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Protein

Solute carrier family 25 member 36

Gene

Slc25a36

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Mitochondrial transporter that imports/exports pyrimidine nucleotides into and from mitochondria. Transports preferentially cytosine and uracil (deoxy)nucleoside mono-, di-, and triphosphates by uniport and antiport mechanism. Also transports guanine but not adenine (deoxy)nucleotides. Is inhibited strongly by pyridoxal 5'-phosphate, 4,7-diphenyl-1,10-phenanthroline, tannic acid, and mercurials (mercury dichloride, Mersalyl acid, p-hydroxymercuribenzoate). Participates in mitochondrial genome maintenance, regulation of mitochondrial membrane potential and mitochondrial respiration.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 25 member 36
Gene namesi
Name:Slc25a36
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:1924909. Slc25a36.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei7 – 2721Helical; Name=1Sequence analysisAdd
BLAST
Transmembranei41 – 5717Helical; Name=2Sequence analysisAdd
BLAST
Transmembranei111 – 13121Helical; Name=3Sequence analysisAdd
BLAST
Transmembranei180 – 20021Helical; Name=4Sequence analysisAdd
BLAST
Transmembranei226 – 24621Helical; Name=5Sequence analysisAdd
BLAST
Transmembranei291 – 31121Helical; Name=6Sequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • mitochondrial inner membrane Source: UniProtKB-SubCell
  • mitochondrion Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 311311Solute carrier family 25 member 36PRO_0000291798Add
BLAST

Proteomic databases

MaxQBiQ922G0.
PaxDbiQ922G0.
PRIDEiQ922G0.

PTM databases

PhosphoSiteiQ922G0.
SwissPalmiQ922G0.

Expressioni

Gene expression databases

BgeeiQ922G0.
CleanExiMM_SLC25A36.
ExpressionAtlasiQ922G0. baseline and differential.
GenevisibleiQ922G0. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000082302.

Structurei

3D structure databases

ProteinModelPortaliQ922G0.
SMRiQ922G0. Positions 7-307.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati4 – 108105Solcar 1Add
BLAST
Repeati116 – 20388Solcar 2Add
BLAST
Repeati224 – 30885Solcar 3Add
BLAST

Sequence similaritiesi

Contains 3 Solcar repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0757. Eukaryota.
ENOG410XS20. LUCA.
GeneTreeiENSGT00550000074670.
HOGENOMiHOG000188210.
HOVERGENiHBG059891.
InParanoidiQ922G0.
KOiK15116.
OMAiLNGIFDP.
PhylomeDBiQ922G0.
TreeFamiTF314220.

Family and domain databases

Gene3Di1.50.40.10. 1 hit.
InterProiIPR002067. Mit_carrier.
IPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view]
PfamiPF00153. Mito_carr. 3 hits.
[Graphical view]
PRINTSiPR00926. MITOCARRIER.
SUPFAMiSSF103506. SSF103506. 1 hit.
PROSITEiPS50920. SOLCAR. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q922G0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSQRDTLVHL FAGGCGGTVG AILTCPLEVV KTRLQSSSVT LYISEVQLNT
60 70 80 90 100
MAGASVNRVV SPGPLHCLKA ILEKEGPRSL FRGLGPNLVG VAPSRAIYFA
110 120 130 140 150
AYSNCKEKLN GVFDPDSTQV HMASAAMAGF TAITATNPIW LIKTRLQLDA
160 170 180 190 200
RTRGEKQMGA FECVRKVYQT DGLRGFYRGM SASYAGISET VIHFVIYESI
210 220 230 240 250
KQKLLECKTA SMMETDEESV KEASDFVRMM LAAATSKTCA TTIAYPHEVV
260 270 280 290 300
RTRLREEGTK YRSFFQTLSL IVQEEGYGSL YRGLTTHLVR QIPNTAIMMA
310
TYELVVYLLN G
Length:311
Mass (Da):34,170
Last modified:December 1, 2001 - v1
Checksum:i955FFBD45BA78F48
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK042075 mRNA. Translation: BAE20619.1.
AK053646 mRNA. Translation: BAC35461.1.
AK078779 mRNA. Translation: BAC37391.1.
BC008171 mRNA. Translation: AAH08171.1.
CCDSiCCDS23420.1.
RefSeqiNP_620095.1. NM_138756.4.
UniGeneiMm.228067.
Mm.475433.

Genome annotation databases

EnsembliENSMUST00000085206; ENSMUSP00000082302; ENSMUSG00000032449.
GeneIDi192287.
KEGGimmu:192287.
UCSCiuc009rdb.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK042075 mRNA. Translation: BAE20619.1.
AK053646 mRNA. Translation: BAC35461.1.
AK078779 mRNA. Translation: BAC37391.1.
BC008171 mRNA. Translation: AAH08171.1.
CCDSiCCDS23420.1.
RefSeqiNP_620095.1. NM_138756.4.
UniGeneiMm.228067.
Mm.475433.

3D structure databases

ProteinModelPortaliQ922G0.
SMRiQ922G0. Positions 7-307.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000082302.

PTM databases

PhosphoSiteiQ922G0.
SwissPalmiQ922G0.

Proteomic databases

MaxQBiQ922G0.
PaxDbiQ922G0.
PRIDEiQ922G0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000085206; ENSMUSP00000082302; ENSMUSG00000032449.
GeneIDi192287.
KEGGimmu:192287.
UCSCiuc009rdb.1. mouse.

Organism-specific databases

CTDi55186.
MGIiMGI:1924909. Slc25a36.

Phylogenomic databases

eggNOGiKOG0757. Eukaryota.
ENOG410XS20. LUCA.
GeneTreeiENSGT00550000074670.
HOGENOMiHOG000188210.
HOVERGENiHBG059891.
InParanoidiQ922G0.
KOiK15116.
OMAiLNGIFDP.
PhylomeDBiQ922G0.
TreeFamiTF314220.

Miscellaneous databases

NextBioi371286.
PROiQ922G0.
SOURCEiSearch...

Gene expression databases

BgeeiQ922G0.
CleanExiMM_SLC25A36.
ExpressionAtlasiQ922G0. baseline and differential.
GenevisibleiQ922G0. MM.

Family and domain databases

Gene3Di1.50.40.10. 1 hit.
InterProiIPR002067. Mit_carrier.
IPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view]
PfamiPF00153. Mito_carr. 3 hits.
[Graphical view]
PRINTSiPR00926. MITOCARRIER.
SUPFAMiSSF103506. SSF103506. 1 hit.
PROSITEiPS50920. SOLCAR. 3 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Eye, Testis and Thymus.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Mammary tumor.

Entry informationi

Entry nameiS2536_MOUSE
AccessioniPrimary (citable) accession number: Q922G0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 26, 2007
Last sequence update: December 1, 2001
Last modified: May 11, 2016
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.