Q92275 (BAR1_SCHCO) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Pheromone B alpha 1 receptor

Gene names

Name:

BAR1

Organism

Schizophyllum commune (Split gill fungus)

Taxonomic identifier

5334 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Basidiomycota › Agaricomycotina › Agaricomycetes › Agaricomycetidae › Agaricales › Schizophyllaceae › Schizophyllum

Protein attributes

Sequence length	639 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Receptor for the BAP1 pheromone, a prenylated mating factor. Has a role in the initiation of B-regulated nuclear migration.
Subcellular location	Membrane; Multi-pass membrane protein.
Sequence similarities	Belongs to the G-protein coupled receptor 4 family.

Ontologies

Keywords
Biological process	Pheromone response
Cellular component	Membrane
Domain	Transmembrane Transmembrane helix
Molecular function	G-protein coupled receptor Receptor Transducer
Gene Ontology (GO)
Biological_process	response to pheromone Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	mating-type alpha-factor pheromone receptor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 639	639	Pheromone B alpha 1 receptor		PRO_0000195070
Regions
	Transmembrane	8 – 28	21	Helical; Potential
	Transmembrane	37 – 57	21	Helical; Potential
	Transmembrane	70 – 90	21	Helical; Potential
	Transmembrane	113 – 133	21	Helical; Potential
	Transmembrane	163 – 183	21	Helical; Potential
	Transmembrane	209 – 229	21	Helical; Potential
	Transmembrane	272 – 292	21	Helical; Potential
Experimental info
	Sequence conflict	71	1	S → C in CAA54915. Ref.2
	Sequence conflict	109	1	K → E in CAA54915. Ref.2
	Sequence conflict	131	1	Q → R in CAA54915. Ref.2
	Sequence conflict	155	1	P → A Ref.2
	Sequence conflict	157	1	T → N Ref.2
	Sequence conflict	177	1	V → G in CAA54915. Ref.2
	Sequence conflict	304	1	R → K in CAA54915. Ref.2
	Sequence conflict	348	1	N → S in CAA54915. Ref.2
	Sequence conflict	358	1	F → L Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Q92275 [UniParc]. Last modified July 15, 1998. Version 2. Checksum: B21A6881579139E0	FASTA	639	69,967
	10 20 30 40 50 60 MLDPLYPLFP IFAFLGFVLA ILPLPWHLQA WNSGTCFFMM WTALGCLNQF INSVAWADDA 70 80 90 100 110 120 MNKAPVWCEI SIRILMGASV GIPASSLCII RRLYYIAKVR AVSKTRAEKM RAILVDALIC 130 140 150 160 170 180 VLFPLVYIAL QYIVQGHRFN ILENIGCYPA VTNTPVTYVV SYVWPVLLGL ISATYGVMAL 190 200 210 220 230 240 LQFNKHRLQF SQFLHTHSTL SASRYLRLMA LALTEMMCTM PLGIFVIVLN SKTENIQPWV 250 260 270 280 290 300 SLAVTHYGFG RIDQVPAIVW RSQHLIVVCN ELTRWCAPVS AFIFFFYFGF AEEARRNYAA 310 320 330 340 350 360 AWRRVCRALG LPERVPSLPT TKKPFSSSDN KGSGFAEKFA AKAKGFSNFN VKDFTSEFTS 370 380 390 400 410 420 KAHDFTSKAK QYTLPRPMPQ TLSSSGFSSS DSTRFGSSVD GKELPSPTTK EFSSPIPIHL 430 440 450 460 470 480 SGMQTLASFD SNKDLPSPPA YDIEAQYGPY NIDNRVSYHI ADTGVRASYP MGVAYSSDSE 490 500 510 520 530 540 HRRIVPHHST VPHHSTADEP ASPALPDTPS SCSSSATFST LQSRDFIVLP SSADVTRRDS 550 560 570 580 590 600 GSSAGGVAST SRPTRAGPPR LPSLSQLFGI SSMRGQEGDV EAQGEEMAAD VDVSEMVLDT 610 620 630 LAPASIIAAT TTAGAPATTT PDRGEPDVPT SPRTHRASV

References

[1]	"Allelic divergence at B alpha 1 pheromone receptor genes of Schizophyllum commune." Wendland J., Kothe E. FEMS Microbiol. Lett. 145:451-455(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: 1-69.
[2]	"The mating-type locus B alpha 1 of Schizophyllum commune contains a pheromone receptor gene and putative pheromone genes." Wendland J., Vaillancourt L.J., Hegner J., Lengeler K.B., Laddison K.J., Specht C.A., Raper C.A., Kothe E. EMBO J. 14:5271-5278(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-359. Strain: ATCC 44201 / CBS 340.81 / UVM 4-40 / 4-40.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X94996 Genomic DNA. Translation: CAA64453.1. X77949 Genomic DNA. Translation: CAA54915.1.
PIR	S61919.
3D structure databases
ModBase	Search...
Protein family/group databases
GPCRDB	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
InterPro	IPR000481. GPCR_Pheromne_B_alpha_rcpt. IPR001499. GPCR_STE3. [Graphical view]
Pfam	PF02076. STE3. 1 hit. [Graphical view]
PRINTS	PR00899. GPCRSTE3. PR00901. PHEROMONEBAR.
ProtoNet	Search...

Entry information

Entry name

BAR1_SCHCO

Accession

Primary (citable) accession number: Q92275
Secondary accession number(s): P87022

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	July 15, 1998
Last modified:	April 3, 2013
This is version 52 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program