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Q922Q2

- RIOK1_MOUSE

UniProt

Q922Q2 - RIOK1_MOUSE

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Protein

Serine/threonine-protein kinase RIO1

Gene

Riok1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei207 – 2071ATPBy similarity
Active sitei323 – 3231Proton acceptorBy similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. protein serine/threonine kinase activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein kinase RIO1 (EC:2.7.11.1)
Alternative name(s):
RIO kinase 1
Gene namesi
Name:Riok1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 13

Organism-specific databases

MGIiMGI:1918590. Riok1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 567567Serine/threonine-protein kinase RIO1PRO_0000314490Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei21 – 211PhosphoserineBy similarity
Modified residuei22 – 221PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ922Q2.
PRIDEiQ922Q2.

PTM databases

PhosphoSiteiQ922Q2.

Expressioni

Gene expression databases

BgeeiQ922Q2.
CleanExiMM_RIOK1.
GenevestigatoriQ922Q2.

Structurei

3D structure databases

ProteinModelPortaliQ922Q2.
SMRiQ922Q2. Positions 162-429.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini179 – 478300Protein kinaseAdd
BLAST

Sequence similaritiesi

Contains 1 protein kinase domain.Curated

Phylogenomic databases

eggNOGiCOG1718.
GeneTreeiENSGT00390000004370.
HOGENOMiHOG000166501.
HOVERGENiHBG056997.
InParanoidiQ922Q2.
KOiK07178.
OMAiVEPDHPR.
OrthoDBiEOG7JT6W1.
PhylomeDBiQ922Q2.
TreeFamiTF105831.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR018934. RIO-like_kinase.
IPR000687. RIO_kinase.
IPR018935. RIO_kinase_CS.
IPR017407. Ser/Thr_kinase_Rio1.
[Graphical view]
PfamiPF01163. RIO1. 1 hit.
[Graphical view]
PIRSFiPIRSF038147. Ser/Thr_PK_RIO1. 1 hit.
SMARTiSM00090. RIO. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS01245. RIO1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q922Q2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDCSLDRMAS VVPGQFDDAD SSDSENKELQ PIHAEDGGVL LKSLQNAAAE
60 70 80 90 100
VKGDAETDEE DDYDDDDDWY LDDATGKLTK GCTWNGGSNY QANRQTSNYN
110 120 130 140 150
SAKMSTPIDK SLRKFENKIN LNKLNVTDSV TNKVTVKLRQ KEAESYRIKD
160 170 180 190 200
KADRATVEQV LDPRTRMILF KLLHKDHISE IHGCISTGKE ANVYYASTPS
210 220 230 240 250
GESRAIKIYK TSILMFKDRD KYVTGEFRFR RGYCKGNPRK MVRTWAEKEM
260 270 280 290 300
RNLCRLKTAN IPCPEPIRLR SHVLLMGFIG KDDMPAPLLK NVQLSESKAR
310 320 330 340 350
ELYLQVIQYM RKMYQDARLV HADLSEFNML YHGGDVYIID VSQSVEHDHP
360 370 380 390 400
HALEFLRKDC TNVNDFFSKH AVAVMTVREL FDFVTDPSIT ADNMDAYLEK
410 420 430 440 450
AMEIASQRTK EEKTSQDHVD EEVFKQAYIP RTLNEVKNYE RDVDIMMRLK
460 470 480 490 500
EEDMALNTQQ DNILYQTVMG LKKDLSGVQK VPALLESEVK EETCFGSDDA
510 520 530 540 550
GGSECSDTVS EEQEDQAGCR NHIADPDIDK KERKKMVKEA QREKRKNKIP
560
KHVKKRKEKT AKAKKGK
Length:567
Mass (Da):64,910
Last modified:January 15, 2008 - v2
Checksum:iD2A1863DF0132366
GO

Sequence cautioni

The sequence BAB29195.1 differs from that shown. Reason: Intron retention.
The sequence BAB29195.1 differs from that shown. Reason: Frameshift at position 434.
The sequence AAH02158.1 differs from that shown. Reason: Erroneous initiation.
The sequence BAB29195.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
The sequence BAB30687.2 differs from that shown. Reason: Erroneous initiation.

