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Protein

Leucine-rich repeat-containing protein 59

Gene

Lrrc59

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Required for nuclear import of FGF1, but not that of FGF2. Might regulate nuclear import of exogenous FGF1 by facilitating interaction with the nuclear import machinery and by transporting cytosolic FGF1 to, and possibly through, the nuclear pores (By similarity).By similarity

GO - Molecular functioni

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine-rich repeat-containing protein 59
Gene namesi
Name:Lrrc59
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:2138133. Lrrc59.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 244CytoplasmicSequence analysisAdd BLAST244
Transmembranei245 – 265HelicalSequence analysisAdd BLAST21
Topological domaini266 – 307LumenalSequence analysisAdd BLAST42

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002351601 – 307Leucine-rich repeat-containing protein 59Add BLAST307

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1
Modified residuei23PhosphoserineCombined sources1
Modified residuei25PhosphoserineBy similarity1
Modified residuei73N6-succinyllysineCombined sources1
Modified residuei135N6-acetyllysineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ922Q8.
MaxQBiQ922Q8.
PaxDbiQ922Q8.
PeptideAtlasiQ922Q8.
PRIDEiQ922Q8.

PTM databases

iPTMnetiQ922Q8.
PhosphoSitePlusiQ922Q8.
SwissPalmiQ922Q8.

Expressioni

Gene expression databases

BgeeiENSMUSG00000020869.
CleanExiMM_LRRC59.
GenevisibleiQ922Q8. MM.

Interactioni

Subunit structurei

Can form homodimers. Interacts with SGO1. Interacts with FGF1.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi221020. 1 interactor.
IntActiQ922Q8. 7 interactors.
MINTiMINT-1860666.
STRINGi10090.ENSMUSP00000021239.

Structurei

3D structure databases

ProteinModelPortaliQ922Q8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati10 – 31LRR 1Add BLAST22
Repeati40 – 62LRR 2Add BLAST23
Repeati63 – 84LRR 3Add BLAST22
Repeati86 – 107LRR 4Add BLAST22
Repeati109 – 128LRR 5Add BLAST20

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili148 – 216Sequence analysisAdd BLAST69

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi251 – 257Poly-Leu7

Sequence similaritiesi

Contains 5 LRR (leucine-rich) repeats.Curated

Keywords - Domaini

Coiled coil, Leucine-rich repeat, Repeat, Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0473. Eukaryota.
ENOG4111GH4. LUCA.
GeneTreeiENSGT00390000017385.
HOGENOMiHOG000073534.
HOVERGENiHBG081933.
InParanoidiQ922Q8.
OMAiDILQWVL.
OrthoDBiEOG091G0EHN.
PhylomeDBiQ922Q8.
TreeFamiTF316929.

Family and domain databases

Gene3Di3.80.10.10. 1 hit.
InterProiIPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
[Graphical view]
PfamiPF13855. LRR_8. 1 hit.
[Graphical view]
SMARTiSM00369. LRR_TYP. 4 hits.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 1 hit.
PROSITEiPS51450. LRR. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q922Q8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTKAGSKGGN LRDKLDGNEL DLSLSDLNEV PVKELAALPK ATVLDLSCNK
60 70 80 90 100
LSTLPSDFCG LTHLVKLDLS KNKLQQLPAD FGRLVNLQHL DLLNNRLVTL
110 120 130 140 150
PVSFAQLKNL KWLDLKDNPL DPVLAKVAGD CLDEKQCKQC ANKVLQHMKA
160 170 180 190 200
VQADQERERQ RRLEVEREAE KKREAKQQAK EAKERELRKR EKAEEKERRR
210 220 230 240 250
KEYDAQKASK REQEKKPKKE ANQAPKSKSG SRPRKPPPRK HTRSWAVLKV
260 270 280 290 300
LLLLLLLCVA GGLVVCRVTG LHQQPLCTSV NTIYDNAVQG LRHHEILQWV

