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Q922J6

- TSN2_MOUSE

UniProt

Q922J6 - TSN2_MOUSE

Protein

Tetraspanin-2

Gene

Tspan2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 100 (01 Oct 2014)
      Sequence version 1 (01 Dec 2001)
      Previous versions | rss
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    Functioni

    May play a role in signalling in oligodendrocytes in the early stages of their terminal differentiation into myelin-forming glia and may also function in stabilizing the mature sheath.By similarity

    GO - Biological processi

    1. astrocyte development Source: MGI
    2. axon development Source: MGI
    3. brain development Source: Ensembl
    4. inflammatory response Source: MGI
    5. microglia development Source: MGI
    6. myelination Source: MGI
    7. oligodendrocyte differentiation Source: MGI

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Tetraspanin-2
    Short name:
    Tspan-2
    Gene namesi
    Name:Tspan2
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 3

    Organism-specific databases

    MGIiMGI:1917997. Tspan2.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. myelin sheath Source: MGI
    3. plasma membrane Source: MGI

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 221221Tetraspanin-2PRO_0000219237Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi139 – 1391N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    MaxQBiQ922J6.
    PaxDbiQ922J6.
    PRIDEiQ922J6.

    Expressioni

    Gene expression databases

    ArrayExpressiQ922J6.
    BgeeiQ922J6.
    CleanExiMM_TSPAN2.
    GenevestigatoriQ922J6.

    Interactioni

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000029451.

    Structurei

    3D structure databases

    ProteinModelPortaliQ922J6.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 1313CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini35 – 5420ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini76 – 9015CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini112 – 18877ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini210 – 22112CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei14 – 3421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei55 – 7521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei91 – 11121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei189 – 20921HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the tetraspanin (TM4SF) family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG293348.
    GeneTreeiENSGT00680000099842.
    HOGENOMiHOG000230651.
    HOVERGENiHBG002324.
    InParanoidiQ922J6.
    KOiK17354.
    OMAiWFRFGGT.
    OrthoDBiEOG72JWHF.
    PhylomeDBiQ922J6.
    TreeFamiTF352895.

    Family and domain databases

    Gene3Di1.10.1450.10. 1 hit.
    InterProiIPR028977. CD81_LEL.
    IPR000301. Tetraspanin.
    IPR018499. Tetraspanin/Peripherin.
    IPR018503. Tetraspanin_CS.
    IPR008952. Tetraspanin_EC2.
    [Graphical view]
    PfamiPF00335. Tetraspannin. 1 hit.
    [Graphical view]
    PIRSFiPIRSF002419. Tetraspanin. 1 hit.
    PRINTSiPR00259. TMFOUR.
    SUPFAMiSSF48652. SSF48652. 1 hit.
    PROSITEiPS00421. TM4_1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q922J6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGRFRGGLRC IKYLLLGFNL LFWLAGSAVI AFGLWFRFGG TMKDLSSEDK    50
    SPEYFYVGLY VLVGAGALMM TVGFFGCCGA MRESQCVLGS FFTCLLVIFA 100
    AEVTTGVFAF IGKDVAIRHV QSMYEEAYSD YLKDRARGNG TLITFHSAFQ 150
    CCGKESSEQV QPTCPKELPG HKNCIDKIET VISAKLQLIG IVGIGIAGLT 200
    IFGMIFSMVL CCAIRNSRDV I 221
    Length:221
    Mass (Da):24,181
    Last modified:December 1, 2001 - v1
    Checksum:i9DF8BE399DD3EE5A
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti68 – 681L → M in BAB31109. (PubMed:16141072)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK018178 mRNA. Translation: BAB31109.1.
    AK032520 mRNA. Translation: BAC27907.1.
    AK049888 mRNA. Translation: BAC33972.1.
    AK079560 mRNA. Translation: BAC37684.1.
    BC007185 mRNA. Translation: AAH07185.1.
    CCDSiCCDS17688.1.
    RefSeqiNP_081809.2. NM_027533.3.
    UniGeneiMm.27469.

    Genome annotation databases

    EnsembliENSMUST00000029451; ENSMUSP00000029451; ENSMUSG00000027858.
    GeneIDi70747.
    KEGGimmu:70747.
    UCSCiuc008qrw.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK018178 mRNA. Translation: BAB31109.1 .
    AK032520 mRNA. Translation: BAC27907.1 .
    AK049888 mRNA. Translation: BAC33972.1 .
    AK079560 mRNA. Translation: BAC37684.1 .
    BC007185 mRNA. Translation: AAH07185.1 .
    CCDSi CCDS17688.1.
    RefSeqi NP_081809.2. NM_027533.3.
    UniGenei Mm.27469.

    3D structure databases

    ProteinModelPortali Q922J6.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000029451.

    Proteomic databases

    MaxQBi Q922J6.
    PaxDbi Q922J6.
    PRIDEi Q922J6.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000029451 ; ENSMUSP00000029451 ; ENSMUSG00000027858 .
    GeneIDi 70747.
    KEGGi mmu:70747.
    UCSCi uc008qrw.2. mouse.

    Organism-specific databases

    CTDi 10100.
    MGIi MGI:1917997. Tspan2.

    Phylogenomic databases

    eggNOGi NOG293348.
    GeneTreei ENSGT00680000099842.
    HOGENOMi HOG000230651.
    HOVERGENi HBG002324.
    InParanoidi Q922J6.
    KOi K17354.
    OMAi WFRFGGT.
    OrthoDBi EOG72JWHF.
    PhylomeDBi Q922J6.
    TreeFami TF352895.

    Miscellaneous databases

    NextBioi 332187.
    PROi Q922J6.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q922J6.
    Bgeei Q922J6.
    CleanExi MM_TSPAN2.
    Genevestigatori Q922J6.

    Family and domain databases

    Gene3Di 1.10.1450.10. 1 hit.
    InterProi IPR028977. CD81_LEL.
    IPR000301. Tetraspanin.
    IPR018499. Tetraspanin/Peripherin.
    IPR018503. Tetraspanin_CS.
    IPR008952. Tetraspanin_EC2.
    [Graphical view ]
    Pfami PF00335. Tetraspannin. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF002419. Tetraspanin. 1 hit.
    PRINTSi PR00259. TMFOUR.
    SUPFAMi SSF48652. SSF48652. 1 hit.
    PROSITEi PS00421. TM4_1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Hypothalamus and Medulla oblongata.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    3. Lubec G., Kang S.U.
      Submitted (APR-2007) to UniProtKB
      Cited for: PROTEIN SEQUENCE OF 155-166, IDENTIFICATION BY MASS SPECTROMETRY.
      Strain: C57BL/6.
      Tissue: Brain.

    Entry informationi

    Entry nameiTSN2_MOUSE
    AccessioniPrimary (citable) accession number: Q922J6
    Secondary accession number(s): Q543K4, Q9D397
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 19, 2002
    Last sequence update: December 1, 2001
    Last modified: October 1, 2014
    This is version 100 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3