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Protein

Farnesyl pyrophosphate synthase

Gene

fpp

Organism
Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the sequential condensation of isopentenyl pyrophosphate with the allylic pyrophosphates, dimethylallyl pyrophosphate, and then with the resultant geranylpyrophosphate to the ultimate product farnesyl pyrophosphate.

Catalytic activityi

Dimethylallyl diphosphate + isopentenyl diphosphate = diphosphate + geranyl diphosphate.
Geranyl diphosphate + isopentenyl diphosphate = diphosphate + (2E,6E)-farnesyl diphosphate.

Cofactori

Mg2+By similarityNote: Binds 3 Mg2+ ions per subunit.By similarity

Pathwayi: farnesyl diphosphate biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes farnesyl diphosphate from geranyl diphosphate and isopentenyl diphosphate.
Proteins known to be involved in this subpathway in this organism are:
  1. Farnesyl pyrophosphate synthase (fpp), Geranylgeranyl pyrophosphate synthase (al-3)
This subpathway is part of the pathway farnesyl diphosphate biosynthesis, which is itself part of Isoprenoid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes farnesyl diphosphate from geranyl diphosphate and isopentenyl diphosphate, the pathway farnesyl diphosphate biosynthesis and in Isoprenoid biosynthesis.

Pathwayi: geranyl diphosphate biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes geranyl diphosphate from dimethylallyl diphosphate and isopentenyl diphosphate.
Proteins known to be involved in this subpathway in this organism are:
  1. Farnesyl pyrophosphate synthase (fpp), Geranylgeranyl pyrophosphate synthase (al-3)
This subpathway is part of the pathway geranyl diphosphate biosynthesis, which is itself part of Isoprenoid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes geranyl diphosphate from dimethylallyl diphosphate and isopentenyl diphosphate, the pathway geranyl diphosphate biosynthesis and in Isoprenoid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei50Isopentenyl diphosphateBy similarity1
Binding sitei53Isopentenyl diphosphateBy similarity1
Binding sitei88Isopentenyl diphosphateBy similarity1
Metal bindingi95Magnesium 1By similarity1
Metal bindingi95Magnesium 2By similarity1
Metal bindingi99Magnesium 1By similarity1
Metal bindingi99Magnesium 2By similarity1
Binding sitei104Dimethylallyl diphosphateBy similarity1
Binding sitei105Isopentenyl diphosphateBy similarity1
Binding sitei192Dimethylallyl diphosphateBy similarity1
Binding sitei193Dimethylallyl diphosphateBy similarity1
Binding sitei232Dimethylallyl diphosphateBy similarity1
Metal bindingi235Magnesium 3By similarity1
Binding sitei249Dimethylallyl diphosphateBy similarity1
Binding sitei258Dimethylallyl diphosphateBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processIsoprene biosynthesis, Lipid biosynthesis, Lipid metabolism
LigandMagnesium, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00259; UER00368
UPA00260; UER00369

Names & Taxonomyi

Protein namesi
Recommended name:
Farnesyl pyrophosphate synthase (EC:2.5.1.10)
Short name:
FPP synthase
Short name:
FPS
Alternative name(s):
(2E,6E)-farnesyl diphosphate synthase
Dimethylallyltranstransferase (EC:2.5.1.1)
Farnesyl diphosphate synthase
Geranyltranstransferase
Gene namesi
Name:fpp
Synonyms:fpps
ORF Names:123A4.020, NCU01175
OrganismiNeurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Taxonomic identifieri367110 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeSordarialesSordariaceaeNeurospora
Proteomesi

Organism-specific databases

EuPathDBiFungiDB:NCU01175

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001239501 – 347Farnesyl pyrophosphate synthaseAdd BLAST347

Proteomic databases

PRIDEiQ92250

Structurei

3D structure databases

ProteinModelPortaliQ92250
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the FPP/GGPP synthase family.Curated

Phylogenomic databases

HOGENOMiHOG000160912
InParanoidiQ92250
KOiK00787
OMAiITAPEDH
OrthoDBiEOG092C35ZD

Family and domain databases

Gene3Di1.10.600.10, 1 hit
InterProiView protein in InterPro
IPR008949 Isoprenoid_synthase_dom_sf
IPR000092 Polyprenyl_synt
IPR033749 Polyprenyl_synt_CS
PfamiView protein in Pfam
PF00348 polyprenyl_synt, 1 hit
SUPFAMiSSF48576 SSF48576, 1 hit
PROSITEiView protein in PROSITE
PS00723 POLYPRENYL_SYNTHASE_1, 1 hit
PS00444 POLYPRENYL_SYNTHASE_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q92250-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKTTTLKEF ESVFPKLEEA LLEYAKAYKL PEQMLSWYKQ SLEVNTLGGK
60 70 80 90 100
CNRGMSVPDS ASILLGRPLT EEEYFQAATL GWMTELLQAF FLVSDDIMDS
110 120 130 140 150
SITRRGKPCW YRQEGVGMVA INDAFMLESA IYTLLKKYFR SHPRYVDFLE
160 170 180 190 200
LFHEVTFQTE MGQLCDLLTA PEDKVDLDNF SMDKYTFIVI YKTAYYSFYL
210 220 230 240 250
PVALAMYMLD IATPENLKQA EDILIPLGEY FQVQDDYLDN FGLPEHIGKI
260 270 280 290 300
GTDIQDNKCS WLVNKALSIV TPEQRKTLEE NYGRKDKAKE AVIKQLYDDL
310 320 330 340
KLEDHYKQYE EERVGEIRKM IDAIDESKGL KKQVFEAFLG KIYKRSK
Length:347
Mass (Da):40,278
Last modified:June 7, 2005 - v2
Checksum:i83F4DC7C4D61212F
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti134L → R in CAA65645 (PubMed:8753652).Curated1
Sequence conflicti321I → N in CAA65645 (PubMed:8753652).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X96944 Genomic DNA Translation: CAA65645.1
AL670009 Genomic DNA Translation: CAD21355.1
CM002240 Genomic DNA Translation: EAA32305.1
PIRiS71436
RefSeqiXP_961541.1, XM_956448.2

Genome annotation databases

EnsemblFungiiEAA32305; EAA32305; NCU01175
GeneIDi3877737
KEGGincr:NCU01175

Similar proteinsi

Entry informationi

Entry nameiFPPS_NEUCR
AccessioniPrimary (citable) accession number: Q92250
Secondary accession number(s): Q1K859, Q8X0Y6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: June 7, 2005
Last modified: March 28, 2018
This is version 113 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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