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti436 – 4361V → E in BAB29195. (PubMed:16141072)Curated
Sequence conflicti492 – 4921E → K in BAB29195. (PubMed:16141072)Curated
Sequence conflicti528 – 5281I → V in AAH02158. (PubMed:15489334)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK014182 mRNA. Translation: BAB29195.1. Sequence problems.
AK017312 mRNA. Translation: BAB30687.2. Different initiation.
AK152707 mRNA. Translation: BAE31434.1.
AC140331 Genomic DNA. No translation available.
CT010477 Genomic DNA. No translation available.
BC002158 mRNA. Translation: AAH02158.1. Different initiation.
CCDSiCCDS26461.1.
RefSeqiNP_077204.2. NM_024242.3.
UniGeneiMm.297130.

Genome annotation databases

EnsembliENSMUST00000021866; ENSMUSP00000021866; ENSMUSG00000021428.
GeneIDi71340.
KEGGimmu:71340.
UCSCiuc007qdi.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK014182 mRNA. Translation: BAB29195.1 . Sequence problems.
AK017312 mRNA. Translation: BAB30687.2 . Different initiation.
AK152707 mRNA. Translation: BAE31434.1 .
AC140331 Genomic DNA. No translation available.
CT010477 Genomic DNA. No translation available.
BC002158 mRNA. Translation: AAH02158.1 . Different initiation.
CCDSi CCDS26461.1.
RefSeqi NP_077204.2. NM_024242.3.
UniGenei Mm.297130.

3D structure databases

ProteinModelPortali Q922Q2.
SMRi Q922Q2. Positions 162-429.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei Q922Q2.

Proteomic databases

MaxQBi Q922Q2.
PRIDEi Q922Q2.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000021866 ; ENSMUSP00000021866 ; ENSMUSG00000021428 .
GeneIDi 71340.
KEGGi mmu:71340.
UCSCi uc007qdi.2. mouse.

Organism-specific databases

CTDi 83732.
MGIi MGI:1918590. Riok1.

Phylogenomic databases

eggNOGi COG1718.
GeneTreei ENSGT00390000004370.
HOGENOMi HOG000166501.
HOVERGENi HBG056997.
InParanoidi Q922Q2.
KOi K07178.
OMAi VEPDHPR.
OrthoDBi EOG7JT6W1.
PhylomeDBi Q922Q2.
TreeFami TF105831.

Miscellaneous databases

ChiTaRSi RIOK1. mouse.
NextBioi 333585.
PROi Q922Q2.
SOURCEi Search...

Gene expression databases

Bgeei Q922Q2.
CleanExi MM_RIOK1.
Genevestigatori Q922Q2.

Family and domain databases

InterProi IPR011009. Kinase-like_dom.
IPR018934. RIO-like_kinase.
IPR000687. RIO_kinase.
IPR018935. RIO_kinase_CS.
IPR017407. Ser/Thr_kinase_Rio1.
[Graphical view ]
Pfami PF01163. RIO1. 1 hit.
[Graphical view ]
PIRSFi PIRSF038147. Ser/Thr_PK_RIO1. 1 hit.
SMARTi SM00090. RIO. 1 hit.
[Graphical view ]
SUPFAMi SSF56112. SSF56112. 1 hit.
PROSITEi PS01245. RIO1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Bone marrow macrophage, Embryonic head and Head.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 192-567.
    Tissue: Mammary gland.

Entry informationi

Entry nameiRIOK1_MOUSE
AccessioniPrimary (citable) accession number: Q922Q2
Secondary accession number(s): Q3U7D5
, Q99LZ1, Q9CU84, Q9CXN9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: January 15, 2008
Last modified: October 29, 2014
This is version 71 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3