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Q92250

- FPPS_NEUCR

UniProt

Q92250 - FPPS_NEUCR

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Protein

Farnesyl pyrophosphate synthase

Gene

fpp

Organism
Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the sequential condensation of isopentenyl pyrophosphate with the allylic pyrophosphates, dimethylallyl pyrophosphate, and then with the resultant geranylpyrophosphate to the ultimate product farnesyl pyrophosphate.

Catalytic activityi

Dimethylallyl diphosphate + isopentenyl diphosphate = diphosphate + geranyl diphosphate.
Geranyl diphosphate + isopentenyl diphosphate = diphosphate + (2E,6E)-farnesyl diphosphate.

Cofactori

Mg2+By similarityNote: Binds 3 Mg(2+) ions per subunit.By similarity

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei50 – 501Isopentenyl diphosphateBy similarity
Binding sitei53 – 531Isopentenyl diphosphateBy similarity
Binding sitei88 – 881Isopentenyl diphosphateBy similarity
Metal bindingi95 – 951Magnesium 1By similarity
Metal bindingi95 – 951Magnesium 2By similarity
Metal bindingi99 – 991Magnesium 1By similarity
Metal bindingi99 – 991Magnesium 2By similarity
Binding sitei104 – 1041Dimethylallyl diphosphateBy similarity
Binding sitei105 – 1051Isopentenyl diphosphateBy similarity
Binding sitei192 – 1921Dimethylallyl diphosphateBy similarity
Binding sitei193 – 1931Dimethylallyl diphosphateBy similarity
Binding sitei232 – 2321Dimethylallyl diphosphateBy similarity
Metal bindingi235 – 2351Magnesium 3By similarity
Binding sitei249 – 2491Dimethylallyl diphosphateBy similarity
Binding sitei258 – 2581Dimethylallyl diphosphateBy similarity

GO - Molecular functioni

  1. dimethylallyltranstransferase activity Source: UniProtKB-EC
  2. geranyltranstransferase activity Source: UniProtKB-EC
  3. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. farnesyl diphosphate biosynthetic process Source: UniProtKB-UniPathway
  2. geranyl diphosphate biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Isoprene biosynthesis, Lipid biosynthesis, Lipid metabolism

Keywords - Ligandi

Magnesium, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00259; UER00368.
UPA00260; UER00369.

Names & Taxonomyi

Protein namesi
Recommended name:
Farnesyl pyrophosphate synthase (EC:2.5.1.10)
Short name:
FPP synthase
Short name:
FPS
Alternative name(s):
(2E,6E)-farnesyl diphosphate synthase
Dimethylallyltranstransferase (EC:2.5.1.1)
Farnesyl diphosphate synthase
Geranyltranstransferase
Gene namesi
Name:fpp
Synonyms:fpps
ORF Names:123A4.020, NCU01175
OrganismiNeurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Taxonomic identifieri367110 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeSordarialesSordariaceaeNeurospora
ProteomesiUP000001805: Chromosome 2, Linkage Group V

Subcellular locationi

GO - Cellular componenti

  1. endoplasmic reticulum Source: EnsemblFungi
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 347347Farnesyl pyrophosphate synthasePRO_0000123950Add
BLAST

Proteomic databases

PRIDEiQ92250.

Interactioni

Protein-protein interaction databases

STRINGi5141.NCU01175.1.

Structurei

3D structure databases

ProteinModelPortaliQ92250.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the FPP/GGPP synthase family.Curated

Phylogenomic databases

eggNOGiCOG0142.
HOGENOMiHOG000160912.
InParanoidiQ92250.
KOiK00787.
OMAiFRRFEQH.
OrthoDBiEOG79GTJ1.

Family and domain databases

Gene3Di1.10.600.10. 1 hit.
InterProiIPR000092. Polyprenyl_synt.
IPR008949. Terpenoid_synth.
[Graphical view]
PfamiPF00348. polyprenyl_synt. 1 hit.
[Graphical view]
SUPFAMiSSF48576. SSF48576. 1 hit.
PROSITEiPS00723. POLYPRENYL_SYNTHASE_1. 1 hit.
PS00444. POLYPRENYL_SYNTHASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q92250-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAKTTTLKEF ESVFPKLEEA LLEYAKAYKL PEQMLSWYKQ SLEVNTLGGK
60 70 80 90 100
CNRGMSVPDS ASILLGRPLT EEEYFQAATL GWMTELLQAF FLVSDDIMDS
110 120 130 140 150
SITRRGKPCW YRQEGVGMVA INDAFMLESA IYTLLKKYFR SHPRYVDFLE
160 170 180 190 200
LFHEVTFQTE MGQLCDLLTA PEDKVDLDNF SMDKYTFIVI YKTAYYSFYL
210 220 230 240 250
PVALAMYMLD IATPENLKQA EDILIPLGEY FQVQDDYLDN FGLPEHIGKI
260 270 280 290 300
GTDIQDNKCS WLVNKALSIV TPEQRKTLEE NYGRKDKAKE AVIKQLYDDL
310 320 330 340
KLEDHYKQYE EERVGEIRKM IDAIDESKGL KKQVFEAFLG KIYKRSK
Length:347
Mass (Da):40,278
Last modified:June 7, 2005 - v2
Checksum:i83F4DC7C4D61212F
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti134 – 1341L → R in CAA65645. (PubMed:8753652)Curated
Sequence conflicti321 – 3211I → N in CAA65645. (PubMed:8753652)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X96944 Genomic DNA. Translation: CAA65645.1.
AL670009 Genomic DNA. Translation: CAD21355.1.
CM002240 Genomic DNA. Translation: EAA32305.1.
PIRiS71436.
RefSeqiXP_961541.1. XM_956448.1.
UniGeneiNcr.15758.

Genome annotation databases

EnsemblFungiiEFNCRT00000004433; EFNCRP00000004433; EFNCRG00000004427.
GeneIDi3877737.
KEGGincr:NCU01175.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X96944 Genomic DNA. Translation: CAA65645.1 .
AL670009 Genomic DNA. Translation: CAD21355.1 .
CM002240 Genomic DNA. Translation: EAA32305.1 .
PIRi S71436.
RefSeqi XP_961541.1. XM_956448.1.
UniGenei Ncr.15758.

3D structure databases

ProteinModelPortali Q92250.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 5141.NCU01175.1.

Proteomic databases

PRIDEi Q92250.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii EFNCRT00000004433 ; EFNCRP00000004433 ; EFNCRG00000004427 .
GeneIDi 3877737.
KEGGi ncr:NCU01175.

Phylogenomic databases

eggNOGi COG0142.
HOGENOMi HOG000160912.
InParanoidi Q92250.
KOi K00787.
OMAi FRRFEQH.
OrthoDBi EOG79GTJ1.

Enzyme and pathway databases

UniPathwayi UPA00259 ; UER00368 .
UPA00260 ; UER00369 .

Family and domain databases

Gene3Di 1.10.600.10. 1 hit.
InterProi IPR000092. Polyprenyl_synt.
IPR008949. Terpenoid_synth.
[Graphical view ]
Pfami PF00348. polyprenyl_synt. 1 hit.
[Graphical view ]
SUPFAMi SSF48576. SSF48576. 1 hit.
PROSITEi PS00723. POLYPRENYL_SYNTHASE_1. 1 hit.
PS00444. POLYPRENYL_SYNTHASE_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The isoprenoid pathway: cloning and characterization of fungal FPPS genes."
    Homann V., Mende K., Arntz C., Ilardi V., Macino G., Morelli G., Bose G., Tudzynski B.
    Curr. Genet. 30:232-239(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987.
  2. "What's in the genome of a filamentous fungus? Analysis of the Neurospora genome sequence."
    Mannhaupt G., Montrone C., Haase D., Mewes H.-W., Aign V., Hoheisel J.D., Fartmann B., Nyakatura G., Kempken F., Maier J., Schulte U.
    Nucleic Acids Res. 31:1944-1954(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987.
  3. "The genome sequence of the filamentous fungus Neurospora crassa."
    Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D., Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B., Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M., Qui D.
    , Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M., Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U., Kothe G.O., Jedd G., Mewes H.-W., Staben C., Marcotte E., Greenberg D., Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S., Kamal M., Kamvysselis M., Mauceli E.W., Bielke C., Rudd S., Frishman D., Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S., Cogoni C., Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A., DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R., Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R., Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I., Sachs M.S., Lander E.S., Nusbaum C., Birren B.W.
    Nature 422:859-868(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987.

Entry informationi

Entry nameiFPPS_NEUCR
AccessioniPrimary (citable) accession number: Q92250
Secondary accession number(s): Q1K859, Q8X0Y6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: June 7, 2005
Last modified: November 26, 2014
This is version 95 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3