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Q92215 (TOXC_COCCA) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 75. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Putative fatty acid synthase subunit TOXC

Including the following 5 domains:

  1. 3-hydroxyacyl-[acyl-carrier-protein] dehydratase
    EC=4.2.1.59
  2. Enoyl-[acyl-carrier-protein] reductase [NADH]
    EC=1.3.1.9
  3. [Acyl-carrier-protein] acetyltransferase
    EC=2.3.1.38
  4. [Acyl-carrier-protein] malonyltransferase
    EC=2.3.1.39
  5. S-acyl fatty acid synthase thioesterase
    EC=3.1.2.14
Gene names
Name:TOXC
OrganismCochliobolus carbonum (Bipolaris zeicola)
Taxonomic identifier5017 [NCBI]
Taxonomic lineageEukaryota › Fungi › Dikarya › Ascomycota › Pezizomycotina › Dothideomycetes › Pleosporomycetidae › Pleosporales › Pleosporineae › Pleosporaceae › Cochliobolus

Protein attributes

Sequence length2080 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Essential role in the production of HC-toxin and in pathogenicity of the fungus on maize. May contribute to the synthesis of the decanoic backbone of 2-amino-9,10-epoxi-8-oxodecanoic acid. This protein contains domains similar to those of a fatty acid synthase beta subunit, namely: [acyl-carrier protein] acetyltransferase and malonyltransferase, S-acyl fatty acid synthase thioesterase, enoyl-[acyl-carrier-protein] reductase, and 3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase. Ref.1

Catalytic activity

Acetyl-CoA + [acyl-carrier-protein] = CoA + acetyl-[acyl-carrier-protein].

Malonyl-CoA + [acyl-carrier-protein] = CoA + malonyl-[acyl-carrier-protein].

A (3R)-3-hydroxyacyl-[acyl-carrier protein] = a trans-2-enoyl-[acyl-carrier protein] + H2O.

Acyl-[acyl-carrier-protein] + NAD+ = trans-2,3-dehydroacyl-[acyl-carrier-protein] + NADH.

Oleoyl-[acyl-carrier-protein] + H2O = [acyl-carrier-protein] + oleate.

Pathway

Mycotoxin biosynthesis; HC-toxin biosynthesis.

Sequence similarities

Belongs to the fungal fatty acid synthetase subunit beta family.

Contains 1 MaoC-like domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 20802080Putative fatty acid synthase subunit TOXC
PRO_0000180291

Regions

Domain1538 – 1667130MaoC-like
Region1 – 468468Acetyltransferase By similarity
Region481 – 869389Enoyl reductase By similarity UniProtKB P34229
Region1155 – 1644490Dehydratase By similarity UniProtKB P34229
Region1645 – 1865221Malonyl/palmitoyl transferase By similarity UniProtKB P34229

Sites

Active site2761For acetyltransferase activity By similarity UniProtKB P34229
Active site18281For malonyltransferase activity By similarity UniProtKB P34229

Sequences

Sequence LengthMass (Da)Tools
Q92215 [UniParc].

Last modified February 1, 1997. Version 1.
Checksum: 424D3C489EF67087

FASTA2,080232,268
        10         20         30         40         50         60 
MLLTAQIPES LTPFSISHGS LSVSWLLPYR LHCYATRLYR TFEATLAARS DNSEHPITLL 

        70         80         90        100        110        120 
SSVELAAHYM CYVAHETQAN TDRACTQTHD ISKLLLEDFE ATFLRSNDIH TLASALPSSD 

       130        140        150        160        170        180 
SAKDELLRCY YETCFITKHN TPLNESALLK AAREGIVSLY TTFSGQGCGG RYFDELRELF 

       190        200        210        220        230        240 
RLYPSFVGTL ISESGNLFRE LASNPSAGRL FSKGFDIMAW LHHPQTTPDT EYLISAPVSF 

