Reviewed,
UniProtKB/Swiss-Prot Q922K9 (FRK_MOUSE)
Last modified
February 9, 2010.
Version 74.
History...
Clusters with 100%,
90%,
50% identity |
Documents (4) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Tyrosine-protein kinase FRK EC=2.7.10.2 Alternative name(s): FYN-related kinase Beta-cell Src-homology tyrosine kinase Short name=BSK Intestine tyrosine kinase | ||||
| Gene names |
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| Organism | Mus musculus (Mouse) | ||||
| Taxonomic identifier | 10090 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus |
Protein attributes
| Sequence length | 512 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | Positively regulates PTEN protein stability through phosphorylation of PTEN on 'Tyr-336', which in turn prevents its ubiquitination and degradation possibly by reducing its binding to NEDD4. May function as a tumor suppressor By similarity. |
| Catalytic activity | ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate. |
| Subunit structure | Interacts (via the SH3-domain) with PTEN By similarity. |
| Subcellular location | Cytoplasm Probable. |
| Tissue specificity | Expressed in intestinal tract, fetal and adult islets of Langerhans, kidney, liver and lung. Ref.1 Ref.2 |
| Sequence similarities | Belongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamily. Contains 1 protein kinase domain. Contains 1 SH2 domain. Contains 1 SH3 domain. |
Ontologies
| Keywords | |
|---|---|
| Cellular component | Cytoplasm |
| Disease | Tumor suppressor |
| Domain | SH2 domain SH3 domain |
| Ligand | ATP-binding Nucleotide-binding |
| Molecular function | Kinase Transferase Tyrosine-protein kinase |
| PTM | Lipoprotein Myristate Phosphoprotein |
| Technical term | 3D-structure |
| Gene Ontology (GO) | |
| Biological process | protein amino acid phosphorylation Inferred from electronic annotation. Source: InterPro |
| Cellular component | cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | ATP binding Inferred from electronic annotation. Source: UniProtKB-KW non-membrane spanning protein tyrosine kinase activityInferred from electronic annotation. Source: EC protein bindingInferred from electronic annotation. Source: InterPro |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Initiator methionine | 1 | 1 | Removed By similarity | ||||||
| Chain | 2 – 512 | 511 | Tyrosine-protein kinase FRK | PRO_0000260826 | |||||
Regions | |||||||||
| Domain | 42 – 117 | 76 | SH3 | ||||||
| Domain | 123 – 215 | 93 | SH2 | ||||||
| Domain | 241 – 498 | 258 | Protein kinase | ||||||
| Nucleotide binding | 247 – 255 | 9 | ATP By similarity | ||||||
Sites | |||||||||
| Active site | 361 | 1 | Proton acceptor By similarity | ||||||
| Binding site | 269 | 1 | ATP By similarity | ||||||
Amino acid modifications | |||||||||
| Modified residue | 53 | 1 | Phosphotyrosine By similarity | ||||||
| Modified residue | 69 | 1 | Phosphoserine By similarity | ||||||
| Modified residue | 394 | 1 | Phosphotyrosine; by autocatalysis By similarity | ||||||
| Modified residue | 504 | 1 | Phosphotyrosine By similarity | ||||||
| Lipidation | 2 | 1 | N-myristoyl glycine By similarity | ||||||
Experimental info | |||||||||
| Sequence conflict | 154 | 1 | S → T in CAA88658. Ref.1 | ||||||
| Sequence conflict | 237 | 1 | D → H in CAA88658. Ref.1 | ||||||
| Sequence conflict | 335 | 1 | L → F in CAA88658. Ref.1 | ||||||
| Sequence conflict | 335 | 1 | L → F in AAA65197. Ref.2 | ||||||
| Sequence conflict | 509 | 1 | N → K in CAA88658. Ref.1 | ||||||
| Sequence conflict | 509 | 1 | N → K in AAA65197. Ref.2 | ||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "iyk, a novel intracellular protein tyrosine kinase differentially expressed in the mouse mammary gland and intestine." Thuveson M., Albrecht D., Zuercher G., Andres A., Ziemiecki A. Biochem. Biophys. Res. Commun. 209:582-589(1995) [PubMed: 7733928] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY. Strain: BALB/c. Tissue: Mammary gland. |
| [2] | "Cloning of BSK, a murine FRK homologue with a specific pattern of tissue distribution." Oberg-Welsh C., Welsh M. Gene 152:239-242(1995) [PubMed: 7835707] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY. |
