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Protein

E3 ubiquitin-protein ligase TRAF7

Gene

Traf7

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

E3 ubiquitin ligase capable of auto-ubiquitination, following phosphorylation by MAP3K3. Potentiates MEKK3-mediated activation of the NF-kappa-B, JUN/AP1 and DDIT3 transcriptional regulators. Induces apoptosis when overexpressed (By similarity).By similarity

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri55 – 8935RING-typePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri146 – 21671TRAF-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Apoptosis, Transcription, Transcription regulation, Ubl conjugation pathway

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
E3 ubiquitin-protein ligase TRAF7 (EC:6.3.2.-)
Alternative name(s):
TNF receptor-associated factor 7
Gene namesi
Name:Traf7Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:3042141. Traf7.

Subcellular locationi

  • Cytoplasmic vesicle By similarity

  • Note: Colocalizes with MAP3K3 to vesicle-like structures throughout the cytoplasm.By similarity

GO - Cellular componenti

  • cytoplasmic, membrane-bounded vesicle Source: UniProtKB-SubCell
  • cytosol Source: MGI
  • intracellular membrane-bounded organelle Source: MGI
  • nucleus Source: MGI
  • perinuclear region of cytoplasm Source: MGI
  • plasma membrane Source: MGI
  • ubiquitin ligase complex Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasmic vesicle

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 594594E3 ubiquitin-protein ligase TRAF7PRO_0000051297Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei12 – 121PhosphoserineCombined sources
Modified residuei15 – 151PhosphoserineCombined sources

Post-translational modificationi

Phosphorylated by MAP3K3.By similarity
Ubiquitinates itself upon phosphorylation.By similarity

Keywords - PTMi

Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ922B6.
MaxQBiQ922B6.
PaxDbiQ922B6.
PRIDEiQ922B6.

PTM databases

iPTMnetiQ922B6.

Expressioni

Gene expression databases

BgeeiQ922B6.
CleanExiMM_TRAF7.

Interactioni

Subunit structurei

Homodimer. Interacts with MAP3K3 and promotes the kinase activity of this enzyme (By similarity).By similarity

Protein-protein interaction databases

IntActiQ922B6. 1 interaction.
MINTiMINT-4138429.
STRINGi10090.ENSMUSP00000085812.

Structurei

3D structure databases

ProteinModelPortaliQ922B6.
SMRiQ922B6. Positions 55-190, 316-592.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati318 – 35740WD 1Sequence analysisAdd
BLAST
Repeati361 – 39838WD 2Sequence analysisAdd
BLAST
Repeati401 – 43737WD 3Sequence analysisAdd
BLAST
Repeati439 – 47840WD 4Sequence analysisAdd
BLAST
Repeati481 – 51838WD 5Sequence analysisAdd
BLAST
Repeati521 – 56242WD 6Sequence analysisAdd
BLAST
Repeati565 – 59329WD 7Sequence analysisAdd
BLAST

