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Q922K9

- FRK_MOUSE

UniProt

Q922K9 - FRK_MOUSE

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Protein
Tyrosine-protein kinase FRK
Gene
Frk, Bsk, Iyk
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Non-receptor tyrosine-protein kinase that negatively regulates cell proliferation. Positively regulates PTEN protein stability through phosphorylation of PTEN on 'Tyr-336', which in turn prevents its ubiquitination and degradation, possibly by reducing its binding to NEDD4. May function as a tumor suppressor By similarity.

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei269 – 2691ATP By similarity
Active sitei361 – 3611Proton acceptor By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi247 – 2559ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. non-membrane spanning protein tyrosine kinase activity Source: UniProtKB-EC

GO - Biological processi

  1. cell differentiation Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase, Tyrosine-protein kinase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Tyrosine-protein kinase FRK (EC:2.7.10.2)
Alternative name(s):
Beta-cell Src-homology tyrosine kinase
Short name:
BSK
FYN-related kinase
Intestine tyrosine kinase
Gene namesi
Name:Frk
Synonyms:Bsk, Iyk
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 10

Organism-specific databases

MGIiMGI:103265. Frk.

Subcellular locationi

Cytoplasm By similarity. Nucleus By similarity
Note: Predominantly found in the nucleus, with a small fraction found in the cell periphery By similarity.

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
  2. nucleus Source: UniProtKB-SubCell
  3. plasma membrane Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Disruption phenotypei

Mice are viable and do not show any histological abnormalities in epithelial tissues or develop any pathological and/or metabolic disorders associated with the failure of epithelial organs.1 Publication

Keywords - Diseasei

Tumor suppressor

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 512512Tyrosine-protein kinase FRK
PRO_0000260826Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei394 – 3941Phosphotyrosine; by autocatalysis1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ922K9.
PaxDbiQ922K9.
PRIDEiQ922K9.

PTM databases

PhosphoSiteiQ922K9.

Expressioni

Tissue specificityi

Expressed in intestinal tract, fetal and adult islets of Langerhans, kidney, liver and lung.2 Publications

Gene expression databases

BgeeiQ922K9.
CleanExiMM_FRK.
GenevestigatoriQ922K9.

Interactioni

Subunit structurei

Interacts (via the SH3-domain) with PTEN. Interacts with RB1 By similarity.

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000019913.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi52 – 587
Beta strandi63 – 675
Beta strandi76 – 805
Beta strandi83 – 919
Beta strandi103 – 1086
Turni109 – 1113
Beta strandi112 – 1143
Helixi116 – 1205
Beta strandi122 – 1243
Helixi130 – 1378
Beta strandi138 – 1414
Beta strandi147 – 1515
Beta strandi153 – 1575
Beta strandi159 – 1679
Beta strandi169 – 1768
Beta strandi178 – 1803
Beta strandi182 – 1854
Beta strandi188 – 1925
Helixi193 – 2008
Beta strandi205 – 2095

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2D8JNMR-A52-115[»]
2DLYNMR-A113-220[»]
ProteinModelPortaliQ922K9.
SMRiQ922K9. Positions 49-510.

Miscellaneous databases

EvolutionaryTraceiQ922K9.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini42 – 11776SH3
Add
BLAST
Domaini123 – 21593SH2
Add
BLAST
Domaini241 – 498258Protein kinase
Add
BLAST

Sequence similaritiesi

Contains 1 SH2 domain.
Contains 1 SH3 domain.

Keywords - Domaini

SH2 domain, SH3 domain

Phylogenomic databases

eggNOGiCOG0515.
GeneTreeiENSGT00640000091347.
HOGENOMiHOG000233858.
HOVERGENiHBG008761.
InParanoidiQ922K9.
KOiK08892.
OMAiVSHYTKT.
OrthoDBiEOG7GTT2V.
PhylomeDBiQ922K9.
TreeFamiTF351634.

