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Protein

Tyrosine-protein kinase FRK

Gene

Frk

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Non-receptor tyrosine-protein kinase that negatively regulates cell proliferation. Positively regulates PTEN protein stability through phosphorylation of PTEN on 'Tyr-336', which in turn prevents its ubiquitination and degradation, possibly by reducing its binding to NEDD4. May function as a tumor suppressor (By similarity).By similarity

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei269ATPPROSITE-ProRule annotation1
Active sitei361Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi247 – 255ATPPROSITE-ProRule annotation9

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase, Tyrosine-protein kinase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-MMU-6798695. Neutrophil degranulation.

Names & Taxonomyi

Protein namesi
Recommended name:
Tyrosine-protein kinase FRK (EC:2.7.10.2)
Alternative name(s):
Beta-cell Src-homology tyrosine kinase
Short name:
BSK
FYN-related kinase
Intestine tyrosine kinase
Gene namesi
Name:Frk
Synonyms:Bsk, Iyk
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:103265. Frk.

Subcellular locationi

  • Cytoplasm By similarity
  • Nucleus By similarity

  • Note: Predominantly found in the nucleus, with a small fraction found in the cell periphery.By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Disruption phenotypei

Mice are viable and do not show any histological abnormalities in epithelial tissues or develop any pathological and/or metabolic disorders associated with the failure of epithelial organs.1 Publication

Keywords - Diseasei

Tumor suppressor

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002608261 – 512Tyrosine-protein kinase FRKAdd BLAST512

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei185PhosphothreonineBy similarity1
Modified residuei394Phosphotyrosine; by autocatalysis1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ922K9.
PaxDbiQ922K9.
PeptideAtlasiQ922K9.
PRIDEiQ922K9.

PTM databases

iPTMnetiQ922K9.
PhosphoSitePlusiQ922K9.

Expressioni

Tissue specificityi

Expressed in intestinal tract, fetal and adult islets of Langerhans, kidney, liver and lung.2 Publications

Gene expression databases

BgeeiENSMUSG00000019779.
CleanExiMM_FRK.
GenevisibleiQ922K9. MM.

Interactioni

Subunit structurei

Interacts (via the SH3-domain) with PTEN. Interacts with RB1 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000019913.

Structurei

Secondary structure

1512
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi52 – 58Combined sources7
Beta strandi63 – 67Combined sources5
Beta strandi76 – 80Combined sources5
Beta strandi83 – 91Combined sources9
Beta strandi103 – 108Combined sources6
Turni109 – 111Combined sources3
Beta strandi112 – 114Combined sources3
Helixi116 – 120Combined sources5
Beta strandi122 – 124Combined sources3
Helixi130 – 137Combined sources8
Beta strandi138 – 141Combined sources4
Beta strandi147 – 151Combined sources5
Beta strandi153 – 157Combined sources5
Beta strandi159 – 167Combined sources9
Beta strandi169 – 176Combined sources8
Beta strandi178 – 180Combined sources3
Beta strandi182 – 185Combined sources4
Beta strandi188 – 192Combined sources5
Helixi193 – 200Combined sources8
Beta strandi205 – 209Combined sources5

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2D8JNMR-A52-115[»]
2DLYNMR-A113-220[»]
ProteinModelPortaliQ922K9.
SMRiQ922K9.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ922K9.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini42 – 117SH3PROSITE-ProRule annotationAdd BLAST76
Domaini123 – 215SH2PROSITE-ProRule annotationAdd BLAST93
Domaini241 – 498Protein kinasePROSITE-ProRule annotationAdd BLAST258

Sequence similaritiesi

Belongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamily.PROSITE-ProRule annotation
Contains 1 protein kinase domain.PROSITE-ProRule annotation
Contains 1 SH2 domain.PROSITE-ProRule annotation
Contains 1 SH3 domain.PROSITE-ProRule annotation

Keywords - Domaini

SH2 domain, SH3 domain

Phylogenomic databases

eggNOGiKOG0197. Eukaryota.
COG0515. LUCA.
GeneTreeiENSGT00760000118938.
HOGENOMiHOG000233858.
HOVERGENiHBG008761.
InParanoidiQ922K9.
KOiK08892.
OMAiIRTNKFS.
OrthoDBiEOG091G0D46.
PhylomeDBiQ922K9.
TreeFamiTF351634.

