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Q922I5

- FOXI1_MOUSE

UniProt

Q922I5 - FOXI1_MOUSE

Protein

Forkhead box protein I1

Gene

Foxi1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 106 (01 Oct 2014)
      Sequence version 2 (26 Jun 2007)
      Previous versions | rss
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    Functioni

    Transcriptional activator required for the development of normal hearing, sense of balance and kidney function. Required for the expression of SLC26A4/PDS, JAG1 and COCH in a subset of epithelial cells and the development of the endolymphatic system in the inner ear. Also required for the expression of SLC4A1/AE1, SLC4A9/AE4, ATP6V1B1 and the differentiation of intercalated cells in the epithelium of distal renal tubules.2 Publications

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi117 – 21195Fork-headPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. sequence-specific DNA binding Source: UniProtKB
    2. sequence-specific DNA binding transcription factor activity Source: Ensembl
    3. transcription regulatory region DNA binding Source: MGI

    GO - Biological processi

    1. inner ear morphogenesis Source: MGI
    2. positive regulation of transcription, DNA-templated Source: UniProtKB
    3. positive regulation of transcription from RNA polymerase II promoter Source: MGI
    4. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Activator

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Forkhead box protein I1
    Gene namesi
    Name:Foxi1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 11

    Organism-specific databases

    MGIiMGI:1096329. Foxi1.

    Subcellular locationi

    GO - Cellular componenti

    1. nucleus Source: UniProtKB

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Disruption phenotypei

    Mice are deaf, impaired in their sense of balance and suffer from distal renal tubular acidosis.2 Publications

    Keywords - Diseasei

    Deafness

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 372372Forkhead box protein I1PRO_0000091847Add
    BLAST

    Proteomic databases

    PRIDEiQ922I5.

    PTM databases

    PhosphoSiteiQ922I5.

    Expressioni

    Tissue specificityi

    Expressed in intercalated cells of the epithelium of the distal renal tubule.1 Publication

    Developmental stagei

    Expressed in the entire otic vesicle at stage E9.5 gradually restricted to the epithelium of the endolymphatic ducts at stage E16.5.1 Publication

    Gene expression databases

    BgeeiQ922I5.
    CleanExiMM_FOXI1.
    GenevestigatoriQ922I5.

    Interactioni

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000058651.

    Structurei

    3D structure databases

    ProteinModelPortaliQ922I5.
    SMRiQ922I5. Positions 115-206.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi7 – 8781Pro-richAdd
    BLAST

    Sequence similaritiesi

    Contains 1 fork-head DNA-binding domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG5025.
    GeneTreeiENSGT00740000114928.
    HOGENOMiHOG000236333.
    HOVERGENiHBG067944.
    InParanoidiQ922I5.
    KOiK09401.
    OMAiQAYGVQR.
    OrthoDBiEOG7T4MKQ.
    PhylomeDBiQ922I5.
    TreeFamiTF316127.

    Family and domain databases

    Gene3Di1.10.10.10. 1 hit.
    InterProiIPR001766. TF_fork_head.
    IPR018122. TF_fork_head_CS.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view]
    PfamiPF00250. Fork_head. 1 hit.
    [Graphical view]
    PRINTSiPR00053. FORKHEAD.
    SMARTiSM00339. FH. 1 hit.
    [Graphical view]
    PROSITEiPS00657. FORK_HEAD_1. 1 hit.
    PS00658. FORK_HEAD_2. 1 hit.
    PS50039. FORK_HEAD_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q922I5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSSFDLPAPS PPRCSPQFPS IGQEPPEMNL YYENFFHPQG MPSPQRPTSF    50
    EGGGEYGTTP NPYLWLNGPA MTPPPYLPGT NASPFLPQAY GMQRQLLPSD 100
    LGWLPIPSQE ELMKLVRPPY SYSALIAMAI HGAPDQRLTL SQIYQYVADN 150
    FPFYNKSKAG WQNSIRHNLS LNDCFKKVPR DEDDPGKGNY WTLDPNCEKM 200
    FDNGNFRRKR KRKSDSSSST SSLASEKTEN GLLASSPKPT EPQEVLDTAS 250
    PDTTTSSPEK RSSPAPSGTP CLNNFLSTMT AYVSGTNPIS RSVATPGLSS 300
    EPIDKMGQNS LNFNSYTPLT NLSSHGNGGE WANPVATNAL GYGGSVFNQF 350
    SPHFYNSINT NGILFPREGT EV 372
    Length:372
    Mass (Da):40,798
    Last modified:June 26, 2007 - v2
    Checksum:i3856C263040CFB44
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti66 – 661L → F in BAB31957. (PubMed:16141072)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK019994 mRNA. Translation: BAB31957.2.
    AL671971 Genomic DNA. Translation: CAI25209.1.
    BC007475 mRNA. Translation: AAH07475.2.
    CCDSiCCDS24539.1.
    RefSeqiNP_076396.3. NM_023907.4.
    UniGeneiMm.32926.

