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Q92250

- FPPS_NEUCR

UniProt

Q92250 - FPPS_NEUCR

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Protein
Farnesyl pyrophosphate synthase
Gene
fpp, fpps, 123A4.020, NCU01175
Organism
Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Status
Reviewed - Annotation score: 4 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the sequential condensation of isopentenyl pyrophosphate with the allylic pyrophosphates, dimethylallyl pyrophosphate, and then with the resultant geranylpyrophosphate to the ultimate product farnesyl pyrophosphate.

Catalytic activityi

Dimethylallyl diphosphate + isopentenyl diphosphate = diphosphate + geranyl diphosphate.
Geranyl diphosphate + isopentenyl diphosphate = diphosphate + (2E,6E)-farnesyl diphosphate.

Cofactori

Binds 3 magnesium ions per subunit By similarity.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei50 – 501Isopentenyl diphosphate By similarity
Binding sitei53 – 531Isopentenyl diphosphate By similarity
Binding sitei88 – 881Isopentenyl diphosphate By similarity
Metal bindingi95 – 951Magnesium 1 By similarity
Metal bindingi95 – 951Magnesium 2 By similarity
Metal bindingi99 – 991Magnesium 1 By similarity
Metal bindingi99 – 991Magnesium 2 By similarity
Binding sitei104 – 1041Dimethylallyl diphosphate By similarity
Binding sitei105 – 1051Isopentenyl diphosphate By similarity
Binding sitei192 – 1921Dimethylallyl diphosphate By similarity
Binding sitei193 – 1931Dimethylallyl diphosphate By similarity
Binding sitei232 – 2321Dimethylallyl diphosphate By similarity
Metal bindingi235 – 2351Magnesium 3 By similarity
Binding sitei249 – 2491Dimethylallyl diphosphate By similarity
Binding sitei258 – 2581Dimethylallyl diphosphate By similarity

GO - Molecular functioni

  1. dimethylallyltranstransferase activity Source: UniProtKB-EC
  2. geranyltranstransferase activity Source: UniProtKB-EC
  3. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. farnesyl diphosphate biosynthetic process Source: UniProtKB-UniPathway
  2. geranyl diphosphate biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Isoprene biosynthesis, Lipid biosynthesis, Lipid metabolism

Keywords - Ligandi

Magnesium, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00259; UER00368.
UPA00260; UER00369.

Names & Taxonomyi

Protein namesi
Recommended name:
Farnesyl pyrophosphate synthase (EC:2.5.1.10)
Short name:
FPP synthase
Short name:
FPS
Alternative name(s):
(2E,6E)-farnesyl diphosphate synthase
Dimethylallyltranstransferase (EC:2.5.1.1)
Farnesyl diphosphate synthase
Geranyltranstransferase
Gene namesi
Name:fpp
Synonyms:fpps
ORF Names:123A4.020, NCU01175
OrganismiNeurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Taxonomic identifieri367110 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeSordarialesSordariaceaeNeurospora
ProteomesiUP000001805: Chromosome 2, Linkage Group V

Subcellular locationi

GO - Cellular componenti

  1. endoplasmic reticulum Source: EnsemblFungi
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 347347Farnesyl pyrophosphate synthase
PRO_0000123950Add
BLAST

Proteomic databases

PRIDEiQ92250.

Interactioni

Protein-protein interaction databases

STRINGi5141.NCU01175.1.

Structurei

3D structure databases

ProteinModelPortaliQ92250.

Family & Domainsi

Sequence similaritiesi

Belongs to the FPP/GGPP synthase family.

Phylogenomic databases

eggNOGiCOG0142.
HOGENOMiHOG000160912.
KOiK00787.
OMAiFRRFEQH.
OrthoDBiEOG79GTJ1.

Family and domain databases

Gene3Di1.10.600.10. 1 hit.
InterProiIPR000092. Polyprenyl_synt.
IPR008949. Terpenoid_synth.
[Graphical view]
PfamiPF00348. polyprenyl_synt. 1 hit.
[Graphical view]
SUPFAMiSSF48576. SSF48576. 1 hit.
PROSITEiPS00723. POLYPRENYL_SYNTHASE_1. 1 hit.
PS00444. POLYPRENYL_SYNTHASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q92250-1 [UniParc]FASTAAdd to Basket