       250        260        270        280        290        300 
PIIGLVQLGH YAVSCRAMGL DPGAFQRSIR GSTGHSQGIV VAAAMSAADS WEAFDRLAIS 

       310        320        330        340        350        360 
CLTVLFWIGV RSQQAAPQMS LSPAQIQDSI DHNEDVPSPM LSIIGLSRLD VQMHIDSINH 

       370        380        390        400        410        420 
YLPQSEHISI SLVNGGRHIV VSGLPSTLYR FNLLLRKIKV PDHSGQPRAT SKQKKAQFSA 

       430        440        450        460        470        480 
RFLPITVPFH SHHLVSVGSV LEEDLKNVFI GSKDLGFPVF NTYTGRDLRA EVIGNIVPAL 

       490        500        510        520        530        540 
VRMVTQYPVF WGAAVEFPGA THILEFGPGG LSGSGALTSH IKNGTGVRVI FAGLTSGSNR 

       550        560        570        580        590        600 
QVGYKQELFA RDTCHVKFAD DWSRKYAPSL VRTSNNSIVV NTKMSRLLGL PPIMVGGMTP 

       610        620        630        640        650        660 
TTAAWGFVAA TMNAGYHIEL AAGGYSDANA FENALLNIQK TTASGRGITV NLIYLSSHAV 

       670        680        690        700        710        720 
NWQIPLLRRL IIDGFRIEGI TIGGGVPSID VAKEYITTLG IKHIGFKPGP TTAIDAVIEI 

       730        740        750        760        770        780 
AQANPTFPVF LQWTGGRSGG HHSNEDFHQP ILETYDRIRQ CDNIILIAGS GFGGAADTYP 

       790        800        810        820        830        840 
YITGEWSLRY DFPPMPFDGC LLGSRVMVAK EARTSPAAKR VIVETEGLND NEWRRTYEEA 

       850        860        870        880        890        900 
AGGIITVQSE MGQPIHKIAT RGVLFWAKLD QMIFSLPKEK RIAELQKHRS WIIKGLNDDF 

       910        920        930        940        950        960 
QKPWFGRDSA DQVVELRDMT YAEVLRRMVQ LLYVKHQRRW IHSSYAVLFK AFVNRLEERF 

       970        980        990       1000       1010       1020 
TTKTVQSYLI QDCKTIDDPY NIITVVLLQY QQAIKETILT PDVEYFLLLC KRRGQKPVPF 

      1030       1040       1050       1060       1070       1080 
VPALDEDFEF FFKKDSLWQS EDLEAVVDQD VGRTCILQGP VAAKYSVKVD EPIAEILGSI 

      1090       1100       1110       1120       1130       1140 
HQGHVTRLRE ERYCATLDSI PFVEYFGGES IQLDMSSLAD GIEQSHNEQA SIYSLPSSLS 

      1150       1160       1170       1180       1190       1200 
MPLPAVDVWM SLLAGKSRSW RHAIMSAGIV IQENKCVANP MRRLFAPAHG IRVQIRKPDV 

      1210       1220       1230       1240       1250       1260 
PSQTEVVLEE QQESGIYEVA VRAGLNEDGE IIVEMFERRN MSDLVVSLPC DSGTKPEYGY 

      1270       1280       1290       1300       1310       1320 
APIREIMEDR NERIRRFYWS IWFGKSHPIL EGSLSDSFEC GKEKITRQHV ESFIQAINNS 

      1330       1340       1350       1360       1370       1380 
TRTHKNFLEP ATNVSISFAI PVAWKAIVKP LFLNALNGDL LQLVHLSNEF RMTPGAEPLK 

      1390       1400       1410       1420       1430       1440 
IGEEVSTVAR INAIMNQDSG KMVEVSAAVL RGKEIVVEII SRFLYRGAFV DFKDTFQWRD 

