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Protein

Cell division cycle-associated 7-like protein

Gene

Cdca7l

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Plays a role in transcriptional regulation as a repressor that inhibits monoamine oxidase A (MAOA) activity and gene expression by binding to the promoter. Plays an important oncogenic role in mediating the full transforming effect of MYC in medulloblastoma cells (By similarity). Involved in apoptotic signaling pathways; May act downstream of P38-kinase and BCL-2, but upstream of CASP3/caspase-3 as well as CCND1/cyclin D1 and E2F1.By similarity1 Publication

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Cell division cycle-associated 7-like protein
Alternative name(s):
Transcription factor RAM2
Gene namesi
Name:Cdca7l
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 12

Organism-specific databases

MGIiMGI:2384982. Cdca7l.

Subcellular locationi

  • Cytoplasm By similarity
  • Nucleus By similarity

  • Note: Associates with chromatin. Translocates from cytoplasm to nucleus under dexamethasone induction (By similarity).By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002493141 – 438Cell division cycle-associated 7-like proteinAdd BLAST438

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei21PhosphoserineBy similarity1
Modified residuei75PhosphothreonineBy similarity1
Modified residuei77PhosphoserineBy similarity1
Modified residuei101PhosphoserineBy similarity1
Modified residuei104PhosphoserineBy similarity1
Modified residuei135PhosphoserineBy similarity1
Modified residuei136PhosphoserineBy similarity1
Modified residuei159PhosphoserineBy similarity1
Modified residuei183PhosphoserineCombined sources1
Modified residuei185PhosphoserineCombined sources1
Modified residuei249PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ922M5.
MaxQBiQ922M5.
PaxDbiQ922M5.
PeptideAtlasiQ922M5.
PRIDEiQ922M5.

PTM databases

iPTMnetiQ922M5.
PhosphoSitePlusiQ922M5.

Expressioni

Tissue specificityi

Expressed in all tissues but not detected in total brain.1 Publication

Gene expression databases

BgeeiENSMUSG00000021175.
CleanExiMM_CDCA7L.
ExpressionAtlasiQ922M5. baseline and differential.
GenevisibleiQ922M5. MM.

Interactioni

Subunit structurei

Interacts with MYC and PSIP1.By similarity

Protein-protein interaction databases

BioGridi229982. 1 interactor.
STRINGi10090.ENSMUSP00000021592.

Structurei

3D structure databases

ProteinModelPortaliQ922M5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni56 – 115PSIP1-bindingBy similarityAdd BLAST60
Regioni201 – 223MYC-bindingBy similarityAdd BLAST23

Phylogenomic databases

eggNOGiENOG410IYXY. Eukaryota.
ENOG410XQV7. LUCA.
GeneTreeiENSGT00390000014657.
HOGENOMiHOG000231812.
HOVERGENiHBG060300.
InParanoidiQ922M5.
OMAiITRRMNP.
OrthoDBiEOG091G0A11.
PhylomeDBiQ922M5.
TreeFamiTF101076.

Family and domain databases

InterProiIPR033578. CDCA7L.
IPR018866. Znf-4CXXC_R1.
[Graphical view]
PANTHERiPTHR31169:SF4. PTHR31169:SF4. 1 hit.
PfamiPF10497. zf-4CXXC_R1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q922M5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MELATRSQIP KEVADIFSAP SDDEEFVGFQ DDVPMQNLSE SCGSLDSREL
60 70 80 90 100
EKQQNVCFRS KYFTEELRRI FKEDTDSEME DFEGFTESEL NMSSNPELME
110 120 130 140 150
SELSDSDKAY PVMNDAEEDD EEEAAPRRGR STRRSSFGLR VAFQFPTKKL
160 170 180 190 200
ARTPDKDSSH LLDSKTDLRR KKSSRQPKGK EDSASDAEDE SRAESQENSD
210 220 230 240 250
ALLKRAMNIK ENKAMLAQLL AELNSVPDFF PVRTPPSASR RRTPRRAFSE
260 270 280 290 300
GQITRRMNPT RSARPPEKFA LENFTFSATK LTEELYSFRR RKTISGGKCQ
310 320 330 340 350
TYRRHRISSF RSVKDITEED LENIAITVRD KVYDKVLGNT CHQCRQKTID
360 370 380 390 400
TKTVCRNQSC GGVRGQFCGP CLRNRYGEDV RTALLDPKWT CPPCRGICNC
410 420 430
SYCRRRDGRC ATGILIHLAK FYGYDNVKEY LESLQKQL
Length:438
Mass (Da):50,248
Last modified:December 1, 2001 - v1
Checksum:iD0BB5A15A0321ABA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK149673 mRNA. Translation: BAE29017.1.
BC006933 mRNA. Translation: AAH06933.1.
CCDSiCCDS49197.1.
RefSeqiNP_666152.1. NM_146040.1.
UniGeneiMm.281149.

Genome annotation databases

EnsembliENSMUST00000021592; ENSMUSP00000021592; ENSMUSG00000021175.
GeneIDi217946.
KEGGimmu:217946.
UCSCiuc007pid.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK149673 mRNA. Translation: BAE29017.1.
BC006933 mRNA. Translation: AAH06933.1.
CCDSiCCDS49197.1.
RefSeqiNP_666152.1. NM_146040.1.
UniGeneiMm.281149.

3D structure databases

ProteinModelPortaliQ922M5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi229982. 1 interactor.
STRINGi10090.ENSMUSP00000021592.

PTM databases

iPTMnetiQ922M5.
PhosphoSitePlusiQ922M5.

Proteomic databases

EPDiQ922M5.
MaxQBiQ922M5.
PaxDbiQ922M5.
PeptideAtlasiQ922M5.
PRIDEiQ922M5.

Protocols and materials databases

DNASUi217946.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000021592; ENSMUSP00000021592; ENSMUSG00000021175.
GeneIDi217946.
KEGGimmu:217946.
UCSCiuc007pid.1. mouse.

Organism-specific databases

CTDi55536.
MGIiMGI:2384982. Cdca7l.

Phylogenomic databases

eggNOGiENOG410IYXY. Eukaryota.
ENOG410XQV7. LUCA.
GeneTreeiENSGT00390000014657.
HOGENOMiHOG000231812.
HOVERGENiHBG060300.
InParanoidiQ922M5.
OMAiITRRMNP.
OrthoDBiEOG091G0A11.
PhylomeDBiQ922M5.
TreeFamiTF101076.

Miscellaneous databases

PROiQ922M5.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000021175.
CleanExiMM_CDCA7L.
ExpressionAtlasiQ922M5. baseline and differential.
GenevisibleiQ922M5. MM.

Family and domain databases

InterProiIPR033578. CDCA7L.
IPR018866. Znf-4CXXC_R1.
[Graphical view]
PANTHERiPTHR31169:SF4. PTHR31169:SF4. 1 hit.
PfamiPF10497. zf-4CXXC_R1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCDA7L_MOUSE
AccessioniPrimary (citable) accession number: Q922M5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 5, 2006
Last sequence update: December 1, 2001
Last modified: November 2, 2016
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.