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Q92215

- TOXC_COCCA

UniProt

Q92215 - TOXC_COCCA

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Protein

Putative fatty acid synthase subunit TOXC

Gene

TOXC

Organism
Cochliobolus carbonum (Bipolaris zeicola)
Status
Reviewed - Annotation score: 5 out of 5- Protein inferred from homologyi

Functioni

Essential role in the production of HC-toxin and in pathogenicity of the fungus on maize. May contribute to the synthesis of the decanoic backbone of 2-amino-9,10-epoxi-8-oxodecanoic acid. This protein contains domains similar to those of a fatty acid synthase beta subunit, namely: [acyl-carrier protein] acetyltransferase and malonyltransferase, S-acyl fatty acid synthase thioesterase, enoyl-[acyl-carrier-protein] reductase, and 3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase.1 Publication

Catalytic activityi

Acetyl-CoA + [acyl-carrier-protein] = CoA + acetyl-[acyl-carrier-protein].
Malonyl-CoA + an [acyl-carrier-protein] = CoA + a malonyl-[acyl-carrier-protein].
A (3R)-3-hydroxyacyl-[acyl-carrier protein] = a trans-2-enoyl-[acyl-carrier protein] + H2O.
An acyl-[acyl-carrier protein] + NAD+ = a trans-2,3-dehydroacyl-[acyl-carrier protein] + NADH.
Oleoyl-[acyl-carrier-protein] + H2O = [acyl-carrier-protein] + oleate.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei276 – 2761For acetyltransferase activityBy similarity
Active sitei1828 – 18281For malonyltransferase activityBy similarity

GO - Molecular functioni

  1. [acyl-carrier-protein] S-acetyltransferase activity Source: UniProtKB-EC
  2. [acyl-carrier-protein] S-malonyltransferase activity Source: UniProtKB-EC
  3. 3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity Source: UniProtKB-EC
  4. enoyl-[acyl-carrier-protein] reductase (NADH) activity Source: UniProtKB-EC
  5. myristoyl-[acyl-carrier-protein] hydrolase activity Source: UniProtKB-EC
  6. oleoyl-[acyl-carrier-protein] hydrolase activity Source: UniProtKB-EC
  7. palmitoyl-[acyl-carrier-protein] hydrolase activity Source: UniProtKB-EC

GO - Biological processi

  1. fatty acid biosynthetic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Lyase, Oxidoreductase, Transferase

Keywords - Biological processi

Fatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism

Keywords - Ligandi

NAD, NADP

Enzyme and pathway databases

UniPathwayiUPA00874.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative fatty acid synthase subunit TOXC
Including the following 5 domains:
3-hydroxyacyl-[acyl-carrier-protein] dehydratase (EC:4.2.1.59)
Enoyl-[acyl-carrier-protein] reductase [NADH] (EC:1.3.1.9)
[Acyl-carrier-protein] acetyltransferase (EC:2.3.1.38)
[Acyl-carrier-protein] malonyltransferase (EC:2.3.1.39)
S-acyl fatty acid synthase thioesterase (EC:3.1.2.14)
Gene namesi
Name:TOXC
OrganismiCochliobolus carbonum (Bipolaris zeicola)Imported
Taxonomic identifieri5017 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaDothideomycetesPleosporomycetidaePleosporalesPleosporineaePleosporaceaeBipolaris

Subcellular locationi

GO - Cellular componenti

  1. fatty acid synthase complex Source: InterPro
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 20802080Putative fatty acid synthase subunit TOXCPRO_0000180291Add
BLAST

Proteomic databases

PRIDEiQ92215.

Structurei

3D structure databases

ProteinModelPortaliQ92215.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1538 – 1667130MaoC-likeAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 468468AcetyltransferaseBy similarityAdd
BLAST
Regioni481 – 869389Enoyl reductaseBy similarityAdd
BLAST
Regioni1155 – 1644490DehydrataseBy similarityAdd
BLAST
Regioni1645 – 1865221Malonyl/palmitoyl transferaseBy similarityAdd
BLAST

Sequence similaritiesi

Contains 1 MaoC-like domain.Curated

Family and domain databases

Gene3Di3.10.129.10. 1 hit.
3.40.366.10. 5 hits.
InterProiIPR001227. Ac_transferase_dom.
IPR014043. Acyl_transferase.
IPR016035. Acyl_Trfase/lysoPLipase.
IPR013565. DUF1729.
IPR003965. Fatty_acid_synthase.
IPR016452. Fatty_acid_Synthase_bsu_fun.
IPR029069. HotDog_dom.
IPR002539. MaoC_dom.
[Graphical view]
PfamiPF00698. Acyl_transf_1. 1 hit.
PF08354. DUF1729. 1 hit.
PF01575. MaoC_dehydratas. 1 hit.
[Graphical view]
PIRSFiPIRSF005562. FAS_yeast_beta. 1 hit.
PRINTSiPR01483. FASYNTHASE.
SUPFAMiSSF52151. SSF52151. 5 hits.
SSF54637. SSF54637. 2 hits.

