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Q92215

- TOXC_COCCA

UniProt

Q92215 - TOXC_COCCA

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Protein

Putative fatty acid synthase subunit TOXC

Gene
TOXC
Organism
Cochliobolus carbonum (Bipolaris zeicola)
Status
Reviewed - Annotation score: 5 out of 5 - Protein inferred from homologyi

Functioni

Essential role in the production of HC-toxin and in pathogenicity of the fungus on maize. May contribute to the synthesis of the decanoic backbone of 2-amino-9,10-epoxi-8-oxodecanoic acid. This protein contains domains similar to those of a fatty acid synthase beta subunit, namely: [acyl-carrier protein] acetyltransferase and malonyltransferase, S-acyl fatty acid synthase thioesterase, enoyl-[acyl-carrier-protein] reductase, and 3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase.1 Publication

Catalytic activityi

Acetyl-CoA + [acyl-carrier-protein] = CoA + acetyl-[acyl-carrier-protein].
Malonyl-CoA + an [acyl-carrier-protein] = CoA + a malonyl-[acyl-carrier-protein].
A (3R)-3-hydroxyacyl-[acyl-carrier protein] = a trans-2-enoyl-[acyl-carrier protein] + H2O.
An acyl-[acyl-carrier protein] + NAD+ = a trans-2,3-dehydroacyl-[acyl-carrier protein] + NADH.
Oleoyl-[acyl-carrier-protein] + H2O = [acyl-carrier-protein] + oleate.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei276 – 2761For acetyltransferase activity By similarityBy similarity
Active sitei1828 – 18281For malonyltransferase activity By similarityBy similarity

GO - Molecular functioni

  1. [acyl-carrier-protein] S-acetyltransferase activity Source: UniProtKB-EC
  2. [acyl-carrier-protein] S-malonyltransferase activity Source: UniProtKB-EC
  3. 3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity Source: UniProtKB-EC
  4. enoyl-[acyl-carrier-protein] reductase (NADH) activity Source: UniProtKB-EC
  5. myristoyl-[acyl-carrier-protein] hydrolase activity Source: UniProtKB-EC
  6. oleoyl-[acyl-carrier-protein] hydrolase activity Source: UniProtKB-EC
  7. palmitoyl-[acyl-carrier-protein] hydrolase activity Source: UniProtKB-EC

GO - Biological processi

  1. fatty acid biosynthetic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Lyase, Oxidoreductase, Transferase

Keywords - Biological processi

Fatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism

Keywords - Ligandi

NAD, NADP

Enzyme and pathway databases

UniPathwayiUPA00874.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative fatty acid synthase subunit TOXC
Including the following 5 domains:
3-hydroxyacyl-[acyl-carrier-protein] dehydratase (EC:4.2.1.59)
Enoyl-[acyl-carrier-protein] reductase [NADH] (EC:1.3.1.9)
[Acyl-carrier-protein] acetyltransferase (EC:2.3.1.38)
[Acyl-carrier-protein] malonyltransferase (EC:2.3.1.39)
S-acyl fatty acid synthase thioesterase (EC:3.1.2.14)
Gene namesi
Name:TOXC
OrganismiCochliobolus carbonum (Bipolaris zeicola)
Taxonomic identifieri5017 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaDothideomycetesPleosporomycetidaePleosporalesPleosporineaePleosporaceaeBipolaris

Subcellular locationi

GO - Cellular componenti

  1. fatty acid synthase complex Source: InterPro
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 20802080Putative fatty acid synthase subunit TOXCPRO_0000180291Add
BLAST

Proteomic databases

PRIDEiQ92215.

Structurei

3D structure databases

ProteinModelPortaliQ92215.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1538 – 1667130MaoC-likeAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 468468Acetyltransferase By similarityAdd
BLAST
Regioni481 – 869389Enoyl reductase By similarityBy similarityAdd
BLAST
Regioni1155 – 1644490Dehydratase By similarityBy similarityAdd
BLAST
Regioni1645 – 1865221Malonyl/palmitoyl transferase By similarityBy similarityAdd
BLAST

Sequence similaritiesi

Contains 1 MaoC-like domain.

