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Protein

Mannose-1-phosphate guanyltransferase alpha

Gene

Gmppa

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May serve as a regulatory subunit and allow allosteric feedback inhibition of GMPPB by GDP-mannose.By similarity

Caution

GMPPA is a close homolog of GMPPB, that has been shown to catalyze the formation of GDP-mannose, an essential precursor of glycan moieties of glycoproteins and glycolipids. It has been hypothesized that GMPPA might serve as a regulatory subunit and allow allosteric feedback inhibition of GMPPB by GDP-mannose. Alignment of GMPPAs and GMPPBs from various species shows that GMPPAs are characterized by a 2 amino acid-insertion (residues 11-12) in a highly conserved motif that borders the catalytic pocket and binds the nucleotide substrate in homologous enzymes. This insertion might inactivate the ancestral catalytic site, converting it to an allosteric site (PubMed:24035193).1 Publication

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Mannose-1-phosphate guanyltransferase alpha
Alternative name(s):
GDP-mannose pyrophosphorylase A
GTP-mannose-1-phosphate guanylyltransferase alpha
Gene namesi
Name:Gmppa
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:1916330 Gmppa

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003278731 – 420Mannose-1-phosphate guanyltransferase alphaAdd BLAST420

Proteomic databases

EPDiQ922H4
MaxQBiQ922H4
PaxDbiQ922H4
PRIDEiQ922H4

PTM databases

iPTMnetiQ922H4
PhosphoSitePlusiQ922H4
SwissPalmiQ922H4

Expressioni

Tissue specificityi

Widely expressed.1 Publication

Gene expression databases

BgeeiENSMUSG00000033021
ExpressionAtlasiQ922H4 baseline and differential
GenevisibleiQ922H4 MM

Interactioni

Subunit structurei

Associates with GMPPB.By similarity

Protein-protein interaction databases

IntActiQ922H4, 1 interactor
MINTiQ922H4
STRINGi10090.ENSMUSP00000035564

Structurei

3D structure databases

ProteinModelPortaliQ922H4
SMRiQ922H4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1460 Eukaryota
COG1208 LUCA
GeneTreeiENSGT00530000063581
HOGENOMiHOG000283479
HOVERGENiHBG059531
InParanoidiQ922H4
KOiK00966
OMAiANRHYLA
OrthoDBiEOG091G07X0
PhylomeDBiQ922H4
TreeFamiTF300832

Family and domain databases

Gene3Di3.90.550.10, 1 hit
InterProiView protein in InterPro
IPR001451 Hexapep
IPR018357 Hexapep_transf_CS
IPR005835 NTP_transferase_dom
IPR029044 Nucleotide-diphossugar_trans
PfamiView protein in Pfam
PF00132 Hexapep, 1 hit
PF00483 NTP_transferase, 1 hit
SUPFAMiSSF53448 SSF53448, 1 hit
PROSITEiView protein in PROSITE
PS00101 HEXAPEP_TRANSFERASES, 1 hit

Sequencei

Sequence statusi: Complete.

Q922H4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLKAVILIGG PQKGTRFRPL SFEVPKPLFP VAGVPMIQHH IEACAQVPGM
60 70 80 90 100
QEILLIGFYQ PDEALTQFLE AAQQEFNLPV RYLQEFAPLG TGGGLYHFRD
110 120 130 140 150
QILAGAPEAF FVLNADVCSD FPLSAMLEAH RRQRHPFLLL GTTANRTQSL
160 170 180 190 200
NYGCIVENPQ THEVLHYVEK PSTFISDIIN CGIYLFSPEA LKPLRDVFQR
210 220 230 240 250
NQQDGQLEES PGSWPGAGTI RLEQDVFSAL AGQGQIYVHL TDGIWSQIKS
260 270 280 290 300
AGSALYASRL YLGRYQITHP ERLARHTPGG PRIRGNVYIH PTAKVAPSAV
310 320 330 340 350
LGPNVSIGKG VTIGEGVRLR ESIVLHGATL QEHTCVLHSI VGWGSTVGRW
360 370 380 390 400
ARVEGTPNDP NPNDPRARMD SESLFKDGKL LPAITILGCR VRIPAEVLIL
410 420
NSIVLPHKEL SRSFTNQIIL
Length:420
Mass (Da):46,244
Last modified:December 1, 2001 - v1
Checksum:i31D8581EA51B2F60
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti23E → V in BAE29590 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK150473 mRNA Translation: BAE29590.1
BC008116 mRNA Translation: AAH08116.1
CCDSiCCDS15072.1
RefSeqiNP_598469.1, NM_133708.3
XP_006496599.1, XM_006496536.1
XP_006496600.1, XM_006496537.2
XP_006496601.1, XM_006496538.1
UniGeneiMm.23951

Genome annotation databases

EnsembliENSMUST00000037796; ENSMUSP00000035564; ENSMUSG00000033021
ENSMUST00000113584; ENSMUSP00000109214; ENSMUSG00000033021
GeneIDi69080
KEGGimmu:69080
UCSCiuc007bpd.1 mouse

Similar proteinsi

Entry informationi

Entry nameiGMPPA_MOUSE
AccessioniPrimary (citable) accession number: Q922H4
Secondary accession number(s): Q3UCM2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: December 1, 2001
Last modified: May 23, 2018
This is version 117 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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