Reviewed, UniProtKB/Swiss-Prot Q92235 (FPPS_GIBFU)

Names and origin

Protein names

Recommended name:
    Farnesyl pyrophosphate synthetase
      Short name=FPP synthetase
      Short name=FPS
Alternative name(s):
    Farnesyl diphosphate synthetase
Including the following 2 domains:
    1- Recommended name:
            Dimethylallyltranstransferase
              EC=2.5.1.1
    2- Recommended name:
            Geranyltranstransferase
              EC=2.5.1.10

Gene names

Name:

FPPS

Organism

Gibberella fujikuroi (Bakanae and foot rot disease fungus) (Fusarium moniliforme)

Taxonomic identifier

5127 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Pezizomycotina › Sordariomycetes › Hypocreomycetidae › Hypocreales › Nectriaceae › Gibberella › Gibberella fujikuroi complex

Protein attributes

Sequence length	347 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Catalyzes the sequential condensation of isopentenyl pyrophosphate with the allylic pyrophosphates, dimethylallyl pyrophosphate, and then with the resultant geranylpyrophosphate to the ultimate product farnesyl pyrophosphate.
Catalytic activity	Dimethylallyl diphosphate + isopentenyl diphosphate = diphosphate + geranyl diphosphate. Geranyl diphosphate + isopentenyl diphosphate = diphosphate + trans,trans-farnesyl diphosphate.
Pathway	Isoprenoid biosynthesis; farnesyl-PP biosynthesis; farnesyl-PP from geranyl-PP and isopentenyl-PP: step 1/1. Isoprenoid biosynthesis; geranyl-PP biosynthesis; geranyl-PP from dimethylallyl-PP and isopentenyl-PP: step 1/1.
Subcellular location	Cytoplasm.
Sequence similarities	Belongs to the FPP/GGPP synthetase family.

Ontologies

Keywords
Biological process	Cholesterol biosynthesis Isoprene biosynthesis Lipid synthesis Steroid biosynthesis Sterol biosynthesis
Cellular component	Cytoplasm
Molecular function	Transferase
Gene Ontology (GO)
Biological process	cholesterol biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW isoprenoid biosynthetic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	dimethylallyltranstransferase activity Inferred from electronic annotation. Source: EC geranyltranstransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 347	347	Farnesyl pyrophosphate synthetase		PRO_0000123948
Sites
	Active site	184	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q92235-1 [UniParc]. Last modified February 1, 1997. Version 1. Checksum: DC39B016658441E4	FASTA	347	40,236
	10 20 30 40 50 60 MAQQTTLQEF NSVYPKLEEA LLDHARSYKL PQEQLDWYKR SLEVNPLGGK CNRGMSVPDS 70 80 90 100 110 120 VSLLLEKPLT EEQYFQAATL GWMTELLQAF FLVSDDIMDS SITRRGQPCW YRQEGVGMIA 130 140 150 160 170 180 INDAFMLESA IYTLLKKYFR SHPAYFDLIE SFHETTFQTE LGQLCDLLTA PEDNVNLDNF 190 200 210 220 230 240 SLEKYSFIVI YKTAYYSFYL PVALALHQLN LATPSNLKQA EDILIPLGEY FQIQDDYLDN 250 260 270 280 290 300 FGKPEHIGKI GTDIKDNKCS WLVNQALAVA TPEQRKILEE NYGRKDDEKE KVVKKLYDDL 310 320 330 340 NLEQRYLDYE EKVVGQIRER IANIDENDGL KKTVFEAFLA KIYKRSK

References

[1]	"The isoprenoid pathway: cloning and characterization of fungal FPPS genes." Homann V., Mende K., Arntz C., Ilardi V., Macino G., Morelli G., Bose G., Tudzynski B. Curr. Genet. 30:232-239(1996) [PubMed: 8753652] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: m567.

Cross-references

Sequence databases
EMBLGenBankDDBJ	X96940 Genomic DNA. Translation: CAA65641.1.
PIR	S71435.
3D structure databases
HSSP	HSSP built from PDB template 1UBX based on UniProtKB P08836.
ModBase	Search...
Family and domain databases
InterPro	IPR000092. Polyprenyl_synt. IPR008949. Terpenoid_synth. [Graphical view]
Gene3D	G3DSA:1.10.600.10. Terpenoid_synth. 1 hit.
Pfam	PF00348. polyprenyl_synt. 1 hit. [Graphical view]
PROSITE	PS00723. POLYPRENYL_SYNTHET_1. 1 hit. PS00444. POLYPRENYL_SYNTHET_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

FPPS_GIBFU

Accession

Primary (citable) accession number: Q92235

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1998
Last sequence update:	February 1, 1997
Last modified:	November 25, 2008
This is version 44 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)