Family and domain databases

Gene3Di3.10.129.10. 1 hit.
3.40.366.10. 5 hits.
InterProiIPR001227. Ac_transferase_dom.
IPR014043. Acyl_transferase.
IPR016035. Acyl_Trfase/lysoPLipase.
IPR013565. DUF1729.
IPR003965. Fatty_acid_synthase.
IPR016452. Fatty_acid_Synthase_bsu_fun.
IPR029069. HotDog_dom.
IPR002539. MaoC_dom.
[Graphical view]
PfamiPF00698. Acyl_transf_1. 1 hit.
PF08354. DUF1729. 1 hit.
PF01575. MaoC_dehydratas. 1 hit.
[Graphical view]
PIRSFiPIRSF005562. FAS_yeast_beta. 1 hit.
PRINTSiPR01483. FASYNTHASE.
SUPFAMiSSF52151. SSF52151. 5 hits.
SSF54637. SSF54637. 2 hits.

Sequencei

Sequence statusi: Complete.

Q92215-1 [UniParc]FASTAAdd to Basket

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MLLTAQIPES LTPFSISHGS LSVSWLLPYR LHCYATRLYR TFEATLAARS     50
DNSEHPITLL SSVELAAHYM CYVAHETQAN TDRACTQTHD ISKLLLEDFE 100
ATFLRSNDIH TLASALPSSD SAKDELLRCY YETCFITKHN TPLNESALLK 150
AAREGIVSLY TTFSGQGCGG RYFDELRELF RLYPSFVGTL ISESGNLFRE 200
LASNPSAGRL FSKGFDIMAW LHHPQTTPDT EYLISAPVSF PIIGLVQLGH 250
YAVSCRAMGL DPGAFQRSIR GSTGHSQGIV VAAAMSAADS WEAFDRLAIS 300
CLTVLFWIGV RSQQAAPQMS LSPAQIQDSI DHNEDVPSPM LSIIGLSRLD 350
VQMHIDSINH YLPQSEHISI SLVNGGRHIV VSGLPSTLYR FNLLLRKIKV 400
PDHSGQPRAT SKQKKAQFSA RFLPITVPFH SHHLVSVGSV LEEDLKNVFI 450
GSKDLGFPVF NTYTGRDLRA EVIGNIVPAL VRMVTQYPVF WGAAVEFPGA 500
THILEFGPGG LSGSGALTSH IKNGTGVRVI FAGLTSGSNR QVGYKQELFA 550
RDTCHVKFAD DWSRKYAPSL VRTSNNSIVV NTKMSRLLGL PPIMVGGMTP 600
TTAAWGFVAA TMNAGYHIEL AAGGYSDANA FENALLNIQK TTASGRGITV 650
NLIYLSSHAV NWQIPLLRRL IIDGFRIEGI TIGGGVPSID VAKEYITTLG 700
IKHIGFKPGP TTAIDAVIEI AQANPTFPVF LQWTGGRSGG HHSNEDFHQP 750
ILETYDRIRQ CDNIILIAGS GFGGAADTYP YITGEWSLRY DFPPMPFDGC 800
LLGSRVMVAK EARTSPAAKR VIVETEGLND NEWRRTYEEA AGGIITVQSE 850
MGQPIHKIAT RGVLFWAKLD QMIFSLPKEK RIAELQKHRS WIIKGLNDDF 900
QKPWFGRDSA DQVVELRDMT YAEVLRRMVQ LLYVKHQRRW IHSSYAVLFK 950
AFVNRLEERF TTKTVQSYLI QDCKTIDDPY NIITVVLLQY QQAIKETILT 1000
PDVEYFLLLC KRRGQKPVPF VPALDEDFEF FFKKDSLWQS EDLEAVVDQD 1050
VGRTCILQGP VAAKYSVKVD EPIAEILGSI HQGHVTRLRE ERYCATLDSI 1100
PFVEYFGGES IQLDMSSLAD GIEQSHNEQA SIYSLPSSLS MPLPAVDVWM 1150
SLLAGKSRSW RHAIMSAGIV IQENKCVANP MRRLFAPAHG IRVQIRKPDV 1200
PSQTEVVLEE QQESGIYEVA VRAGLNEDGE IIVEMFERRN MSDLVVSLPC 1250
DSGTKPEYGY APIREIMEDR NERIRRFYWS IWFGKSHPIL EGSLSDSFEC 1300
GKEKITRQHV ESFIQAINNS TRTHKNFLEP ATNVSISFAI PVAWKAIVKP 1350
LFLNALNGDL LQLVHLSNEF RMTPGAEPLK IGEEVSTVAR INAIMNQDSG 1400
KMVEVSAAVL RGKEIVVEII SRFLYRGAFV DFKDTFQWRD EPLMQIQLAT 1450
SKHIAVLRTR EWFVPTQGCN IDLVGHTLTF QMRSLYKFQS KTVFRRIETH 1500
GKVTLELAPQ KIVQVATVQY EVGICHSNTV IEFLDRYGSY SQNSVDFEDP 1550
VSVPNNGESL VICAPSSNEA YARTSGDLNP IHVSRTFAEY AGLPGLITHG 1600
MYCSAAIQDL VERLVADGNA GRIRQFSMSF VGMVLPNQKL EVKLEHIGMV 1650
EGMIRLHIEA RAQETGHRVI VGEAKITQKM TTYVFTGQGS QEKGMGMDLY 1700
NQCPAAREVW DRGDKYFLHK YGFAITTIVR DNPKQLTVHF GGRQGEAIRQ 1750
NYINMKVETV AEDGSIQYEK LFKDVDHNTQ FYTFRSPTGL LSATQFTQPA 1800
LSLMARASFE HLQIQGLVDG NCYYAGHSLG EFSALAAVAG IMSVESQALI 1850
AFYRGLTMQK AVNRDESGRS NYSMCAVDPS RISATYDEEA FLTIVREIAA 1900
ETGWLLEVVN FNVANKQYVC AGNLHALDTL AGVTDRLRLL QINASEMEEC 1950
LHEIIRQCVQ ETKSKSTPLE LTRGIATIPL QGIDVPFHST FLRGGVRHFR 2000
EFLHENIDKR NINPAKLIGR YIPNVTARSF QISKDYFQYV YDLTGSSQLR 2050
DALKNWDIYE KSNGEESNGV EECSECRNSL 2080
Length:2,080
Mass (Da):232,268
Last modified:February 1, 1997 - v1
Checksum:i424D3C489EF67087
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U73650 Genomic DNA. Translation: AAC62818.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U73650 Genomic DNA. Translation: AAC62818.1 .

