Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q92250

- FPPS_NEUCR

UniProt

Q92250 - FPPS_NEUCR

Protein

Farnesyl pyrophosphate synthase

Gene

fpp

Organism
Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 93 (01 Oct 2014)
      Sequence version 2 (07 Jun 2005)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Catalyzes the sequential condensation of isopentenyl pyrophosphate with the allylic pyrophosphates, dimethylallyl pyrophosphate, and then with the resultant geranylpyrophosphate to the ultimate product farnesyl pyrophosphate.

    Catalytic activityi

    Dimethylallyl diphosphate + isopentenyl diphosphate = diphosphate + geranyl diphosphate.
    Geranyl diphosphate + isopentenyl diphosphate = diphosphate + (2E,6E)-farnesyl diphosphate.

    Cofactori

    Binds 3 magnesium ions per subunit.By similarity

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei50 – 501Isopentenyl diphosphateBy similarity
    Binding sitei53 – 531Isopentenyl diphosphateBy similarity
    Binding sitei88 – 881Isopentenyl diphosphateBy similarity
    Metal bindingi95 – 951Magnesium 1By similarity
    Metal bindingi95 – 951Magnesium 2By similarity
    Metal bindingi99 – 991Magnesium 1By similarity
    Metal bindingi99 – 991Magnesium 2By similarity
    Binding sitei104 – 1041Dimethylallyl diphosphateBy similarity
    Binding sitei105 – 1051Isopentenyl diphosphateBy similarity
    Binding sitei192 – 1921Dimethylallyl diphosphateBy similarity
    Binding sitei193 – 1931Dimethylallyl diphosphateBy similarity
    Binding sitei232 – 2321Dimethylallyl diphosphateBy similarity
    Metal bindingi235 – 2351Magnesium 3By similarity
    Binding sitei249 – 2491Dimethylallyl diphosphateBy similarity
    Binding sitei258 – 2581Dimethylallyl diphosphateBy similarity

    GO - Molecular functioni

    1. dimethylallyltranstransferase activity Source: UniProtKB-EC
    2. geranyltranstransferase activity Source: UniProtKB-EC
    3. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. farnesyl diphosphate biosynthetic process Source: UniProtKB-UniPathway
    2. geranyl diphosphate biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Transferase

    Keywords - Biological processi

    Isoprene biosynthesis, Lipid biosynthesis, Lipid metabolism

    Keywords - Ligandi

    Magnesium, Metal-binding

    Enzyme and pathway databases

    UniPathwayiUPA00259; UER00368.
    UPA00260; UER00369.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Farnesyl pyrophosphate synthase (EC:2.5.1.10)
    Short name:
    FPP synthase
    Short name:
    FPS
    Alternative name(s):
    (2E,6E)-farnesyl diphosphate synthase
    Dimethylallyltranstransferase (EC:2.5.1.1)
    Farnesyl diphosphate synthase
    Geranyltranstransferase
    Gene namesi
    Name:fpp
    Synonyms:fpps
    ORF Names:123A4.020, NCU01175
    OrganismiNeurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
    Taxonomic identifieri367110 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeSordarialesSordariaceaeNeurospora
    ProteomesiUP000001805: Chromosome 2, Linkage Group V

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum Source: EnsemblFungi

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 347347Farnesyl pyrophosphate synthasePRO_0000123950Add
    BLAST

    Proteomic databases

    PRIDEiQ92250.

    Interactioni

    Protein-protein interaction databases

    STRINGi5141.NCU01175.1.

    Structurei

    3D structure databases

    ProteinModelPortaliQ92250.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the FPP/GGPP synthase family.Curated

    Phylogenomic databases

    eggNOGiCOG0142.
    HOGENOMiHOG000160912.
    KOiK00787.
    OMAiFRRFEQH.
    OrthoDBiEOG79GTJ1.

