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Protein

Forkhead box protein I1

Gene

Foxi1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Transcriptional activator required for the development of normal hearing, sense of balance and kidney function. Required for the expression of SLC26A4/PDS, JAG1 and COCH in a subset of epithelial cells and the development of the endolymphatic system in the inner ear. Also required for the expression of SLC4A1/AE1, SLC4A9/AE4, ATP6V1B1 and the differentiation of intercalated cells in the epithelium of distal renal tubules.2 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi117 – 211Fork-headPROSITE-ProRule annotationAdd BLAST95

GO - Molecular functioni

GO - Biological processi

  • cell differentiation Source: GO_Central
  • inner ear morphogenesis Source: MGI
  • positive regulation of transcription, DNA-templated Source: UniProtKB
  • positive regulation of transcription from RNA polymerase II promoter Source: NTNU_SB

Keywordsi

Molecular functionActivator, DNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Forkhead box protein I1
Gene namesi
Name:Foxi1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1096329. Foxi1.

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Disruption phenotypei

Mice are deaf, impaired in their sense of balance and suffer from distal renal tubular acidosis.2 Publications

Keywords - Diseasei

Deafness

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000918471 – 372Forkhead box protein I1Add BLAST372

Proteomic databases

PaxDbiQ922I5.
PRIDEiQ922I5.

PTM databases

PhosphoSitePlusiQ922I5.

Expressioni

Tissue specificityi

Expressed in intercalated cells of the epithelium of the distal renal tubule.1 Publication

Developmental stagei

Expressed in the entire otic vesicle at stage E9.5 gradually restricted to the epithelium of the endolymphatic ducts at stage E16.5.1 Publication

Gene expression databases

BgeeiENSMUSG00000047861.
CleanExiMM_FOXI1.
GenevisibleiQ922I5. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000058651.

Structurei

3D structure databases

ProteinModelPortaliQ922I5.
SMRiQ922I5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi7 – 87Pro-richAdd BLAST81

Phylogenomic databases

eggNOGiKOG2294. Eukaryota.
COG5025. LUCA.
GeneTreeiENSGT00760000118904.
HOGENOMiHOG000236333.
HOVERGENiHBG067944.
InParanoidiQ922I5.
KOiK09401.
OMAiNQFSPHF.
OrthoDBiEOG091G0ESH.
PhylomeDBiQ922I5.
TreeFamiTF316127.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiView protein in InterPro
IPR001766. Fork_head_dom.
IPR033065. Foxi1.
IPR018122. TF_fork_head_CS_1.
IPR030456. TF_fork_head_CS_2.
IPR011991. WHTH_DNA-bd_dom.
PANTHERiPTHR11829:SF239. PTHR11829:SF239. 1 hit.
PfamiView protein in Pfam
PF00250. Forkhead. 1 hit.
PRINTSiPR00053. FORKHEAD.
SMARTiView protein in SMART
SM00339. FH. 1 hit.
SUPFAMiSSF46785. SSF46785. 1 hit.
PROSITEiView protein in PROSITE
PS00657. FORK_HEAD_1. 1 hit.
PS00658. FORK_HEAD_2. 1 hit.
PS50039. FORK_HEAD_3. 1 hit.

Sequencei

Sequence statusi: Complete.

Q922I5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSFDLPAPS PPRCSPQFPS IGQEPPEMNL YYENFFHPQG MPSPQRPTSF
60 70 80 90 100
EGGGEYGTTP NPYLWLNGPA MTPPPYLPGT NASPFLPQAY GMQRQLLPSD
110 120 130 140 150
LGWLPIPSQE ELMKLVRPPY SYSALIAMAI HGAPDQRLTL SQIYQYVADN
160 170 180 190 200
FPFYNKSKAG WQNSIRHNLS LNDCFKKVPR DEDDPGKGNY WTLDPNCEKM
210 220 230 240 250
FDNGNFRRKR KRKSDSSSST SSLASEKTEN GLLASSPKPT EPQEVLDTAS
260 270 280 290 300
PDTTTSSPEK RSSPAPSGTP CLNNFLSTMT AYVSGTNPIS RSVATPGLSS
310 320 330 340 350
EPIDKMGQNS LNFNSYTPLT NLSSHGNGGE WANPVATNAL GYGGSVFNQF
360 370
SPHFYNSINT NGILFPREGT EV
Length:372
Mass (Da):40,798
Last modified:June 26, 2007 - v2
Checksum:i3856C263040CFB44
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti66L → F in BAB31957 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK019994 mRNA. Translation: BAB31957.2.
AL671971 Genomic DNA. Translation: CAI25209.1.
BC007475 mRNA. Translation: AAH07475.2.
CCDSiCCDS24539.1.
RefSeqiNP_076396.3. NM_023907.4.
UniGeneiMm.32926.

Genome annotation databases

EnsembliENSMUST00000060271; ENSMUSP00000058651; ENSMUSG00000047861.
GeneIDi14233.
KEGGimmu:14233.
UCSCiuc007ikw.1. mouse.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiFOXI1_MOUSE
AccessioniPrimary (citable) accession number: Q922I5
Secondary accession number(s): Q5SRI5, Q9D299
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 7, 2006
Last sequence update: June 26, 2007
Last modified: July 5, 2017
This is version 128 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot