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Protein

Mannose-1-phosphate guanyltransferase alpha

Gene

Gmppa

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May serve as a regulatory subunit and allow allosteric feedback inhibition of GMPPB by GDP-mannose.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Mannose-1-phosphate guanyltransferase alpha
Alternative name(s):
GDP-mannose pyrophosphorylase A
GTP-mannose-1-phosphate guanylyltransferase alpha
Gene namesi
Name:Gmppa
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:1916330. Gmppa.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003278731 – 420Mannose-1-phosphate guanyltransferase alphaAdd BLAST420

Proteomic databases

EPDiQ922H4.
MaxQBiQ922H4.
PaxDbiQ922H4.
PRIDEiQ922H4.

PTM databases

iPTMnetiQ922H4.
PhosphoSitePlusiQ922H4.

Expressioni

Tissue specificityi

Widely expressed.1 Publication

Gene expression databases

BgeeiENSMUSG00000033021.
ExpressionAtlasiQ922H4. baseline and differential.
GenevisibleiQ922H4. MM.

Interactioni

Subunit structurei

Associates with GMPPB.By similarity

Protein-protein interaction databases

IntActiQ922H4. 1 interactor.
MINTiMINT-4122789.
STRINGi10090.ENSMUSP00000035564.

Structurei

3D structure databases

ProteinModelPortaliQ922H4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1460. Eukaryota.
COG1208. LUCA.
GeneTreeiENSGT00530000063581.
HOGENOMiHOG000283479.
HOVERGENiHBG059531.
InParanoidiQ922H4.
KOiK00966.
OMAiRLYLNQY.
OrthoDBiEOG091G07X0.
PhylomeDBiQ922H4.
TreeFamiTF300832.

Family and domain databases

Gene3Di3.90.550.10. 1 hit.
InterProiIPR001451. Hexapep.
IPR018357. Hexapep_transf_CS.
IPR005835. NTP_transferase_dom.
IPR029044. Nucleotide-diphossugar_trans.
[Graphical view]
PfamiPF00132. Hexapep. 1 hit.
PF00483. NTP_transferase. 1 hit.
[Graphical view]
SUPFAMiSSF53448. SSF53448. 1 hit.
PROSITEiPS00101. HEXAPEP_TRANSFERASES. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q922H4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLKAVILIGG PQKGTRFRPL SFEVPKPLFP VAGVPMIQHH IEACAQVPGM
60 70 80 90 100
QEILLIGFYQ PDEALTQFLE AAQQEFNLPV RYLQEFAPLG TGGGLYHFRD
110 120 130 140 150
QILAGAPEAF FVLNADVCSD FPLSAMLEAH RRQRHPFLLL GTTANRTQSL
160 170 180 190 200
NYGCIVENPQ THEVLHYVEK PSTFISDIIN CGIYLFSPEA LKPLRDVFQR
210 220 230 240 250
NQQDGQLEES PGSWPGAGTI RLEQDVFSAL AGQGQIYVHL TDGIWSQIKS
260 270 280 290 300
AGSALYASRL YLGRYQITHP ERLARHTPGG PRIRGNVYIH PTAKVAPSAV
310 320 330 340 350
LGPNVSIGKG VTIGEGVRLR ESIVLHGATL QEHTCVLHSI VGWGSTVGRW
360 370 380 390 400
ARVEGTPNDP NPNDPRARMD SESLFKDGKL LPAITILGCR VRIPAEVLIL
410 420
NSIVLPHKEL SRSFTNQIIL
Length:420
Mass (Da):46,244
Last modified:December 1, 2001 - v1
Checksum:i31D8581EA51B2F60
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti23E → V in BAE29590 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK150473 mRNA. Translation: BAE29590.1.
BC008116 mRNA. Translation: AAH08116.1.
CCDSiCCDS15072.1.
RefSeqiNP_598469.1. NM_133708.3.
XP_006496599.1. XM_006496536.1.
XP_006496600.1. XM_006496537.2.
XP_006496601.1. XM_006496538.1.
UniGeneiMm.23951.

Genome annotation databases

EnsembliENSMUST00000037796; ENSMUSP00000035564; ENSMUSG00000033021.
ENSMUST00000113584; ENSMUSP00000109214; ENSMUSG00000033021.
GeneIDi69080.
KEGGimmu:69080.
UCSCiuc007bpd.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK150473 mRNA. Translation: BAE29590.1.
BC008116 mRNA. Translation: AAH08116.1.
CCDSiCCDS15072.1.
RefSeqiNP_598469.1. NM_133708.3.
XP_006496599.1. XM_006496536.1.
XP_006496600.1. XM_006496537.2.
XP_006496601.1. XM_006496538.1.
UniGeneiMm.23951.

3D structure databases

ProteinModelPortaliQ922H4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ922H4. 1 interactor.
MINTiMINT-4122789.
STRINGi10090.ENSMUSP00000035564.

PTM databases

iPTMnetiQ922H4.
PhosphoSitePlusiQ922H4.

Proteomic databases

EPDiQ922H4.
MaxQBiQ922H4.
PaxDbiQ922H4.
PRIDEiQ922H4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000037796; ENSMUSP00000035564; ENSMUSG00000033021.
ENSMUST00000113584; ENSMUSP00000109214; ENSMUSG00000033021.
GeneIDi69080.
KEGGimmu:69080.
UCSCiuc007bpd.1. mouse.

Organism-specific databases

CTDi29926.
MGIiMGI:1916330. Gmppa.

Phylogenomic databases

eggNOGiKOG1460. Eukaryota.
COG1208. LUCA.
GeneTreeiENSGT00530000063581.
HOGENOMiHOG000283479.
HOVERGENiHBG059531.
InParanoidiQ922H4.
KOiK00966.
OMAiRLYLNQY.
OrthoDBiEOG091G07X0.
PhylomeDBiQ922H4.
TreeFamiTF300832.

Miscellaneous databases

ChiTaRSiGmppa. mouse.
PROiQ922H4.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000033021.
ExpressionAtlasiQ922H4. baseline and differential.
GenevisibleiQ922H4. MM.

Family and domain databases

Gene3Di3.90.550.10. 1 hit.
InterProiIPR001451. Hexapep.
IPR018357. Hexapep_transf_CS.
IPR005835. NTP_transferase_dom.
IPR029044. Nucleotide-diphossugar_trans.
[Graphical view]
PfamiPF00132. Hexapep. 1 hit.
PF00483. NTP_transferase. 1 hit.
[Graphical view]
SUPFAMiSSF53448. SSF53448. 1 hit.
PROSITEiPS00101. HEXAPEP_TRANSFERASES. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGMPPA_MOUSE
AccessioniPrimary (citable) accession number: Q922H4
Secondary accession number(s): Q3UCM2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: December 1, 2001
Last modified: November 2, 2016
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Caution

GMPPA is a close homolog of GMPPB, that has been shown to catalyze the formation of GDP-mannose, an essential precursor of glycan moieties of glycoproteins and glycolipids. It has been hypothesized that GMPPA might serve as a regulatory subunit and allow allosteric feedback inhibition of GMPPB by GDP-mannose. Alignment of GMPPAs and GMPPBs from various species shows that GMPPAs are characterized by a 2 amino acid-insertion (residues 11-12) in a highly conserved motif that borders the catalytic pocket and binds the nucleotide substrate in homologous enzymes. This insertion might inactivate the ancestral catalytic site, converting it to an allosteric site (PubMed:24035193).1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.