    Family and domain databases

    Gene3Di1.10.600.10. 1 hit.
    InterProiIPR000092. Polyprenyl_synt.
    IPR008949. Terpenoid_synth.
    [Graphical view]
    PfamiPF00348. polyprenyl_synt. 1 hit.
    [Graphical view]
    SUPFAMiSSF48576. SSF48576. 1 hit.
    PROSITEiPS00723. POLYPRENYL_SYNTHASE_1. 1 hit.
    PS00444. POLYPRENYL_SYNTHASE_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q92250-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAKTTTLKEF ESVFPKLEEA LLEYAKAYKL PEQMLSWYKQ SLEVNTLGGK    50
    CNRGMSVPDS ASILLGRPLT EEEYFQAATL GWMTELLQAF FLVSDDIMDS 100
    SITRRGKPCW YRQEGVGMVA INDAFMLESA IYTLLKKYFR SHPRYVDFLE 150
    LFHEVTFQTE MGQLCDLLTA PEDKVDLDNF SMDKYTFIVI YKTAYYSFYL 200
    PVALAMYMLD IATPENLKQA EDILIPLGEY FQVQDDYLDN FGLPEHIGKI 250
    GTDIQDNKCS WLVNKALSIV TPEQRKTLEE NYGRKDKAKE AVIKQLYDDL 300
    KLEDHYKQYE EERVGEIRKM IDAIDESKGL KKQVFEAFLG KIYKRSK 347
    Length:347
    Mass (Da):40,278
    Last modified:June 7, 2005 - v2
    Checksum:i83F4DC7C4D61212F
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti134 – 1341L → R in CAA65645. (PubMed:8753652)Curated
    Sequence conflicti321 – 3211I → N in CAA65645. (PubMed:8753652)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X96944 Genomic DNA. Translation: CAA65645.1.
    AL670009 Genomic DNA. Translation: CAD21355.1.
    CM002240 Genomic DNA. Translation: EAA32305.1.
    PIRiS71436.
    RefSeqiXP_961541.1. XM_956448.1.
    UniGeneiNcr.15758.

    Genome annotation databases

    EnsemblFungiiEFNCRT00000004433; EFNCRP00000004433; EFNCRG00000004427.
    GeneIDi3877737.
    KEGGincr:NCU01175.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X96944 Genomic DNA. Translation: CAA65645.1 .
    AL670009 Genomic DNA. Translation: CAD21355.1 .
    CM002240 Genomic DNA. Translation: EAA32305.1 .
    PIRi S71436.
    RefSeqi XP_961541.1. XM_956448.1.
    UniGenei Ncr.15758.

    3D structure databases

    ProteinModelPortali Q92250.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 5141.NCU01175.1.

    Proteomic databases

    PRIDEi Q92250.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii EFNCRT00000004433 ; EFNCRP00000004433 ; EFNCRG00000004427 .
    GeneIDi 3877737.
    KEGGi ncr:NCU01175.

    Phylogenomic databases

    eggNOGi COG0142.
    HOGENOMi HOG000160912.
    KOi K00787.
    OMAi FRRFEQH.
    OrthoDBi EOG79GTJ1.

    Enzyme and pathway databases

    UniPathwayi UPA00259 ; UER00368 .
    UPA00260 ; UER00369 .

    Family and domain databases

    Gene3Di 1.10.600.10. 1 hit.
    InterProi IPR000092. Polyprenyl_synt.
    IPR008949. Terpenoid_synth.
    [Graphical view ]
    Pfami PF00348. polyprenyl_synt. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48576. SSF48576. 1 hit.
    PROSITEi PS00723. POLYPRENYL_SYNTHASE_1. 1 hit.
    PS00444. POLYPRENYL_SYNTHASE_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The isoprenoid pathway: cloning and characterization of fungal FPPS genes."
      Homann V., Mende K., Arntz C., Ilardi V., Macino G., Morelli G., Bose G., Tudzynski B.
      Curr. Genet. 30:232-239(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987.
    2. "What's in the genome of a filamentous fungus? Analysis of the Neurospora genome sequence."
      Mannhaupt G., Montrone C., Haase D., Mewes H.-W., Aign V., Hoheisel J.D., Fartmann B., Nyakatura G., Kempken F., Maier J., Schulte U.
      Nucleic Acids Res. 31:1944-1954(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987.
    3. "The genome sequence of the filamentous fungus Neurospora crassa."
      Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D., Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B., Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M., Qui D.
      , Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M., Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U., Kothe G.O., Jedd G., Mewes H.-W., Staben C., Marcotte E., Greenberg D., Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S., Kamal M., Kamvysselis M., Mauceli E.W., Bielke C., Rudd S., Frishman D., Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S., Cogoni C., Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A., DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R., Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R., Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I., Sachs M.S., Lander E.S., Nusbaum C., Birren B.W.
      Nature 422:859-868(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987.

    Entry informationi

    Entry nameiFPPS_NEUCR
    AccessioniPrimary (citable) accession number: Q92250
    Secondary accession number(s): Q1K859, Q8X0Y6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: June 7, 2005
    Last modified: October 1, 2014
    This is version 93 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3