LQTDSQQ
Length:307
Mass (Da):34,877
Last modified:December 1, 2001 - v1
Checksum:i549CD3B145413A32
GO

Sequence cautioni

The sequence AAH06877 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAE35030 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAE38865 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAE39660 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti189K → E in BAE38865 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK053450 mRNA. Translation: BAC35390.1.
AK159374 mRNA. Translation: BAE35030.1. Different initiation.
AK159552 mRNA. Translation: BAE35177.1.
AK166576 mRNA. Translation: BAE38865.1. Different initiation.
AK167604 mRNA. Translation: BAE39660.1. Different initiation.
AK169390 mRNA. Translation: BAE41137.1.
AL645764 Genomic DNA. Translation: CAI24964.1.
BC006877 mRNA. Translation: AAH06877.1. Different initiation.
BC066172 mRNA. Translation: AAH66172.1.
CCDSiCCDS25261.1.
RefSeqiNP_598568.1. NM_133807.1.
UniGeneiMm.172720.

Genome annotation databases

EnsembliENSMUST00000021239; ENSMUSP00000021239; ENSMUSG00000020869.
GeneIDi98238.
KEGGimmu:98238.
UCSCiuc007kze.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK053450 mRNA. Translation: BAC35390.1.
AK159374 mRNA. Translation: BAE35030.1. Different initiation.
AK159552 mRNA. Translation: BAE35177.1.
AK166576 mRNA. Translation: BAE38865.1. Different initiation.
AK167604 mRNA. Translation: BAE39660.1. Different initiation.
AK169390 mRNA. Translation: BAE41137.1.
AL645764 Genomic DNA. Translation: CAI24964.1.
BC006877 mRNA. Translation: AAH06877.1. Different initiation.
BC066172 mRNA. Translation: AAH66172.1.
CCDSiCCDS25261.1.
RefSeqiNP_598568.1. NM_133807.1.
UniGeneiMm.172720.

3D structure databases

ProteinModelPortaliQ922Q8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi221020. 1 interactor.
IntActiQ922Q8. 7 interactors.
MINTiMINT-1860666.
STRINGi10090.ENSMUSP00000021239.

PTM databases

iPTMnetiQ922Q8.
PhosphoSitePlusiQ922Q8.
SwissPalmiQ922Q8.

Proteomic databases

EPDiQ922Q8.
MaxQBiQ922Q8.
PaxDbiQ922Q8.
PeptideAtlasiQ922Q8.
PRIDEiQ922Q8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000021239; ENSMUSP00000021239; ENSMUSG00000020869.
GeneIDi98238.
KEGGimmu:98238.
UCSCiuc007kze.1. mouse.

Organism-specific databases

CTDi55379.
MGIiMGI:2138133. Lrrc59.

Phylogenomic databases

eggNOGiKOG0473. Eukaryota.
ENOG4111GH4. LUCA.
GeneTreeiENSGT00390000017385.
HOGENOMiHOG000073534.
HOVERGENiHBG081933.
InParanoidiQ922Q8.
OMAiDILQWVL.
OrthoDBiEOG091G0EHN.
PhylomeDBiQ922Q8.
TreeFamiTF316929.

Miscellaneous databases

ChiTaRSiLrrc59. mouse.
PROiQ922Q8.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000020869.
CleanExiMM_LRRC59.
GenevisibleiQ922Q8. MM.

Family and domain databases

Gene3Di3.80.10.10. 1 hit.
InterProiIPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
[Graphical view]
PfamiPF13855. LRR_8. 1 hit.
[Graphical view]
SMARTiSM00369. LRR_TYP. 4 hits.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 1 hit.
PROSITEiPS51450. LRR. 4 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiLRC59_MOUSE
AccessioniPrimary (citable) accession number: Q922Q8
Secondary accession number(s): Q3TJ35
, Q3TLC7, Q3TWT9, Q3TX86
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 16, 2006
Last sequence update: December 1, 2001
Last modified: November 2, 2016
This is version 132 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.