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Protein

Sperm-specific antigen 2 homolog

Gene

Ssfa2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Sperm-specific antigen 2 homolog
Alternative name(s):
Ki-ras-induced actin-interacting protein
Gene namesi
Name:Ssfa2
Synonyms:Kiaa1927, Krap
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1917849. Ssfa2.

Subcellular locationi

  • Cytoplasm 1 Publication

  • Note: Located near the plasma membrane. Associated with actin filaments. May also exist as a membrane-bound form with extracellular regions (By similarity).By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000722121 – 1252Sperm-specific antigen 2 homologAdd BLAST1252

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei85PhosphothreonineCombined sources1
Modified residuei90PhosphoserineCombined sources1
Modified residuei109PhosphoserineCombined sources1
Modified residuei207PhosphoserineBy similarity1
Modified residuei268PhosphoserineCombined sources1
Modified residuei328PhosphoserineBy similarity1
Modified residuei465PhosphoserineCombined sources1
Modified residuei643PhosphoserineBy similarity1
Modified residuei667PhosphoserineCombined sources1
Modified residuei736PhosphoserineCombined sources1
Modified residuei738PhosphoserineCombined sources1
Modified residuei745PhosphoserineCombined sources1
Modified residuei758PhosphoserineBy similarity1
Modified residuei766PhosphoserineBy similarity1
Cross-linki807Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei866PhosphoserineCombined sources1
Modified residuei898PhosphoserineBy similarity1
Modified residuei1036PhosphoserineCombined sources1
Modified residuei1051PhosphoserineCombined sources1
Modified residuei1056PhosphoserineCombined sources1
Modified residuei1059PhosphoserineCombined sources1
Modified residuei1114PhosphoserineBy similarity1
Modified residuei1149PhosphothreonineBy similarity1
Modified residuei1154PhosphoserineCombined sources1
Modified residuei1161PhosphothreonineBy similarity1

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiQ922B9.
PeptideAtlasiQ922B9.
PRIDEiQ922B9.

PTM databases

iPTMnetiQ922B9.
PhosphoSitePlusiQ922B9.

Expressioni

Gene expression databases

BgeeiENSMUSG00000027007.
CleanExiMM_SSFA2.
ExpressionAtlasiQ922B9. baseline and differential.
GenevisibleiQ922B9. MM.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000107415.

Structurei

3D structure databases

ProteinModelPortaliQ922B9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili955 – 1031Sequence analysisAdd BLAST77

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IERU. Eukaryota.
ENOG410ZSFW. LUCA.
GeneTreeiENSGT00530000063345.
HOVERGENiHBG082646.
InParanoidiQ922B9.
OMAiQSTCSLH.
OrthoDBiEOG091G011N.
TreeFamiTF331566.

