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Protein

Transmembrane protein 132A

Gene

Tmem132a

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May play a role in embryonic and postnatal development of the brain. Increased resistance to cell death induced by serum starvation in cultured cells. Regulates cAMP-induced GFAP gene expression via STAT3 phosphorylation (By similarity).By similarity

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protein 132A
Alternative name(s):
HSPA5-binding protein 1
Gene namesi
Name:Tmem132a
Synonyms:Kiaa1583
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 19

Organism-specific databases

MGIiMGI:2147810. Tmem132a.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini33 – 846814ExtracellularSequence analysisAdd
BLAST
Transmembranei847 – 86721HelicalSequence analysisAdd
BLAST
Topological domaini868 – 1018151CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3232Sequence analysisAdd
BLAST
Chaini33 – 1018986Transmembrane protein 132APRO_0000287097Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi276 – 2761N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ922P8.
PaxDbiQ922P8.
PRIDEiQ922P8.

PTM databases

iPTMnetiQ922P8.
PhosphoSiteiQ922P8.

Expressioni

Gene expression databases

BgeeiQ922P8.
CleanExiMM_TMEM132A.
ExpressionAtlasiQ922P8. baseline and differential.
GenevisibleiQ922P8. MM.

Interactioni

Subunit structurei

Interacts with HSPA5/GRP78.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000025645.

Structurei

3D structure databases

ProteinModelPortaliQ922P8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni606 – 911306Binds to HSPA5/GRP78By similarityAdd
BLAST
Regioni666 – 1018353Confers cellular localization similar to full-length formBy similarityAdd
BLAST

Sequence similaritiesi

Belongs to the TMEM132 family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4789. Eukaryota.
ENOG410XQCD. LUCA.
GeneTreeiENSGT00550000074550.
HOGENOMiHOG000154481.
HOVERGENiHBG099719.
InParanoidiQ922P8.
KOiK17599.
OMAiYQRKEPP.
OrthoDBiEOG7DJSKK.
PhylomeDBiQ922P8.
TreeFamiTF314981.

Family and domain databases

InterProiIPR026307. TMEM132.
IPR031436. TMEM132_C.
IPR031437. TMEM132_M.
IPR031435. TMEM132_N.
[Graphical view]
PANTHERiPTHR13388. PTHR13388. 1 hit.
PfamiPF16070. TMEM132. 1 hit.
PF15706. TMEM132D_C. 1 hit.
PF15705. TMEM132D_N. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q922P8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTERKAAAPR GPYGAWFCLL VALALEVVRV SSNHDTLDPI YLPVALELLD
60 70 80 90 100
APEHFRVQQV GHYPPANSSL ASRSETFLLM QPWPRAQPLL RASYPPFATQ
110 120 130 140 150
QVVPPRVTEP HRRPVPWDVR AVSVEAAVTP AEPYARVLFH LKGQDWPPGP
160 170 180 190 200
GSLPCARLHA THPAGTAHRA CRFQPSLGAC VVELQFPSHW FSQSATTRAE
210 220 230 240 250
LAYTLEPAGE GPGGCGLGTE EEPREQALPV GGVELHPEDP PQYQEVPLDE
260 270 280 290 300
AVTLRAPDVP MRPGQLFTAT LLLRHNFTAS LLTLRIKVKK GLQVIAARPA
310 320 330 340 350
QPTLWTAKLD RFKGSKHHTS LITCHRAGPA GPDSSPLELS EFLWVDFAVE
360 370 380 390 400
NSTGGGVAVT RPVTWQLEYP GQAPEAEKDK MVWEILVSER DIRALIPLAK
410 420 430 440 450
AEELVNTAPL TGVPQRIPVR LVTVDSGGAL EEVTEHIGCE SANTQVLQVS
460 470 480 490 500
EACDAVFVAG QESRGAKGVR VDFWWRRLRA SLKLTVWAPL LPLRIELTDT
510 520 530 540 550
TLEQIRGWRV PGSAEGQLEP ETAAEEVERR SRGCRLQYQR AGVRFLVPFA
560 570 580 590 600
AHPLDGGRRL THLLGPDWLL DVSHLVAAHA HVQDPRIASL EGGRILVGRE
610 620 630 640 650
PGVTSIEVRS PLSDAILGEQ ALAVTDDKVS VLDLRVQPVM GISLSLSRGM
660 670 680 690 700
SHPGEVTATC WAQSALPAPK QEVALSLWLS FSDHTLAPAE LYDRNDLGLS
710 720 730 740 750
VSAEEPSAVL PAEEQGAQLG VVVSGVGAEG LPLHVALHPP EPCRRGRHRV
760 770 780 790 800
PLASGTAWLG LPPLPTPVPA LPSSPVRTSP FTEATVEGKR QIAGDMGGHV
810 820 830 840 850
GIRGKFERAE EEAGKEENEA KEEEEDEEEM VPAPQRVTDL ELGMYALLGI
860 870 880 890 900
FCLAILIFLV NGVVFVLRYQ RKEPPDSATD PASPQPHNWV WLGTNQEELS
910 920 930 940 950
RQLDRCSSSG PPKGEGGCPC ESGAGGDAST VAPSASESPA GSSSTLARKE
960 970 980 990 1000
AGGRRKRVEF VTFAPAPPTQ PPEEPVGAPA VQSILVAGEE DIRWVCEDMG
1010
LKDPEELRNY MERIRGSS
Length:1,018
Mass (Da):110,239
Last modified:September 19, 2006 - v2
Checksum:i7BDFA487B5B51648
GO

