated

Phylogenomic databases

eggNOGiKOG2175. Eukaryota.
ENOG410XQ7A. LUCA.
GeneTreeiENSGT00390000018199.
HOVERGENiHBG056624.
InParanoidiQ922R5.
KOiK17491.
OMAiDITQDPI.
OrthoDBiEOG091G02OO.
PhylomeDBiQ922R5.
TreeFamiTF315190.

Family and domain databases

Gene3Di1.25.10.10. 1 hit.
2.30.29.30. 1 hit.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR006887. DUF625.
IPR011993. PH_dom-like.
[Graphical view]
PfamiPF04802. SMK-1. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 2 hits.
SSF50729. SSF50729. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q922R5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSDTRRRVKV YTLNEDRQWD DRGTGHVSST YVEELKGMSL LVRAESDGSL
60 70 80 90 100
LLESKINPNT AYQKQQDTLI VWSEAENYDL ALSFQEKAGC DEIWEKICQV
110 120 130 140 150
QGKDPSVEVT QDLIDESEEE RFEEMPETSH LIDLPACELS KLEEIADLVT
160 170 180 190 200
SVLSSPIRRE KLALALENEG YIKKLLQLFQ ACENLENTEG LHHLYEIIRG
210 220 230 240 250
ILFLNKATLF EVMFSDECIM DVVGCLEYDP ALAQPKRHRE FLTKTAKFKE
260 270 280 290 300
VIPITDSELR QKIHQTYRVQ YIQDIILPTP SVFEENFLST LTSFIFFNKV
310 320 330 340 350
EIVSMLQEDE KFLSEVFAQL TDEATDDDKR RELVNFFKEF CAFSQTLQPQ
360 370 380 390 400
NRDAFFKTLA KLGILPALEI VMGMDDLQVR SAATDIFSYL VEFSPSMVRE
410 420 430 440 450
FVMQEAQQSD DDVLLINVVI EQMICDTDPE LGGAVQLMGL LRTLIDPENM
460 470 480 490 500
LATTNKTEKS EFLNFFYNHC MHVLTAPLLT NTSEDKCEKD NMLGSNTTNT
510 520 530 540 550
ICPDNYQTAQ LLALILELLT FCVEHHTYHI KNYIMNKDLL RRVLVLMNSK
560 570 580 590 600
HTFLALCALR FMRRIIGLKD EFYNRYITKG NLFEPVINAL LDNGTRYNLL
610 620 630 640 650
NSAVIELFEF IRVEDIKSLT AHIVENFYKA LESIEYVQTF KGLKTKYEQE
660 670 680 690 700
KDRQNQKLNS VPSILRSNRF RRDAKALEED EEMWFNEDDD EEGKAVITPV
710 720 730 740 750
EKSKTEDDFP DSYEKFMETK KAKESEDKEN LPKRASSGGF KFTFSHSPSA
760 770 780 790 800
TNGTNSTNSK SVVSQTTPAS SNVASSKTTS LATSVTATKG NLVGLVDYPD
810 820
DEEEDEEEES SPRKRPRLGS
Length:820
Mass (Da):93,934
Last modified:October 31, 2006 - v2
Checksum:i7B5A35D71663AB91
GO
Isoform 2 (identifier: Q922R5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     614-616: EDI → VSL
     617-820: Missing.

Show »
Length:616
Mass (Da):70,969
Checksum:i1F8918F53FA0208D
GO

Sequence cautioni

The sequence BAC98154 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti110T → I in BAC30967 (PubMed:16141072).Curated1
Sequence conflicti136A → T in BAC41046 (PubMed:19468303).Curated1
Sequence conflicti136A → T in AAH06870 (PubMed:15489334).Curated1
Sequence conflicti261Q → P in BAC41046 (PubMed:19468303).Curated1
Sequence conflicti333L → W in BAC41046 (PubMed:19468303).Curated1
Sequence conflicti357K → Q in BAC41046 (PubMed:19468303).Curated1
Sequence conflicti374M → V in BAC41046 (PubMed:19468303).Curated1
Sequence conflicti374M → V in AAH06870 (PubMed:15489334).Curated1
Sequence conflicti548N → D in BAC41046 (PubMed:19468303).Curated1
Sequence conflicti565I → V in BAC41046 (PubMed:19468303).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_021264614 – 616EDI → VSL in isoform 2. 1 Publication3
Alternative sequenceiVSP_021265617 – 820Missing in isoform 2. 1 PublicationAdd BLAST204