| [3] | "The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. Hayashizaki Y.Science 309:1559-1563(2005) [PubMed: 16141072] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: C57BL/6J. Tissue: Kidney, Mammary gland and Skin. |
| [4] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: FVB/N. Tissue: Mammary tumor. |
| [5] | "Solution structure of the SH3 and SH2 domains of FYN-related kinase." RIKEN structural genomics initiative (RSGI) Submitted (OCT-2006) to the PDB data bank Cited for: STRUCTURE BY NMR OF 50-220. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| EMBL GenBank DDBJ | Z48757 mRNA. Translation: CAA88658.1. L36132 mRNA. Translation: AAA65197.1. AK028855 mRNA. Translation: BAC26155.1. AK052614 mRNA. Translation: BAC35063.1. AK166379 mRNA. Translation: BAE38741.1. BC007137 mRNA. Translation: AAH07137.1. | ||||||||||||||||||
| IPI | IPI00462777. | ||||||||||||||||||
| PIR | I49552. | ||||||||||||||||||
| RefSeq | NP_001153016.1. NP_034367.2. | ||||||||||||||||||
| UniGene | Mm.332432 | ||||||||||||||||||
3D structure databases | |||||||||||||||||||
| PDBe RCSB PDB PDBj |
| ||||||||||||||||||
| SMR | Q922K9. Positions 49-115, 113-223. | ||||||||||||||||||
| ModBase | Search... | ||||||||||||||||||
Protein-protein interaction databases | |||||||||||||||||||
| STRING | Q922K9. | ||||||||||||||||||
PTM databases | |||||||||||||||||||
| PhosphoSite | Q922K9. | ||||||||||||||||||
Proteomic databases | |||||||||||||||||||
| PRIDE | Q922K9. | ||||||||||||||||||
Genome annotation databases | |||||||||||||||||||
| Ensembl | ENSMUST00000019913; ENSMUSP00000019913; ENSMUSG00000019779; Mus musculus. [Genome view] | ||||||||||||||||||
| GeneID | 14302. | ||||||||||||||||||
| KEGG | mmu:14302. | ||||||||||||||||||
| UCSC | uc007euy.1. mouse. | ||||||||||||||||||
Organism-specific databases | |||||||||||||||||||
| CTD | 14302. | ||||||||||||||||||
| MGI | MGI:103265. Frk. | ||||||||||||||||||
Phylogenomic databases | |||||||||||||||||||
| eggNOG | roNOG06372. | ||||||||||||||||||
| HOGENOM | HBG755340. | ||||||||||||||||||
| HOVERGEN | Q922K9. | ||||||||||||||||||
| InParanoid | Q922K9. | ||||||||||||||||||
| OMA | QNDAGSK. | ||||||||||||||||||
| OrthoDB | EOG9QRKQD. | ||||||||||||||||||
| PhylomeDB | Q922K9. | ||||||||||||||||||
Enzyme and pathway databases | |||||||||||||||||||
| BRENDA | 2.7.10.2. 244. | ||||||||||||||||||
Gene expression databases | |||||||||||||||||||
| ArrayExpress | Q922K9. | ||||||||||||||||||
| Bgee | Q922K9. | ||||||||||||||||||
| CleanEx | MM_FRK. | ||||||||||||||||||
| Genevestigator | Q922K9. | ||||||||||||||||||
| GermOnline | ENSMUSG00000019779. Mus musculus. | ||||||||||||||||||
Family and domain databases | |||||||||||||||||||
| InterPro | IPR011009. Kinase-like_dom. IPR000719. Prot_kinase_cat_dom. IPR017441. Protein_kinase_ATP_BS. IPR000980. SH2. IPR001452. SH3_domain. IPR020473. SH3_region. IPR020702. Tyr_kinase_non-rcpt_FRK. IPR020635. Tyr_Pkinase_cat_dom. IPR020685. Tyr_prot_kinase. IPR008266. Tyr_prot_kinase_AS. [Graphical view] | ||||||||||||||||||
| Gene3D | G3DSA:3.30.505.10. SH2. 1 hit. | ||||||||||||||||||
| PANTHER | PTHR23256:SF146. Tyr_kinase_non-rcpt_FRK. 1 hit. PTHR23256. Tyr_prot_kinase. 1 hit. | ||||||||||||||||||
| Pfam | PF00017. SH2. 1 hit. PF00018. SH3_1. 1 hit. [Graphical view] | ||||||||||||||||||
| PRINTS | PR00401. SH2DOMAIN. PR00452. SH3DOMAIN. | ||||||||||||||||||
| SMART | SM00252. SH2. 1 hit. SM00326. SH3. 1 hit. SM00219. TyrKc. 1 hit. [Graphical view] | ||||||||||||||||||
| PROSITE | PS00107. PROTEIN_KINASE_ATP. 1 hit. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00109. PROTEIN_KINASE_TYR. 1 hit. PS50001. SH2. 1 hit. PS50002. SH3. 1 hit. [Graphical view] | ||||||||||||||||||
| ProtoNet | Search... | ||||||||||||||||||
Other Resources | |||||||||||||||||||
| NextBio | 285723. | ||||||||||||||||||
| SOURCE | Search... | ||||||||||||||||||
Entry information
| Entry name | FRK_MOUSE | ||||||||
| Accession | Primary (citable) accession number: Q922K9 Secondary accession number(s): Q61364, Q61745 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| MGD cross-references Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot |
| PDB cross-references Index of Protein Data Bank (PDB) cross-references |
| Human and mouse protein kinases Human and mouse protein kinases: classification and index |
| SIMILARITY comments Index of protein domains and families |

Clusters with