Family and domain databases

Gene3Di3.30.505.10. 1 hit.
InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR000980. SH2.
IPR001452. SH3_domain.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
[Graphical view]
PfamiPF07714. Pkinase_Tyr. 1 hit.
PF00017. SH2. 1 hit.
PF00018. SH3_1. 1 hit.
[Graphical view]
PRINTSiPR00401. SH2DOMAIN.
PR00452. SH3DOMAIN.
PR00109. TYRKINASE.
SMARTiSM00252. SH2. 1 hit.
SM00326. SH3. 1 hit.
SM00219. TyrKc. 1 hit.
[Graphical view]
SUPFAMiSSF50044. SSF50044. 1 hit.
SSF55550. SSF55550. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
PS50001. SH2. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q922K9-1 [UniParc]FASTAAdd to Basket

« Hide

MGSVCVRLWA YLQPFLPCWS QEADKSVVIE NPGAFCPPEA PRSQEPERSH    50
GQYFVALFDY QARTAEDLSF RAGDKLQVLD TSHEGWWLAR HLEKKGTGLG 100
QQLQGYIPSN YVAEDRSLQA EPWFFGAIKR ADAEKQLLYS ENQTGAFLIR 150
ESESQKGDFS LSVLDEGVVK HYRIRRLDEG GFFLTRRKVF STLNEFVNYY 200
TTTSDGLCVK LEKPCLKIQV PTPFDLSYKT ADQWEIDRNS IQLLKRLGSG 250
QFGEVWEGLW NNTTPVAVKT LKPGSMDPND FLREAQIMKS LRHPKLIQLY 300
AVCTLEDPIY IITELMRHGS LQEYLQNDGG SKIHLIQQVD MAAQVASGMA 350
YLESQNYIHR DLAARNVLVG EHNIYKVADF GLARVFKVDN EDIYESKHEI 400
KLPVKWTAPE AIRTNKFSIK SDVWSFGILL YEIITYGKMP YSGMTGAQVI 450
QMLSQNYRLP QPSNCPQQFY SIMLECWNVE PKQRPTFETL HWKLEDYFET 500
DCSYSDTNNF IN 512
Length:512
Mass (Da):58,844
Last modified:January 23, 2007 - v3
Checksum:iB79A0BC07B9EC5F8
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti154 – 1541S → T in CAA88658. 1 Publication
Sequence conflicti237 – 2371D → H in CAA88658. 1 Publication
Sequence conflicti335 – 3351L → F in CAA88658. 1 Publication
Sequence conflicti335 – 3351L → F in AAA65197. 1 Publication
Sequence conflicti509 – 5091N → K in CAA88658. 1 Publication
Sequence conflicti509 – 5091N → K in AAA65197. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z48757 mRNA. Translation: CAA88658.1.
L36132 mRNA. Translation: AAA65197.1.
AK028855 mRNA. Translation: BAC26155.1.
AK052614 mRNA. Translation: BAC35063.1.
AK166379 mRNA. Translation: BAE38741.1.
BC007137 mRNA. Translation: AAH07137.1.
CCDSiCCDS23781.1.
PIRiI49552.
RefSeqiNP_001153016.1. NM_001159544.1.
NP_034367.2. NM_010237.3.
XP_006512597.1. XM_006512534.1.
XP_006512598.1. XM_006512535.1.
XP_006512599.1. XM_006512536.1.
UniGeneiMm.332432.

Genome annotation databases

EnsembliENSMUST00000019913; ENSMUSP00000019913; ENSMUSG00000019779.
ENSMUST00000170771; ENSMUSP00000130289; ENSMUSG00000019779.
GeneIDi14302.
KEGGimmu:14302.
UCSCiuc007euy.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z48757 mRNA. Translation: CAA88658.1 .
L36132 mRNA. Translation: AAA65197.1 .
AK028855 mRNA. Translation: BAC26155.1 .
AK052614 mRNA. Translation: BAC35063.1 .
AK166379 mRNA. Translation: BAE38741.1 .
BC007137 mRNA. Translation: AAH07137.1 .
CCDSi CCDS23781.1.
PIRi I49552.
RefSeqi NP_001153016.1. NM_001159544.1.
NP_034367.2. NM_010237.3.
XP_006512597.1. XM_006512534.1.
XP_006512598.1. XM_006512535.1.
XP_006512599.1. XM_006512536.1.
UniGenei Mm.332432.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2D8J NMR - A 52-115 [» ]
2DLY NMR - A 113-220 [» ]
ProteinModelPortali Q922K9.
SMRi Q922K9. Positions 49-510.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000019913.