Sequencei

Sequence statusi: Complete.

Q92215-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLLTAQIPES LTPFSISHGS LSVSWLLPYR LHCYATRLYR TFEATLAARS
60 70 80 90 100
DNSEHPITLL SSVELAAHYM CYVAHETQAN TDRACTQTHD ISKLLLEDFE
110 120 130 140 150
ATFLRSNDIH TLASALPSSD SAKDELLRCY YETCFITKHN TPLNESALLK
160 170 180 190 200
AAREGIVSLY TTFSGQGCGG RYFDELRELF RLYPSFVGTL ISESGNLFRE
210 220 230 240 250
LASNPSAGRL FSKGFDIMAW LHHPQTTPDT EYLISAPVSF PIIGLVQLGH
260 270 280 290 300
YAVSCRAMGL DPGAFQRSIR GSTGHSQGIV VAAAMSAADS WEAFDRLAIS
310 320 330 340 350
CLTVLFWIGV RSQQAAPQMS LSPAQIQDSI DHNEDVPSPM LSIIGLSRLD
360 370 380 390 400
VQMHIDSINH YLPQSEHISI SLVNGGRHIV VSGLPSTLYR FNLLLRKIKV
410 420 430 440 450
PDHSGQPRAT SKQKKAQFSA RFLPITVPFH SHHLVSVGSV LEEDLKNVFI
460 470 480 490 500
GSKDLGFPVF NTYTGRDLRA EVIGNIVPAL VRMVTQYPVF WGAAVEFPGA
510 520 530 540 550
THILEFGPGG LSGSGALTSH IKNGTGVRVI FAGLTSGSNR QVGYKQELFA
560 570 580 590 600
RDTCHVKFAD DWSRKYAPSL VRTSNNSIVV NTKMSRLLGL PPIMVGGMTP
610 620 630 640 650
TTAAWGFVAA TMNAGYHIEL AAGGYSDANA FENALLNIQK TTASGRGITV
660 670 680 690 700
NLIYLSSHAV NWQIPLLRRL IIDGFRIEGI TIGGGVPSID VAKEYITTLG
710 720 730 740 750
IKHIGFKPGP TTAIDAVIEI AQANPTFPVF LQWTGGRSGG HHSNEDFHQP
760 770 780 790 800
ILETYDRIRQ CDNIILIAGS GFGGAADTYP YITGEWSLRY DFPPMPFDGC
810 820 830 840 850
LLGSRVMVAK EARTSPAAKR VIVETEGLND NEWRRTYEEA AGGIITVQSE
860 870 880 890 900
MGQPIHKIAT RGVLFWAKLD QMIFSLPKEK RIAELQKHRS WIIKGLNDDF
910 920 930 940 950
QKPWFGRDSA DQVVELRDMT YAEVLRRMVQ LLYVKHQRRW IHSSYAVLFK
960 970 980 990 1000
AFVNRLEERF TTKTVQSYLI QDCKTIDDPY NIITVVLLQY QQAIKETILT
1010 1020 1030 1040 1050
PDVEYFLLLC KRRGQKPVPF VPALDEDFEF FFKKDSLWQS EDLEAVVDQD
1060 1070 1080 1090 1100
VGRTCILQGP VAAKYSVKVD EPIAEILGSI HQGHVTRLRE ERYCATLDSI
1110 1120 1130 1140 1150
PFVEYFGGES IQLDMSSLAD GIEQSHNEQA SIYSLPSSLS MPLPAVDVWM
1160 1170 1180 1190 1200
SLLAGKSRSW RHAIMSAGIV IQENKCVANP MRRLFAPAHG IRVQIRKPDV
1210 1220 1230 1240 1250
PSQTEVVLEE QQESGIYEVA VRAGLNEDGE IIVEMFERRN MSDLVVSLPC
1260 1270 1280 1290 1300
DSGTKPEYGY APIREIMEDR NERIRRFYWS IWFGKSHPIL EGSLSDSFEC
1310 1320 1330 1340 1350
GKEKITRQHV ESFIQAINNS TRTHKNFLEP ATNVSISFAI PVAWKAIVKP
1360 1370 1380 1390 1400
LFLNALNGDL LQLVHLSNEF RMTPGAEPLK IGEEVSTVAR INAIMNQDSG
1410 1420 1430 1440 1450
KMVEVSAAVL RGKEIVVEII SRFLYRGAFV DFKDTFQWRD EPLMQIQLAT
1460 1470 1480 1490 1500
SKHIAVLRTR EWFVPTQGCN IDLVGHTLTF QMRSLYKFQS KTVFRRIETH
1510 1520 1530 1540 1550
GKVTLELAPQ KIVQVATVQY EVGICHSNTV IEFLDRYGSY SQNSVDFEDP
1560 1570 1580 1590 1600
VSVPNNGESL VICAPSSNEA YARTSGDLNP IHVSRTFAEY AGLPGLITHG
1610 1620 1630 1640 1650
MYCSAAIQDL VERLVADGNA GRIRQFSMSF VGMVLPNQKL EVKLEHIGMV
1660 1670 1680 1690 1700
EGMIRLHIEA RAQETGHRVI VGEAKITQKM TTYVFTGQGS QEKGMGMDLY
1710 1720 1730 1740 1750
NQCPAAREVW DRGDKYFLHK YGFAITTIVR DNPKQLTVHF GGRQGEAIRQ
1760 1770 1780 1790 1800
NYINMKVETV AEDGSIQYEK LFKDVDHNTQ FYTFRSPTGL LSATQFTQPA
1810 1820 1830 1840 1850
LSLMARASFE HLQIQGLVDG NCYYAGHSLG EFSALAAVAG IMSVESQALI
1860 1870 1880 1890 1900
AFYRGLTMQK AVNRDESGRS NYSMCAVDPS RISATYDEEA FLTIVREIAA
1910 1920 1930 1940 1950
ETGWLLEVVN FNVANKQYVC AGNLHALDTL AGVTDRLRLL QINASEMEEC
1960 1970 1980 1990 2000
LHEIIRQCVQ ETKSKSTPLE LTRGIATIPL QGIDVPFHST FLRGGVRHFR
2010 2020 2030 2040 2050
EFLHENIDKR NINPAKLIGR YIPNVTARSF QISKDYFQYV YDLTGSSQLR
2060 2070 2080
DALKNWDIYE KSNGEESNGV EECSECRNSL
Length:2,080
Mass (Da):232,268
Last modified:February 1, 1997 - v1
Checksum:i424D3C489EF67087
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U73650 Genomic DNA. Translation: AAC62818.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U73650 Genomic DNA. Translation: AAC62818.1 .