3D structure databases

ProteinModelPortali Q92215.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi Q92215.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Enzyme and pathway databases

UniPathwayi UPA00874 .

Family and domain databases

Gene3Di 3.10.129.10. 1 hit.
3.40.366.10. 5 hits.
InterProi IPR001227. Ac_transferase_dom.
IPR014043. Acyl_transferase.
IPR016035. Acyl_Trfase/lysoPLipase.
IPR013565. DUF1729.
IPR003965. Fatty_acid_synthase.
IPR016452. Fatty_acid_Synthase_bsu_fun.
IPR029069. HotDog_dom.
IPR002539. MaoC_dom.
[Graphical view ]
Pfami PF00698. Acyl_transf_1. 1 hit.
PF08354. DUF1729. 1 hit.
PF01575. MaoC_dehydratas. 1 hit.
[Graphical view ]
PIRSFi PIRSF005562. FAS_yeast_beta. 1 hit.
PRINTSi PR01483. FASYNTHASE.
SUPFAMi SSF52151. SSF52151. 5 hits.
SSF54637. SSF54637. 2 hits.
ProtoNeti Search...

Publicationsi

  1. "A fatty acid synthase gene in Cochliobolus carbonum required for production of HC-toxin, cyclo(D-prolyl-L-alanyl-D-alanyl-L-2-amino-9, 10-epoxi-8-oxodecanoyl)."
    Ahn J.-H., Walton J.D.
    Mol. Plant Microbe Interact. 10:207-214(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION.
    Strain: ATCC 90305 / SB111 / 2R15.

Entry informationi

Entry nameiTOXC_COCCA
AccessioniPrimary (citable) accession number: Q92215
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 30, 2003
Last sequence update: February 1, 1997
Last modified: September 3, 2014
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Multifunctional enzyme

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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