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK129344 mRNA. Translation: BAC98154.1. Different initiation.
AK037253 mRNA. Translation: BAC29779.2.
AK041513 mRNA. Translation: BAC30967.1.
AK090014 mRNA. Translation: BAC41046.1.
AK133211 mRNA. Translation: BAE21560.1.
BX000351, BX294116 Genomic DNA. Translation: CAI25082.1.
BX000351, BX294116 Genomic DNA. Translation: CAI25083.1.
BX294116, BX000351 Genomic DNA. Translation: CAI35921.1.
BX294116, BX000351 Genomic DNA. Translation: CAI35922.1.
BC006870 mRNA. Translation: AAH06870.1.
CCDSiCCDS24492.1. [Q922R5-1]
RefSeqiNP_598795.2. NM_134034.2. [Q922R5-1]
UniGeneiMm.276386.

Genome annotation databases

EnsembliENSMUST00000020755; ENSMUSP00000020755; ENSMUSG00000020463. [Q922R5-1]
ENSMUST00000102856; ENSMUSP00000099920; ENSMUSG00000020463. [Q922R5-2]
GeneIDi104570.
KEGGimmu:104570.
UCSCiuc007igq.2. mouse. [Q922R5-2]
uc007igs.2. mouse. [Q922R5-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK129344 mRNA. Translation: BAC98154.1. Different initiation.
AK037253 mRNA. Translation: BAC29779.2.
AK041513 mRNA. Translation: BAC30967.1.
AK090014 mRNA. Translation: BAC41046.1.
AK133211 mRNA. Translation: BAE21560.1.
BX000351, BX294116 Genomic DNA. Translation: CAI25082.1.
BX000351, BX294116 Genomic DNA. Translation: CAI25083.1.
BX294116, BX000351 Genomic DNA. Translation: CAI35921.1.
BX294116, BX000351 Genomic DNA. Translation: CAI35922.1.
BC006870 mRNA. Translation: AAH06870.1.
CCDSiCCDS24492.1. [Q922R5-1]
RefSeqiNP_598795.2. NM_134034.2. [Q922R5-1]
UniGeneiMm.276386.

3D structure databases

ProteinModelPortaliQ922R5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000020755.

PTM databases

iPTMnetiQ922R5.
PhosphoSitePlusiQ922R5.

Proteomic databases

EPDiQ922R5.
PaxDbiQ922R5.
PeptideAtlasiQ922R5.
PRIDEiQ922R5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000020755; ENSMUSP00000020755; ENSMUSG00000020463. [Q922R5-1]
ENSMUST00000102856; ENSMUSP00000099920; ENSMUSG00000020463. [Q922R5-2]
GeneIDi104570.
KEGGimmu:104570.
UCSCiuc007igq.2. mouse. [Q922R5-2]
uc007igs.2. mouse. [Q922R5-1]

Organism-specific databases

CTDi104570.
MGIiMGI:2144474. Smek2.
RougeiSearch...

Phylogenomic databases

eggNOGiKOG2175. Eukaryota.
ENOG410XQ7A. LUCA.
GeneTreeiENSGT00390000018199.
HOVERGENiHBG056624.
InParanoidiQ922R5.
KOiK17491.
OMAiDITQDPI.
OrthoDBiEOG091G02OO.
PhylomeDBiQ922R5.
TreeFamiTF315190.

Miscellaneous databases

ChiTaRSiSmek2. mouse.
PROiQ922R5.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000020463.
ExpressionAtlasiQ922R5. baseline and differential.
GenevisibleiQ922R5. MM.

Family and domain databases

Gene3Di1.25.10.10. 1 hit.
2.30.29.30. 1 hit.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR006887. DUF625.
IPR011993. PH_dom-like.
[Graphical view]
PfamiPF04802. SMK-1. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 2 hits.
SSF50729. SSF50729. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiP4R3B_MOUSE
AccessioniPrimary (citable) accession number: Q922R5
Secondary accession number(s): Q3V0E4
, Q5M6V9, Q5RJC0, Q5RJC1, Q6ZPS5, Q8BTK2, Q8BY94, Q8BYY0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: October 31, 2006
Last modified: November 30, 2016
This is version 109 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.