Family and domain databases

Gene3Di3.30.505.10. 1 hit.
InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR000980. SH2.
IPR001452. SH3_domain.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
[Graphical view]
PfamiPF07714. Pkinase_Tyr. 1 hit.
PF00017. SH2. 1 hit.
PF00018. SH3_1. 1 hit.
[Graphical view]
PRINTSiPR00401. SH2DOMAIN.
PR00452. SH3DOMAIN.
PR00109. TYRKINASE.
SMARTiSM00252. SH2. 1 hit.
SM00326. SH3. 1 hit.
SM00219. TyrKc. 1 hit.
[Graphical view]
SUPFAMiSSF50044. SSF50044. 1 hit.
SSF55550. SSF55550. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
PS50001. SH2. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q922K9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGSVCVRLWA YLQPFLPCWS QEADKSVVIE NPGAFCPPEA PRSQEPERSH
60 70 80 90 100
GQYFVALFDY QARTAEDLSF RAGDKLQVLD TSHEGWWLAR HLEKKGTGLG
110 120 130 140 150
QQLQGYIPSN YVAEDRSLQA EPWFFGAIKR ADAEKQLLYS ENQTGAFLIR
160 170 180 190 200
ESESQKGDFS LSVLDEGVVK HYRIRRLDEG GFFLTRRKVF STLNEFVNYY
210 220 230 240 250
TTTSDGLCVK LEKPCLKIQV PTPFDLSYKT ADQWEIDRNS IQLLKRLGSG
260 270 280 290 300
QFGEVWEGLW NNTTPVAVKT LKPGSMDPND FLREAQIMKS LRHPKLIQLY
310 320 330 340 350
AVCTLEDPIY IITELMRHGS LQEYLQNDGG SKIHLIQQVD MAAQVASGMA
360 370 380 390 400
YLESQNYIHR DLAARNVLVG EHNIYKVADF GLARVFKVDN EDIYESKHEI
410 420 430 440 450
KLPVKWTAPE AIRTNKFSIK SDVWSFGILL YEIITYGKMP YSGMTGAQVI
460 470 480 490 500
QMLSQNYRLP QPSNCPQQFY SIMLECWNVE PKQRPTFETL HWKLEDYFET
510
DCSYSDTNNF IN
Length:512
Mass (Da):58,844
Last modified:January 23, 2007 - v3
Checksum:iB79A0BC07B9EC5F8
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti154S → T in CAA88658 (PubMed:7733928).Curated1
Sequence conflicti237D → H in CAA88658 (PubMed:7733928).Curated1
Sequence conflicti335L → F in CAA88658 (PubMed:7733928).Curated1
Sequence conflicti335L → F in AAA65197 (PubMed:7835707).Curated1
Sequence conflicti509N → K in CAA88658 (PubMed:7733928).Curated1
Sequence conflicti509N → K in AAA65197 (PubMed:7835707).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z48757 mRNA. Translation: CAA88658.1.
L36132 mRNA. Translation: AAA65197.1.
AK028855 mRNA. Translation: BAC26155.1.
AK052614 mRNA. Translation: BAC35063.1.
AK166379 mRNA. Translation: BAE38741.1.
BC007137 mRNA. Translation: AAH07137.1.
CCDSiCCDS23781.1.
PIRiI49552.
RefSeqiNP_001153016.1. NM_001159544.1.
NP_034367.2. NM_010237.3.
XP_006512597.1. XM_006512534.3.
XP_006512598.1. XM_006512535.3.
XP_006512599.1. XM_006512536.3.
UniGeneiMm.332432.

Genome annotation databases

EnsembliENSMUST00000019913; ENSMUSP00000019913; ENSMUSG00000019779.
ENSMUST00000170771; ENSMUSP00000130289; ENSMUSG00000019779.
GeneIDi14302.
KEGGimmu:14302.
UCSCiuc007euy.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z48757 mRNA. Translation: CAA88658.1.
L36132 mRNA. Translation: AAA65197.1.
AK028855 mRNA. Translation: BAC26155.1.
AK052614 mRNA. Translation: BAC35063.1.
AK166379 mRNA. Translation: BAE38741.1.
BC007137 mRNA. Translation: AAH07137.1.
CCDSiCCDS23781.1.
PIRiI49552.
RefSeqiNP_001153016.1. NM_001159544.1.
NP_034367.2. NM_010237.3.
XP_006512597.1. XM_006512534.3.
XP_006512598.1. XM_006512535.3.
XP_006512599.1. XM_006512536.3.
UniGeneiMm.332432.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2D8JNMR-A52-115[»]
2DLYNMR-A113-220[»]
ProteinModelPortaliQ922K9.
SMRiQ922K9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000019913.

PTM databases

iPTMnetiQ922K9.
PhosphoSitePlusiQ922K9.

Proteomic databases

MaxQBiQ922K9.
PaxDbiQ922K9.
PeptideAtlasiQ922K9.
PRIDEiQ922K9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000019913; ENSMUSP00000019913; ENSMUSG00000019779.
ENSMUST00000170771; ENSMUSP00000130289; ENSMUSG00000019779.
GeneIDi14302.
KEGGimmu:14302.
UCSCiuc007euy.2. mouse.

Organism-specific databases

CTDi2444.
MGIiMGI:103265. Frk.

Phylogenomic databases

eggNOGiKOG0197. Eukaryota.
COG0515. LUCA.
GeneTreeiENSGT00760000118938.
HOGENOMiHOG000233858.
HOVERGENiHBG008761.
InParanoidiQ922K9.
KOiK08892.
OMAiIRTNKFS.
OrthoDBiEOG091G0D46.
PhylomeDBiQ922K9.
TreeFamiTF351634.

Enzyme and pathway databases

ReactomeiR-MMU-6798695. Neutrophil degranulation.

Miscellaneous databases

EvolutionaryTraceiQ922K9.
PROiQ922K9.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000019779.
CleanExiMM_FRK.
GenevisibleiQ922K9. MM.

Family and domain databases

Gene3Di3.30.505.10. 1 hit.
InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR000980. SH2.
IPR001452. SH3_domain.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
[Graphical view]
PfamiPF07714. Pkinase_Tyr. 1 hit.
PF00017. SH2. 1 hit.
PF00018. SH3_1. 1 hit.
[Graphical view]
PRINTSiPR00401. SH2DOMAIN.
PR00452. SH3DOMAIN.
PR00109. TYRKINASE.
SMARTiSM00252. SH2. 1 hit.
SM00326. SH3. 1 hit.
SM00219. TyrKc. 1 hit.
[Graphical view]
SUPFAMiSSF50044. SSF50044. 1 hit.
SSF55550. SSF55550. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
PS50001. SH2. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFRK_MOUSE
AccessioniPrimary (citable) accession number: Q922K9
Secondary accession number(s): Q61364, Q61745
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: January 23, 2007
Last modified: November 30, 2016
This is version 131 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.