      1450       1460       1470       1480       1490       1500 
EPLMQIQLAT SKHIAVLRTR EWFVPTQGCN IDLVGHTLTF QMRSLYKFQS KTVFRRIETH 

      1510       1520       1530       1540       1550       1560 
GKVTLELAPQ KIVQVATVQY EVGICHSNTV IEFLDRYGSY SQNSVDFEDP VSVPNNGESL 

      1570       1580       1590       1600       1610       1620 
VICAPSSNEA YARTSGDLNP IHVSRTFAEY AGLPGLITHG MYCSAAIQDL VERLVADGNA 

      1630       1640       1650       1660       1670       1680 
GRIRQFSMSF VGMVLPNQKL EVKLEHIGMV EGMIRLHIEA RAQETGHRVI VGEAKITQKM 

      1690       1700       1710       1720       1730       1740 
TTYVFTGQGS QEKGMGMDLY NQCPAAREVW DRGDKYFLHK YGFAITTIVR DNPKQLTVHF 

      1750       1760       1770       1780       1790       1800 
GGRQGEAIRQ NYINMKVETV AEDGSIQYEK LFKDVDHNTQ FYTFRSPTGL LSATQFTQPA 

      1810       1820       1830       1840       1850       1860 
LSLMARASFE HLQIQGLVDG NCYYAGHSLG EFSALAAVAG IMSVESQALI AFYRGLTMQK 

      1870       1880       1890       1900       1910       1920 
AVNRDESGRS NYSMCAVDPS RISATYDEEA FLTIVREIAA ETGWLLEVVN FNVANKQYVC 

      1930       1940       1950       1960       1970       1980 
AGNLHALDTL AGVTDRLRLL QINASEMEEC LHEIIRQCVQ ETKSKSTPLE LTRGIATIPL 

      1990       2000       2010       2020       2030       2040 
QGIDVPFHST FLRGGVRHFR EFLHENIDKR NINPAKLIGR YIPNVTARSF QISKDYFQYV 

      2050       2060       2070       2080 
YDLTGSSQLR DALKNWDIYE KSNGEESNGV EECSECRNSL

« Hide

References

[1]"A fatty acid synthase gene in Cochliobolus carbonum required for production of HC-toxin, cyclo(D-prolyl-L-alanyl-D-alanyl-L-2-amino-9, 10-epoxi-8-oxodecanoyl)."
Ahn J.-H., Walton J.D.
Mol. Plant Microbe Interact. 10:207-214(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION.
Strain: ATCC 90305 / SB111 / 2R15.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		U73650 Genomic DNA. Translation: AAC62818.1.

3D structure databases

ProteinModelPortalQ92215.
ModBaseSearch...

Proteomic databases

PRIDEQ92215.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Enzyme and pathway databases

UniPathwayUPA00874.

Family and domain databases

Gene3D3.40.366.10. 5 hits.
InterProIPR001227. Ac_transferase_dom.
IPR014043. Acyl_transferase.
IPR016035. Acyl_Trfase/lysoPLipase.
IPR013565. DUF1729.
IPR003965. Fatty_acid_synthase.
IPR016452. Fatty_acid_Synthase_bsu_fun.
IPR002539. MaoC_dom.
[Graphical view]
PfamPF00698. Acyl_transf_1. 1 hit.
PF08354. DUF1729. 1 hit.
PF01575. MaoC_dehydratas. 1 hit.
[Graphical view]
PIRSFPIRSF005562. FAS_yeast_beta. 1 hit.
PRINTSPR01483. FASYNTHASE.
SUPFAMSSF52151. Acyl_Trfase/lysoPlipase. 2 hits.
ProtoNetSearch...

Entry information

Entry nameTOXC_COCCA
AccessionPrimary (citable) accession number: Q92215
Entry history
Integrated into UniProtKB/Swiss-Prot: April 30, 2003
Last sequence update: February 1, 1997
Last modified: April 3, 2013
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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