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Protein

O-acetyl-ADP-ribose deacetylase MACROD1

Gene

Macrod1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Removes ADP-ribose from glutamate residues in proteins bearing a single ADP-ribose moiety. Inactive towards proteins bearing poly-ADP-ribose. Deacetylates O-acetyl-ADP ribose, a signaling molecule generated by the deacetylation of acetylated lysine residues in histones and other proteins. Plays a role in estrogen signaling. Binds to androgen receptor (AR) and amplifies the transactivation function of AR in response to androgen (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei304SubstrateBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processDNA damage

Names & Taxonomyi

Protein namesi
Recommended name:
O-acetyl-ADP-ribose deacetylase MACROD1 (EC:3.2.2.-, EC:3.5.1.-)
Alternative name(s):
MACRO domain-containing protein 1
Protein LRP16
[Protein ADP-ribosylglutamate] hydrolase
Gene namesi
Name:Macrod1
Synonyms:Lrp16
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 19

Organism-specific databases

MGIiMGI:2147583 Macrod1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000844861 – 323O-acetyl-ADP-ribose deacetylase MACROD1Add BLAST323

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei94N6-succinyllysineCombined sources1
Modified residuei101N6-succinyllysineCombined sources1
Modified residuei127N6-succinyllysineCombined sources1
Cross-linki136Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei161N6-acetyllysineCombined sources1

Keywords - PTMi

Acetylation, Isopeptide bond, Ubl conjugation

Proteomic databases

EPDiQ922B1
MaxQBiQ922B1
PaxDbiQ922B1
PeptideAtlasiQ922B1
PRIDEiQ922B1

PTM databases

iPTMnetiQ922B1
PhosphoSitePlusiQ922B1
SwissPalmiQ922B1

Expressioni

Gene expression databases

BgeeiENSMUSG00000036278
CleanExiMM_MACROD1
GenevisibleiQ922B1 MM

Interactioni

Subunit structurei

Interacts with ESR1. Interacts with AR (via macro domain).By similarity

Protein-protein interaction databases

IntActiQ922B1 1 interactor.
MINTiQ922B1
STRINGi10090.ENSMUSP00000039507

Structurei

3D structure databases

ProteinModelPortaliQ922B1
SMRiQ922B1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini139 – 320MacroPROSITE-ProRule annotationAdd BLAST182

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni157 – 159Substrate bindingBy similarity3
Regioni170 – 172Substrate bindingBy similarity3
Regioni177 – 182Substrate bindingBy similarity6
Regioni265 – 271Substrate bindingBy similarity7

Phylogenomic databases

eggNOGiKOG2633 Eukaryota
COG2110 LUCA
GeneTreeiENSGT00520000055566
HOGENOMiHOG000086960
HOVERGENiHBG052356
InParanoidiQ922B1
OMAiKITCGYR
OrthoDBiEOG091G0NNH
PhylomeDBiQ922B1
TreeFamiTF341440

Family and domain databases

InterProiView protein in InterPro
IPR002589 Macro_dom
PfamiView protein in Pfam
PF01661 Macro, 1 hit
SMARTiView protein in SMART
SM00506 A1pp, 1 hit
PROSITEiView protein in PROSITE
PS51154 MACRO, 1 hit

Sequencei

Sequence statusi: Complete.

Q922B1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLQSQVSGR LAQLRAAGQL LVSLRPWPGR SAGGPRPRGS ACGPLVALGE
60 70 80 90 100
HGYCAWLSAG VGAWGAAGRG AWVRTWAPLA MAAKVDLSTS TDWKEAKSFL
110 120 130 140 150
KGLSDKQREE HYFCKDFIKL KKIPTWKETA KGLAVKVEDP KYKKDKQLNE
160 170 180 190 200
KISLYRGDIT KLEVDAIVNA ANSSLLGGGG VDGCIHRAAG SLLTDECRTL
210 220 230 240 250
QNCETGKAKI TCGYRLPAKY VIHTVGPIAV GQPTASQAAE LRSCYLSSLD
260 270 280 290 300
LLLEHRLRSV AFPCISTGVF GYPNEEAAEV VLASLREWLE QHKDKVDRLI
310 320
ICVFLEKDEG IYRERLPHYF PVA
Length:323
Mass (Da):35,295
Last modified:June 16, 2003 - v2
Checksum:i57842C4F20833A33
GO

Sequence cautioni

The sequence AAH08653 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAC35234 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK052998 mRNA Translation: BAC35234.1 Different initiation.
BC008653 mRNA Translation: AAH08653.1 Different initiation.
CCDSiCCDS50376.1
RefSeqiNP_598908.2, NM_134147.4
UniGeneiMm.439977

Genome annotation databases

EnsembliENSMUST00000040261; ENSMUSP00000039507; ENSMUSG00000036278
GeneIDi107227
KEGGimmu:107227
UCSCiuc008gkg.2 mouse

Similar proteinsi

Entry informationi

Entry nameiMACD1_MOUSE
AccessioniPrimary (citable) accession number: Q922B1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 16, 2003
Last sequence update: June 16, 2003
Last modified: February 28, 2018
This is version 113 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome