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Protein

Solute carrier family 25 member 36

Gene

Slc25a36

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Mitochondrial transporter that imports/exports pyrimidine nucleotides into and from mitochondria. Transports preferentially cytosine and uracil (deoxy)nucleoside mono-, di-, and triphosphates by uniport and antiport mechanism. Also transports guanine but not adenine (deoxy)nucleotides. Is inhibited strongly by pyridoxal 5'-phosphate, 4,7-diphenyl-1,10-phenanthroline, tannic acid, and mercurials (mercury dichloride, Mersalyl acid, p-hydroxymercuribenzoate). Participates in mitochondrial genome maintenance, regulation of mitochondrial membrane potential and mitochondrial respiration.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processTransport

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 25 member 36
Gene namesi
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:1924909. Slc25a36.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei7 – 27Helical; Name=1Sequence analysisAdd BLAST21
Transmembranei41 – 57Helical; Name=2Sequence analysisAdd BLAST17
Transmembranei111 – 131Helical; Name=3Sequence analysisAdd BLAST21
Transmembranei180 – 200Helical; Name=4Sequence analysisAdd BLAST21
Transmembranei226 – 246Helical; Name=5Sequence analysisAdd BLAST21
Transmembranei291 – 311Helical; Name=6Sequence analysisAdd BLAST21

GO - Cellular componenti

  • integral component of membrane Source: GO_Central
  • mitochondrial inner membrane Source: GO_Central
  • mitochondrion Source: MGI

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002917981 – 311Solute carrier family 25 member 36Add BLAST311

Proteomic databases

MaxQBiQ922G0.
PaxDbiQ922G0.
PeptideAtlasiQ922G0.
PRIDEiQ922G0.

PTM databases

PhosphoSitePlusiQ922G0.
SwissPalmiQ922G0.

Expressioni

Gene expression databases

BgeeiENSMUSG00000032449.
CleanExiMM_SLC25A36.
ExpressionAtlasiQ922G0. baseline and differential.
GenevisibleiQ922G0. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000082302.

Structurei

3D structure databases

ProteinModelPortaliQ922G0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati4 – 108Solcar 1Add BLAST105
Repeati116 – 203Solcar 2Add BLAST88
Repeati224 – 308Solcar 3Add BLAST85

Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0757. Eukaryota.
ENOG410XS20. LUCA.
GeneTreeiENSGT00550000074670.
HOGENOMiHOG000188210.
HOVERGENiHBG059891.
InParanoidiQ922G0.
KOiK15116.
OMAiQSDFYQA.
OrthoDBiEOG091G0BCW.
PhylomeDBiQ922G0.
TreeFamiTF314220.

Family and domain databases

Gene3Di1.50.40.10. 1 hit.
InterProiView protein in InterPro
IPR002067. Mit_carrier.
IPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
PfamiView protein in Pfam
PF00153. Mito_carr. 3 hits.
PRINTSiPR00926. MITOCARRIER.
SUPFAMiSSF103506. SSF103506. 1 hit.
PROSITEiView protein in PROSITE
PS50920. SOLCAR. 3 hits.

Sequencei

Sequence statusi: Complete.

Q922G0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSQRDTLVHL FAGGCGGTVG AILTCPLEVV KTRLQSSSVT LYISEVQLNT
60 70 80 90 100
MAGASVNRVV SPGPLHCLKA ILEKEGPRSL FRGLGPNLVG VAPSRAIYFA
110 120 130 140 150
AYSNCKEKLN GVFDPDSTQV HMASAAMAGF TAITATNPIW LIKTRLQLDA
160 170 180 190 200
RTRGEKQMGA FECVRKVYQT DGLRGFYRGM SASYAGISET VIHFVIYESI
210 220 230 240 250
KQKLLECKTA SMMETDEESV KEASDFVRMM LAAATSKTCA TTIAYPHEVV
260 270 280 290 300
RTRLREEGTK YRSFFQTLSL IVQEEGYGSL YRGLTTHLVR QIPNTAIMMA
310
TYELVVYLLN G
Length:311
Mass (Da):34,170
Last modified:December 1, 2001 - v1
Checksum:i955FFBD45BA78F48
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK042075 mRNA. Translation: BAE20619.1.
AK053646 mRNA. Translation: BAC35461.1.
AK078779 mRNA. Translation: BAC37391.1.
BC008171 mRNA. Translation: AAH08171.1.
CCDSiCCDS23420.1.
RefSeqiNP_620095.1. NM_138756.4.
UniGeneiMm.228067.
Mm.475433.

Genome annotation databases

EnsembliENSMUST00000085206; ENSMUSP00000082302; ENSMUSG00000032449.
GeneIDi192287.
KEGGimmu:192287.
UCSCiuc009rdb.1. mouse.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiS2536_MOUSE
AccessioniPrimary (citable) accession number: Q922G0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 26, 2007
Last sequence update: December 1, 2001
Last modified: July 5, 2017
This is version 122 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families