Family and domain databases

InterProiIPR029325. IP3R-bd.
IPR026648. SSFA2.
IPR029326. SSFA2_C.
[Graphical view]
PANTHERiPTHR17469:SF11. PTHR17469:SF11. 3 hits.
PfamiPF14722. KRAP_IP3R_bind. 1 hit.
PF14723. SSFA2_C. 1 hit.
[Graphical view]
SMARTiSM01257. KRAP_IP3R_bind. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q922B9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MNRPLSAEAE EELEWQVASR RRKAWAKCRS SWQASETEDL STETTTQDED
60 70 80 90 100
EDDEEDLPGT KLPAPAGRGN VPNEKIAIWL KDCRTPLGAS LDEQSSGTPK
110 120 130 140 150
GVLVRNGGSF EDDLSLGAEA NHLHEPDAQV ENCNNILAKE RRLQFHQKGR
160 170 180 190 200
SMNSTGSGKS SGTVSSVSEL LELYEEDPEE ILYNLGFGRD EPDIASKIPS
210 220 230 240 250
RFFNSSSFAR GIDIKVFLSA QMQRMEVENP NYALTSRFRQ IEVLTTVANA
260 270 280 290 300
FSSLYSQVSG TPLQRIGSMS SVTSTKEVAD SPPPLTRSNT ANRLMKTLSK
310 320 330 340 350
LNLCVDKTEK GEGGSSPATE KGRTLSISLS EDGGGGKSDP KLQKVVKKKE
360 370 380 390 400
SSSMLATVTE EVSGSSSTVT DSVDADRLSE EADSTISHQE ESEESREAHS
410 420 430 440 450
QEKDPLRKSA VTDPDLGHDG RVSSHCELES SSELKSAQAS SSEKEPCAPL
460 470 480 490 500
TIPSIRNIMT QQKDSFEMEE VQSTEGEAPH VPATCQLSLA KSKRDHLLRT
510 520 530 540 550
ASQHSDSSGF AEDSTDCVSL NHLLVNESLQ AMGSSADSCD SETTVTSLGE
560 570 580 590 600
DHVTPTAQDQ PYFNESEEES LAPLQKGRAK VEIVAEKRKA DNQDFPQCVT
610 620 630 640 650
AENAGNNEST KGPCEPGHQI TETGEHPPLA ATGELPREES VESDVEKGSE
660 670 680 690 700
CEFAQYTTHH ILRSLASFEA QGSGMSSEKK TGFPSSVDRV NTALQRAQMK
710 720 730 740 750
VCSMSGQRVG RSLIKSKDLL KQRYLLAKAG YPLRRSQSLP TTLLSPVRVV
760 770 780 790 800
SSVNVRLSPG KETRCSPPSF TYKYTPEEEQ DLEKQGTEHD GQSLVKSTIF
810 820 830 840 850
IPPPSVKKEE APQSEGTRLE ECHHGRLAPC PQFAPISQST CSLHSVHSEW
860 870 880 890 900
QDRPLCEHMR TLSAHSVPNI SGAACSAFSP FGCPYSHRHA AHPYRACSVN
910 920 930 940 950
PPSAIEMQLR RVLHDIRSSL QNLSQYPMTR GPDLAAAPYS TQNSSVLPLY
960 970 980 990 1000
ENTFQELQVV RRSLNLFRTQ MMDLELAMLR QQTVVYPHMT EEDRYEVDQL
1010 1020 1030 1040 1050
QGLRNSVRME LQDLEMQLEE RLLGLDEQLR AVRVPSPFRP SALPGMCGSR
1060 1070 1080 1090 1100
SVDNLSCPSP LNVMEPVTEL IREQSYLKSE LGLGLGDMAY EIPPGESSES
1110 1120 1130 1140 1150
VFSQATSESS SVCSSPSHTN RRSRGLPGSK PRARLVARKK IFRASVALTP
1160 1170 1180 1190 1200
TAPSRTGSVQ TPPDLESSEE AGGAEEASPV VGLASHVEEE PEDLSLMPAA
1210 1220 1230 1240 1250
EEMHRNVEQD ELQQVIREIK ESIVGEIRRE IVSGLLAAVS SSKAPGPKQD

SH
Length:1,252
Mass (Da):136,947
Last modified:July 27, 2011 - v3
Checksum:i2FA8C5874C1A573E
GO
Isoform 2 (identifier: Q922B9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1063: Missing.

Note: No experimental confirmation available.
Show »
Length:189
Mass (Da):20,231
Checksum:iCF2713BFF32BE690
GO
Isoform 3 (identifier: Q922B9-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-151: Missing.

Show »
Length:1,101
Mass (Da):120,168
Checksum:i1399760C3C962FA9
GO

Sequence cautioni

The sequence AAH08560 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAH18526 differs from that shown. Reason: Erroneous termination at position 1249. Translated as Gln.Curated
The sequence AAI22520 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAC29756 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti319T → A in BAC87833 (PubMed:14673706).Curated1
Sequence conflicti319T → A in AAI22520 (PubMed:15489334).Curated1
Sequence conflicti319T → A in AAI41884 (PubMed:15489334).Curated1
Sequence conflicti319T → A in BAC41485 (PubMed:12465718).Curated1
Sequence conflicti1071I → M in BAC87833 (PubMed:14673706).Curated1
Sequence conflicti1071I → M in AAH18526 (PubMed:15489334).Curated1
Sequence conflicti1071I → M in AAI41884 (PubMed:15489334).Curated1
Sequence conflicti1071I → M in AAI22520 (PubMed:15489334).Curated1
Sequence conflicti1071I → M in BAC41485 (PubMed:12465718).Curated1
Sequence conflicti1240S → A in BAC87833 (PubMed:14673706).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0238691 – 1063Missing in isoform 2. 1 PublicationAdd BLAST1063
Alternative sequenceiVSP_0238681 – 151Missing in isoform 3. 1 PublicationAdd BLAST151

