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Protein

Chitinase domain-containing protein 1

Gene

Chid1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Saccharide- and LPS-binding protein with possible roles in pathogen sensing and endotoxin neutralization. Ligand-binding specificity relates to the length of the oligosaccharides, with preference for chitotetraose (in vitro) (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Immunity, Innate immunity

Enzyme and pathway databases

ReactomeiR-MMU-114608. Platelet degranulation.

Names & Taxonomyi

Protein namesi
Recommended name:
Chitinase domain-containing protein 1
Gene namesi
Name:Chid1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:1915288. Chid1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Lysosome, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
ChainiPRO_000028060920 – 393Chitinase domain-containing protein 1Add BLAST374

Proteomic databases

PaxDbiQ922Q9.
PeptideAtlasiQ922Q9.
PRIDEiQ922Q9.

PTM databases

iPTMnetiQ922Q9.
PhosphoSitePlusiQ922Q9.

Expressioni

Gene expression databases

BgeeiENSMUSG00000025512.
CleanExiMM_CHID1.
ExpressionAtlasiQ922Q9. baseline and differential.
GenevisibleiQ922Q9. MM.

Interactioni

Subunit structurei

Interacts with STAB1.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000130360.

Structurei

3D structure databases

ProteinModelPortaliQ922Q9.
SMRiQ922Q9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyl hydrolase 18 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG2091. Eukaryota.
ENOG410XQB6. LUCA.
GeneTreeiENSGT00390000012069.
HOGENOMiHOG000006155.
HOVERGENiHBG055278.
InParanoidiQ922Q9.
KOiK17525.
PhylomeDBiQ922Q9.
TreeFamiTF319271.

Family and domain databases

Gene3Di3.20.20.80. 1 hit.
InterProiIPR011583. Chitinase_II.
IPR001223. Glyco_hydro18_cat.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PfamiPF00704. Glyco_hydro_18. 1 hit.
[Graphical view]
SMARTiSM00636. Glyco_18. 1 hit.
[Graphical view]
SUPFAMiSSF51445. SSF51445. 2 hits.

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q922Q9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MWPLLHVLWL ALVCGSVHTT LSKSDAKKAA SKMLLEKTQF SDKPVQDRGL
60 70 80 90 100
VVTDIKAEDV VLEHRSYCSS RARERNFAGE VLGYVTPWNS HGYDVAKVFG
110 120 130 140 150
SKFTQISPVW LQLKRRGREM FEITGLHDVD QGWMRAVKKH AKGVRIVPRL
160 170 180 190 200
LFEDWTYDDF RNVLDSEDEI EELSKTVAQV AKNQHFDGFV VEVWSQLLSQ
210 220 230 240 250
KHVGLIHMLT HLAEALHQAR LLVILVIPPA VTPGTDQLGM FTHKEFEQLA
260 270 280 290 300
PILDGFSLMT YDYSTSQQPG PNAPLSWIRA CVQVLDPKSQ WRSKILLGLN
310 320 330 340 350
FYGMDYAASK DAREPVIGAR YVQTLKDHRP RVVWDSQAAE HFFEYKKNRG
360 370 380 390
GRHVVFYPTL KSLQVRLELA RELGVGVSIW ELGQGLDYFY DLL
Length:393
Mass (Da):44,906
Last modified:December 1, 2001 - v1
Checksum:i492C5C84288B1DDC
GO
Isoform 2 (identifier: Q922Q9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     235-320: Missing.

Show »
Length:307
Mass (Da):35,241
Checksum:i73C8E8B8E07C632F
GO

Sequence cautioni

The sequence AAH61063 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAB29142 differs from that shown. Reason: Erroneous termination at position 306. Translated as Tyr.Curated
The sequence BAC34365 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAE35662 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti334W → R in BAE35662 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_023827235 – 320Missing in isoform 2. 1 PublicationAdd BLAST86

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK014071 mRNA. Translation: BAB29142.1. Sequence problems.
AK050655 mRNA. Translation: BAC34365.1. Different initiation.
AK160156 mRNA. Translation: BAE35662.1. Different initiation.
BC006876 mRNA. Translation: AAH06876.1.
BC061063 mRNA. Translation: AAH61063.1. Different initiation.
RefSeqiNP_001136153.1. NM_001142681.1.
NP_080798.2. NM_026522.5.
UniGeneiMm.245355.

Genome annotation databases

EnsembliENSMUST00000118694; ENSMUSP00000112891; ENSMUSG00000025512. [Q922Q9-2]
ENSMUST00000153191; ENSMUSP00000114693; ENSMUSG00000025512. [Q922Q9-1]
GeneIDi68038.
KEGGimmu:68038.
UCSCiuc009klp.2. mouse. [Q922Q9-2]
uc009klq.2. mouse. [Q922Q9-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK014071 mRNA. Translation: BAB29142.1. Sequence problems.
AK050655 mRNA. Translation: BAC34365.1. Different initiation.
AK160156 mRNA. Translation: BAE35662.1. Different initiation.
BC006876 mRNA. Translation: AAH06876.1.
BC061063 mRNA. Translation: AAH61063.1. Different initiation.
RefSeqiNP_001136153.1. NM_001142681.1.
NP_080798.2. NM_026522.5.
UniGeneiMm.245355.

3D structure databases

ProteinModelPortaliQ922Q9.
SMRiQ922Q9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000130360.

PTM databases

iPTMnetiQ922Q9.
PhosphoSitePlusiQ922Q9.

Proteomic databases

PaxDbiQ922Q9.
PeptideAtlasiQ922Q9.
PRIDEiQ922Q9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000118694; ENSMUSP00000112891; ENSMUSG00000025512. [Q922Q9-2]
ENSMUST00000153191; ENSMUSP00000114693; ENSMUSG00000025512. [Q922Q9-1]
GeneIDi68038.
KEGGimmu:68038.
UCSCiuc009klp.2. mouse. [Q922Q9-2]
uc009klq.2. mouse. [Q922Q9-1]

Organism-specific databases

CTDi66005.
MGIiMGI:1915288. Chid1.

Phylogenomic databases

eggNOGiKOG2091. Eukaryota.
ENOG410XQB6. LUCA.
GeneTreeiENSGT00390000012069.
HOGENOMiHOG000006155.
HOVERGENiHBG055278.
InParanoidiQ922Q9.
KOiK17525.
PhylomeDBiQ922Q9.
TreeFamiTF319271.

Enzyme and pathway databases

ReactomeiR-MMU-114608. Platelet degranulation.

Miscellaneous databases

ChiTaRSiChid1. mouse.
PROiQ922Q9.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000025512.
CleanExiMM_CHID1.
ExpressionAtlasiQ922Q9. baseline and differential.
GenevisibleiQ922Q9. MM.

Family and domain databases

Gene3Di3.20.20.80. 1 hit.
InterProiIPR011583. Chitinase_II.
IPR001223. Glyco_hydro18_cat.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PfamiPF00704. Glyco_hydro_18. 1 hit.
[Graphical view]
SMARTiSM00636. Glyco_18. 1 hit.
[Graphical view]
SUPFAMiSSF51445. SSF51445. 2 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiCHID1_MOUSE
AccessioniPrimary (citable) accession number: Q922Q9
Secondary accession number(s): Q3TVF7
, Q6P8U4, Q8C7C5, Q9CXR7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: December 1, 2001
Last modified: November 2, 2016
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.