PTM databases

PhosphoSitei Q922K9.

Proteomic databases

MaxQBi Q922K9.
PaxDbi Q922K9.
PRIDEi Q922K9.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000019913 ; ENSMUSP00000019913 ; ENSMUSG00000019779 .
ENSMUST00000170771 ; ENSMUSP00000130289 ; ENSMUSG00000019779 .
GeneIDi 14302.
KEGGi mmu:14302.
UCSCi uc007euy.2. mouse.

Organism-specific databases

CTDi 2444.
MGIi MGI:103265. Frk.

Phylogenomic databases

eggNOGi COG0515.
GeneTreei ENSGT00640000091347.
HOGENOMi HOG000233858.
HOVERGENi HBG008761.
InParanoidi Q922K9.
KOi K08892.
OMAi VSHYTKT.
OrthoDBi EOG7GTT2V.
PhylomeDBi Q922K9.
TreeFami TF351634.

Miscellaneous databases

EvolutionaryTracei Q922K9.
NextBioi 285723.
PROi Q922K9.
SOURCEi Search...

Gene expression databases

Bgeei Q922K9.
CleanExi MM_FRK.
Genevestigatori Q922K9.

Family and domain databases

Gene3Di 3.30.505.10. 1 hit.
InterProi IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR000980. SH2.
IPR001452. SH3_domain.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
[Graphical view ]
Pfami PF07714. Pkinase_Tyr. 1 hit.
PF00017. SH2. 1 hit.
PF00018. SH3_1. 1 hit.
[Graphical view ]
PRINTSi PR00401. SH2DOMAIN.
PR00452. SH3DOMAIN.
PR00109. TYRKINASE.
SMARTi SM00252. SH2. 1 hit.
SM00326. SH3. 1 hit.
SM00219. TyrKc. 1 hit.
[Graphical view ]
SUPFAMi SSF50044. SSF50044. 1 hit.
SSF55550. SSF55550. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
PS50001. SH2. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "iyk, a novel intracellular protein tyrosine kinase differentially expressed in the mouse mammary gland and intestine."
    Thuveson M., Albrecht D., Zuercher G., Andres A., Ziemiecki A.
    Biochem. Biophys. Res. Commun. 209:582-589(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    Strain: BALB/c.
    Tissue: Mammary gland.
  2. "Cloning of BSK, a murine FRK homologue with a specific pattern of tissue distribution."
    Oberg-Welsh C., Welsh M.
    Gene 152:239-242(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
  3. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Kidney, Mammary gland and Skin.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Mammary tumor.
  5. "Characterization of mice deficient in the Src family nonreceptor tyrosine kinase Frk/rak."
    Chandrasekharan S., Qiu T.H., Alkharouf N., Brantley K., Mitchell J.B., Liu E.T.
    Mol. Cell. Biol. 22:5235-5247(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: DISRUPTION PHENOTYPE.
  6. "The tyrosine kinase FRK/RAK participates in cytokine-induced islet cell cytotoxicity."
    Welsh M., Welsh C., Ekman M., Dixelius J., Hagerkvist R., Anneren C., Akerblom B., Mahboobi S., Chandrasekharan S., Liu E.T.
    Biochem. J. 382:261-268(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: AUTOPHOSPHORYLATION AT TYR-394.
  7. "Solution structure of the SH3 and SH2 domains of FYN-related kinase."
    RIKEN structural genomics initiative (RSGI)
    Submitted (OCT-2006) to the PDB data bank
    Cited for: STRUCTURE BY NMR OF 50-220.

Entry informationi

Entry nameiFRK_MOUSE
AccessioniPrimary (citable) accession number: Q922K9
Secondary accession number(s): Q61364, Q61745
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: January 23, 2007
Last modified: July 9, 2014
This is version 110 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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