    Genome annotation databases

    EnsembliENSMUST00000060271; ENSMUSP00000058651; ENSMUSG00000047861.
    GeneIDi14233.
    KEGGimmu:14233.
    UCSCiuc007ikw.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK019994 mRNA. Translation: BAB31957.2 .
    AL671971 Genomic DNA. Translation: CAI25209.1 .
    BC007475 mRNA. Translation: AAH07475.2 .
    CCDSi CCDS24539.1.
    RefSeqi NP_076396.3. NM_023907.4.
    UniGenei Mm.32926.

    3D structure databases

    ProteinModelPortali Q922I5.
    SMRi Q922I5. Positions 115-206.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000058651.

    PTM databases

    PhosphoSitei Q922I5.

    Proteomic databases

    PRIDEi Q922I5.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000060271 ; ENSMUSP00000058651 ; ENSMUSG00000047861 .
    GeneIDi 14233.
    KEGGi mmu:14233.
    UCSCi uc007ikw.1. mouse.

    Organism-specific databases

    CTDi 2299.
    MGIi MGI:1096329. Foxi1.

    Phylogenomic databases

    eggNOGi COG5025.
    GeneTreei ENSGT00740000114928.
    HOGENOMi HOG000236333.
    HOVERGENi HBG067944.
    InParanoidi Q922I5.
    KOi K09401.
    OMAi QAYGVQR.
    OrthoDBi EOG7T4MKQ.
    PhylomeDBi Q922I5.
    TreeFami TF316127.

    Miscellaneous databases

    NextBioi 285511.
    PROi Q922I5.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q922I5.
    CleanExi MM_FOXI1.
    Genevestigatori Q922I5.

    Family and domain databases

    Gene3Di 1.10.10.10. 1 hit.
    InterProi IPR001766. TF_fork_head.
    IPR018122. TF_fork_head_CS.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view ]
    Pfami PF00250. Fork_head. 1 hit.
    [Graphical view ]
    PRINTSi PR00053. FORKHEAD.
    SMARTi SM00339. FH. 1 hit.
    [Graphical view ]
    PROSITEi PS00657. FORK_HEAD_1. 1 hit.
    PS00658. FORK_HEAD_2. 1 hit.
    PS50039. FORK_HEAD_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6JImported.
      Tissue: ThymusImported.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: FVB/N.
      Tissue: Mammary tumor.
    4. "Lack of pendrin expression leads to deafness and expansion of the endolymphatic compartment in inner ears of Foxi1 null mutant mice."
      Hulander M., Kiernan A.E., Blomqvist S.R., Carlsson P., Samuelsson E.-J., Johansson B.R., Steel K.P., Enerbaeck S.
      Development 130:2013-2025(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, DEVELOPMENTAL STAGE, DISRUPTION PHENOTYPE.
    5. "Distal renal tubular acidosis in mice that lack the forkhead transcription factor Foxi1."
      Blomqvist S.R., Vidarsson H., Fitzgerald S., Johansson B.R., Ollerstam A., Brown R., Persson A.E.G., Bergstroem G., Enerbaeck S.
      J. Clin. Invest. 113:1560-1570(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, TISSUE SPECIFICITY, DISRUPTION PHENOTYPE.

    Entry informationi

    Entry nameiFOXI1_MOUSE
    AccessioniPrimary (citable) accession number: Q922I5
    Secondary accession number(s): Q5SRI5, Q9D299
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 7, 2006
    Last sequence update: June 26, 2007
    Last modified: October 1, 2014
    This is version 106 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3