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Protein

Farnesyl pyrophosphate synthase

Gene

fpp

Organism
Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the sequential condensation of isopentenyl pyrophosphate with the allylic pyrophosphates, dimethylallyl pyrophosphate, and then with the resultant geranylpyrophosphate to the ultimate product farnesyl pyrophosphate.

Catalytic activityi

Dimethylallyl diphosphate + isopentenyl diphosphate = diphosphate + geranyl diphosphate.
Geranyl diphosphate + isopentenyl diphosphate = diphosphate + (2E,6E)-farnesyl diphosphate.

Cofactori

Mg2+By similarityNote: Binds 3 Mg2+ ions per subunit.By similarity

Pathwayi: farnesyl diphosphate biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes farnesyl diphosphate from geranyl diphosphate and isopentenyl diphosphate.
Proteins known to be involved in this subpathway in this organism are:
  1. Farnesyl pyrophosphate synthase (fpp), Geranylgeranyl pyrophosphate synthase (al-3)
This subpathway is part of the pathway farnesyl diphosphate biosynthesis, which is itself part of Isoprenoid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes farnesyl diphosphate from geranyl diphosphate and isopentenyl diphosphate, the pathway farnesyl diphosphate biosynthesis and in Isoprenoid biosynthesis.

Pathwayi: geranyl diphosphate biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes geranyl diphosphate from dimethylallyl diphosphate and isopentenyl diphosphate.
Proteins known to be involved in this subpathway in this organism are:
  1. Farnesyl pyrophosphate synthase (fpp), Geranylgeranyl pyrophosphate synthase (al-3)
This subpathway is part of the pathway geranyl diphosphate biosynthesis, which is itself part of Isoprenoid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes geranyl diphosphate from dimethylallyl diphosphate and isopentenyl diphosphate, the pathway geranyl diphosphate biosynthesis and in Isoprenoid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei50Isopentenyl diphosphateBy similarity1
Binding sitei53Isopentenyl diphosphateBy similarity1
Binding sitei88Isopentenyl diphosphateBy similarity1
Metal bindingi95Magnesium 1By similarity1
Metal bindingi95Magnesium 2By similarity1
Metal bindingi99Magnesium 1By similarity1
Metal bindingi99Magnesium 2By similarity1
Binding sitei104Dimethylallyl diphosphateBy similarity1
Binding sitei105Isopentenyl diphosphateBy similarity1
Binding sitei192Dimethylallyl diphosphateBy similarity1
Binding sitei193Dimethylallyl diphosphateBy similarity1
Binding sitei232Dimethylallyl diphosphateBy similarity1
Metal bindingi235Magnesium 3By similarity1
Binding sitei249Dimethylallyl diphosphateBy similarity1
Binding sitei258Dimethylallyl diphosphateBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Isoprene biosynthesis, Lipid biosynthesis, Lipid metabolism

Keywords - Ligandi

Magnesium, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00259; UER00368.
UPA00260; UER00369.

Names & Taxonomyi

Protein namesi
Recommended name:
Farnesyl pyrophosphate synthase (EC:2.5.1.10)
Short name:
FPP synthase
Short name:
FPS
Alternative name(s):
(2E,6E)-farnesyl diphosphate synthase
Dimethylallyltranstransferase (EC:2.5.1.1)
Farnesyl diphosphate synthase
Geranyltranstransferase
Gene namesi
Name:fpp
Synonyms:fpps
ORF Names:123A4.020, NCU01175
OrganismiNeurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Taxonomic identifieri367110 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeSordarialesSordariaceaeNeurospora
Proteomesi
  • UP000001805 Componenti: Chromosome 2, Linkage Group V

Organism-specific databases

EuPathDBiFungiDB:NCU01175.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001239501 – 347Farnesyl pyrophosphate synthaseAdd BLAST347

Proteomic databases

PRIDEiQ92250.

Structurei

3D structure databases

ProteinModelPortaliQ92250.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the FPP/GGPP synthase family.Curated

Phylogenomic databases

HOGENOMiHOG000160912.
InParanoidiQ92250.
KOiK00787.
OMAiRMAGVTD.
OrthoDBiEOG092C35ZD.

