Reviewed, UniProtKB/Swiss-Prot Q92236 (GGPPS_GIBFU)

Names and origin

Protein names

Recommended name:
    Geranylgeranyl pyrophosphate synthetase
      Short name=GGPP synthetase
      Short name=GGPPSase
Alternative name(s):
    Geranylgeranyl diphosphate synthase
Including the following 3 domains:
    1- Recommended name:
            Dimethylallyltranstransferase
              EC=2.5.1.1
    2- Recommended name:
            Geranyltranstransferase
              EC=2.5.1.10
    3- Recommended name:
            Farnesyltranstransferase
              EC=2.5.1.29

Gene names

Name:	GGS
Synonyms:	GGPPS

Organism

Gibberella fujikuroi (Bakanae and foot rot disease fungus) (Fusarium moniliforme)

Taxonomic identifier

5127 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Pezizomycotina › Sordariomycetes › Hypocreomycetidae › Hypocreales › Nectriaceae › Gibberella › Gibberella fujikuroi complex

Protein attributes

Sequence length	418 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Catalyzes the trans-addition of the three molecules of IPP onto DMAPP to form geranylgeranyl pyrophosphate.
Catalytic activity	Dimethylallyl diphosphate + isopentenyl diphosphate = diphosphate + geranyl diphosphate. Geranyl diphosphate + isopentenyl diphosphate = diphosphate + trans,trans-farnesyl diphosphate. Trans,trans-farnesyl diphosphate + isopentenyl diphosphate = diphosphate + geranylgeranyl diphosphate.
Pathway	Isoprenoid biosynthesis; farnesyl-PP biosynthesis; farnesyl-PP from geranyl-PP and isopentenyl-PP: step 1/1. Isoprenoid biosynthesis; geranyl-PP biosynthesis; geranyl-PP from dimethylallyl-PP and isopentenyl-PP: step 1/1. Isoprenoid biosynthesis; geranylgeranyl-PP biosynthesis; geranylgeranyl-PP from farnesyl-PP and isopentenyl-PP: step 1/1.
Subcellular location	Cytoplasm.
Sequence similarities	Belongs to the FPP/GGPP synthetase family.

Ontologies

Keywords
Biological process	Isoprene biosynthesis
Cellular component	Cytoplasm
Molecular function	Transferase
Technical term	Multifunctional enzyme
Gene Ontology (GO)
Biological process	isoprenoid biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	dimethylallyltranstransferase activity Inferred from electronic annotation. Source: EC farnesyltranstransferase activity Inferred from electronic annotation. Source: EC geranyltranstransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 418	418	Geranylgeranyl pyrophosphate synthetase		PRO_0000123965
Sites
	Active site	269	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q92236-1 [UniParc]. Last modified February 1, 1997. Version 1. Checksum: BE2A0F1EA7D176C9	FASTA	418	46,477
	10 20 30 40 50 60 MIPTADPILS FNPEALPPSA LHMLSLSPKA MEKMSGISNP LVSPNAIPPR TSSTGIPTSL 70 80 90 100 110 120 NATPTKPVLR PVPEGDWLSQ KQLSPRAQMS NAGYGVMQAP NPPPDPERYA HEDLEFTAKR 130 140 150 160 170 180 SWTDEKENVV RGPYDYVISH PGKDFRAQLI GAFNVWLDVP TSSLEVITRV VGMLHESSLL 190 200 210 220 230 240 IDDVQDSSEL RRGFPVAHNI FGVAQTINSG NYIYFVALQE LHKLNNPELI TIFSDELVNL 250 260 270 280 290 300 HRGQGMDLFW CDTLTCPTEE DYLEMVGNKT GGLFRLGIKL MAAEANGPSP TDCVPLVNLI 310 320 330 340 350 360 GLIFQIRDDY MNLSSKEYSH NKGMCEDLTE GKFSFPVIHS IRTNPTNLQL INILKQKTSD 370 380 390 400 410 TQIKRYAVAY MESTGSFEYT RKVLSVLIER ARKMAEELDQ GRGSTKGIQK ILDKMAIQ

References

[1]	"The geranylgeranyl diphosphate synthase gene of Gibberella fujikuroi: isolation and expression." Mende K., Homann V., Tudzynski B. Mol. Gen. Genet. 255:96-105(1997) [PubMed: 9230902] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: m567.

Cross-references

Sequence databases
EMBLGenBankDDBJ	X96943 Genomic DNA. Translation: CAA65644.1.
3D structure databases
ModBase	Search...
Enzyme and pathway databases
BRENDA	2.5.1.1. 97815. 2.5.1.10. 97815. 2.5.1.29. 97815.
Family and domain databases
InterPro	IPR000092. Polyprenyl_synt. IPR017446. Polyprenyl_synth-rel. IPR008949. Terpenoid_synth. [Graphical view]
Gene3D	G3DSA:1.10.600.10. Terpenoid_synth. 1 hit.
PANTHER	PTHR12001. Polyprenyl_synt. 1 hit.
Pfam	PF00348. polyprenyl_synt. 1 hit. [Graphical view]
PROSITE	PS00723. POLYPRENYL_SYNTHET_1. 1 hit. PS00444. POLYPRENYL_SYNTHET_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GGPPS_GIBFU

Accession

Primary (citable) accession number: Q92236

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	February 1, 1997
Last modified:	June 16, 2009
This is version 56 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)