Sequence cautioni

The sequence BAC33373.1 differs from that shown. Reason: Erroneous termination at position 660. Translated as Cys.Curated
The sequence BAD32485.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti386 – 3861L → M in BAC33373 (PubMed:16141072).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK173207 mRNA. Translation: BAD32485.1. Different initiation.
AK048556 mRNA. Translation: BAC33373.1. Sequence problems.
BC006896 mRNA. Translation: AAH06896.2.
CCDSiCCDS29589.1.
RefSeqiNP_598565.2. NM_133804.2.
UniGeneiMm.490254.

Genome annotation databases

EnsembliENSMUST00000025645; ENSMUSP00000025645; ENSMUSG00000024736.
GeneIDi98170.
KEGGimmu:98170.
UCSCiuc008grc.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK173207 mRNA. Translation: BAD32485.1. Different initiation.
AK048556 mRNA. Translation: BAC33373.1. Sequence problems.
BC006896 mRNA. Translation: AAH06896.2.
CCDSiCCDS29589.1.
RefSeqiNP_598565.2. NM_133804.2.
UniGeneiMm.490254.

3D structure databases

ProteinModelPortaliQ922P8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000025645.

PTM databases

iPTMnetiQ922P8.
PhosphoSiteiQ922P8.

Proteomic databases

MaxQBiQ922P8.
PaxDbiQ922P8.
PRIDEiQ922P8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000025645; ENSMUSP00000025645; ENSMUSG00000024736.
GeneIDi98170.
KEGGimmu:98170.
UCSCiuc008grc.1. mouse.

Organism-specific databases

CTDi54972.
MGIiMGI:2147810. Tmem132a.
RougeiSearch...

Phylogenomic databases

eggNOGiKOG4789. Eukaryota.
ENOG410XQCD. LUCA.
GeneTreeiENSGT00550000074550.
HOGENOMiHOG000154481.
HOVERGENiHBG099719.
InParanoidiQ922P8.
KOiK17599.
OMAiYQRKEPP.
OrthoDBiEOG7DJSKK.
PhylomeDBiQ922P8.
TreeFamiTF314981.

Miscellaneous databases

ChiTaRSiTmem132a. mouse.
NextBioi353338.
PROiQ922P8.
SOURCEiSearch...

Gene expression databases

BgeeiQ922P8.
CleanExiMM_TMEM132A.
ExpressionAtlasiQ922P8. baseline and differential.
GenevisibleiQ922P8. MM.

Family and domain databases

InterProiIPR026307. TMEM132.
IPR031436. TMEM132_C.
IPR031437. TMEM132_M.
IPR031435. TMEM132_N.
[Graphical view]
PANTHERiPTHR13388. PTHR13388. 1 hit.
PfamiPF16070. TMEM132. 1 hit.
PF15706. TMEM132D_C. 1 hit.
PF15705. TMEM132D_N. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
    Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S., Saga Y., Seino S., Nishimura M., Kaisho T., Hoshino K., Kitamura H., Nagase T., Ohara O., Koga H.
    DNA Res. 11:205-218(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Head.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Mammary tumor.
  4. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain.

Entry informationi

Entry nameiT132A_MOUSE
AccessioniPrimary (citable) accession number: Q922P8
Secondary accession number(s): Q69ZF9, Q8BX93
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: September 19, 2006
Last modified: January 20, 2016
This is version 91 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.