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Protein

O-acetyl-ADP-ribose deacetylase MACROD1

Gene

Macrod1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Removes ADP-ribose from glutamate residues in proteins bearing a single ADP-ribose moiety. Inactive towards proteins bearing poly-ADP-ribose. Deacetylates O-acetyl-ADP ribose, a signaling molecule generated by the deacetylation of acetylated lysine residues in histones and other proteins. Plays a role in estrogen signaling. Binds to androgen receptor (AR) and amplifies the transactivation function of AR in response to androgen (By similarity).By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei304 – 3041SubstrateBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

DNA damage

Names & Taxonomyi

Protein namesi
Recommended name:
O-acetyl-ADP-ribose deacetylase MACROD1 (EC:3.2.2.-, EC:3.5.1.-)
Alternative name(s):
MACRO domain-containing protein 1
Protein LRP16
[Protein ADP-ribosylglutamate] hydrolase
Gene namesi
Name:Macrod1
Synonyms:Lrp16
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 19

Organism-specific databases

MGIiMGI:2147583. Macrod1.

Subcellular locationi

  • Nucleus By similarity

  • Note: Recruited to DNA lesions, probably via mono-APD-ribosylated proteins.By similarity

GO - Cellular componenti

  • mitochondrion Source: MGI
  • nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 323323O-acetyl-ADP-ribose deacetylase MACROD1PRO_0000084486Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei94 – 941N6-succinyllysineCombined sources
Modified residuei101 – 1011N6-succinyllysineCombined sources
Modified residuei127 – 1271N6-succinyllysineCombined sources
Modified residuei161 – 1611N6-acetyllysineCombined sources

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ922B1.
MaxQBiQ922B1.
PaxDbiQ922B1.
PeptideAtlasiQ922B1.
PRIDEiQ922B1.

PTM databases

iPTMnetiQ922B1.
PhosphoSiteiQ922B1.
SwissPalmiQ922B1.

Expressioni

Gene expression databases

BgeeiENSMUSG00000036278.
CleanExiMM_MACROD1.
GenevisibleiQ922B1. MM.

Interactioni

Subunit structurei

Interacts with ESR1. Interacts with AR (via macro domain).By similarity

Protein-protein interaction databases

IntActiQ922B1. 1 interaction.
MINTiMINT-1860392.
STRINGi10090.ENSMUSP00000039507.

Structurei

3D structure databases

ProteinModelPortaliQ922B1.
SMRiQ922B1. Positions 89-323.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini139 – 320182MacroPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni157 – 1593Substrate bindingBy similarity
Regioni170 – 1723Substrate bindingBy similarity
Regioni177 – 1826Substrate bindingBy similarity
Regioni265 – 2717Substrate bindingBy similarity

Sequence similaritiesi

Contains 1 Macro domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG2633. Eukaryota.
COG2110. LUCA.
GeneTreeiENSGT00520000055566.
HOGENOMiHOG000086960.
HOVERGENiHBG052356.
InParanoidiQ922B1.
OMAiKITCGYR.
OrthoDBiEOG091G0NNH.
PhylomeDBiQ922B1.
TreeFamiTF341440.

Family and domain databases

InterProiIPR002589. Macro_dom.
[Graphical view]
PfamiPF01661. Macro. 1 hit.
[Graphical view]
SMARTiSM00506. A1pp. 1 hit.
[Graphical view]
PROSITEiPS51154. MACRO. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q922B1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLQSQVSGR LAQLRAAGQL LVSLRPWPGR SAGGPRPRGS ACGPLVALGE
60 70 80 90 100
HGYCAWLSAG VGAWGAAGRG AWVRTWAPLA MAAKVDLSTS TDWKEAKSFL
110 120 130 140 150
KGLSDKQREE HYFCKDFIKL KKIPTWKETA KGLAVKVEDP KYKKDKQLNE
160 170 180 190 200
KISLYRGDIT KLEVDAIVNA ANSSLLGGGG VDGCIHRAAG SLLTDECRTL
210 220 230 240 250
QNCETGKAKI TCGYRLPAKY VIHTVGPIAV GQPTASQAAE LRSCYLSSLD
260 270 280 290 300
LLLEHRLRSV AFPCISTGVF GYPNEEAAEV VLASLREWLE QHKDKVDRLI
310 320
ICVFLEKDEG IYRERLPHYF PVA
Length:323
Mass (Da):35,295
Last modified:June 16, 2003 - v2
Checksum:i57842C4F20833A33
GO

Sequence cautioni

The sequence AAH08653 differs from that shown. Reason: Erroneous initiation. Curated
The sequence BAC35234 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK052998 mRNA. Translation: BAC35234.1. Different initiation.
BC008653 mRNA. Translation: AAH08653.1. Different initiation.
CCDSiCCDS50376.1.
RefSeqiNP_598908.2. NM_134147.4.
UniGeneiMm.439977.

Genome annotation databases

EnsembliENSMUST00000040261; ENSMUSP00000039507; ENSMUSG00000036278.
GeneIDi107227.
KEGGimmu:107227.
UCSCiuc008gkg.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK052998 mRNA. Translation: BAC35234.1. Different initiation.
BC008653 mRNA. Translation: AAH08653.1. Different initiation.
CCDSiCCDS50376.1.
RefSeqiNP_598908.2. NM_134147.4.
UniGeneiMm.439977.

3D structure databases

ProteinModelPortaliQ922B1.
SMRiQ922B1. Positions 89-323.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ922B1. 1 interaction.
MINTiMINT-1860392.
STRINGi10090.ENSMUSP00000039507.

PTM databases

iPTMnetiQ922B1.
PhosphoSiteiQ922B1.
SwissPalmiQ922B1.

Proteomic databases

EPDiQ922B1.
MaxQBiQ922B1.
PaxDbiQ922B1.
PeptideAtlasiQ922B1.
PRIDEiQ922B1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000040261; ENSMUSP00000039507; ENSMUSG00000036278.
GeneIDi107227.
KEGGimmu:107227.
UCSCiuc008gkg.2. mouse.

Organism-specific databases

CTDi28992.
MGIiMGI:2147583. Macrod1.

Phylogenomic databases

eggNOGiKOG2633. Eukaryota.
COG2110. LUCA.
GeneTreeiENSGT00520000055566.
HOGENOMiHOG000086960.
HOVERGENiHBG052356.
InParanoidiQ922B1.
OMAiKITCGYR.
OrthoDBiEOG091G0NNH.
PhylomeDBiQ922B1.
TreeFamiTF341440.

Miscellaneous databases

ChiTaRSiMacrod1. mouse.
PROiQ922B1.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000036278.
CleanExiMM_MACROD1.
GenevisibleiQ922B1. MM.

Family and domain databases

InterProiIPR002589. Macro_dom.
[Graphical view]
PfamiPF01661. Macro. 1 hit.
[Graphical view]
SMARTiSM00506. A1pp. 1 hit.
[Graphical view]
PROSITEiPS51154. MACRO. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMACD1_MOUSE
AccessioniPrimary (citable) accession number: Q922B1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 16, 2003
Last sequence update: June 16, 2003
Last modified: September 7, 2016
This is version 107 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.