3D structure databases

ProteinModelPortali Q92215.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi Q92215.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Enzyme and pathway databases

UniPathwayi UPA00874 .

Family and domain databases

Gene3Di 3.10.129.10. 1 hit.
3.40.366.10. 5 hits.
InterProi IPR001227. Ac_transferase_dom.
IPR014043. Acyl_transferase.
IPR016035. Acyl_Trfase/lysoPLipase.
IPR013565. DUF1729.
IPR003965. Fatty_acid_synthase.
IPR016452. Fatty_acid_Synthase_bsu_fun.
IPR029069. HotDog_dom.
IPR002539. MaoC_dom.
[Graphical view ]
Pfami PF00698. Acyl_transf_1. 1 hit.
PF08354. DUF1729. 1 hit.
PF01575. MaoC_dehydratas. 1 hit.
[Graphical view ]
PIRSFi PIRSF005562. FAS_yeast_beta. 1 hit.
PRINTSi PR01483. FASYNTHASE.
SUPFAMi SSF52151. SSF52151. 5 hits.
SSF54637. SSF54637. 2 hits.
ProtoNeti Search...

Publicationsi

  1. "A fatty acid synthase gene in Cochliobolus carbonum required for production of HC-toxin, cyclo(D-prolyl-L-alanyl-D-alanyl-L-2-amino-9, 10-epoxi-8-oxodecanoyl)."
    Ahn J.-H., Walton J.D.
    Mol. Plant Microbe Interact. 10:207-214(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION.
    Strain: ATCC 90305 / SB111 / 2R15.

Entry informationi

Entry nameiTOXC_COCCA
AccessioniPrimary (citable) accession number: Q92215
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 30, 2003
Last sequence update: February 1, 1997
Last modified: October 1, 2014
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Multifunctional enzyme

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3