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Q92241 (PHO85_KLULA) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 95. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Negative regulator of the PHO system

EC=2.7.11.22
Alternative name(s):
Serine/threonine-protein kinase PHO85
Gene names
Name:PHO85
Ordered Locus Names:KLLA0D11990g
OrganismKluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica) [Complete proteome]
Taxonomic identifier284590 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeKluyveromyces

Protein attributes

Sequence length304 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

When phosphate concentrations are high it phosphorylates the PHO4 transcription factor thus establishing repression By similarity.

Catalytic activity

ATP + a protein = ADP + a phosphoprotein.

Subunit structure

Interacts with a number of cyclins By similarity.

Sequence similarities

Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.

Contains 1 protein kinase domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 304304Negative regulator of the PHO system
PRO_0000086519

Regions

Domain7 – 297291Protein kinase
Nucleotide binding13 – 219ATP By similarity

Sites

Active site1331Proton acceptor By similarity
Binding site361ATP By similarity

Experimental info

Sequence conflict1011S → P in CAA64698. Ref.1
Sequence conflict1891S → L in CAA64698. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q92241 [UniParc].

Last modified September 27, 2004. Version 2.
Checksum: CC1BD5B7A9997BC7

FASTA30434,658
        10         20         30         40         50         60 
MVAPSQFKQL EKVGNGTYAT VYKGLNKTTG VYVALKEVKL DSEEGTPSTA IREISLMKEL 

        70         80         90        100        110        120 
KHDNIVRLFD VIHTENKLTL VFEFMDNDLK KFMDNRNKGN SHKGLEMDLV KYFQWQLLQG 

       130        140        150        160        170        180 
VAFCHENRIL HRDLKPQNLL INNRGQLKLG DFGLARAFGI PVNTFSSEVV TLWYRAPDVL 

       190        200        210        220        230        240 
MGSRNYCTSI DIWSCGCILA EMIMGKPLFP GSNDEEQLKL IFDTMGTPVE QTWPQVTQLA 

       250        260        270        280        290        300 
KYNPLLPPHM PRDLKQLLQN NTEEVLDDNV VDLLHGLLQL NPDARLSAKD ALNHPWFAEY 


NHAN 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X95418 Genomic DNA. Translation: CAA64698.1.
CR382124 Genomic DNA. Translation: CAH00692.1.
RefSeqXP_453596.1. XM_453596.1.

3D structure databases

ProteinModelPortalQ92241.
SMRQ92241. Positions 19-302.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID2893430.
KEGGkla:KLLA0D11990g.

Phylogenomic databases

eggNOGCOG0515.
HOGENOMHOG000233024.
KOK06655.
OMAEYKPNFH.
OrthoDBEOG7K3TWD.

Family and domain databases

InterProIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMSSF56112. SSF56112. 1 hit.
PROSITEPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePHO85_KLULA
AccessionPrimary (citable) accession number: Q92241
Secondary accession number(s): Q6CR43
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: September 27, 2004
Last modified: April 16, 2014
This is version 95 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families