##gff-version 3 Q92249 UniProtKB Signal peptide 1 18 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255 Q92249 UniProtKB Chain 19 369 . . . ID=PRO_0000034244;Note=Protein disulfide-isomerase erp38 Q92249 UniProtKB Domain 19 130 . . . Note=Thioredoxin 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00691 Q92249 UniProtKB Domain 131 251 . . . Note=Thioredoxin 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00691 Q92249 UniProtKB Motif 366 369 . . . Note=Prevents secretion from ER;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU10138 Q92249 UniProtKB Active site 50 50 . . . Note=Nucleophile;Ontology_term=ECO:0000250;evidence=ECO:0000250 Q92249 UniProtKB Active site 53 53 . . . Note=Nucleophile;Ontology_term=ECO:0000250;evidence=ECO:0000250 Q92249 UniProtKB Active site 170 170 . . . Note=Nucleophile;Ontology_term=ECO:0000250;evidence=ECO:0000250 Q92249 UniProtKB Active site 173 173 . . . Note=Nucleophile;Ontology_term=ECO:0000250;evidence=ECO:0000250 Q92249 UniProtKB Site 51 51 . . . Note=Contributes to redox potential value;Ontology_term=ECO:0000250;evidence=ECO:0000250 Q92249 UniProtKB Site 52 52 . . . Note=Contributes to redox potential value;Ontology_term=ECO:0000250;evidence=ECO:0000250 Q92249 UniProtKB Site 116 116 . . . Note=Lowers pKa of C-terminal Cys of first active site;Ontology_term=ECO:0000250;evidence=ECO:0000250 Q92249 UniProtKB Site 171 171 . . . Note=Contributes to redox potential value;Ontology_term=ECO:0000250;evidence=ECO:0000250 Q92249 UniProtKB Site 172 172 . . . Note=Contributes to redox potential value;Ontology_term=ECO:0000250;evidence=ECO:0000250 Q92249 UniProtKB Site 237 237 . . . Note=Lowers pKa of C-terminal Cys of second active site;Ontology_term=ECO:0000250;evidence=ECO:0000250 Q92249 UniProtKB Disulfide bond 50 53 . . . Note=Redox-active;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00691 Q92249 UniProtKB Disulfide bond 170 173 . . . Note=Redox-active;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00691 Q92249 UniProtKB Sequence conflict 154 154 . . . Note=A->P;Ontology_term=ECO:0000305;evidence=ECO:0000305