« Hide

MAKTTTLKEF ESVFPKLEEA LLEYAKAYKL PEQMLSWYKQ SLEVNTLGGK    50
CNRGMSVPDS ASILLGRPLT EEEYFQAATL GWMTELLQAF FLVSDDIMDS 100
SITRRGKPCW YRQEGVGMVA INDAFMLESA IYTLLKKYFR SHPRYVDFLE 150
LFHEVTFQTE MGQLCDLLTA PEDKVDLDNF SMDKYTFIVI YKTAYYSFYL 200
PVALAMYMLD IATPENLKQA EDILIPLGEY FQVQDDYLDN FGLPEHIGKI 250
GTDIQDNKCS WLVNKALSIV TPEQRKTLEE NYGRKDKAKE AVIKQLYDDL 300
KLEDHYKQYE EERVGEIRKM IDAIDESKGL KKQVFEAFLG KIYKRSK 347
Length:347
Mass (Da):40,278
Last modified:June 7, 2005 - v2
Checksum:i83F4DC7C4D61212F
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti134 – 1341L → R in CAA65645. 1 Publication
Sequence conflicti321 – 3211I → N in CAA65645. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X96944 Genomic DNA. Translation: CAA65645.1.
AL670009 Genomic DNA. Translation: CAD21355.1.
CM002240 Genomic DNA. Translation: EAA32305.1.
PIRiS71436.
RefSeqiXP_961541.1. XM_956448.1.
UniGeneiNcr.15758.

Genome annotation databases

EnsemblFungiiEFNCRT00000004433; EFNCRP00000004433; EFNCRG00000004427.
GeneIDi3877737.
KEGGincr:NCU01175.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X96944 Genomic DNA. Translation: CAA65645.1 .
AL670009 Genomic DNA. Translation: CAD21355.1 .
CM002240 Genomic DNA. Translation: EAA32305.1 .
PIRi S71436.
RefSeqi XP_961541.1. XM_956448.1.
UniGenei Ncr.15758.

3D structure databases

ProteinModelPortali Q92250.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 5141.NCU01175.1.

Proteomic databases

PRIDEi Q92250.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii EFNCRT00000004433 ; EFNCRP00000004433 ; EFNCRG00000004427 .
GeneIDi 3877737.
KEGGi ncr:NCU01175.

Phylogenomic databases

eggNOGi COG0142.
HOGENOMi HOG000160912.
KOi K00787.
OMAi FRRFEQH.
OrthoDBi EOG79GTJ1.

Enzyme and pathway databases

UniPathwayi UPA00259 ; UER00368 .
UPA00260 ; UER00369 .

Family and domain databases

Gene3Di 1.10.600.10. 1 hit.
InterProi IPR000092. Polyprenyl_synt.
IPR008949. Terpenoid_synth.
[Graphical view ]
Pfami PF00348. polyprenyl_synt. 1 hit.
[Graphical view ]
SUPFAMi SSF48576. SSF48576. 1 hit.
PROSITEi PS00723. POLYPRENYL_SYNTHASE_1. 1 hit.
PS00444. POLYPRENYL_SYNTHASE_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The isoprenoid pathway: cloning and characterization of fungal FPPS genes."
    Homann V., Mende K., Arntz C., Ilardi V., Macino G., Morelli G., Bose G., Tudzynski B.
    Curr. Genet. 30:232-239(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987.
  2. "What's in the genome of a filamentous fungus? Analysis of the Neurospora genome sequence."
    Mannhaupt G., Montrone C., Haase D., Mewes H.-W., Aign V., Hoheisel J.D., Fartmann B., Nyakatura G., Kempken F., Maier J., Schulte U.
    Nucleic Acids Res. 31:1944-1954(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987.
  3. "The genome sequence of the filamentous fungus Neurospora crassa."
    Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D., Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B., Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M., Qui D.
    , Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M., Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U., Kothe G.O., Jedd G., Mewes H.-W., Staben C., Marcotte E., Greenberg D., Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S., Kamal M., Kamvysselis M., Mauceli E.W., Bielke C., Rudd S., Frishman D., Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S., Cogoni C., Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A., DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R., Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R., Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I., Sachs M.S., Lander E.S., Nusbaum C., Birren B.W.
    Nature 422:859-868(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987.

Entry informationi

Entry nameiFPPS_NEUCR
AccessioniPrimary (citable) accession number: Q92250
Secondary accession number(s): Q1K859, Q8X0Y6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: June 7, 2005
Last modified: May 14, 2014
This is version 92 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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