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Protein

Adenosine 3'-phospho 5'-phosphosulfate transporter 2

Gene

Slc35b3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Mediates the transport of adenosine 3'-phospho 5'-phosphosulfate (PAPS), from cytosol into Golgi. PAPS is a universal sulfuryl donor for sulfation events that take place in the Golgi. Compensates for the insufficient expression of SLC35B2/PAPST1 during the synthesis of sulfated glycoconjugates in the colon (By similarity).By similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Biological processi

Transport

Enzyme and pathway databases

ReactomeiR-MMU-174362. Transport and synthesis of PAPS.
R-MMU-727802. Transport of nucleotide sugars.

Names & Taxonomyi

Protein namesi
Recommended name:
Adenosine 3'-phospho 5'-phosphosulfate transporter 2
Alternative name(s):
PAPS transporter 2
Solute carrier family 35 member B3
Gene namesi
Name:Slc35b3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 13

Organism-specific databases

MGIiMGI:1913978. Slc35b3.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei46 – 66HelicalSequence analysisAdd BLAST21
Transmembranei79 – 99HelicalSequence analysisAdd BLAST21
Transmembranei115 – 135HelicalSequence analysisAdd BLAST21
Transmembranei138 – 158HelicalSequence analysisAdd BLAST21
Transmembranei168 – 188HelicalSequence analysisAdd BLAST21
Transmembranei191 – 211HelicalSequence analysisAdd BLAST21
Transmembranei235 – 255HelicalSequence analysisAdd BLAST21
Transmembranei266 – 285HelicalSequence analysisAdd BLAST20
Transmembranei292 – 314HelicalSequence analysisAdd BLAST23
Transmembranei317 – 337HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002133801 – 369Adenosine 3'-phospho 5'-phosphosulfate transporter 2Add BLAST369

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi39N-linked (GlcNAc...)Sequence analysis1
Glycosylationi222N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ922Q5.
PRIDEiQ922Q5.

PTM databases

iPTMnetiQ922Q5.
PhosphoSitePlusiQ922Q5.

Expressioni

Gene expression databases

BgeeiENSMUSG00000021432.
CleanExiMM_SLC35B3.
ExpressionAtlasiQ922Q5. baseline and differential.
GenevisibleiQ922Q5. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000021870.

Structurei

3D structure databases

ProteinModelPortaliQ922Q5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1582. Eukaryota.
COG0697. LUCA.
GeneTreeiENSGT00530000063090.
HOGENOMiHOG000006136.
HOVERGENiHBG066829.
InParanoidiQ922Q5.
KOiK15277.
PhylomeDBiQ922Q5.

Family and domain databases

InterProiIPR013657. UAA.
[Graphical view]
PfamiPF08449. UAA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q922Q5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDLKFNNSRK YVSISVPSKT QAMSPHIKSV EDVVVLGVNL SKFSKLTQFL
60 70 80 90 100
ICVAGVFVFY LIYGYLQELI FSVEGFKPYG WYLTLVQFAF YSVFGLIELQ
110 120 130 140 150
LTQDRRRRIP GKTYMLIAFL TVGTMGLSNT SLGYLNYPTQ VIFKCCKLIP
160 170 180 190 200
VMLGGVFIQG KRYNLADVSA AVCMSLGLIW FTLADSTIAP NFNLTGVMLI
210 220 230 240 250
SLALCADAVI GNVQEKAMKL HNASNSEMVL YSYSIGFVYI LLGLSCTSGL
260 270 280 290 300
GPAVAFCSKN PVGTYGYAFL FSLTGYFGIS FVLALIKIFG ALLAVTVTTG
310 320 330 340 350
RKAMTVVLSF LFFAKPFTFQ YIWSGLLVVL GIFLNVYSKN MDKIRLPSVY
360
NMIKKAMDMK KSRTLAQTV
Length:369
Mass (Da):40,889
Last modified:December 1, 2001 - v1
Checksum:iF7B617947AD6476D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK076592 mRNA. Translation: BAC36405.1.
AK077208 mRNA. Translation: BAC36684.1.
AK141280 mRNA. Translation: BAE24633.1.
BC006881 mRNA. Translation: AAH06881.1.
CCDSiCCDS26466.1.
RefSeqiNP_001163901.1. NM_001170430.1.
NP_001163902.1. NM_001170431.1.
NP_598821.1. NM_134060.4.
XP_017170845.1. XM_017315356.1.
UniGeneiMm.255506.

Genome annotation databases

EnsembliENSMUST00000167513; ENSMUSP00000126016; ENSMUSG00000021432.
GeneIDi108652.
KEGGimmu:108652.
UCSCiuc007qdy.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK076592 mRNA. Translation: BAC36405.1.
AK077208 mRNA. Translation: BAC36684.1.
AK141280 mRNA. Translation: BAE24633.1.
BC006881 mRNA. Translation: AAH06881.1.
CCDSiCCDS26466.1.
RefSeqiNP_001163901.1. NM_001170430.1.
NP_001163902.1. NM_001170431.1.
NP_598821.1. NM_134060.4.
XP_017170845.1. XM_017315356.1.
UniGeneiMm.255506.

3D structure databases

ProteinModelPortaliQ922Q5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000021870.

PTM databases

iPTMnetiQ922Q5.
PhosphoSitePlusiQ922Q5.

Proteomic databases

PaxDbiQ922Q5.
PRIDEiQ922Q5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000167513; ENSMUSP00000126016; ENSMUSG00000021432.
GeneIDi108652.
KEGGimmu:108652.
UCSCiuc007qdy.2. mouse.

Organism-specific databases

CTDi51000.
MGIiMGI:1913978. Slc35b3.

Phylogenomic databases

eggNOGiKOG1582. Eukaryota.
COG0697. LUCA.
GeneTreeiENSGT00530000063090.
HOGENOMiHOG000006136.
HOVERGENiHBG066829.
InParanoidiQ922Q5.
KOiK15277.
PhylomeDBiQ922Q5.

Enzyme and pathway databases

ReactomeiR-MMU-174362. Transport and synthesis of PAPS.
R-MMU-727802. Transport of nucleotide sugars.

Miscellaneous databases

ChiTaRSiSlc35b3. mouse.
PROiQ922Q5.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000021432.
CleanExiMM_SLC35B3.
ExpressionAtlasiQ922Q5. baseline and differential.
GenevisibleiQ922Q5. MM.

Family and domain databases

InterProiIPR013657. UAA.
[Graphical view]
PfamiPF08449. UAA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiS35B3_MOUSE
AccessioniPrimary (citable) accession number: Q922Q5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: December 1, 2001
Last modified: November 30, 2016
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.