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Protein

Tetraspanin-2

Gene

Tspan2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May play a role in signalling in oligodendrocytes in the early stages of their terminal differentiation into myelin-forming glia and may also function in stabilizing the mature sheath.By similarity

GO - Biological processi

  • astrocyte development Source: MGI
  • axon development Source: MGI
  • brain development Source: Ensembl
  • cell surface receptor signaling pathway Source: GO_Central
  • inflammatory response Source: MGI
  • microglia development Source: MGI
  • myelination Source: MGI
  • oligodendrocyte differentiation Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Tetraspanin-2
Short name:
Tspan-2
Gene namesi
Name:Tspan2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:1917997. Tspan2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 13CytoplasmicSequence analysisAdd BLAST13
Transmembranei14 – 34HelicalSequence analysisAdd BLAST21
Topological domaini35 – 54ExtracellularSequence analysisAdd BLAST20
Transmembranei55 – 75HelicalSequence analysisAdd BLAST21
Topological domaini76 – 90CytoplasmicSequence analysisAdd BLAST15
Transmembranei91 – 111HelicalSequence analysisAdd BLAST21
Topological domaini112 – 188ExtracellularSequence analysisAdd BLAST77
Transmembranei189 – 209HelicalSequence analysisAdd BLAST21
Topological domaini210 – 221CytoplasmicSequence analysisAdd BLAST12

GO - Cellular componenti

  • integral component of plasma membrane Source: GO_Central
  • myelin sheath Source: MGI
  • plasma membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002192371 – 221Tetraspanin-2Add BLAST221

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi139N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ922J6.
PaxDbiQ922J6.
PRIDEiQ922J6.

PTM databases

iPTMnetiQ922J6.
PhosphoSitePlusiQ922J6.

Expressioni

Gene expression databases

BgeeiENSMUSG00000027858.
CleanExiMM_TSPAN2.
ExpressionAtlasiQ922J6. baseline and differential.
GenevisibleiQ922J6. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000029451.

Structurei

3D structure databases

ProteinModelPortaliQ922J6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the tetraspanin (TM4SF) family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3882. Eukaryota.
ENOG4111IRY. LUCA.
GeneTreeiENSGT00760000118983.
HOGENOMiHOG000230651.
HOVERGENiHBG002324.
InParanoidiQ922J6.
KOiK17354.
OMAiIFAAEIT.
OrthoDBiEOG091G0K9H.
PhylomeDBiQ922J6.
TreeFamiTF352895.

Family and domain databases

Gene3Di1.10.1450.10. 1 hit.
InterProiIPR028977. CD81_LEL.
IPR000301. Tetraspanin.
IPR018499. Tetraspanin/Peripherin.
IPR018503. Tetraspanin_CS.
IPR008952. Tetraspanin_EC2.
[Graphical view]
PfamiPF00335. Tetraspannin. 1 hit.
[Graphical view]
PIRSFiPIRSF002419. Tetraspanin. 1 hit.
PRINTSiPR00259. TMFOUR.
SUPFAMiSSF48652. SSF48652. 1 hit.
PROSITEiPS00421. TM4_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q922J6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGRFRGGLRC IKYLLLGFNL LFWLAGSAVI AFGLWFRFGG TMKDLSSEDK
60 70 80 90 100
SPEYFYVGLY VLVGAGALMM TVGFFGCCGA MRESQCVLGS FFTCLLVIFA
110 120 130 140 150
AEVTTGVFAF IGKDVAIRHV QSMYEEAYSD YLKDRARGNG TLITFHSAFQ
160 170 180 190 200
CCGKESSEQV QPTCPKELPG HKNCIDKIET VISAKLQLIG IVGIGIAGLT
210 220
IFGMIFSMVL CCAIRNSRDV I
Length:221
Mass (Da):24,181
Last modified:December 1, 2001 - v1
Checksum:i9DF8BE399DD3EE5A
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti68L → M in BAB31109 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK018178 mRNA. Translation: BAB31109.1.
AK032520 mRNA. Translation: BAC27907.1.
AK049888 mRNA. Translation: BAC33972.1.
AK079560 mRNA. Translation: BAC37684.1.
BC007185 mRNA. Translation: AAH07185.1.
CCDSiCCDS17688.1.
RefSeqiNP_081809.2. NM_027533.3.
UniGeneiMm.27469.

Genome annotation databases

EnsembliENSMUST00000029451; ENSMUSP00000029451; ENSMUSG00000027858.
GeneIDi70747.
KEGGimmu:70747.
UCSCiuc008qrw.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK018178 mRNA. Translation: BAB31109.1.
AK032520 mRNA. Translation: BAC27907.1.
AK049888 mRNA. Translation: BAC33972.1.
AK079560 mRNA. Translation: BAC37684.1.
BC007185 mRNA. Translation: AAH07185.1.
CCDSiCCDS17688.1.
RefSeqiNP_081809.2. NM_027533.3.
UniGeneiMm.27469.

3D structure databases

ProteinModelPortaliQ922J6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000029451.

PTM databases

iPTMnetiQ922J6.
PhosphoSitePlusiQ922J6.

Proteomic databases

MaxQBiQ922J6.
PaxDbiQ922J6.
PRIDEiQ922J6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000029451; ENSMUSP00000029451; ENSMUSG00000027858.
GeneIDi70747.
KEGGimmu:70747.
UCSCiuc008qrw.2. mouse.

Organism-specific databases

CTDi10100.
MGIiMGI:1917997. Tspan2.

Phylogenomic databases

eggNOGiKOG3882. Eukaryota.
ENOG4111IRY. LUCA.
GeneTreeiENSGT00760000118983.
HOGENOMiHOG000230651.
HOVERGENiHBG002324.
InParanoidiQ922J6.
KOiK17354.
OMAiIFAAEIT.
OrthoDBiEOG091G0K9H.
PhylomeDBiQ922J6.
TreeFamiTF352895.

Miscellaneous databases

ChiTaRSiTspan2. mouse.
PROiQ922J6.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000027858.
CleanExiMM_TSPAN2.
ExpressionAtlasiQ922J6. baseline and differential.
GenevisibleiQ922J6. MM.

Family and domain databases

Gene3Di1.10.1450.10. 1 hit.
InterProiIPR028977. CD81_LEL.
IPR000301. Tetraspanin.
IPR018499. Tetraspanin/Peripherin.
IPR018503. Tetraspanin_CS.
IPR008952. Tetraspanin_EC2.
[Graphical view]
PfamiPF00335. Tetraspannin. 1 hit.
[Graphical view]
PIRSFiPIRSF002419. Tetraspanin. 1 hit.
PRINTSiPR00259. TMFOUR.
SUPFAMiSSF48652. SSF48652. 1 hit.
PROSITEiPS00421. TM4_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTSN2_MOUSE
AccessioniPrimary (citable) accession number: Q922J6
Secondary accession number(s): Q543K4, Q9D397
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 19, 2002
Last sequence update: December 1, 2001
Last modified: November 2, 2016
This is version 116 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.