Family and domain databases

Gene3Di1.10.600.10. 1 hit.
InterProiIPR008949. Isoprenoid_synthase_dom.
IPR000092. Polyprenyl_synt.
IPR033749. Polyprenyl_synt_CS.
[Graphical view]
PfamiPF00348. polyprenyl_synt. 1 hit.
[Graphical view]
SUPFAMiSSF48576. SSF48576. 1 hit.
PROSITEiPS00723. POLYPRENYL_SYNTHASE_1. 1 hit.
PS00444. POLYPRENYL_SYNTHASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q92250-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKTTTLKEF ESVFPKLEEA LLEYAKAYKL PEQMLSWYKQ SLEVNTLGGK
60 70 80 90 100
CNRGMSVPDS ASILLGRPLT EEEYFQAATL GWMTELLQAF FLVSDDIMDS
110 120 130 140 150
SITRRGKPCW YRQEGVGMVA INDAFMLESA IYTLLKKYFR SHPRYVDFLE
160 170 180 190 200
LFHEVTFQTE MGQLCDLLTA PEDKVDLDNF SMDKYTFIVI YKTAYYSFYL
210 220 230 240 250
PVALAMYMLD IATPENLKQA EDILIPLGEY FQVQDDYLDN FGLPEHIGKI
260 270 280 290 300
GTDIQDNKCS WLVNKALSIV TPEQRKTLEE NYGRKDKAKE AVIKQLYDDL
310 320 330 340
KLEDHYKQYE EERVGEIRKM IDAIDESKGL KKQVFEAFLG KIYKRSK
Length:347
Mass (Da):40,278
Last modified:June 7, 2005 - v2
Checksum:i83F4DC7C4D61212F
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti134L → R in CAA65645 (PubMed:8753652).Curated1
Sequence conflicti321I → N in CAA65645 (PubMed:8753652).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X96944 Genomic DNA. Translation: CAA65645.1.
AL670009 Genomic DNA. Translation: CAD21355.1.
CM002240 Genomic DNA. Translation: EAA32305.1.
PIRiS71436.
RefSeqiXP_961541.1. XM_956448.2.

Genome annotation databases

EnsemblFungiiEAA32305; EAA32305; NCU01175.
GeneIDi3877737.
KEGGincr:NCU01175.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X96944 Genomic DNA. Translation: CAA65645.1.
AL670009 Genomic DNA. Translation: CAD21355.1.
CM002240 Genomic DNA. Translation: EAA32305.1.
PIRiS71436.
RefSeqiXP_961541.1. XM_956448.2.

3D structure databases

ProteinModelPortaliQ92250.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiQ92250.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiEAA32305; EAA32305; NCU01175.
GeneIDi3877737.
KEGGincr:NCU01175.

Organism-specific databases

EuPathDBiFungiDB:NCU01175.

Phylogenomic databases

HOGENOMiHOG000160912.
InParanoidiQ92250.
KOiK00787.
OMAiRMAGVTD.
OrthoDBiEOG092C35ZD.

Enzyme and pathway databases

UniPathwayiUPA00259; UER00368.
UPA00260; UER00369.

Family and domain databases

Gene3Di1.10.600.10. 1 hit.
InterProiIPR008949. Isoprenoid_synthase_dom.
IPR000092. Polyprenyl_synt.
IPR033749. Polyprenyl_synt_CS.
[Graphical view]
PfamiPF00348. polyprenyl_synt. 1 hit.
[Graphical view]
SUPFAMiSSF48576. SSF48576. 1 hit.
PROSITEiPS00723. POLYPRENYL_SYNTHASE_1. 1 hit.
PS00444. POLYPRENYL_SYNTHASE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFPPS_NEUCR
AccessioniPrimary (citable) accession number: Q92250
Secondary accession number(s): Q1K859, Q8X0Y6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: June 7, 2005
Last modified: November 30, 2016
This is version 108 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.