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Protein

E3 ubiquitin-protein ligase TRAF7

Gene

Traf7

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

E3 ubiquitin ligase capable of auto-ubiquitination, following phosphorylation by MAP3K3. Potentiates MEKK3-mediated activation of the NF-kappa-B, JUN/AP1 and DDIT3 transcriptional regulators. Induces apoptosis when overexpressed.By similarity

Catalytic activityi

S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N6-ubiquitinyl-[acceptor protein]-L-lysine.

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri55 – 89RING-typePROSITE-ProRule annotationAdd BLAST35
Zinc fingeri146 – 216TRAF-typePROSITE-ProRule annotationAdd BLAST71

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processApoptosis, Transcription, Transcription regulation, Ubl conjugation pathway
LigandMetal-binding, Zinc

Enzyme and pathway databases

UniPathwayiUPA00143

Names & Taxonomyi

Protein namesi
Recommended name:
E3 ubiquitin-protein ligase TRAF7 (EC:2.3.2.27)
Alternative name(s):
RING-type E3 ubiquitin transferase TRAF7Curated
TNF receptor-associated factor 7
Gene namesi
Name:Traf7Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:3042141 Traf7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasmic vesicle

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000512971 – 594E3 ubiquitin-protein ligase TRAF7Add BLAST594

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei12PhosphoserineCombined sources1
Modified residuei15PhosphoserineCombined sources1

Post-translational modificationi

Phosphorylated by MAP3K3.By similarity
Ubiquitinates itself upon phosphorylation.By similarity

Keywords - PTMi

Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ922B6
MaxQBiQ922B6
PaxDbiQ922B6
PRIDEiQ922B6

PTM databases

iPTMnetiQ922B6

Expressioni

Gene expression databases

CleanExiMM_TRAF7

Interactioni

Subunit structurei

Homodimer. Interacts with MAP3K3 and promotes the kinase activity of this enzyme.By similarity

Protein-protein interaction databases

IntActiQ922B6, 1 interactor
MINTiQ922B6
STRINGi10090.ENSMUSP00000085812

Structurei

3D structure databases

ProteinModelPortaliQ922B6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati318 – 357WD 1Sequence analysisAdd BLAST40
Repeati361 – 398WD 2Sequence analysisAdd BLAST38
Repeati401 – 437WD 3Sequence analysisAdd BLAST37
Repeati439 – 478WD 4Sequence analysisAdd BLAST40
Repeati481 – 518WD 5Sequence analysisAdd BLAST38
Repeati521 – 562WD 6Sequence analysisAdd BLAST42
Repeati565 – 593WD 7Sequence analysisAdd BLAST29

Sequence similaritiesi

Belongs to the WD repeat TRAF7 family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri55 – 89RING-typePROSITE-ProRule annotationAdd BLAST35
Zinc fingeri146 – 216TRAF-typePROSITE-ProRule annotationAdd BLAST71

Keywords - Domaini

Repeat, WD repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG0274 Eukaryota
KOG0297 Eukaryota
ENOG410XNP5 LUCA
HOGENOMiHOG000220840
HOVERGENiHBG055270
InParanoidiQ922B6

Family and domain databases

Gene3Di2.130.10.10, 2 hits
3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR020472 G-protein_beta_WD-40_rep
IPR008974 TRAF-like
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR019775 WD40_repeat_CS
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
IPR027370 Znf-RING_LisH
IPR001841 Znf_RING
IPR013083 Znf_RING/FYVE/PHD
IPR017907 Znf_RING_CS
IPR001293 Znf_TRAF
PfamiView protein in Pfam
PF00400 WD40, 4 hits
PF13445 zf-RING_UBOX, 1 hit
PRINTSiPR00320 GPROTEINBRPT
SMARTiView protein in SMART
SM00184 RING, 1 hit
SM00320 WD40, 7 hits
SUPFAMiSSF49599 SSF49599, 2 hits
SSF50978 SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS00678 WD_REPEATS_1, 2 hits
PS50082 WD_REPEATS_2, 5 hits
PS50294 WD_REPEATS_REGION, 1 hit
PS00518 ZF_RING_1, 1 hit
PS50089 ZF_RING_2, 1 hit
PS50145 ZF_TRAF, 1 hit

Sequencei

Sequence statusi: Complete.

Q922B6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPPINTPRRS DSAISVRSLH SESSMSLRST FSLPEEEEEP EPLVFAEQPS
60 70 80 90 100
VKLCCQLCCS VFKDPVITTC GHTFCRRCAL KSEKCPVDNA KLTVVVNNIA
110 120 130 140 150
VAEQIGELFI HCRHGCHAAG TGKPGVFEVD PRGCPFTIKL SARKDHESSC
160 170 180 190 200
DYRPVRCPNN PSCPPLLKMN LEAHLKECEH IKCPHSKYGC TFIGNQDTYE
210 220 230 240 250
THLETCRFEG LKEFLQQTDD RFHEMHVALA QKDQEIAFLR SMLGKLSEKI
260 270 280 290 300
DQLEKSLELK FDVLDENQSK LSEDLMEFRR DASMLNDELS HINARLNMGI
310 320 330 340 350
LGSYDPQQIF KCKGTFVGHQ GPVWCLCVYS MGDLLFSGSS DKTIKVWDTC
360 370 380 390 400
TTYKCQKTLE GHDGIVLALC IQGCKLYSGS ADCTIIVWDI QNLQKVNTIR
410 420 430 440 450
AHDNPVCTLV SSHNMLFSGS LKAIKVWDIV GTELKLKKEL TGLNHWVRAL
460 470 480 490 500
VAAQSYLYSG SYQTIKIWDI RTLDCIHVLQ TSGGSVYSIA VTNHHIVCGT
510 520 530 540 550
YENLIHVWDI ESKEQVRTLT GHVGTVYALA VISTPDQTKV FSASYDRSLR
560 570 580 590
VWSMDNMICT QTLLRHQGSV TALAVSRGRL FSGAVDSTVK VWTC
Length:594
Mass (Da):66,487
Last modified:December 1, 2001 - v1
Checksum:i18009319608AD0B2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC005649 mRNA Translation: AAH05649.1
BC008598 mRNA Translation: AAH08598.1
UniGeneiMm.275150

Genome annotation databases

UCSCiuc008awr.2 mouse

Similar proteinsi

Entry informationi

Entry nameiTRAF7_MOUSE
AccessioniPrimary (citable) accession number: Q922B6
Secondary accession number(s): Q99JV3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: December 1, 2001
Last modified: March 28, 2018
This is version 135 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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