Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Tyrosine-protein kinase FRK

Gene

Frk

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Non-receptor tyrosine-protein kinase that negatively regulates cell proliferation. Positively regulates PTEN protein stability through phosphorylation of PTEN on 'Tyr-336', which in turn prevents its ubiquitination and degradation, possibly by reducing its binding to NEDD4. May function as a tumor suppressor (By similarity).By similarity

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei269ATPPROSITE-ProRule annotation1
Active sitei361Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi247 – 255ATPPROSITE-ProRule annotation9

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase, Tyrosine-protein kinase
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-MMU-6798695 Neutrophil degranulation
R-MMU-8948751 Regulation of PTEN stability and activity

Names & Taxonomyi

Protein namesi
Recommended name:
Tyrosine-protein kinase FRK (EC:2.7.10.2)
Alternative name(s):
Beta-cell Src-homology tyrosine kinase
Short name:
BSK
FYN-related kinase
Intestine tyrosine kinase
Gene namesi
Name:Frk
Synonyms:Bsk, Iyk
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi

Organism-specific databases

MGIiMGI:103265 Frk

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Disruption phenotypei

Mice are viable and do not show any histological abnormalities in epithelial tissues or develop any pathological and/or metabolic disorders associated with the failure of epithelial organs.1 Publication

Keywords - Diseasei

Tumor suppressor

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002608261 – 512Tyrosine-protein kinase FRKAdd BLAST512

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei185PhosphothreonineBy similarity1
Modified residuei394Phosphotyrosine; by autocatalysis1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ922K9
PaxDbiQ922K9
PeptideAtlasiQ922K9
PRIDEiQ922K9

PTM databases

iPTMnetiQ922K9
PhosphoSitePlusiQ922K9

Expressioni

Tissue specificityi

Expressed in intestinal tract, fetal and adult islets of Langerhans, kidney, liver and lung.2 Publications

Gene expression databases

BgeeiENSMUSG00000019779
CleanExiMM_FRK
GenevisibleiQ922K9 MM

Interactioni

Subunit structurei

Interacts (via the SH3-domain) with PTEN. Interacts with RB1 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000019913

Structurei

Secondary structure

1512
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi52 – 58Combined sources7
Beta strandi63 – 67Combined sources5
Beta strandi76 – 80Combined sources5
Beta strandi83 – 91Combined sources9
Beta strandi103 – 108Combined sources6
Turni109 – 111Combined sources3
Beta strandi112 – 114Combined sources3
Helixi116 – 120Combined sources5
Beta strandi122 – 124Combined sources3
Helixi130 – 137Combined sources8
Beta strandi138 – 141Combined sources4
Beta strandi147 – 151Combined sources5
Beta strandi153 – 157Combined sources5
Beta strandi159 – 167Combined sources9
Beta strandi169 – 176Combined sources8
Beta strandi178 – 180Combined sources3
Beta strandi182 – 185Combined sources4
Beta strandi188 – 192Combined sources5
Helixi193 – 200Combined sources8
Beta strandi205 – 209Combined sources5

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2D8JNMR-A52-115[»]
2DLYNMR-A113-220[»]
ProteinModelPortaliQ922K9
SMRiQ922K9
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ922K9

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini49 – 117SH3PROSITE-ProRule annotationAdd BLAST69
Domaini123 – 215SH2PROSITE-ProRule annotationAdd BLAST93
Domaini241 – 498Protein kinasePROSITE-ProRule annotationAdd BLAST258

Sequence similaritiesi

Belongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamily.PROSITE-ProRule annotation

Keywords - Domaini

SH2 domain, SH3 domain

Phylogenomic databases

eggNOGiKOG0197 Eukaryota
COG0515 LUCA
GeneTreeiENSGT00760000118938
HOGENOMiHOG000233858
HOVERGENiHBG008761
InParanoidiQ922K9
KOiK08892
OMAiSDGLCVK
OrthoDBiEOG091G0D46
PhylomeDBiQ922K9
TreeFamiTF351634

