Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Protein ABHD14A

Gene

Abhd14a

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Possible role in granule neuron development.1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei147 – 1471Charge relay systemBy similarity
Active sitei198 – 1981Charge relay systemBy similarity
Active sitei225 – 2251Charge relay systemBy similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Protein family/group databases

ESTHERimouse-Dorz1. CIB-CCG1-interacting-factor-B.
MEROPSiS33.981.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein ABHD14ACurated (EC:3.-.-.-)
Alternative name(s):
Alpha/beta hydrolase domain-containing protein 14ACurated
Short name:
Abhydrolase domain-containing protein 14AImported
Down-regulated in Zic-1-mutant protein
Gene namesi
Name:Abhd14aImported
Synonyms:Dorz1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1915894. Abhd14a.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei11 – 3121Helical; Signal-anchor for type II membrane proteinSequence analysisAdd
BLAST

GO - Cellular componenti

  • cytoplasm Source: MGI
  • extracellular exosome Source: MGI
  • integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 247247Protein ABHD14APRO_0000282286Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi43 – 431N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ922Q6.
PeptideAtlasiQ922Q6.
PRIDEiQ922Q6.

PTM databases

PhosphoSiteiQ922Q6.

Expressioni

Tissue specificityi

Widely expressed. Higher expression is detected in brain, kidney, heart, testis, ovary and uterus.1 Publication

Developmental stagei

Expressed in cerebellum during embryogenesis. Highly expressed at E17.5 in the cerebellar granule neurons precursors.1 Publication

Gene expression databases

CleanExiMM_ABHD14A.

Structurei

3D structure databases

ProteinModelPortaliQ922Q6.
SMRiQ922Q6. Positions 57-246.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the AB hydrolase superfamily. ABHD14 family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000028065.
HOVERGENiHBG001936.
InParanoidiQ922Q6.
PhylomeDBiQ922Q6.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR000073. AB_hydrolase_1.
[Graphical view]
PfamiPF12697. Abhydrolase_6. 1 hit.
[Graphical view]
SUPFAMiSSF53474. SSF53474. 1 hit.

Sequencei

Sequence statusi: Complete.

Q922Q6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVQKFMSRYQ AALLGLGLLL VFLLYMGLPG PPEQTSRLWR GPNVTVLTGL
60 70 80 90 100
TRGNSRIFYR EVLPIQQACR AEVVFLHGKA FNSHTWEQLG TLQLLSERGY
110 120 130 140 150
RAVAIDLPGF GNSAPSEEVS TEAGRVELLE RVFQDLQVQN TVLVSPSLSG
160 170 180 190 200
SYALPFLMQN HHQLRGFVPI APTYTRNYAQ EQFRAVKTPT LILYGELDHT
210 220 230 240
LARESLQQLR HLPNHSMVKL RDAGHACYLH KPEAFHLALL AFLDHLP
Length:247
Mass (Da):27,839
Last modified:April 3, 2007 - v2
Checksum:i53586C5C42575A19
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti227 – 2271C → R in AAH06879 (PubMed:15489334).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB073619 mRNA. Translation: BAB91136.1.
BC006879 mRNA. Translation: AAH06879.1.
UniGeneiMm.268925.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB073619 mRNA. Translation: BAB91136.1.
BC006879 mRNA. Translation: AAH06879.1.
UniGeneiMm.268925.

3D structure databases

ProteinModelPortaliQ922Q6.
SMRiQ922Q6. Positions 57-246.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

ESTHERimouse-Dorz1. CIB-CCG1-interacting-factor-B.
MEROPSiS33.981.

PTM databases

PhosphoSiteiQ922Q6.

Proteomic databases

MaxQBiQ922Q6.
PeptideAtlasiQ922Q6.
PRIDEiQ922Q6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

MGIiMGI:1915894. Abhd14a.

Phylogenomic databases

HOGENOMiHOG000028065.
HOVERGENiHBG001936.
InParanoidiQ922Q6.
PhylomeDBiQ922Q6.

Miscellaneous databases

PROiQ922Q6.
SOURCEiSearch...

Gene expression databases

CleanExiMM_ABHD14A.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR000073. AB_hydrolase_1.
[Graphical view]
PfamiPF12697. Abhydrolase_6. 1 hit.
[Graphical view]
SUPFAMiSSF53474. SSF53474. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiABHEA_MOUSE
AccessioniPrimary (citable) accession number: Q922Q6
Secondary accession number(s): Q8K4S5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: April 3, 2007
Last modified: July 6, 2016
This is version 88 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Caution

It is uncertain whether Met-1 or Met-6 is the initiator.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.