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Protein

E3 ubiquitin-protein ligase TRAF7

Gene

Traf7

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

E3 ubiquitin ligase capable of auto-ubiquitination, following phosphorylation by MAP3K3. Potentiates MEKK3-mediated activation of the NF-kappa-B, JUN/AP1 and DDIT3 transcriptional regulators. Induces apoptosis when overexpressed.By similarity

Catalytic activityi

S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N6-ubiquitinyl-[acceptor protein]-L-lysine.

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri55 – 89RING-typePROSITE-ProRule annotationAdd BLAST35
Zinc fingeri146 – 216TRAF-typePROSITE-ProRule annotationAdd BLAST71

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processApoptosis, Transcription, Transcription regulation, Ubl conjugation pathway
LigandMetal-binding, Zinc

Enzyme and pathway databases

UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
E3 ubiquitin-protein ligase TRAF7 (EC:2.3.2.27)
Alternative name(s):
RING-type E3 ubiquitin transferase TRAF7Curated
TNF receptor-associated factor 7
Gene namesi
Name:Traf7Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:3042141. Traf7.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasmic vesicle

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000512971 – 594E3 ubiquitin-protein ligase TRAF7Add BLAST594

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei12PhosphoserineCombined sources1
Modified residuei15PhosphoserineCombined sources1

Post-translational modificationi

Phosphorylated by MAP3K3.By similarity
Ubiquitinates itself upon phosphorylation.By similarity

Keywords - PTMi

Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ922B6.
MaxQBiQ922B6.
PaxDbiQ922B6.
PRIDEiQ922B6.

PTM databases

iPTMnetiQ922B6.

Expressioni

Gene expression databases

CleanExiMM_TRAF7.

Interactioni

Subunit structurei

Homodimer. Interacts with MAP3K3 and promotes the kinase activity of this enzyme.By similarity

Protein-protein interaction databases

IntActiQ922B6. 1 interactor.
MINTiMINT-4138429.
STRINGi10090.ENSMUSP00000085812.

Structurei

3D structure databases

ProteinModelPortaliQ922B6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati318 – 357WD 1Sequence analysisAdd BLAST40
Repeati361 – 398WD 2Sequence analysisAdd BLAST38
Repeati401 – 437WD 3Sequence analysisAdd BLAST37
Repeati439 – 478WD 4Sequence analysisAdd BLAST40
Repeati481 – 518WD 5Sequence analysisAdd BLAST38
Repeati521 – 562WD 6Sequence analysisAdd BLAST42
Repeati565 – 593WD 7Sequence analysisAdd BLAST29

Sequence similaritiesi

Belongs to the WD repeat TRAF7 family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri55 – 89RING-typePROSITE-ProRule annotationAdd BLAST35
Zinc fingeri146 – 216TRAF-typePROSITE-ProRule annotationAdd BLAST71

Keywords - Domaini

Repeat, WD repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG0274. Eukaryota.
KOG0297. Eukaryota.
ENOG410XNP5. LUCA.
HOGENOMiHOG000220840.
HOVERGENiHBG055270.
InParanoidiQ922B6.

Family and domain databases

Gene3Di2.130.10.10. 3 hits.
3.30.40.10. 2 hits.
InterProiView protein in InterPro
IPR020472. G-protein_beta_WD-40_rep.
IPR008974. TRAF-like.
IPR015943. WD40/YVTN_repeat-like_dom_sf.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
IPR036322. WD40_repeat_dom_sf.
IPR027370. Znf-RING_LisH.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR017907. Znf_RING_CS.
IPR001293. Znf_TRAF.
PfamiView protein in Pfam
PF00400. WD40. 4 hits.
PF13445. zf-RING_UBOX. 1 hit.
PRINTSiPR00320. GPROTEINBRPT.
SMARTiView protein in SMART
SM00184. RING. 1 hit.
SM00320. WD40. 7 hits.
SUPFAMiSSF49599. SSF49599. 2 hits.
SSF50978. SSF50978. 1 hit.
PROSITEiView protein in PROSITE
PS00678. WD_REPEATS_1. 2 hits.
PS50082. WD_REPEATS_2. 5 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
PS00518. ZF_RING_1. 1 hit.
PS50089. ZF_RING_2. 1 hit.
PS50145. ZF_TRAF. 1 hit.

Sequencei

Sequence statusi: Complete.

Q922B6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPPINTPRRS DSAISVRSLH SESSMSLRST FSLPEEEEEP EPLVFAEQPS
60 70 80 90 100
VKLCCQLCCS VFKDPVITTC GHTFCRRCAL KSEKCPVDNA KLTVVVNNIA
110 120 130 140 150
VAEQIGELFI HCRHGCHAAG TGKPGVFEVD PRGCPFTIKL SARKDHESSC
160 170 180 190 200
DYRPVRCPNN PSCPPLLKMN LEAHLKECEH IKCPHSKYGC TFIGNQDTYE
210 220 230 240 250
THLETCRFEG LKEFLQQTDD RFHEMHVALA QKDQEIAFLR SMLGKLSEKI
260 270 280 290 300
DQLEKSLELK FDVLDENQSK LSEDLMEFRR DASMLNDELS HINARLNMGI
310 320 330 340 350
LGSYDPQQIF KCKGTFVGHQ GPVWCLCVYS MGDLLFSGSS DKTIKVWDTC
360 370 380 390 400
TTYKCQKTLE GHDGIVLALC IQGCKLYSGS ADCTIIVWDI QNLQKVNTIR
410 420 430 440 450
AHDNPVCTLV SSHNMLFSGS LKAIKVWDIV GTELKLKKEL TGLNHWVRAL
460 470 480 490 500
VAAQSYLYSG SYQTIKIWDI RTLDCIHVLQ TSGGSVYSIA VTNHHIVCGT
510 520 530 540 550
YENLIHVWDI ESKEQVRTLT GHVGTVYALA VISTPDQTKV FSASYDRSLR
560 570 580 590
VWSMDNMICT QTLLRHQGSV TALAVSRGRL FSGAVDSTVK VWTC
Length:594
Mass (Da):66,487
Last modified:December 1, 2001 - v1
Checksum:i18009319608AD0B2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC005649 mRNA. Translation: AAH05649.1.
BC008598 mRNA. Translation: AAH08598.1.
UniGeneiMm.275150.

Genome annotation databases

UCSCiuc008awr.2. mouse.

Similar proteinsi

Entry informationi

Entry nameiTRAF7_MOUSE
AccessioniPrimary (citable) accession number: Q922B6
Secondary accession number(s): Q99JV3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: December 1, 2001
Last modified: November 22, 2017
This is version 133 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families