Family and domain databases

CDDicd10369 SH2_Src_Frk, 1 hit
Gene3Di3.30.505.10, 1 hit
InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR001245 Ser-Thr/Tyr_kinase_cat_dom
IPR000980 SH2
IPR036860 SH2_dom_sf
IPR035805 SH2_Frk
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
IPR008266 Tyr_kinase_AS
IPR020635 Tyr_kinase_cat_dom
PfamiView protein in Pfam
PF07714 Pkinase_Tyr, 1 hit
PF00017 SH2, 1 hit
PF00018 SH3_1, 1 hit
PRINTSiPR00401 SH2DOMAIN
PR00452 SH3DOMAIN
PR00109 TYRKINASE
SMARTiView protein in SMART
SM00252 SH2, 1 hit
SM00326 SH3, 1 hit
SM00219 TyrKc, 1 hit
SUPFAMiSSF50044 SSF50044, 1 hit
SSF55550 SSF55550, 1 hit
SSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00109 PROTEIN_KINASE_TYR, 1 hit
PS50001 SH2, 1 hit
PS50002 SH3, 1 hit

Sequencei

Sequence statusi: Complete.

Q922K9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGSVCVRLWA YLQPFLPCWS QEADKSVVIE NPGAFCPPEA PRSQEPERSH
60 70 80 90 100
GQYFVALFDY QARTAEDLSF RAGDKLQVLD TSHEGWWLAR HLEKKGTGLG
110 120 130 140 150
QQLQGYIPSN YVAEDRSLQA EPWFFGAIKR ADAEKQLLYS ENQTGAFLIR
160 170 180 190 200
ESESQKGDFS LSVLDEGVVK HYRIRRLDEG GFFLTRRKVF STLNEFVNYY
210 220 230 240 250
TTTSDGLCVK LEKPCLKIQV PTPFDLSYKT ADQWEIDRNS IQLLKRLGSG
260 270 280 290 300
QFGEVWEGLW NNTTPVAVKT LKPGSMDPND FLREAQIMKS LRHPKLIQLY
310 320 330 340 350
AVCTLEDPIY IITELMRHGS LQEYLQNDGG SKIHLIQQVD MAAQVASGMA
360 370 380 390 400
YLESQNYIHR DLAARNVLVG EHNIYKVADF GLARVFKVDN EDIYESKHEI
410 420 430 440 450
KLPVKWTAPE AIRTNKFSIK SDVWSFGILL YEIITYGKMP YSGMTGAQVI
460 470 480 490 500
QMLSQNYRLP QPSNCPQQFY SIMLECWNVE PKQRPTFETL HWKLEDYFET
510
DCSYSDTNNF IN
Length:512
Mass (Da):58,844
Last modified:January 23, 2007 - v3
Checksum:iB79A0BC07B9EC5F8
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti154S → T in CAA88658 (PubMed:7733928).Curated1
Sequence conflicti237D → H in CAA88658 (PubMed:7733928).Curated1
Sequence conflicti335L → F in CAA88658 (PubMed:7733928).Curated1
Sequence conflicti335L → F in AAA65197 (PubMed:7835707).Curated1
Sequence conflicti509N → K in CAA88658 (PubMed:7733928).Curated1
Sequence conflicti509N → K in AAA65197 (PubMed:7835707).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z48757 mRNA Translation: CAA88658.1
L36132 mRNA Translation: AAA65197.1
AK028855 mRNA Translation: BAC26155.1
AK052614 mRNA Translation: BAC35063.1
AK166379 mRNA Translation: BAE38741.1
BC007137 mRNA Translation: AAH07137.1
CCDSiCCDS23781.1
PIRiI49552
RefSeqiNP_001153016.1, NM_001159544.1
NP_034367.2, NM_010237.3
XP_006512597.1, XM_006512534.3
XP_006512598.1, XM_006512535.3
XP_006512599.1, XM_006512536.3
UniGeneiMm.332432

Genome annotation databases

EnsembliENSMUST00000019913; ENSMUSP00000019913; ENSMUSG00000019779
ENSMUST00000170771; ENSMUSP00000130289; ENSMUSG00000019779
GeneIDi14302
KEGGimmu:14302
UCSCiuc007euy.2 mouse

Similar proteinsi

Entry informationi

Entry nameiFRK_MOUSE
AccessioniPrimary (citable) accession number: Q922K9
Secondary accession number(s): Q61364, Q61745
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: January 23, 2007
Last modified: May 23, 2018
This is version 141 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  4. SIMILARITY comments
    Index of protein domains and families

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health