Sequence similaritiesi

Belongs to the WD repeat TRAF7 family.Curated
Contains 1 RING-type zinc finger.PROSITE-ProRule annotation
Contains 1 TRAF-type zinc finger.PROSITE-ProRule annotation
Contains 7 WD repeats.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri55 – 8935RING-typePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri146 – 21671TRAF-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, WD repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG0274. Eukaryota.
KOG0297. Eukaryota.
ENOG410XNP5. LUCA.
HOGENOMiHOG000220840.
HOVERGENiHBG055270.
InParanoidiQ922B6.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
3.30.40.10. 1 hit.
3.90.890.10. 1 hit.
InterProiIPR020472. G-protein_beta_WD-40_rep.
IPR013323. SIAH-type.
IPR008974. TRAF-like.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
IPR027370. Znf-RING_LisH.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR017907. Znf_RING_CS.
IPR001293. Znf_TRAF.
[Graphical view]
PfamiPF00400. WD40. 4 hits.
PF13445. zf-RING_UBOX. 1 hit.
[Graphical view]
PRINTSiPR00320. GPROTEINBRPT.
SMARTiSM00184. RING. 1 hit.
SM00320. WD40. 7 hits.
[Graphical view]
SUPFAMiSSF49599. SSF49599. 2 hits.
SSF50978. SSF50978. 1 hit.
PROSITEiPS00678. WD_REPEATS_1. 2 hits.
PS50082. WD_REPEATS_2. 5 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
PS00518. ZF_RING_1. 1 hit.
PS50089. ZF_RING_2. 1 hit.
PS50145. ZF_TRAF. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q922B6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPPINTPRRS DSAISVRSLH SESSMSLRST FSLPEEEEEP EPLVFAEQPS
60 70 80 90 100
VKLCCQLCCS VFKDPVITTC GHTFCRRCAL KSEKCPVDNA KLTVVVNNIA
110 120 130 140 150
VAEQIGELFI HCRHGCHAAG TGKPGVFEVD PRGCPFTIKL SARKDHESSC
160 170 180 190 200
DYRPVRCPNN PSCPPLLKMN LEAHLKECEH IKCPHSKYGC TFIGNQDTYE
210 220 230 240 250
THLETCRFEG LKEFLQQTDD RFHEMHVALA QKDQEIAFLR SMLGKLSEKI
260 270 280 290 300
DQLEKSLELK FDVLDENQSK LSEDLMEFRR DASMLNDELS HINARLNMGI
310 320 330 340 350
LGSYDPQQIF KCKGTFVGHQ GPVWCLCVYS MGDLLFSGSS DKTIKVWDTC
360 370 380 390 400
TTYKCQKTLE GHDGIVLALC IQGCKLYSGS ADCTIIVWDI QNLQKVNTIR
410 420 430 440 450
AHDNPVCTLV SSHNMLFSGS LKAIKVWDIV GTELKLKKEL TGLNHWVRAL
460 470 480 490 500
VAAQSYLYSG SYQTIKIWDI RTLDCIHVLQ TSGGSVYSIA VTNHHIVCGT
510 520 530 540 550
YENLIHVWDI ESKEQVRTLT GHVGTVYALA VISTPDQTKV FSASYDRSLR
560 570 580 590
VWSMDNMICT QTLLRHQGSV TALAVSRGRL FSGAVDSTVK VWTC
Length:594
Mass (Da):66,487
Last modified:December 1, 2001 - v1
Checksum:i18009319608AD0B2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC005649 mRNA. Translation: AAH05649.1.
BC008598 mRNA. Translation: AAH08598.1.
UniGeneiMm.275150.

Genome annotation databases

UCSCiuc008awr.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC005649 mRNA. Translation: AAH05649.1.
BC008598 mRNA. Translation: AAH08598.1.
UniGeneiMm.275150.

3D structure databases

ProteinModelPortaliQ922B6.
SMRiQ922B6. Positions 55-190, 316-592.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ922B6. 1 interaction.
MINTiMINT-4138429.
STRINGi10090.ENSMUSP00000085812.

PTM databases

iPTMnetiQ922B6.

Proteomic databases

EPDiQ922B6.
MaxQBiQ922B6.
PaxDbiQ922B6.
PRIDEiQ922B6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

UCSCiuc008awr.2. mouse.

Organism-specific databases

MGIiMGI:3042141. Traf7.

Phylogenomic databases

eggNOGiKOG0274. Eukaryota.
KOG0297. Eukaryota.
ENOG410XNP5. LUCA.
HOGENOMiHOG000220840.
HOVERGENiHBG055270.
InParanoidiQ922B6.

Enzyme and pathway databases

UniPathwayiUPA00143.

Miscellaneous databases

PROiQ922B6.
SOURCEiSearch...

Gene expression databases

BgeeiQ922B6.
CleanExiMM_TRAF7.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
3.30.40.10. 1 hit.
3.90.890.10. 1 hit.
InterProiIPR020472. G-protein_beta_WD-40_rep.
IPR013323. SIAH-type.
IPR008974. TRAF-like.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
IPR027370. Znf-RING_LisH.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR017907. Znf_RING_CS.
IPR001293. Znf_TRAF.
[Graphical view]
PfamiPF00400. WD40. 4 hits.
PF13445. zf-RING_UBOX. 1 hit.
[Graphical view]
PRINTSiPR00320. GPROTEINBRPT.
SMARTiSM00184. RING. 1 hit.
SM00320. WD40. 7 hits.
[Graphical view]
SUPFAMiSSF49599. SSF49599. 2 hits.
SSF50978. SSF50978. 1 hit.
PROSITEiPS00678. WD_REPEATS_1. 2 hits.
PS50082. WD_REPEATS_2. 5 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
PS00518. ZF_RING_1. 1 hit.
PS50089. ZF_RING_2. 1 hit.
PS50145. ZF_TRAF. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/NImported.
    Tissue: Mammary tumor.
  2. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-12 AND SER-15, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Testis.

Entry informationi

Entry nameiTRAF7_MOUSE
AccessioniPrimary (citable) accession number: Q922B6
Secondary accession number(s): Q99JV3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: December 1, 2001
Last modified: June 8, 2016
This is version 121 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.