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB120565 mRNA. Translation: BAC87833.1.
AL844577, AL928770 Genomic DNA. Translation: CAM14505.1.
AL928770, AL844577 Genomic DNA. Translation: CAM17563.1.
BC008560 mRNA. Translation: AAH08560.1. Different initiation.
BC018526 mRNA. Translation: AAH18526.3. Different termination.
BC079535 mRNA. Translation: AAH79535.1.
BC115799 mRNA. Translation: AAI15800.1.
BC122519 mRNA. Translation: AAI22520.1. Different initiation.
BC141883 mRNA. Translation: AAI41884.1.
AK037213 mRNA. Translation: BAC29756.1. Different initiation.
AB093303 mRNA. Translation: BAC41485.1.
CCDSiCCDS16170.1. [Q922B9-1]
RefSeqiNP_542125.3. NM_080558.4. [Q922B9-1]
UniGeneiMm.272881.

Genome annotation databases

EnsembliENSMUST00000111785; ENSMUSP00000107415; ENSMUSG00000027007. [Q922B9-1]
GeneIDi70599.
KEGGimmu:70599.
UCSCiuc008kgw.2. mouse. [Q922B9-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB120565 mRNA. Translation: BAC87833.1.
AL844577, AL928770 Genomic DNA. Translation: CAM14505.1.
AL928770, AL844577 Genomic DNA. Translation: CAM17563.1.
BC008560 mRNA. Translation: AAH08560.1. Different initiation.
BC018526 mRNA. Translation: AAH18526.3. Different termination.
BC079535 mRNA. Translation: AAH79535.1.
BC115799 mRNA. Translation: AAI15800.1.
BC122519 mRNA. Translation: AAI22520.1. Different initiation.
BC141883 mRNA. Translation: AAI41884.1.
AK037213 mRNA. Translation: BAC29756.1. Different initiation.
AB093303 mRNA. Translation: BAC41485.1.
CCDSiCCDS16170.1. [Q922B9-1]
RefSeqiNP_542125.3. NM_080558.4. [Q922B9-1]
UniGeneiMm.272881.

3D structure databases

ProteinModelPortaliQ922B9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000107415.

PTM databases

iPTMnetiQ922B9.
PhosphoSitePlusiQ922B9.

Proteomic databases

PaxDbiQ922B9.
PeptideAtlasiQ922B9.
PRIDEiQ922B9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000111785; ENSMUSP00000107415; ENSMUSG00000027007. [Q922B9-1]
GeneIDi70599.
KEGGimmu:70599.
UCSCiuc008kgw.2. mouse. [Q922B9-1]

Organism-specific databases

CTDi6744.
MGIiMGI:1917849. Ssfa2.
RougeiSearch...

Phylogenomic databases

eggNOGiENOG410IERU. Eukaryota.
ENOG410ZSFW. LUCA.
GeneTreeiENSGT00530000063345.
HOVERGENiHBG082646.
InParanoidiQ922B9.
OMAiQSTCSLH.
OrthoDBiEOG091G011N.
TreeFamiTF331566.

Miscellaneous databases

ChiTaRSiSsfa2. mouse.
PROiQ922B9.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000027007.
CleanExiMM_SSFA2.
ExpressionAtlasiQ922B9. baseline and differential.
GenevisibleiQ922B9. MM.

Family and domain databases

InterProiIPR029325. IP3R-bd.
IPR026648. SSFA2.
IPR029326. SSFA2_C.
[Graphical view]
PANTHERiPTHR17469:SF11. PTHR17469:SF11. 3 hits.
PfamiPF14722. KRAP_IP3R_bind. 1 hit.
PF14723. SSFA2_C. 1 hit.
[Graphical view]
SMARTiSM01257. KRAP_IP3R_bind. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSSFA2_MOUSE
AccessioniPrimary (citable) accession number: Q922B9
Secondary accession number(s): A2AQD4
, A5D8Z6, Q08E80, Q14BJ9, Q544I3, Q68FN1, Q75WU7, Q8CH96, Q8VEF7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 13, 2002
Last sequence update: July 27, 2011
Last modified: November 2, 2016
This is version 118 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.