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Protein

Zinc finger protein 330

Gene

Znf330

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri42 – 58C4-type 1Sequence analysisAdd BLAST17
Zinc fingeri67 – 104C4-type 2Sequence analysisAdd BLAST38
Zinc fingeri129 – 149C4-type 3Sequence analysisAdd BLAST21
Zinc fingeri175 – 189C4-type 4Sequence analysisAdd BLAST15

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 330
Alternative name(s):
Nucleolar autoantigen 36
Nucleolar cysteine-rich protein
Gene namesi
Name:Znf330
Synonyms:Noa36, Zfp330
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:1353574. Zfp330.

Subcellular locationi

  • Nucleus By similarity
  • Nucleusnucleolus By similarity
  • Chromosomecentromere By similarity

  • Note: Predominantly expressed in nucleolus. In mitosis associated with centromeres and concentrated at the midbody in cytokinesis (By similarity).By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Centromere, Chromosome, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000665911 – 316Zinc finger protein 330Add BLAST316

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei287PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ922H9.
PaxDbiQ922H9.
PeptideAtlasiQ922H9.
PRIDEiQ922H9.

PTM databases

iPTMnetiQ922H9.
PhosphoSitePlusiQ922H9.

Expressioni

Gene expression databases

BgeeiENSMUSG00000031711.
CleanExiMM_ZFP330.
GenevisibleiQ922H9. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000034147.

Structurei

3D structure databases

ProteinModelPortaliQ922H9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi3 – 11Nuclear localization signalSequence analysis9

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi268 – 283Asp/Glu-rich (acidic)Add BLAST16

Sequence similaritiesi

Belongs to the NOA36 family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri42 – 58C4-type 1Sequence analysisAdd BLAST17
Zinc fingeri67 – 104C4-type 2Sequence analysisAdd BLAST38
Zinc fingeri129 – 149C4-type 3Sequence analysisAdd BLAST21
Zinc fingeri175 – 189C4-type 4Sequence analysisAdd BLAST15

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiENOG410IEDV. Eukaryota.
ENOG410XNTY. LUCA.
GeneTreeiENSGT00390000017043.
HOGENOMiHOG000030400.
HOVERGENiHBG057282.
InParanoidiQ922H9.
OMAiTHACTCP.
OrthoDBiEOG091G0DRZ.
PhylomeDBiQ922H9.
TreeFamiTF323303.

Family and domain databases

InterProiIPR010531. NOA36.
[Graphical view]
PANTHERiPTHR13214. PTHR13214. 1 hit.
PfamiPF06524. NOA36. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q922H9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPKKKTGARK KAENRREREK QLRASRSTVD LAKHPCNASM ECDKCQRRQK
60 70 80 90 100
NRAFCYFCNS VQKLPICAQC GKTKCMMKSS DCVIKHAGVY STGLAMVGAI
110 120 130 140 150
CDFCEAWVCH GRKCLSTHAC ACPLTDAECV ECERGVWDHG GRIFSCSFCH
160 170 180 190 200
NFLCEDDQFE HQASCQVLEA ETFKCVSCNR LGQHSCLRCK ACFCDEHTRS
210 220 230 240 250
KVFKQEKGKQ PPCPKCGHET QETKDLSMST RSLKFGRQTG GEEDGASGYD
260 270 280 290 300
AYWKNLSSDK YGDTGYHDDD EEEDEAEDEE EEDGKDSDAE SSDLFNNLNL
310
GRTYASGYAH YEEQES
Length:316
Mass (Da):35,608
Last modified:December 1, 2001 - v1
Checksum:iF247E54E19876D60
GO
Isoform 2 (identifier: Q922H9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     302-316: RTYASGYAHYEEQES → KSSPVSRDAM

Note: No experimental confirmation available.
Show »
Length:311
Mass (Da):34,894
Checksum:i9E656A9929FD3933
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_011428302 – 316RTYAS…EEQES → KSSPVSRDAM in isoform 2. 1 PublicationAdd BLAST15

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK050534 mRNA. Translation: BAC34313.1.
AK086617 mRNA. Translation: BAC39702.1.
BC008086 mRNA. Translation: AAH08086.1.
BC030675 mRNA. Translation: AAH30675.1.
BC083081 mRNA. Translation: AAH83081.1.
CCDSiCCDS22447.1. [Q922H9-1]
RefSeqiNP_663575.1. NM_145600.1. [Q922H9-1]
UniGeneiMm.269248.

Genome annotation databases

EnsembliENSMUST00000034147; ENSMUSP00000034147; ENSMUSG00000031711. [Q922H9-1]
GeneIDi30932.
KEGGimmu:30932.
UCSCiuc009mjo.1. mouse. [Q922H9-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK050534 mRNA. Translation: BAC34313.1.
AK086617 mRNA. Translation: BAC39702.1.
BC008086 mRNA. Translation: AAH08086.1.
BC030675 mRNA. Translation: AAH30675.1.
BC083081 mRNA. Translation: AAH83081.1.
CCDSiCCDS22447.1. [Q922H9-1]
RefSeqiNP_663575.1. NM_145600.1. [Q922H9-1]
UniGeneiMm.269248.

3D structure databases

ProteinModelPortaliQ922H9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000034147.

PTM databases

iPTMnetiQ922H9.
PhosphoSitePlusiQ922H9.

Proteomic databases

EPDiQ922H9.
PaxDbiQ922H9.
PeptideAtlasiQ922H9.
PRIDEiQ922H9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000034147; ENSMUSP00000034147; ENSMUSG00000031711. [Q922H9-1]
GeneIDi30932.
KEGGimmu:30932.
UCSCiuc009mjo.1. mouse. [Q922H9-1]

Organism-specific databases

CTDi30932.
MGIiMGI:1353574. Zfp330.

Phylogenomic databases

eggNOGiENOG410IEDV. Eukaryota.
ENOG410XNTY. LUCA.
GeneTreeiENSGT00390000017043.
HOGENOMiHOG000030400.
HOVERGENiHBG057282.
InParanoidiQ922H9.
OMAiTHACTCP.
OrthoDBiEOG091G0DRZ.
PhylomeDBiQ922H9.
TreeFamiTF323303.

Miscellaneous databases

PROiQ922H9.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000031711.
CleanExiMM_ZFP330.
GenevisibleiQ922H9. MM.

Family and domain databases

InterProiIPR010531. NOA36.
[Graphical view]
PANTHERiPTHR13214. PTHR13214. 1 hit.
PfamiPF06524. NOA36. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZN330_MOUSE
AccessioniPrimary (citable) accession number: Q922H9
Secondary accession number(s): Q8C389, Q8K2M4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 31, 2004
Last sequence update: December 1, 2001
Last modified: November 2, 2016
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.