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Protein

BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 3

Gene

Kctd10

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex. The BCR(BACURD3) E3 ubiquitin ligase complex mediates the ubiquitination of target proteins, leading to their degradation by the proteasome (By similarity).By similarity

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Ubl conjugation pathway

Enzyme and pathway databases

UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 3
Short name:
mBACURD3
Alternative name(s):
BTB/POZ domain-containing protein KCTD10
Gene namesi
Name:Kctd10
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:2141207. Kctd10.

Subcellular locationi

GO - Cellular componenti

  • Cul3-RING ubiquitin ligase complex Source: UniProtKB
  • cytoplasm Source: MGI
  • MKS complex Source: UniProtKB
  • nucleoplasm Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 315315BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 3PRO_0000247422Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineBy similarity
Modified residuei23 – 231PhosphoserineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ922M3.
MaxQBiQ922M3.
PaxDbiQ922M3.
PRIDEiQ922M3.

PTM databases

iPTMnetiQ922M3.
PhosphoSiteiQ922M3.

Expressioni

Gene expression databases

BgeeiENSMUSG00000001098.
ExpressionAtlasiQ922M3. baseline and differential.
GenevisibleiQ922M3. MM.

Interactioni

Subunit structurei

Component of the BCR(BACURD3) E3 ubiquitin ligase complex, at least composed of CUL3, KCTD10/BACURD3 and RBX1. Interacts with DNA polymerase delta subunit 2/POLD2. Interacts with PCNA (By similarity). Associated with the tectonic-like complex (also named B9 complex); however as Kctd10 has not been identified in all tectonic-like complexes purifications it is unclear whether it is really part of the complex.By similarity1 Publication

Protein-protein interaction databases

IntActiQ922M3. 3 interactions.
STRINGi10090.ENSMUSP00000001125.

Structurei

3D structure databases

ProteinModelPortaliQ922M3.
SMRiQ922M3. Positions 31-192.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini32 – 10069BTBPROSITE-ProRule annotationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi239 – 2457PCNA-bindingBy similarity

Sequence similaritiesi

Belongs to the BACURD family.Curated
Contains 1 BTB (POZ) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG2716. Eukaryota.
ENOG410XQYZ. LUCA.
GeneTreeiENSGT00530000063071.
HOGENOMiHOG000294088.
HOVERGENiHBG052219.
InParanoidiQ922M3.
KOiK15074.
PhylomeDBiQ922M3.

Family and domain databases

InterProiIPR000210. BTB/POZ_dom.
IPR011333. SKP1/BTB/POZ.
IPR003131. T1-type_BTB.
[Graphical view]
PfamiPF02214. BTB_2. 1 hit.
[Graphical view]
SMARTiSM00225. BTB. 1 hit.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.
PROSITEiPS50097. BTB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q922M3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEEMSGDSVV SSAVPAAATR TTSFKGASPS SKYVKLNVGG ALYYTTMQTL
60 70 80 90 100
TKQDTMLKAM FSGRMEVLTD SEGWILIDRC GKHFGTILNY LRDGGVPLPE
110 120 130 140 150
SRREIEELLA EAKYYLVQGL LEECQAALQN KDTYEPFCKV PVITSSKEEQ
160 170 180 190 200
RLIATSNKPA VKLLYNRSNN KYSYTSNSDD NMLKNIELFD KLSLRFNGRV
210 220 230 240 250
LFIKDVIGDE ICCWSFYGQG RKIAEVCCTS IVYATEKKQT KVEFPEARIY
260 270 280 290 300
EETLNILLYE AQDGRGPDNA LLEATGGAAG RSHHLDEDEE RERERIERVR
310
RIHIKRPDDR AHLHQ
Length:315
Mass (Da):35,701
Last modified:December 1, 2001 - v1
Checksum:i590AEF2D4F22D2D9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK028657 mRNA. Translation: BAC26050.1.
AK041516 mRNA. Translation: BAC30969.1.
AK145295 mRNA. Translation: BAE26350.1.
AK147714 mRNA. Translation: BAE28090.1.
AK161199 mRNA. Translation: BAE36235.1.
AK163351 mRNA. Translation: BAE37313.1.
AK166505 mRNA. Translation: BAE38815.1.
BC006935 mRNA. Translation: AAH06935.1.
CCDSiCCDS19563.1.
RefSeqiNP_001153413.1. NM_001159941.1.
NP_080421.2. NM_026145.4.
UniGeneiMm.238285.
Mm.428824.
Mm.490304.

Genome annotation databases

EnsembliENSMUST00000102581; ENSMUSP00000099641; ENSMUSG00000001098.
GeneIDi330171.
KEGGimmu:330171.
UCSCiuc008yzm.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK028657 mRNA. Translation: BAC26050.1.
AK041516 mRNA. Translation: BAC30969.1.
AK145295 mRNA. Translation: BAE26350.1.
AK147714 mRNA. Translation: BAE28090.1.
AK161199 mRNA. Translation: BAE36235.1.
AK163351 mRNA. Translation: BAE37313.1.
AK166505 mRNA. Translation: BAE38815.1.
BC006935 mRNA. Translation: AAH06935.1.
CCDSiCCDS19563.1.
RefSeqiNP_001153413.1. NM_001159941.1.
NP_080421.2. NM_026145.4.
UniGeneiMm.238285.
Mm.428824.
Mm.490304.

3D structure databases

ProteinModelPortaliQ922M3.
SMRiQ922M3. Positions 31-192.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ922M3. 3 interactions.
STRINGi10090.ENSMUSP00000001125.

PTM databases

iPTMnetiQ922M3.
PhosphoSiteiQ922M3.

Proteomic databases

EPDiQ922M3.
MaxQBiQ922M3.
PaxDbiQ922M3.
PRIDEiQ922M3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000102581; ENSMUSP00000099641; ENSMUSG00000001098.
GeneIDi330171.
KEGGimmu:330171.
UCSCiuc008yzm.2. mouse.

Organism-specific databases

CTDi83892.
MGIiMGI:2141207. Kctd10.

Phylogenomic databases

eggNOGiKOG2716. Eukaryota.
ENOG410XQYZ. LUCA.
GeneTreeiENSGT00530000063071.
HOGENOMiHOG000294088.
HOVERGENiHBG052219.
InParanoidiQ922M3.
KOiK15074.
PhylomeDBiQ922M3.

Enzyme and pathway databases

UniPathwayiUPA00143.

Miscellaneous databases

PROiQ922M3.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000001098.
ExpressionAtlasiQ922M3. baseline and differential.
GenevisibleiQ922M3. MM.

Family and domain databases

InterProiIPR000210. BTB/POZ_dom.
IPR011333. SKP1/BTB/POZ.
IPR003131. T1-type_BTB.
[Graphical view]
PfamiPF02214. BTB_2. 1 hit.
[Graphical view]
SMARTiSM00225. BTB. 1 hit.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.
PROSITEiPS50097. BTB. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiBACD3_MOUSE
AccessioniPrimary (citable) accession number: Q922M3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: December 1, 2001
Last modified: September 7, 2016
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.